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Items: 1 to 50 of 118

1.

Potent in vitro activity of β-D-4'-chloromethyl-2'-deoxy-2'-fluorocytidine against Nipah virus.

Lo MK, Amblard F, Flint M, Chatterjee P, Kasthuri M, Li C, Russell O, Verma K, Bassit L, Schinazi RF, Nichol ST, Spiropoulou CF.

Antiviral Res. 2020 Mar;175:104712. doi: 10.1016/j.antiviral.2020.104712. Epub 2020 Jan 11.

PMID:
31935422
2.

Super-resolution provided by the arbitrarily strong superlinearity of the blackbody radiation.

Graciani G, Amblard F.

Nat Commun. 2019 Dec 17;10(1):5761. doi: 10.1038/s41467-019-13780-4.

3.

Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice.

Amblard F, Boucle S, Bassit L, Cox B, Sari O, Tao S, Chen Z, Ozturk T, Verma K, Russell O, Rat V, de Rocquigny H, Fiquet O, Boussand M, Di Santo J, Strick-Marchand H, Schinazi RF.

Antimicrob Agents Chemother. 2020 Jan 27;64(2). pii: e01701-19. doi: 10.1128/AAC.01701-19. Print 2020 Jan 27.

PMID:
31712213
4.

Intracellular metabolism and potential cardiotoxicity of a β-D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication.

Tao S, Zhou L, Zhang H, Zhou S, Amiralaei S, Shelton J, Ehteshami M, Jiang Y, Amblard F, Coats SJ, Schinazi RF.

Nucleosides Nucleotides Nucleic Acids. 2019 Oct 9:1-21. doi: 10.1080/15257770.2019.1671594. [Epub ahead of print]

PMID:
31595843
5.

Synthesis of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their monophosphate prodrugs.

Cho JH, Bassit LC, Amblard F, Schinazi RF.

Nucleosides Nucleotides Nucleic Acids. 2019 Oct 7:1-17. doi: 10.1080/15257770.2019.1674333. [Epub ahead of print]

PMID:
31588837
6.

Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection.

Zhang H, Zhou L, Amichai S, Zandi K, Cox B, Schinazi R, Amblard F.

Bioorg Med Chem Lett. 2019 Oct 15;29(20):126639. doi: 10.1016/j.bmcl.2019.126639. Epub 2019 Aug 24.

PMID:
31493987
7.

Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.

Zandi K, Amblard F, Amichai S, Bassit L, Tao S, Jiang Y, Zhou L, Ollinger Russell O, Mengshetti S, Schinazi RF.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00889-19. doi: 10.1128/AAC.00889-19. Print 2019 Sep.

8.

Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses.

Zandi K, Bassit L, Amblard F, Cox BD, Hassandarvish P, Moghaddam E, Yueh A, Libanio Rodrigues GO, Passos I, Costa VV, AbuBakar S, Zhou L, Kohler J, Teixeira MM, Schinazi RF.

Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00397-19. doi: 10.1128/AAC.00397-19. Print 2019 Jul.

9.

Whole genome paired-end sequencing elucidates functional and phenotypic consequences of balanced chromosomal rearrangement in patients with developmental disorders.

Schluth-Bolard C, Diguet F, Chatron N, Rollat-Farnier PA, Bardel C, Afenjar A, Amblard F, Amiel J, Blesson S, Callier P, Capri Y, Collignon P, Cordier MP, Coubes C, Demeer B, Chaussenot A, Demurger F, Devillard F, Doco-Fenzy M, Dupont C, Dupont JM, Dupuis-Girod S, Faivre L, Gilbert-Dussardier B, Guerrot AM, Houlier M, Isidor B, Jaillard S, Joly-Hélas G, Kremer V, Lacombe D, Le Caignec C, Lebbar A, Lebrun M, Lesca G, Lespinasse J, Levy J, Malan V, Mathieu-Dramard M, Masson J, Masurel-Paulet A, Mignot C, Missirian C, Morice-Picard F, Moutton S, Nadeau G, Pebrel-Richard C, Odent S, Paquis-Flucklinger V, Pasquier L, Philip N, Plutino M, Pons L, Portnoï MF, Prieur F, Puechberty J, Putoux A, Rio M, Rooryck-Thambo C, Rossi M, Sarret C, Satre V, Siffroi JP, Till M, Touraine R, Toutain A, Toutain J, Valence S, Verloes A, Whalen S, Edery P, Tabet AC, Sanlaville D.

