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Items: 1 to 50 of 89

1.

L1 drives IFN in senescent cells and promotes age-associated inflammation.

De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM.

Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9. Epub 2019 Feb 6.

PMID:
30728521
2.

RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes.

Makin RD, Apicella I, Nagasaka Y, Kaneko H, Turner SD, Kerur N, Ambati J, Gelfand BD.

Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5795-5802. doi: 10.1167/iovs.18-25215.

3.

Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism.

Al-Khalidi R, Panicucci C, Cox P, Chira N, Róg J, Young CNJ, McGeehan RE, Ambati K, Ambati J, Zabłocki K, Gazzerro E, Arkle S, Bruno C, Górecki DC.

Acta Neuropathol Commun. 2018 Apr 11;6(1):27. doi: 10.1186/s40478-018-0530-4.

4.

Pharmacology of Corticosteroids for Diabetic Macular Edema.

Whitcup SM, Cidlowski JA, Csaky KG, Ambati J.

Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):1-12. doi: 10.1167/iovs.17-22259. Review.

5.

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.

Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J.

Nat Med. 2018 Jan;24(1):50-61. doi: 10.1038/nm.4450. Epub 2017 Nov 27.

6.

Alu RNA accumulation induces epithelial-to-mesenchymal transition by modulating miR-566 and is associated with cancer progression.

Di Ruocco F, Basso V, Rivoire M, Mehlen P, Ambati J, De Falco S, Tarallo V.

Oncogene. 2018 Feb 1;37(5):627-637. doi: 10.1038/onc.2017.369. Epub 2017 Oct 9.

7.

Dry Age-Related Macular Degeneration Pharmacology.

Wright CB, Ambati J.

Handb Exp Pharmacol. 2017;242:321-336. doi: 10.1007/164_2016_36.

8.

A Revised Hemodynamic Theory of Age-Related Macular Degeneration.

Gelfand BD, Ambati J.

Trends Mol Med. 2016 Aug;22(8):656-670. doi: 10.1016/j.molmed.2016.06.009. Epub 2016 Jul 13. Review.

9.

Intravenous immune globulin suppresses angiogenesis in mice and humans.

Yasuma R, Cicatiello V, Mizutani T, Tudisco L, Kim Y, Tarallo V, Bogdanovich S, Hirano Y, Kerur N, Li S, Yasuma T, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ambati BK, Helmers SB, Lundberg IE, Viklicky O, Leusen JH, Verbeek JS, Gelfand BD, Bastos-Carvalho A, De Falco S, Ambati J.

Signal Transduct Target Ther. 2016;1. pii: 15002. Epub 2016 Jan 28.

10.

Human IgG1 antibodies suppress angiogenesis in a target-independent manner.

Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-Carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J.

Signal Transduct Target Ther. 2016;1. pii: 15001. Epub 2016 Jan 28.

11.

Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice.

Mizutani T, Fowler BJ, Kim Y, Yasuma R, Krueger LA, Gelfand BD, Ambati J.

Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7122-9. doi: 10.1167/iovs.15-17440.

12.

Complement Activation and Inhibition in Retinal Diseases.

Kleinman ME, Ambati J.

Dev Ophthalmol. 2016;55:46-56. doi: 10.1159/000431141. Epub 2015 Oct 26. Review.

13.

Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.

Gelfand BD, Wright CB, Kim Y, Yasuma T, Yasuma R, Li S, Fowler BJ, Bastos-Carvalho A, Kerur N, Uittenbogaard A, Han YS, Lou D, Kleinman ME, McDonald WH, Núñez G, Georgel P, Dunaief JL, Ambati J.

Cell Rep. 2015 Jun 23;11(11):1686-93. doi: 10.1016/j.celrep.2015.05.023. Epub 2015 Jun 11.

14.

Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models.

Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, De Falco S.

Oncotarget. 2015 Apr 30;6(12):10563-76.

15.

IL-18 is not therapeutic for neovascular age-related macular degeneration.

Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, Núñez G, Ambati BK, Hinton DR, Ambati J.

Nat Med. 2014 Dec;20(12):1372-5. doi: 10.1038/nm.3671. No abstract available.

16.

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.

Fowler BJ, Gelfand BD, Kim Y, Kerur N, Tarallo V, Hirano Y, Amarnath S, Fowler DH, Radwan M, Young MT, Pittman K, Kubes P, Agarwal HK, Parang K, Hinton DR, Bastos-Carvalho A, Li S, Yasuma T, Mizutani T, Yasuma R, Wright C, Ambati J.

Science. 2014 Nov 21;346(6212):1000-3. doi: 10.1126/science.1261754.

17.

DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.

Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16082-7. doi: 10.1073/pnas.1403814111. Epub 2014 Oct 27.

18.

TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.

Kerur N, Hirano Y, Tarallo V, Fowler BJ, Bastos-Carvalho A, Yasuma T, Yasuma R, Kim Y, Hinton DR, Kirschning CJ, Gelfand BD, Ambati J.

Invest Ophthalmol Vis Sci. 2013 Nov 11;54(12):7395-401. doi: 10.1167/iovs.13-12500.

19.

