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Items: 1 to 50 of 69

1.

The Multifaceted S100A4 Protein in Cancer and Inflammation.

Ambartsumian N, Klingelhöfer J, Grigorian M.

Methods Mol Biol. 2019;1929:339-365. doi: 10.1007/978-1-4939-9030-6_22. Review.

PMID:
30710284
2.

Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma.

Mammadova-Bach E, Rupp T, Spenlé C, Jivkov I, Shankaranarayanan P, Klein A, Pisarsky L, Méchine-Neuville A, Cremel G, Kedinger M, De Wever O, Ambartsumian N, Robine S, Pencreach E, Guenot D, Simon-Assmann P, Goetz JG, Orend G, Lefebvre O.

Biol Cell. 2018 Jun 15. doi: 10.1111/boc.201800007. [Epub ahead of print]

PMID:
29907957
3.

The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression.

Atlasi Y, Noori R, Marolin I, Franken P, Brandao J, Biermann K, Collini P, Grigorian M, Lukanidin E, Ambartsumian N, Fodde R.

Eur J Cancer. 2016 Nov;68:114-124. doi: 10.1016/j.ejca.2016.09.012. Epub 2016 Oct 14.

PMID:
27750112
4.

[S100A4, a link between metastasis and inflammation].

Ambartsumian N, Grigorian M.

Mol Biol (Mosk). 2016 Jul-Aug;50(4):577-588. Russian.

5.

S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance.

Grum-Schwensen B, Klingelhöfer J, Beck M, Bonefeld CM, Hamerlik P, Guldberg P, Grigorian M, Lukanidin E, Ambartsumian N.

BMC Cancer. 2015 Feb 12;15:44. doi: 10.1186/s12885-015-1034-2.

6.

Spatial organization of the tenascin-C microenvironment in experimental and human cancer.

Spenlé C, Gasser I, Saupe F, Janssen KP, Arnold C, Klein A, van der Heyden M, Mutterer J, Neuville-Méchine A, Chenard MP, Guenot D, Esposito I, Slotta-Huspenina J, Ambartsumian N, Simon-Assmann P, Orend G.

Cell Adh Migr. 2015;9(1-2):4-13. doi: 10.1080/19336918.2015.1005452.

7.

Screening and identification of small molecule inhibitors of ErbB2-induced invasion.

Brix DM, Rafn B, Bundgaard Clemmensen K, Andersen SH, Ambartsumian N, Jäättelä M, Kallunki T.

Mol Oncol. 2014 Dec;8(8):1703-18. doi: 10.1016/j.molonc.2014.07.004. Epub 2014 Jul 12.

8.

A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4.

Hansen MT, Forst B, Cremers N, Quagliata L, Ambartsumian N, Grum-Schwensen B, Klingelhöfer J, Abdul-Al A, Herrmann P, Osterland M, Stein U, Nielsen GH, Scherer PE, Lukanidin E, Sleeman JP, Grigorian M.

Oncogene. 2015 Jan 22;34(4):424-35. doi: 10.1038/onc.2013.568. Epub 2014 Jan 27.

PMID:
24469032
9.

A generally applicable translational strategy identifies S100A4 as a candidate gene in allergy.

Bruhn S, Fang Y, Barrenäs F, Gustafsson M, Zhang H, Konstantinell A, Krönke A, Sönnichsen B, Bresnick A, Dulyaninova N, Wang H, Zhao Y, Klingelhöfer J, Ambartsumian N, Beck MK, Nestor C, Bona E, Xiang Z, Benson M.

Sci Transl Med. 2014 Jan 8;6(218):218ra4. doi: 10.1126/scitranslmed.3007410.

10.

The S100A4 Oncoprotein Promotes Prostate Tumorigenesis in a Transgenic Mouse Model: Regulating NFκB through the RAGE Receptor.

Siddique HR, Adhami VM, Parray A, Johnson JJ, Siddiqui IA, Shekhani MT, Murtaza I, Ambartsumian N, Konety BR, Mukhtar H, Saleem M.

Genes Cancer. 2013 May;4(5-6):224-34. doi: 10.1177/1947601913492420.

11.

Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function.

Erlandsson MC, Svensson MD, Jonsson IM, Bian L, Ambartsumian N, Andersson S, Peng Z, Vääräniemi J, Ohlsson C, Andersson KME, Bokarewa MI.