J Med Genet. 2019 Aug;56(8):526-535. doi: 10.1136/jmedgenet-2018-105778. Epub 2019 Mar 28.

PMID:
30923172
10.

Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".

Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A.

J Virol. 2019 Jan 17;93(3). pii: e01814-18. doi: 10.1128/JVI.01814-18. Print 2019 Feb 1. No abstract available.

11.

Synthesis and anti-HCV activity of β-d-2'-deoxy-2'-α-chloro-2'-β-fluoro and β-d-2'-deoxy-2'-α-bromo-2'-β-fluoro nucleosides and their phosphoramidate prodrugs.

Ovadia R, Khalil A, Li H, De Schutter C, Mengshetti S, Zhou S, Bassit L, Coats SJ, Amblard F, Schinazi RF.

Bioorg Med Chem. 2019 Feb 15;27(4):664-676. doi: 10.1016/j.bmc.2019.01.005. Epub 2019 Jan 9.

12.

Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.

Mengshetti S, Zhou L, Sari O, De Schutter C, Zhang H, Cho JH, Tao S, Bassit LC, Verma K, Domaoal RA, Ehteshami M, Jiang Y, Ovadia R, Kasthuri M, Ollinger Russell O, McBrayer T, Whitaker T, Pattassery J, Pascual ML, Uher L, Lin BY, Lee S, Amblard F, Coats SJ, Schinazi RF.

J Med Chem. 2019 Feb 28;62(4):1859-1874. doi: 10.1021/acs.jmedchem.8b01300. Epub 2019 Feb 7.

PMID:
30653317
13.

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease.

Muzzarelli KM, Kuiper B, Spellmon N, Brunzelle J, Hackett J, Amblard F, Zhou S, Liu P, Kovari IA, Yang Z, Schinazi RF, Kovari LC.

Biochemistry. 2019 Feb 19;58(7):900-907. doi: 10.1021/acs.biochem.8b01063. Epub 2019 Jan 16.

PMID:
30605321
14.

Deep line-temporal focusing with high axial resolution and a large field-of-view using intracavity control and incoherent pulse shaping.

Lou K, Wang B, Jee AY, Granick S, Amblard F.

Opt Lett. 2018 Oct 15;43(20):4919-4922. doi: 10.1364/OL.43.004919.

PMID:
30320783
15.

Genomic duplication in the 19q13.42 imprinted region identified as a new genetic cause of intrauterine growth restriction.

Petre G, Lorès P, Sartelet H, Truffot A, Poreau B, Brandeis S, Martinez G, Satre V, Harbuz R, Ray PF, Amblard F, Devillard F, Vieville G, Berger F, Jouk PS, Vaiman D, Touré A, Coutton C, Bidart M.

Clin Genet. 2018 Dec;94(6):575-580. doi: 10.1111/cge.13449. Epub 2018 Oct 17.

PMID:
30221343
16.

Substrate curvature affects the shape, orientation, and polarization of renal epithelial cells.

Yu SM, Oh JM, Lee J, Lee-Kwon W, Jung W, Amblard F, Granick S, Cho YK.

Acta Biomater. 2018 Sep 1;77:311-321. doi: 10.1016/j.actbio.2018.07.019. Epub 2018 Jul 11.

PMID:
30006316
17.

Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques.

Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A.

J Virol. 2018 Aug 29;92(18). pii: e00562-18. doi: 10.1128/JVI.00562-18. Print 2018 Sep 15. Erratum in: J Virol. 2019 Jan 17;93(3):.

18.

How to better focus waves by considering symmetry and information loss.

Lou K, Granick S, Amblard F.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6554-6559. doi: 10.1073/pnas.1803652115. Epub 2018 Jun 13.

19.

Microtopographies control the development of basal protrusions in epithelial sheets.

Coscoy S, Baiz S, Octon J, Rhoné B, Perquis L, Tseng Q, Amblard F, Semetey V.

Biointerphases. 2018 Jun 8;13(4):041003. doi: 10.1116/1.5024601.

PMID:
29884026
20.

Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors.