Retinal angiogenesis suppression through small molecule activation of p53.

Chavala SH, Kim Y, Tudisco L, Cicatiello V, Milde T, Kerur N, Claros N, Yanni S, Guaiquil VH, Hauswirth WW, Penn JS, Rafii S, De Falco S, Lee TC, Ambati J.

J Clin Invest. 2013 Oct;123(10):4170-81. doi: 10.1172/JCI67315. Epub 2013 Sep 9.

20.

Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1.

Luo L, Uehara H, Zhang X, Das SK, Olsen T, Holt D, Simonis JM, Jackman K, Singh N, Miya TR, Huang W, Ahmed F, Bastos-Carvalho A, Le YZ, Mamalis C, Chiodo VA, Hauswirth WW, Baffi J, Lacal PM, Orecchia A, Ferrara N, Gao G, Young-Hee K, Fu Y, Owen L, Albuquerque R, Baehr W, Thomas K, Li DY, Chalam KV, Shibuya M, Grisanti S, Wilson DJ, Ambati J, Ambati BK.

Elife. 2013 Jun 18;2:e00324. doi: 10.7554/eLife.00324.

21.

Immunology of age-related macular degeneration.

Ambati J, Atkinson JP, Gelfand BD.

Nat Rev Immunol. 2013 Jun;13(6):438-51. doi: 10.1038/nri3459. Review.

22.

Targeted intraceptor nanoparticle therapy reduces angiogenesis and fibrosis in primate and murine macular degeneration.

Luo L, Zhang X, Hirano Y, Tyagi P, Barabás P, Uehara H, Miya TR, Singh N, Archer B, Qazi Y, Jackman K, Das SK, Olsen T, Chennamaneni SR, Stagg BC, Ahmed F, Emerson L, Zygmunt K, Whitaker R, Mamalis C, Huang W, Gao G, Srinivas SP, Krizaj D, Baffi J, Ambati J, Kompella UB, Ambati BK.

ACS Nano. 2013 Apr 23;7(4):3264-75. doi: 10.1021/nn305958y. Epub 2013 Mar 20.

23.

Clocking in on diabetic retinopathy.

Kleinman ME, Ambati J.

Diabetes. 2013 Jan;62(1):29-30. doi: 10.2337/db12-1151. No abstract available.

24.

Mammary cancer gene therapy targeting lymphangiogenesis: VEGF-C siRNA and soluble VEGF receptor-2, a splicing variant.

Shibata MA, Ambati J, Shibata E, Yoshidome K, Harada-Shiba M.

Med Mol Morphol. 2012 Dec;45(4):179-84. doi: 10.1007/s00795-012-0576-5. Epub 2012 Dec 7. Review.

PMID:
23224595
25.

Inhibition of choroidal and corneal pathologic neovascularization by Plgf1-de gene transfer.

Tarallo V, Bogdanovich S, Hirano Y, Tudisco L, Zentilin L, Giacca M, Ambati J, De Falco S.

Invest Ophthalmol Vis Sci. 2012 Dec 5;53(13):7989-96. doi: 10.1167/iovs.12-10658.

26.

Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR).

Uehara H, Cho Y, Simonis J, Cahoon J, Archer B, Luo L, Das SK, Singh N, Ambati J, Ambati BK.

FASEB J. 2013 Jan;27(1):76-85. doi: 10.1096/fj.12-213835. Epub 2012 Sep 20.

27.

ERK1/2 activation is a therapeutic target in age-related macular degeneration.

Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler BJ, Ambati BK, Bogdanovich S, Chiodo VA, Hauswirth WW, Kugel JF, Goodrich JA, Ponicsan SL, Hinton DR, Kleinman ME, Baffi JZ, Gelfand BD, Ambati J.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13781-6. doi: 10.1073/pnas.1206494109. Epub 2012 Aug 6.

28.

Mechanisms of age-related macular degeneration.

Ambati J, Fowler BJ.

Neuron. 2012 Jul 12;75(1):26-39. doi: 10.1016/j.neuron.2012.06.018. Review.

29.

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.

Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME, Ambati J.

Cell. 2012 May 11;149(4):847-59. doi: 10.1016/j.cell.2012.03.036. Epub 2012 Apr 26.

30.

DFT investigation of NH3 physisorption on CuSO4 impregnated SiO2.

Ambati J, Saiyed H, Rankin SE.

Phys Chem Chem Phys. 2012 May 14;14(18):6617-27. doi: 10.1039/c2cp22539e. Epub 2012 Mar 29.

PMID:
22456452
31.

Engineered silica nanocarriers as a high-payload delivery vehicle for antioxidant enzymes.

Ambati J, Lopez AM, Cochran D, Wattamwar P, Bean K, Dziubla TD, Rankin SE.

Acta Biomater. 2012 Jul;8(6):2096-103. doi: 10.1016/j.actbio.2012.02.012. Epub 2012 Feb 22.

PMID:
22366223
32.

Density functional theory study of semiquinone radical anions of polychlorinated biphenyls in the syn- and anti-like conformation.

Ambati J, Song Y, Rankin SE, Lehmler HJ.