Biochim Biophys Acta. 2013 Dec;1833(12):2653-2663. doi: 10.1016/j.bbamcr.2013.06.020. Epub 2013 Jul 2.

12.

Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts.

Tamaki Y, Iwanaga Y, Niizuma S, Kawashima T, Kato T, Inuzuka Y, Horie T, Morooka H, Takase T, Akahashi Y, Kobuke K, Ono K, Shioi T, Sheikh SP, Ambartsumian N, Lukanidin E, Koshimizu TA, Miyazaki S, Kimura T.

J Mol Cell Cardiol. 2013 Apr;57:72-81. doi: 10.1016/j.yjmcc.2013.01.007. Epub 2013 Jan 23.

PMID:
23352991
13.

Anti-S100A4 antibody suppresses metastasis formation by blocking stroma cell invasion.

Klingelhöfer J, Grum-Schwensen B, Beck MK, Knudsen RS, Grigorian M, Lukanidin E, Ambartsumian N.

Neoplasia. 2012 Dec;14(12):1260-8.

14.

The metastasis-promoting S100A4 protein confers neuroprotection in brain injury.

Dmytriyeva O, Pankratova S, Owczarek S, Sonn K, Soroka V, Ridley CM, Marsolais A, Lopez-Hoyos M, Ambartsumian N, Lukanidin E, Bock E, Berezin V, Kiryushko D.

Nat Commun. 2012;3:1197. doi: 10.1038/ncomms2202.

PMID:
23149742
15.

Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females.

Dempsie Y, Nilsen M, White K, Mair KM, Loughlin L, Ambartsumian N, Rabinovitch M, Maclean MR.

Respir Res. 2011 Dec 20;12:159. doi: 10.1186/1465-9921-12-159.

16.

S100A4 deficiency is associated with efficient bacterial clearance and protects against joint destruction during Staphylococcal infection.

Bian L, Strzyz P, Jonsson IM, Erlandsson M, Hellvard A, Brisslert M, Ohlsson C, Ambartsumian N, Grigorian M, Bokarewa M.

J Infect Dis. 2011 Sep 1;204(5):722-30. doi: 10.1093/infdis/jir369.

PMID:
21844298
17.

Role of fibulin-5 in metastatic organ colonization.

Møller HD, Ralfkjær U, Cremers N, Frankel M, Pedersen RT, Klingelhöfer J, Yanagisawa H, Grigorian M, Guldberg P, Sleeman J, Lukanidin E, Ambartsumian N.

Mol Cancer Res. 2011 May;9(5):553-63. doi: 10.1158/1541-7786.MCR-11-0093. Epub 2011 Mar 31.

18.

Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts.

Olsen CJ, Moreira J, Lukanidin EM, Ambartsumian NS.

BMC Cancer. 2010 Aug 19;10:444. doi: 10.1186/1471-2407-10-444.

19.

Metastasis-inducing S100A4 and RANTES cooperate in promoting tumor progression in mice.

Forst B, Hansen MT, Klingelhöfer J, Møller HD, Nielsen GH, Grum-Schwensen B, Ambartsumian N, Lukanidin E, Grigorian M.

PLoS One. 2010 Apr 28;5(4):e10374. doi: 10.1371/journal.pone.0010374.

20.

Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors.

Grum-Schwensen B, Klingelhöfer J, Grigorian M, Almholt K, Nielsen BS, Lukanidin E, Ambartsumian N.

Cancer Res. 2010 Feb 1;70(3):936-47. doi: 10.1158/0008-5472.CAN-09-3220. Epub 2010 Jan 26.

21.

Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein.

Klingelhöfer J, Møller HD, Sumer EU, Berg CH, Poulsen M, Kiryushko D, Soroka V, Ambartsumian N, Grigorian M, Lukanidin EM.

FEBS J. 2009 Oct;276(20):5936-48. doi: 10.1111/j.1742-4658.2009.07274.x. Epub 2009 Sep 9.

22.

S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4.

Spiekerkoetter E, Guignabert C, de Jesus Perez V, Alastalo TP, Powers JM, Wang L, Lawrie A, Ambartsumian N, Schmidt AM, Berryman M, Ashley RH, Rabinovitch M.

Circ Res. 2009 Sep 25;105(7):639-47, 13 p following 647. doi: 10.1161/CIRCRESAHA.109.205120. Epub 2009 Aug 27.

23.

Metastasis-inducing S100A4 protein: implication in non-malignant human pathologies.

Grigorian M, Ambartsumian N, Lukanidin E.