Amblard F, Zhou S, Liu P, Yoon J, Cox B, Muzzarelli K, Kuiper BD, Kovari LC, Schinazi RF.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2165-2170. doi: 10.1016/j.bmcl.2018.05.012. Epub 2018 May 8.

21.

Expression, Purification and Characterization of a GII.4 Norovirus Protease from Minerva Virus.

Kuiper BD, Muzzarelli KM, Keusch BJ, Holcomb J, Amblard F, Liu P, Zhou S, Kovari IA, Yang Z, Schinazi RF, Kovari LC.

Infect Disord Drug Targets. 2018;18(3):224-232. doi: 10.2174/1871526518666180521091158.

PMID:
29779487
22.

Is sperm FISH analysis still useful for Robertsonian translocations? Meiotic analysis for 23 patients and review of the literature.

Lamotte A, Martinez G, Devillard F, Hograindleur JP, Satre V, Coutton C, Harbuz R, Amblard F, Lespinasse J, Benchaib M, Bessonnat J, Brouillet S, Hennebicq S.

Basic Clin Androl. 2018 May 7;28:5. doi: 10.1186/s12610-018-0069-z. eCollection 2018.

23.

[A specialised consultation for children and young adults with trisomy 21].

Amblard F, Devillard F, Dumortier L, Bricout VA.

Soins Pediatr Pueric. 2018 May - Jun;39(302):36-39. doi: 10.1016/j.spp.2018.03.008. French.

PMID:
29747770
24.

Engineering small tubes with changes in diameter for the study of kidney cell organization.

Venzac B, Madoun R, Benarab T, Monnier S, Cayrac F, Myram S, Leconte L, Amblard F, Viovy JL, Descroix S, Coscoy S.

Biomicrofluidics. 2018 Apr 3;12(2):024114. doi: 10.1063/1.5025027. eCollection 2018 Mar.

25.

Synthesis of (2S)-2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination.

De Schutter C, Sari O, Coats SJ, Amblard F, Schinazi RF.

J Org Chem. 2017 Dec 15;82(24):13171-13178. doi: 10.1021/acs.joc.7b02245. Epub 2017 Dec 4.

PMID:
29140703
26.

Synthesis and anti-HCV activity of a series of β-d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs.

Chen Z, Cox BD, Garnier-Amblard EC, McBrayer TR, Coats SJ, Schinazi RF, Amblard F.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5296-5299. doi: 10.1016/j.bmcl.2017.10.024. Epub 2017 Oct 12.

27.

Metabolism of Nucleosides and Nucleotides Prodrugs.

De Schutter C, Ehteshami M, Hammond ET, Amblard F, Schinazi RF.

Curr Pharm Des. 2017 Oct 11. doi: 10.2174/1381612823666171011104158. [Epub ahead of print]

PMID:
29022511
28.

Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector.

Sari O, Boucle S, Cox BD, Ozturk T, Russell OO, Bassit L, Amblard F, Schinazi RF.

Eur J Med Chem. 2017 Sep 29;138:407-421. doi: 10.1016/j.ejmech.2017.06.062. Epub 2017 Jun 29.

29.

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.

Zhou S, Mahmoud S, Liu P, Zhou L, Ehteshami M, Bassit L, Tao S, Domaoal RA, Sari O, Schutter C, Amiralaei S, Khalil A, Ollinger Russell O, McBrayer T, Whitaker T, Abou-Taleb N, Amblard F, Coats SJ, Schinazi RF.

J Med Chem. 2017 Jul 13;60(13):5424-5437. doi: 10.1021/acs.jmedchem.7b00067. Epub 2017 Jun 26.

PMID:
28595015
30.

Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.

Ehteshami M, Zhou L, Amiralaei S, Shelton JR, Cho JH, Zhang H, Li H, Lu X, Ozturk T, Stanton R, Amblard F, McBrayer TR, Coats SJ, Schinazi RF.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00492-17. doi: 10.1128/AAC.00492-17. Print 2017 Aug.

31.

Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease.

Kuiper BD, Slater K, Spellmon N, Holcomb J, Medapureddy P, Muzzarelli KM, Yang Z, Ovadia R, Amblard F, Kovari IA, Schinazi RF, Kovari LC.

Biochem Biophys Res Commun. 2017 Oct 28;492(4):668-673. doi: 10.1016/j.bbrc.2017.03.108. Epub 2017 Mar 22.

PMID:
28342876
32.

