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Items: 1 to 50 of 152


Targeted TNF-α Overexpression Drives Salivary Gland Inflammation.

Limaye A, Hall BE, Zhang L, Cho A, Prochazkova M, Zheng C, Walker M, Adewusi F, Burbelo PD, Sun ZJ, Ambudkar IS, Dolan JC, Schmidt BL, Kulkarni AB.

J Dent Res. 2019 Jun;98(6):713-719. doi: 10.1177/0022034519837240. Epub 2019 Apr 8.


Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity.

Emrich SM, Yoast RE, Xin P, Zhang X, Pathak T, Nwokonko R, Gueguinou MF, Subedi KP, Zhou Y, Ambudkar IS, Hempel N, Machaca K, Gill DL, Trebak M.

J Biol Chem. 2019 Apr 19;294(16):6318-6332. doi: 10.1074/jbc.RA118.006801. Epub 2019 Mar 1.


Tuning store-operated calcium entry to modulate Ca2+-dependent physiological processes.

Ong HL, Subedi KP, Son GY, Liu X, Ambudkar IS.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1037-1045. doi: 10.1016/j.bbamcr.2018.11.018. Epub 2018 Dec 3. Review.


STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions.

Subedi KP, Ong HL, Son GY, Liu X, Ambudkar IS.

Cell Rep. 2018 Apr 10;23(2):522-534. doi: 10.1016/j.celrep.2018.03.065.


STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function.

Ong HL, Ambudkar IS.

Adv Exp Med Biol. 2017;993:159-188. doi: 10.1007/978-3-319-57732-6_9. Review.


Radiation inhibits salivary gland function by promoting STIM1 cleavage by caspase-3 and loss of SOCE through a TRPM2-dependent pathway.

Liu X, Gong B, de Souza LB, Ong HL, Subedi KP, Cheng KT, Swaim W, Zheng C, Mori Y, Ambudkar IS.

Sci Signal. 2017 Jun 6;10(482). pii: eaal4064. doi: 10.1126/scisignal.aal4064.


TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces.

Ambudkar IS, de Souza LB, Ong HL.

Cell Calcium. 2017 May;63:33-39. doi: 10.1016/j.ceca.2016.12.009. Epub 2016 Dec 30. Review.


Assembly of ER-PM Junctions: A Critical Determinant in the Regulation of SOCE and TRPC1.

Subedi KP, Ong HL, Ambudkar IS.

Adv Exp Med Biol. 2017;981:253-276. doi: 10.1007/978-3-319-55858-5_11.


ROS in Ca(2+) signaling and disease-part 2.

Ambudkar IS, Muallem S.

Cell Calcium. 2016 Sep;60(3):153-4. doi: 10.1016/j.ceca.2016.08.001. Epub 2016 Aug 9. No abstract available.


ROS and Ca(2+)-Partners in sickness and in health.

Ambudkar IS, Muallem S.

Cell Calcium. 2016 Aug;60(2):51-4. doi: 10.1016/j.ceca.2016.06.003. Epub 2016 Jun 15. No abstract available.


Role of TRPC Channels in Store-Operated Calcium Entry.

Ong HL, de Souza LB, Ambudkar IS.

Adv Exp Med Biol. 2016;898:87-109. doi: 10.1007/978-3-319-26974-0_5. Review.


Adenovirus-mediated hAQP1 expression in irradiated mouse salivary glands causes recovery of saliva secretion by enhancing acinar cell volume decrease.

Teos LY, Zheng CY, Liu X, Swaim WD, Goldsmith CM, Cotrim AP, Baum BJ, Ambudkar IS.

Gene Ther. 2016 Jul;23(7):572-9. doi: 10.1038/gt.2016.29. Epub 2016 Mar 11.


Up-regulation of Store-operated Ca2+ Entry and Nuclear Factor of Activated T Cells Promote the Acinar Phenotype of the Primary Human Salivary Gland Cells.

Jang SI, Ong HL, Liu X, Alevizos I, Ambudkar IS.

J Biol Chem. 2016 Apr 15;291(16):8709-20. doi: 10.1074/jbc.M115.701607. Epub 2016 Feb 22.


Calcium signalling in salivary gland physiology and dysfunction.

Ambudkar IS.

J Physiol. 2016 Jun 1;594(11):2813-24. doi: 10.1113/JP271143. Epub 2015 Dec 15. Review.


IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome.

Teos LY, Zhang Y, Cotrim AP, Swaim W, Won JH, Ambrus J, Shen L, Bebris L, Grisius M, Jang SI, Yule DI, Ambudkar IS, Alevizos I.

Sci Rep. 2015 Sep 14;5:13953. doi: 10.1038/srep13953.


Fast endocytic recycling determines TRPC1-STIM1 clustering in ER-PM junctions and plasma membrane function of the channel.

de Souza LB, Ong HL, Liu X, Ambudkar IS.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2709-21. doi: 10.1016/j.bbamcr.2015.07.019. Epub 2015 Jul 30.


Persistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter.