Curr Mol Med. 2008 Sep;8(6):492-6. Review.

PMID:
18781956
24.

Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin.

Spiekerkoetter E, Alvira CM, Kim YM, Bruneau A, Pricola KL, Wang L, Ambartsumian N, Rabinovitch M.

Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L276-89. Epub 2007 Dec 14.

25.

Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer.

Cabezón T, Celis JE, Skibshøj I, Klingelhöfer J, Grigorian M, Gromov P, Rank F, Myklebust JH, Maelandsmo GM, Lukanidin E, Ambartsumian N.

Int J Cancer. 2007 Oct 1;121(7):1433-44.

26.

Up-regulation of metastasis-promoting S100A4 (Mts-1) in rheumatoid arthritis: putative involvement in the pathogenesis of rheumatoid arthritis.

Klingelhöfer J, Senolt L, Baslund B, Nielsen GH, Skibshøj I, Pavelka K, Neidhart M, Gay S, Ambartsumian N, Hansen BS, Petersen J, Lukanidin E, Grigorian M.

Arthritis Rheum. 2007 Mar;56(3):779-89.

27.

Intracellular calcium-binding protein S100A4 influences injury-induced migration of white matter astrocytes.

Fang Z, Duthoit N, Wicher G, Källskog O, Ambartsumian N, Lukanidin E, Takenaga K, Kozlova EN.

Acta Neuropathol. 2006 Mar;111(3):213-9. Epub 2006 Feb 4.

PMID:
16463066
28.

Mts1/S100A4 stimulates human pulmonary artery smooth muscle cell migration through multiple signaling pathways.

Spiekerkoetter E, Lawrie A, Merklinger S, Ambartsumian N, Lukanidin E, Schmidt AM, Rabinovitch M.

Chest. 2005 Dec;128(6 Suppl):577S. No abstract available.

PMID:
16373840
29.

Genetically modified mouse models to study the role of metastasis-promoting S100A4(mts1) protein in metastatic mammary cancer.

Ambartsumian N, Grigorian M, Lukanidin E.

J Dairy Res. 2005;72 Spec No:27-33. Review.

PMID:
16180718
30.

Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension.

Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, Starcher B, Yanagisawa H, Rabinovitch M.

Circ Res. 2005 Sep 16;97(6):596-604. Epub 2005 Aug 18.

PMID:
16109920
31.

Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis.

Christensen C, Ambartsumian N, Gilestro G, Thomsen B, Comoglio P, Tamagnone L, Guldberg P, Lukanidin E.

Cancer Res. 2005 Jul 15;65(14):6167-77.

32.

Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease.

Lawrie A, Spiekerkoetter E, Martinez EC, Ambartsumian N, Sheward WJ, MacLean MR, Harmar AJ, Schmidt AM, Lukanidin E, Rabinovitch M.

Circ Res. 2005 Aug 5;97(3):227-35. Epub 2005 Jul 7.

PMID:
16002749
33.

Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene.

Grum-Schwensen B, Klingelhofer J, Berg CH, El-Naaman C, Grigorian M, Lukanidin E, Ambartsumian N.

Cancer Res. 2005 May 1;65(9):3772-80.

34.

Extracellular S100A4(mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity.

Schmidt-Hansen B, Ornås D, Grigorian M, Klingelhöfer J, Tulchinsky E, Lukanidin E, Ambartsumian N.

Oncogene. 2004 Jul 15;23(32):5487-95.

PMID:
15122322
35.

Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene.

EL Naaman C, Grum-Schwensen B, Mansouri A, Grigorian M, Santoni-Rugiu E, Hansen T, Kriajevska M, Schafer BW, Heizmann CW, Lukanidin E, Ambartsumian N.

Oncogene. 2004 Apr 29;23(20):3670-80.

PMID:
15116098
36.

Functional significance of metastasis-inducing S100A4(Mts1) in tumor-stroma interplay.

Schmidt-Hansen B, Klingelhöfer J, Grum-Schwensen B, Christensen A, Andresen S, Kruse C, Hansen T, Ambartsumian N, Lukanidin E, Grigorian M.

J Biol Chem. 2004 Jun 4;279(23):24498-504. Epub 2004 Mar 26.

37.

Proteomic characterization of the interstitial fluid perfusing the breast tumor microenvironment: a novel resource for biomarker and therapeutic target discovery.

Celis JE, Gromov P, Cabezón T, Moreira JM, Ambartsumian N, Sandelin K, Rank F, Gromova I.

