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Prolonging healthy aging: Longevity vitamins and proteins.

Ames BN.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10836-10844. doi: 10.1073/pnas.1809045115. Epub 2018 Oct 15. Review.


A novel nutritional intervention improves lung function in overweight/obese adolescents with poorly controlled asthma: the Supplemental Nutrition in Asthma Control (SNAC) pilot study.

Bseikri M, McCann JC, Lal A, Fong E, Graves K, Goldrich A, Block D, Gildengoren GL, Mietus-Snyder M, Shigenaga M, Suh J, Hardy K, Ames BN.

FASEB J. 2018 Jul 19:fj201700338. doi: 10.1096/fj.201700338. [Epub ahead of print]


A multicomponent nutrient bar promotes weight loss and improves dyslipidemia and insulin resistance in the overweight/obese: chronic inflammation blunts these improvements.

McCann JC, Shigenaga MK, Mietus-Snyder ML, Lal A, Suh JH, Krauss RM, Gildengorin GL, Goldrich AM, Block DS, Shenvi SV, McHugh TH, Olson DA, Ames BN.

FASEB J. 2015 Aug;29(8):3287-301. doi: 10.1096/fj.15-271833. Epub 2015 Apr 21.


Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior.

Patrick RP, Ames BN.

FASEB J. 2015 Jun;29(6):2207-22. doi: 10.1096/fj.14-268342. Epub 2015 Feb 24. Review.


Enough is enough.

Frei B, Ames BN, Blumberg JB, Willett WC.

Ann Intern Med. 2014 Jun 3;160(11):807. doi: 10.7326/L14-5011. No abstract available.


Thiol/redox metabolomic profiling implicates GSH dysregulation in early experimental graft versus host disease (GVHD).

Suh JH, Kanathezhath B, Shenvi S, Guo H, Zhou A, Tiwana A, Kuypers F, Ames BN, Walters MC.

PLoS One. 2014 Feb 18;9(2):e88868. doi: 10.1371/journal.pone.0088868. eCollection 2014.


Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism.

Patrick RP, Ames BN.

FASEB J. 2014 Jun;28(6):2398-413. doi: 10.1096/fj.13-246546. Epub 2014 Feb 20. Review.


Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.

Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, Nelson JF, Pletcher S, Simpkins JW, Smith D, Wilkinson JE, Miller RA.

Aging Cell. 2014 Apr;13(2):273-82. doi: 10.1111/acel.12170. Epub 2013 Nov 19.


Analysis of data integrity.

McCann JC, Hudes ML, Ames BN.

Anaesthesia. 2012 Sep;67(9):1042-3. doi: 10.1111/j.1365-2044.2012.07272.x. No abstract available.


A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial.

Mietus-Snyder ML, Shigenaga MK, Suh JH, Shenvi SV, Lal A, McHugh T, Olson D, Lilienstein J, Krauss RM, Gildengoren G, McCann JC, Ames BN.

FASEB J. 2012 Aug;26(8):3515-27. doi: 10.1096/fj.11-201558. Epub 2012 May 1.


Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells.

Wang Y, Moreland M, Wagner JG, Ames BN, Illek B, Peden DB, Jiang Q.

J Nutr Biochem. 2012 Jun;23(6):602-8. doi: 10.1016/j.jnutbio.2011.03.003. Epub 2011 Jul 20.


Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging.

McCann JC, Ames BN.

FASEB J. 2011 Jun;25(6):1793-814. doi: 10.1096/fj.11-180885. Epub 2011 Mar 14. Review.


Association of chromosome damage detected as micronuclei with hematological diseases and micronutrient status.

Lal A, Ames BN.

Mutagenesis. 2011 Jan;26(1):57-62. doi: 10.1093/mutage/geq081. Review.


Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake.

Ames BN.

J Nucleic Acids. 2010 Sep 22;2010. pii: 725071. doi: 10.4061/2010/725071.


Optimal micronutrients delay mitochondrial decay and age-associated diseases.

Ames BN.

Mech Ageing Dev. 2010 Jul-Aug;131(7-8):473-9. doi: 10.1016/j.mad.2010.04.005. Epub 2010 Apr 24. Review.


Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?