Zheng C, Baum BJ, Liu X, Goldsmith CM, Perez P, Jang SI, Cotrim AP, McCullagh L, Ambudkar IS, Alevizos I.

Gene Ther. 2015 Sep;22(9):758-66. doi: 10.1038/gt.2015.55. Epub 2015 Jul 16.


Revealing the fate of cell surface human P-glycoprotein (ABCB1): The lysosomal degradation pathway.

Katayama K, Kapoor K, Ohnuma S, Patel A, Swaim W, Ambudkar IS, Ambudkar SV.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2361-70. doi: 10.1016/j.bbamcr.2015.06.001. Epub 2015 Jun 6.


Molecular determinants of TRPC1 regulation within ER-PM junctions.

Ong HL, Ambudkar IS.

Cell Calcium. 2015 Oct;58(4):376-86. doi: 10.1016/j.ceca.2015.03.008. Epub 2015 Apr 10. Review.


STIM2 enhances receptor-stimulated Ca²⁺ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions.

Ong HL, de Souza LB, Zheng C, Cheng KT, Liu X, Goldsmith CM, Feske S, Ambudkar IS.

Sci Signal. 2015 Jan 13;8(359):ra3. doi: 10.1126/scisignal.2005748. Erratum in: Sci Signal. 2015 Feb 3;8(362):er2.


TRPC1 contributes to the Ca2+-dependent regulation of adenylate cyclases.

Willoughby D, Ong HL, De Souza LB, Wachten S, Ambudkar IS, Cooper DM.

Biochem J. 2014 Nov 15;464(1):73-84. doi: 10.1042/BJ20140766.


Trafficking mechanisms and regulation of TRPC channels.

de Souza LB, Ambudkar IS.

Cell Calcium. 2014 Aug;56(2):43-50. doi: 10.1016/j.ceca.2014.05.001. Epub 2014 May 26. Review.


Physiological functions and regulation of TRPC channels.

Ong HL, de Souza LB, Cheng KT, Ambudkar IS.

Handb Exp Pharmacol. 2014;223:1005-34. doi: 10.1007/978-3-319-05161-1_12. Review.


Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca(2+) channel sulfhydration.

Liu Y, Yang R, Liu X, Zhou Y, Qu C, Kikuiri T, Wang S, Zandi E, Du J, Ambudkar IS, Shi S.

Cell Stem Cell. 2014 Jul 3;15(1):66-78. doi: 10.1016/j.stem.2014.03.005. Epub 2014 Apr 10.


Ca²⁺ signaling and regulation of fluid secretion in salivary gland acinar cells.

Ambudkar IS.

Cell Calcium. 2014 Jun;55(6):297-305. doi: 10.1016/j.ceca.2014.02.009. Epub 2014 Feb 19. Review.


Matriptase deletion initiates a Sjögren's syndrome-like disease in mice.

Yin H, Kosa P, Liu X, Swaim WD, Lai Z, Cabrera-Perez J, Di Pasquale G, Ambudkar IS, Bugge TH, Chiorini JA.

PLoS One. 2014 Feb 13;9(2):e82852. doi: 10.1371/journal.pone.0082852. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e98331.


TRPC1: getting physical in space.

Ambudkar IS.

Cell Cycle. 2013 Nov 1;12(21):3355-6. doi: 10.4161/cc.26637. Epub 2013 Sep 27. Review. No abstract available.


Contribution and regulation of TRPC channels in store-operated Ca2+ entry.

Cheng KT, Ong HL, Liu X, Ambudkar IS.

Curr Top Membr. 2013;71:149-79. doi: 10.1016/B978-0-12-407870-3.00007-X. Review.


Active secretion and protective effect of salivary nitrate against stress in human volunteers and rats.

Jin L, Qin L, Xia D, Liu X, Fan Z, Zhang C, Gu L, He J, Ambudkar IS, Deng D, Wang S.

Free Radic Biol Med. 2013 Apr;57:61-7. doi: 10.1016/j.freeradbiomed.2012.12.015. Epub 2012 Dec 28.


Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1.

Pani B, Liu X, Bollimuntha S, Cheng KT, Niesman IR, Zheng C, Achen VR, Patel HH, Ambudkar IS, Singh BB.

J Cell Sci. 2013 Jan 15;126(Pt 2):667-75. doi: 10.1242/jcs.118943. Epub 2012 Nov 30.


Distinct contributions of Orai1 and TRPC1 to agonist-induced [Ca(2+)](i) signals determine specificity of Ca(2+)-dependent gene expression.

Ong HL, Jang SI, Ambudkar IS.

PLoS One. 2012;7(10):e47146. doi: 10.1371/journal.pone.0047146. Epub 2012 Oct 24.


Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients.

Lodola F, Laforenza U, Bonetti E, Lim D, Dragoni S, Bottino C, Ong HL, Guerra G, Ganini C, Massa M, Manzoni M, Ambudkar IS, Genazzani AA, Rosti V, Pedrazzoli P, Tanzi F, Moccia F, Porta C.

PLoS One. 2012;7(9):e42541. doi: 10.1371/journal.pone.0042541. Epub 2012 Sep 25.


STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome.

Cheng KT, Alevizos I, Liu X, Swaim WD, Yin H, Feske S, Oh-hora M, Ambudkar IS.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14544-9. doi: 10.1073/pnas.1207354109. Epub 2012 Aug 17. Erratum in: Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18625.


Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane.

Qin L, Liu X, Sun Q, Fan Z, Xia D, Ding G, Ong HL, Adams D, Gahl WA, Zheng C, Qi S, Jin L, Zhang C, Gu L, He J, Deng D, Ambudkar IS, Wang S.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13434-9. doi: 10.1073/pnas.1116633109. Epub 2012 Jul 9.


Extracellular Ca(2+) sensing in salivary ductal cells.

Bandyopadhyay BC, Swaim WD, Sarkar A, Liu X, Ambudkar IS.

J Biol Chem. 2012 Aug 31;287(36):30305-16. doi: 10.1074/jbc.M112.394122. Epub 2012 Jul 9.


Proteomic Analysis of TRPC Channels.

Lockwich T, Makusky A, Kowalak JA, Markey SP, Ambudkar IS.

In: Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 5.


Heteromeric TRPV4-C1 channels contribute to store-operated Ca(2+) entry in vascular endothelial cells.

Ma X, Cheng KT, Wong CO, O'Neil RG, Birnbaumer L, Ambudkar IS, Yao X.

Cell Calcium. 2011 Dec;50(6):502-9. doi: 10.1016/j.ceca.2011.08.006. Epub 2011 Sep 18.


Ion channels and transporters in cancer. 6. Vascularizing the tumor: TRP channels as molecular targets.

Fiorio Pla A, Avanzato D, Munaron L, Ambudkar IS.

Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C9-15. doi: 10.1152/ajpcell.00280.2011. Epub 2011 Aug 10. Review.


The dynamic complexity of the TRPC1 channelosome.

Ong HL, Ambudkar IS.

Channels (Austin). 2011 Sep-Oct;5(5):424-31. doi: 10.4161/chan.5.5.16471. Epub 2011 Sep 1. Review.


TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling.

Fiorio Pla A, Ong HL, Cheng KT, Brossa A, Bussolati B, Lockwich T, Paria B, Munaron L, Ambudkar IS.

Oncogene. 2012 Jan 12;31(2):200-12. doi: 10.1038/onc.2011.231. Epub 2011 Jun 20.


Dissection of calcium signaling events in exocrine secretion.

Ambudkar IS.

Neurochem Res. 2011 Jul;36(7):1212-21. doi: 10.1007/s11064-011-0465-7. Epub 2011 May 2. Review.


Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions.

Cheng KT, Liu X, Ong HL, Swaim W, Ambudkar IS.

PLoS Biol. 2011 Mar;9(3):e1001025. doi: 10.1371/journal.pbio.1001025. Epub 2011 Mar 8.


Contribution of TRPC1 and Orai1 to Ca(2+) entry activated by store depletion.

Cheng KT, Ong HL, Liu X, Ambudkar IS.

Adv Exp Med Biol. 2011;704:435-49. doi: 10.1007/978-94-007-0265-3_24. Review.


Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells.

Hong JH, Li Q, Kim MS, Shin DM, Feske S, Birnbaumer L, Cheng KT, Ambudkar IS, Muallem S.

Traffic. 2011 Feb;12(2):232-45. doi: 10.1111/j.1600-0854.2010.01138.x. Epub 2010 Nov 24.


Depletion of intracellular Ca2+ stores stimulates the translocation of vanilloid transient receptor potential 4-c1 heteromeric channels to the plasma membrane.

Ma X, Cao J, Luo J, Nilius B, Huang Y, Ambudkar IS, Yao X.

Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2249-55. doi: 10.1161/ATVBAHA.110.212084. Epub 2010 Aug 12.


Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function.

Hall BE, Zheng C, Swaim WD, Cho A, Nagineni CN, Eckhaus MA, Flanders KC, Ambudkar IS, Baum BJ, Kulkarni AB.

Lab Invest. 2010 Apr;90(4):543-55. doi: 10.1038/labinvest.2010.5. Epub 2010 Feb 8.


Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.

Pani B, Ong HL, Brazer SC, Liu X, Rauser K, Singh BB, Ambudkar IS.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20087-92. doi: 10.1073/pnas.0905002106. Epub 2009 Nov 6.


Unraveling smooth muscle contraction: the TRP link.

Ambudkar IS.

Gastroenterology. 2009 Oct;137(4):1211-4. doi: 10.1053/j.gastro.2009.08.025. Epub 2009 Aug 28. No abstract available.


TRPC3 controls agonist-stimulated intracellular Ca2+ release by mediating the interaction between inositol 1,4,5-trisphosphate receptor and RACK1.

Bandyopadhyay BC, Ong HL, Lockwich TP, Liu X, Paria BC, Singh BB, Ambudkar IS.

J Biol Chem. 2008 Nov 21;283(47):32821-30. doi: 10.1074/jbc.M805382200. Epub 2008 Aug 28.

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