J Phys Chem A. 2012 Feb 16;116(6):1586-95. doi: 10.1021/jp2077193. Epub 2012 Feb 6.

33.

A window to innate neuroimmunity: Toll-like receptor-mediated cell responses in the retina.

Kleinman ME, Ambati J.

Adv Exp Med Biol. 2012;723:3-9. doi: 10.1007/978-1-4614-0631-0_1. Review. No abstract available.

34.

Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.

Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJ, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Gelfand BD, Bogdanovich S, Baffi JZ, Ambati J.

Mol Ther. 2012 Jan;20(1):101-8. doi: 10.1038/mt.2011.212. Epub 2011 Oct 11.

35.

Crystal structure and density functional theory studies of toxic quinone metabolites of polychlorinated biphenyls.

Song Y, Ambati J, Parkin S, Rankin SE, Robertson LW, Lehmler HJ.

Chemosphere. 2011 Oct;85(3):386-92. doi: 10.1016/j.chemosphere.2011.07.004. Epub 2011 Aug 6.

36.

Reaction-induced phase separation of bis(triethoxysilyl)ethane upon sol-gel polymerization in acidic conditions.

Ambati J, Rankin SE.

J Colloid Interface Sci. 2011 Oct 15;362(2):345-53. doi: 10.1016/j.jcis.2011.06.064. Epub 2011 Jul 5.

PMID:
21788023
37.

Age-related macular degeneration and the other double helix. The Cogan Lecture.

Ambati J.

Invest Ophthalmol Vis Sci. 2011 Apr 6;52(5):2165-9. doi: 10.1167/iovs.11-7328. Print 2011 Apr.

38.

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.

Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J.

Nature. 2011 Mar 17;471(7338):325-30. doi: 10.1038/nature09830. Epub 2011 Feb 6.

39.

Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis ΔyopM mutant in liver and spleen during systemic plague.

Ye Z, Uittenbogaard AM, Cohen DA, Kaplan AM, Ambati J, Straley SC.

Infect Immun. 2011 Feb;79(2):674-87. doi: 10.1128/IAI.00808-10. Epub 2010 Dec 13.

40.

Determination of 29Si-1H spin-spin coupling constants in organoalkoxysilanes with nontrivial scalar coupling patterns.

Ambati J, Rankin SE.

J Phys Chem A. 2010 Dec 9;114(48):12613-21. doi: 10.1021/jp105644p. Epub 2010 Nov 15.

PMID:
21077652
41.

The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model.

Shibata MA, Ambati J, Shibata E, Albuquerque RJ, Morimoto J, Ito Y, Otsuki Y.

BMC Med. 2010 Nov 3;8:69. doi: 10.1186/1741-7015-8-69.

42.

Soluble VEGFR-2: an antilymphangiogenic variant of VEGF receptors.

Pavlakovic H, Becker J, Albuquerque R, Wilting J, Ambati J.

Ann N Y Acad Sci. 2010 Oct;1207 Suppl 1:E7-15. doi: 10.1111/j.1749-6632.2010.05714.x.

43.

The multifactorial nature of retinal vascular disease.

Kleinman ME, Baffi JZ, Ambati J.

Ophthalmologica. 2010;224 Suppl 1:16-24. doi: 10.1159/000315152. Epub 2010 Aug 18. Review.

44.

Triamcinolone crystal size.

Kleinman ME, Westhouse SJ, Ambati J, Pearson PA, Halperin LS.

Ophthalmology. 2010 Aug;117(8):1654, 1654.e1-4. doi: 10.1016/j.ophtha.2010.01.052. No abstract available.

45.

DFT calculations of indirect 29Si-1H spin-spin coupling constants in organoalkoxysilanes.

Ambati J, Rankin SE.

J Phys Chem A. 2010 Apr 29;114(16):5279-86. doi: 10.1021/jp911327a. Erratum in: J Phys Chem A. 2011 Mar 3;115(8):1452.

PMID:
20361771
46.

Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2.

Becker J, Pavlakovic H, Ludewig F, Wilting F, Weich HA, Albuquerque R, Ambati J, Wilting J.

Clin Cancer Res. 2010 Mar 1;16(5):1431-41. doi: 10.1158/1078-0432.CCR-09-1936. Epub 2010 Feb 23.

47.

Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.

Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J.

Nat Med. 2009 Sep;15(9):1023-30. doi: 10.1038/nm.2018. Epub 2009 Aug 9.

48.

CCR3 is a target for age-related macular degeneration diagnosis and therapy.

Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJ, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J.

Nature. 2009 Jul 9;460(7252):225-30. doi: 10.1038/nature08151. Epub 2009 Jun 14.

49.

Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth.

Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7137-42. doi: 10.1073/pnas.0812317106. Epub 2009 Apr 9.

50.

Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1.

Ponticelli S, Marasco D, Tarallo V, Albuquerque RJ, Mitola S, Takeda A, Stassen JM, Presta M, Ambati J, Ruvo M, De Falco S.

J Biol Chem. 2008 Dec 5;283(49):34250-9. doi: 10.1074/jbc.M806607200. Epub 2008 Oct 15.

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