PBX1 haploinsufficiency leads to syndromic congenital anomalies of the kidney and urinary tract (CAKUT) in humans.

Le Tanno P, Breton J, Bidart M, Satre V, Harbuz R, Ray PF, Bosson C, Dieterich K, Jaillard S, Odent S, Poke G, Beddow R, Digilio MC, Novelli A, Bernardini L, Pisanti MA, Mackenroth L, Hackmann K, Vogel I, Christensen R, Fokstuen S, Béna F, Amblard F, Devillard F, Vieville G, Apostolou A, Jouk PS, Guebre-Egziabher F, Sartelet H, Coutton C.

J Med Genet. 2017 Jul;54(7):502-510. doi: 10.1136/jmedgenet-2016-104435. Epub 2017 Mar 7.

PMID:
28270404
33.

Synthesis and antiviral evaluation of 2',2',3',3'-tetrafluoro nucleoside analogs.

Sari O, Bassit L, Gavegnano C, McBrayer TR, McCormick L, Cox B, Coats SJ, Amblard F, Schinazi RF.

Tetrahedron Lett. 2017 Feb 15;58(7):642-644. doi: 10.1016/j.tetlet.2017.01.006. Epub 2017 Jan 4.

34.

Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.

Ehteshami M, Tao S, Zandi K, Hsiao HM, Jiang Y, Hammond E, Amblard F, Russell OO, Merits A, Schinazi RF.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02395-16. doi: 10.1128/AAC.02395-16. Print 2017 Apr.

35.

Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors.

Boucle S, Lu X, Bassit L, Ozturk T, Russell OO, Amblard F, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):904-910. doi: 10.1016/j.bmcl.2017.01.010. Epub 2017 Jan 6.

36.

Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs.

Shelton J, Lu X, Hollenbaugh JA, Cho JH, Amblard F, Schinazi RF.

Chem Rev. 2016 Dec 14;116(23):14379-14455. Epub 2016 Nov 23. Review.

PMID:
27960273
37.

Microduplication of the ARID1A gene causes intellectual disability with recognizable syndromic features.

Bidart M, El Atifi M, Miladi S, Rendu J, Satre V, Ray PF, Bosson C, Devillard F, Lehalle D, Malan V, Amiel J, Mencarelli MA, Baldassarri M, Renieri A, Clayton-Smith J, Vieville G, Thevenon J, Amblard F, Berger F, Jouk PS, Coutton C.

Genet Med. 2017 Jun;19(6):701-710. doi: 10.1038/gim.2016.180. Epub 2016 Dec 1.

PMID:
27906199
38.

Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates.

Mahmoud S, Li H, McBrayer TR, Bassit L, Hammad SF, Coats SJ, Amblard F, Schinazi RF.

Nucleosides Nucleotides Nucleic Acids. 2017 Jan 2;36(1):66-82. doi: 10.1080/15257770.2016.1218023. Epub 2016 Oct 19.

PMID:
27759481
39.

Polycystins and intercellular mechanotransduction: A precise dosage of polycystin 2 is necessary for alpha-actinin reinforcement of junctions upon mechanical stimulation.

Bhoonderowa L, Hameurlaine F, Arbabian A, Faqir F, Amblard F, Coscoy S.

Exp Cell Res. 2016 Oct 15;348(1):23-35. doi: 10.1016/j.yexcr.2016.08.021. Epub 2016 Aug 26.

PMID:
27575580
40.

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.

Ehteshami M, Tao S, Ozturk T, Zhou L, Cho JH, Zhang H, Amiralaei S, Shelton JR, Lu X, Khalil A, Domaoal RA, Stanton RA, Suesserman JE, Lin B, Lee SS, Amblard F, Whitaker T, Coats SJ, Schinazi RF.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4659-69. doi: 10.1128/AAC.00318-16. Print 2016 Aug.

41.

Patients with multiple morphological abnormalities of the sperm flagella due to DNAH1 mutations have a good prognosis following intracytoplasmic sperm injection.

Wambergue C, Zouari R, Fourati Ben Mustapha S, Martinez G, Devillard F, Hennebicq S, Satre V, Brouillet S, Halouani L, Marrakchi O, Makni M, Latrous H, Kharouf M, Amblard F, Arnoult C, Ray PF, Coutton C.