McCann JC, Ames BN.

Am J Clin Nutr. 2009 Oct;90(4):889-907. doi: 10.3945/ajcn.2009.27930. Epub 2009 Aug 19. Review.


Clinical assay of four thiol amino acid redox couples by LC-MS/MS: utility in thalassemia.

Suh JH, Kim R, Yavuz B, Lee D, Lal A, Ames BN, Shigenaga MK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 15;877(28):3418-27. doi: 10.1016/j.jchromb.2009.06.041. Epub 2009 Jul 2.


Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats.

Wagner JG, Harkema JR, Jiang Q, Illek B, Ames BN, Peden DB.

Toxicol Pathol. 2009 Jun;37(4):481-91. doi: 10.1177/0192623309335630. Epub 2009 Apr 23.


The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.

Shenk JC, Liu J, Fischbach K, Xu K, Puchowicz M, Obrenovich ME, Gasimov E, Alvarez LM, Ames BN, Lamanna JC, Aliev G.

J Neurol Sci. 2009 Aug 15;283(1-2):199-206. doi: 10.1016/j.jns.2009.03.002. Epub 2009 Apr 1.


A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects.

Jiang Q, Moreland M, Ames BN, Yin X.

J Nutr Biochem. 2009 Nov;20(11):894-900. doi: 10.1016/j.jnutbio.2008.08.004. Epub 2008 Nov 6.


Unusual clustering of coefficients of variation in published articles from a medical biochemistry department in India.

Hudes ML, McCann JC, Ames BN.

FASEB J. 2009 Mar;23(3):689-703. doi: 10.1096/fj.08-108910. Epub 2008 Oct 21.


Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.

Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J.

Neurochem Res. 2009 Apr;34(4):755-63. doi: 10.1007/s11064-008-9850-2. Epub 2008 Oct 10.


Daily supplementation with iron increases lipid peroxidation in young women with low iron stores.

King SM, Donangelo CM, Knutson MD, Walter PB, Ames BN, Viteri FE, King JC.

Exp Biol Med (Maywood). 2008 Jun;233(6):701-7. doi: 10.3181/0708-RM-233. Epub 2008 Apr 11.


Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts.

Killilea DW, Ames BN.

Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5768-73. doi: 10.1073/pnas.0712401105. Epub 2008 Apr 7.


Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.

Aliev G, Liu J, Shenk JC, Fischbach K, Pacheco GJ, Chen SG, Obrenovich ME, Ward WF, Richardson AG, Smith MA, Gasimov E, Perry G, Ames BN.

J Cell Mol Med. 2009 Feb;13(2):320-33. doi: 10.1111/j.1582-4934.2008.00324.x. Epub 2008 Mar 28.


Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts.

Lal A, Atamna W, Killilea DW, Suh JH, Ames BN.

Redox Rep. 2008;13(1):2-10. doi: 10.1179/135100008X259150.


Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction?

McCann JC, Ames BN.

FASEB J. 2008 Apr;22(4):982-1001. Epub 2007 Dec 4. Review.


Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma.

Wagner JG, Jiang Q, Harkema JR, Ames BN, Illek B, Roubey RA, Peden DB.

Clin Exp Allergy. 2008 Mar;38(3):501-11. Epub 2007 Oct 26.


An assay for uracil in human DNA at baseline: effect of marginal vitamin B6 deficiency.

Mashiyama ST, Hansen CM, Roitman E, Sarmiento S, Leklem JE, Shultz TD, Ames BN.

Anal Biochem. 2008 Jan 1;372(1):21-31. Epub 2007 Sep 1.


Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways.

Atamna H, Nguyen A, Schultz C, Boyle K, Newberry J, Kato H, Ames BN.

FASEB J. 2008 Mar;22(3):703-12. Epub 2007 Oct 10.


Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol.

Wagner JG, Jiang Q, Harkema JR, Illek B, Patel DD, Ames BN, Peden DB.

Free Radic Biol Med. 2007 Oct 15;43(8):1176-88. Epub 2007 Jul 20.


Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough.

Ames BN, McCann JC, Stampfer MJ, Willett WC.

Am J Clin Nutr. 2007 Aug;86(2):522-3; author reply 523-4. No abstract available.


Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests.

Milgram NW, Araujo JA, Hagen TM, Treadwell BV, Ames BN.

FASEB J. 2007 Nov;21(13):3756-62. Epub 2007 Jul 10.


5-Methyltetrahydrofolate inhibits photosensitization reactions and strand breaks in DNA.

Offer T, Ames BN, Bailey SW, Sabens EA, Nozawa M, Ayling JE.

FASEB J. 2007 Jul;21(9):2101-7. Epub 2007 Mar 6. Erratum in: FASEB J. 2008 Apr;22(4):1287a-1287. FASEB J. 2008 Apr 1;22(4):1287.


Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid.

Jia L, Liu Z, Sun L, Miller SS, Ames BN, Cotman CW, Liu J.

Invest Ophthalmol Vis Sci. 2007 Jan;48(1):339-48.


Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts.

Atamna H, Newberry J, Erlitzki R, Schultz CS, Ames BN.

J Nutr. 2007 Jan;137(1):25-30.


Chronic ethanol perturbs testicular folate metabolism and dietary folate deficiency reduces sex hormone levels in the Yucatan micropig.

Wallock-Montelius LM, Villanueva JA, Chapin RE, Conley AJ, Nguyen HP, Ames BN, Halsted CH.

Biol Reprod. 2007 Mar;76(3):455-65. Epub 2006 Dec 6.


An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring.

McCann JC, Hudes M, Ames BN.

Neurosci Biobehav Rev. 2006;30(5):696-712. Epub 2006 Feb 28. Review.


Measuring chromosome breaks in patients with thalassemia.

Offer T, Bhagat A, Lal A, Atamna W, Singer ST, Vichinsky EP, Kuypers FA, Ames BN.

Ann N Y Acad Sci. 2005;1054:439-44.


The case for strategic international alliances to harness nutritional genomics for public and personal health.

Kaput J, Ordovas JM, Ferguson L, van Ommen B, Rodriguez RL, Allen L, Ames BN, Dawson K, German B, Krauss R, Malyj W, Archer MC, Barnes S, Bartholomew A, Birk R, van Bladeren P, Bradford KJ, Brown KH, Caetano R, Castle D, Chadwick R, Clarke S, Clément K, Cooney CA, Corella D, Manica da Cruz IB, Daniel H, Duster T, Ebbesson SO, Elliott R, Fairweather-Tait S, Felton J, Fenech M, Finley JW, Fogg-Johnson N, Gill-Garrison R, Gibney MJ, Gillies PJ, Gustafsson JA, Hartman JL 4th, He L, Hwang JK, Jais JP, Jang Y, Joost H, Junien C, Kanter M, Kibbe WA, Koletzko B, Korf BR, Kornman K, Krempin DW, Langin D, Lauren DR, Ho Lee J, Leveille GA, Lin SJ, Mathers J, Mayne M, McNabb W, Milner JA, Morgan P, Muller M, Nikolsky Y, van der Ouderaa F, Park T, Pensel N, Perez-Jimenez F, Poutanen K, Roberts M, Saris WH, Schuster G, Shelling AN, Simopoulos AP, Southon S, Tai ES, Towne B, Trayhurn P, Uauy R, Visek WJ, Warden C, Weiss R, Wiencke J, Winkler J, Wolff GL, Zhao-Wilson X, Zucker JD.

Br J Nutr. 2005 Nov;94(5):623-32. Review.


(R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage.

Voloboueva LA, Liu J, Suh JH, Ames BN, Miller SS.

Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4302-10.


Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging.

Ames BN, Atamna H, Killilea DW.

Mol Aspects Med. 2005 Aug-Oct;26(4-5):363-78. Review.


Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning.

Kadiiska MB, Gladen BC, Baird DD, Graham LB, Parker CE, Ames BN, Basu S, Fitzgerald GA, Lawson JA, Marnett LJ, Morrow JD, Murray DM, Plastaras J, Roberts LJ 2nd, Rokach J, Shigenaga MK, Sun J, Walter PB, Tomer KB, Barrett JC, Mason RP.

Free Radic Biol Med. 2005 Mar 15;38(6):711-8.


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