Mol Cell Proteomics. 2004 Apr;3(4):327-44. Epub 2004 Jan 30.

38.

S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathy.

Greenway S, van Suylen RJ, Du Marchie Sarvaas G, Kwan E, Ambartsumian N, Lukanidin E, Rabinovitch M.

Am J Pathol. 2004 Jan;164(1):253-62.

39.

Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research.

Celis JE, Gromov P, Gromova I, Moreira JM, Cabezón T, Ambartsumian N, Grigorian M, Lukanidin E, Thor Straten P, Guldberg P, Bartkova J, Bartek J, Lukas J, Lukas C, Lykkesfeldt A, Jäättelä M, Roepstorff P, Bolund L, Ørntoft T, Brünner N, Overgaard J, Sandelin K, Blichert-Toft M, Mouridsen H, Rank FE.

Mol Cell Proteomics. 2003 Jun;2(6):369-77. Epub 2003 Jun 25.

40.

Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).

Kriajevska M, Fischer-Larsen M, Moertz E, Vorm O, Tulchinsky E, Grigorian M, Ambartsumian N, Lukanidin E.

J Biol Chem. 2002 Feb 15;277(7):5229-35. Epub 2001 Dec 7.

41.

The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor.

Ambartsumian N, Klingelhöfer J, Grigorian M, Christensen C, Kriajevska M, Tulchinsky E, Georgiev G, Berezin V, Bock E, Rygaard J, Cao R, Cao Y, Lukanidin E.

Oncogene. 2001 Aug 2;20(34):4685-95.

42.

Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interaction.

Grigorian M, Andresen S, Tulchinsky E, Kriajevska M, Carlberg C, Kruse C, Cohn M, Ambartsumian N, Christensen A, Selivanova G, Lukanidin E.

J Biol Chem. 2001 Jun 22;276(25):22699-708. Epub 2001 Mar 5.

43.

[Expression of mts1 gene in human breast cancer MCF-7 cells increases their malignancy].

Grigorian MS, Ambartsumian NS, Georgiev GP, Lukanidin EM.

Mol Biol (Mosk). 1999 Jul-Aug;33(4):651-6. Russian. No abstract available.

PMID:
10546219
44.

Tissue-specific posttranscriptional downregulation of expression of the S100A4(mts1) gene in transgenic animals.

Ambartsumian N, Klingelhöfer J, Grigorian M, Karlstrøm O, Sidenius N, Georgiev G, Lukanidin E.

Invasion Metastasis. 1998-1999;18(2):96-104.

PMID:
10364689
45.

Expression of the metastasis-associated mts1 gene during mouse development.

Klingelhöfer J, Ambartsumian NS, Lukanidin EM.

Dev Dyn. 1997 Oct;210(2):87-95.

46.

[Acquisition of ability to metastasize by spontaneous tumors under the effect of metastazin 1 in transgenic animals].

Ambartsumian NS, Grigorian MS, Larsen IF, Karlstrom O, Sidenius N, Rygaard J, Georgiev GP, Lukanidin EM.

Dokl Akad Nauk. 1997 Jun;354(6):821-4. Russian. No abstract available.

PMID:
9289286
47.

[Extrachromosomal DNA spectrum of Bacillus thuringiensis Berliner and Bacillus sphaericus Meyer et Neide].

Chichian VG, Ambartsumian NS, Akopian ZhI, Afrikian EK.

Genetika. 1997 Mar;33(3):308-13. Russian.

PMID:
9244760
48.

Metastasis of mammary carcinomas in GRS/A hybrid mice transgenic for the mts1 gene.

Ambartsumian NS, Grigorian MS, Larsen IF, Karlstrøm O, Sidenius N, Rygaard J, Georgiev G, Lukanidin E.

Oncogene. 1996 Oct 17;13(8):1621-30.

PMID:
8895507
49.

Effect of mts1 (S100A4) expression on the progression of human breast cancer cells.

Grigorian M, Ambartsumian N, Lykkesfeldt AE, Bastholm L, Elling F, Georgiev G, Lukanidin E.

Int J Cancer. 1996 Sep 17;67(6):831-41.

50.

Activation of mts1 transcription by insertion of a retrovirus-like IAP element.

Tarabykina S, Ambartsumian N, Grigorian M, Georgiev G, Lukanidin EM.

Gene. 1996 Feb 12;168(2):151-5.

PMID:
8654935

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