Hum Reprod. 2016 Jun;31(6):1164-72. doi: 10.1093/humrep/dew083. Epub 2016 Apr 19.

PMID:
27094479
42.

Pregnancy outcomes in prenatally diagnosed 47, XXX and 47, XYY syndromes: a 30-year French, retrospective, multicentre study.

Gruchy N, Blondeel E, Le Meur N, Joly-Hélas G, Chambon P, Till M, Herbaux M, Vigouroux-Castera A, Coussement A, Lespinasse J, Amblard F, Jimenez Pocquet M, Lebel-Roy C, Carré-Pigeon F, Flori E, Mugneret F, Jaillard S, Yardin C, Harbuz R, Collonge-Rame MA, Vago P, Valduga M, Leporrier N, Vialard F.

Prenat Diagn. 2016 Jun;36(6):523-9. doi: 10.1002/pd.4817. Epub 2016 May 10.

PMID:
27018091
43.

Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.

Zhou L, Zhang H, Tao S, Ehteshami M, Cho JH, McBrayer TR, Tharnish P, Whitaker T, Amblard F, Coats SJ, Schinazi RF.

ACS Med Chem Lett. 2015 Nov 23;7(1):17-22. doi: 10.1021/acsmedchemlett.5b00402. eCollection 2016 Jan 14.

44.

Microdeletion del(22)(q12.1) excluding the MN1 gene in a patient with craniofacial anomalies.

Bosson C, Devillard F, Satre V, Dieterich K, Ray PF, Morand B, Dubois-Teklali F, Vieville G, Andrieux J, Brouillet S, Amblard F, Jouk PS, Coutton C.

Am J Med Genet A. 2016 Feb;170A(2):498-503. doi: 10.1002/ajmg.a.37450. Epub 2015 Nov 6.

PMID:
26545049
45.

A French multicenter study of over 700 patients with 22q11 deletions diagnosed using FISH or aCGH.

Poirsier C, Besseau-Ayasse J, Schluth-Bolard C, Toutain J, Missirian C, Le Caignec C, Bazin A, de Blois MC, Kuentz P, Catty M, Choiset A, Plessis G, Basinko A, Letard P, Flori E, Jimenez M, Valduga M, Landais E, Lallaoui H, Cartault F, Lespinasse J, Martin-Coignard D, Callier P, Pebrel-Richard C, Portnoi MF, Busa T, Receveur A, Amblard F, Yardin C, Harbuz R, Prieur F, Le Meur N, Pipiras E, Kleinfinger P, Vialard F, Doco-Fenzy M.

Eur J Hum Genet. 2016 Jun;24(6):844-51. doi: 10.1038/ejhg.2015.219. Epub 2015 Oct 28.

46.

Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.

Boucle S, Tao S, Amblard F, Stanton RA, Nettles JH, Li C, McBrayer TR, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3711-5. doi: 10.1016/j.bmcl.2015.06.031. Epub 2015 Jun 15.

47.

Mechanosensitive Adaptation of E-Cadherin Turnover across adherens Junctions.

de Beco S, Perney JB, Coscoy S, Amblard F.

PLoS One. 2015 Jun 5;10(6):e0128281. doi: 10.1371/journal.pone.0128281. eCollection 2015.

48.

β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.

Zhou L, Zhang HW, Tao S, Bassit L, Whitaker T, McBrayer TR, Ehteshami M, Amiralaei S, Pradere U, Cho JH, Amblard F, Bobeck D, Detorio M, Coats SJ, Schinazi RF.

J Med Chem. 2015 Apr 23;58(8):3445-58. doi: 10.1021/jm501874e. Epub 2015 Apr 7.

PMID:
25849312
49.

Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.

Cho JH, Bondana L, Detorio MA, Montero C, Bassit LC, Amblard F, Coats SJ, Schinazi RF.

Bioorg Med Chem. 2014 Dec 1;22(23):6665-6671. doi: 10.1016/j.bmc.2014.10.003. Epub 2014 Oct 13.

50.

Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition.

Nettles JH, Stanton RA, Broyde J, Amblard F, Zhang H, Zhou L, Shi J, McBrayer TR, Whitaker T, Coats SJ, Kohler JJ, Schinazi RF.

J Med Chem. 2014 Dec 11;57(23):10031-43. doi: 10.1021/jm501291c. Epub 2014 Nov 3.

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