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Items: 33


Functional Characterization of Glucocorticoid Receptor Variants Is Required to Avoid Misinterpretation of NGS Data.

Foussier L, Vitellius G, Bouligand J, Amazit L, Bouvattier C, Young J, Trabado S, Lombès M.

J Endocr Soc. 2019 Mar 6;3(5):865-881. doi: 10.1210/js.2019-00028. eCollection 2019 May 1.


Potentiation of mitotane action by rosuvastatin: New insights for adrenocortical carcinoma management.

Boulate G, Amazit L, Naman A, Seck A, Paci A, Lombes A, Pussard E, Baudin E, Lombes M, Hescot S.

Int J Oncol. 2019 Jun;54(6):2149-2156. doi: 10.3892/ijo.2019.4770. Epub 2019 Apr 3.


Crosstalk Between Glucocorticoid Receptor and Early-growth Response Protein 1 Accounts for Repression of Brain-derived Neurotrophic Factor Transcript 4 Expression.

Chen H, Amazit L, Lombès M, Le Menuet D.

Neuroscience. 2019 Feb 10;399:12-27. doi: 10.1016/j.neuroscience.2018.12.012. Epub 2018 Dec 19.


ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure.

Delcour C, Amazit L, Patino LC, Magnin F, Fagart J, Delemer B, Young J, Laissue P, Binart N, Beau I.

Genet Med. 2019 Apr;21(4):930-938. doi: 10.1038/s41436-018-0287-y. Epub 2018 Sep 19.


Corticosteroid receptors adopt distinct cyclical transcriptional signatures.

Le Billan F, Amazit L, Bleakley K, Xue QY, Pussard E, Lhadj C, Kolkhof P, Viengchareun S, Fagart J, Lombès M.

FASEB J. 2018 Oct;32(10):5626-5639. doi: 10.1096/fj.201800391RR. Epub 2018 May 7.


Identifying mitotane-induced mitochondria-associated membranes dysfunctions: metabolomic and lipidomic approaches.

Hescot S, Amazit L, Lhomme M, Travers S, DuBow A, Battini S, Boulate G, Namer IJ, Lombes A, Kontush A, Imperiale A, Baudin E, Lombes M.

Oncotarget. 2017 Jul 4;8(66):109924-109940. doi: 10.18632/oncotarget.18968. eCollection 2017 Dec 15.


RNA-binding protein HuR enhances mineralocorticoid signaling in renal KC3AC1 cells under hypotonicity.

Lema I, Amazit L, Lamribet K, Fagart J, Blanchard A, Lombès M, Cherradi N, Viengchareun S.

Cell Mol Life Sci. 2017 Dec;74(24):4587-4597. doi: 10.1007/s00018-017-2594-x. Epub 2017 Jul 25.


HuR-Dependent Editing of a New Mineralocorticoid Receptor Splice Variant Reveals an Osmoregulatory Loop for Sodium Homeostasis.

Lema I, Amazit L, Lamribet K, Fagart J, Blanchard A, Lombès M, Cherradi N, Viengchareun S.

Sci Rep. 2017 Jul 6;7(1):4835. doi: 10.1038/s41598-017-04838-8.


Three Novel Heterozygous Point Mutations of NR3C1 Causing Glucocorticoid Resistance.

Vitellius G, Fagart J, Delemer B, Amazit L, Ramos N, Bouligand J, Le Billan F, Castinetti F, Guiochon-Mantel A, Trabado S, Lombès M.

Hum Mutat. 2016 Aug;37(8):794-803. doi: 10.1002/humu.23008. Epub 2016 May 11.


Prevalence of KISS1 Receptor mutations in a series of 603 patients with normosmic congenital hypogonadotrophic hypogonadism and characterization of novel mutations: a single-centre study.

Francou B, Paul C, Amazit L, Cartes A, Bouvattier C, Albarel F, Maiter D, Chanson P, Trabado S, Brailly-Tabard S, Brue T, Guiochon-Mantel A, Young J, Bouligand J.

Hum Reprod. 2016 Jun;31(6):1363-74. doi: 10.1093/humrep/dew073. Epub 2016 Apr 19.


Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins.

Mouna L, Hernandez E, Bonte D, Brost R, Amazit L, Delgui LR, Brune W, Geballe AP, Beau I, Esclatine A.

Autophagy. 2016;12(2):327-42. doi: 10.1080/15548627.2015.1125071.


Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1.

Amazit L, Le Billan F, Kolkhof P, Lamribet K, Viengchareun S, Fay MR, Khan JA, Hillisch A, Lombès M, Rafestin-Oblin ME, Fagart J.

J Biol Chem. 2015 Sep 4;290(36):21876-89. doi: 10.1074/jbc.M115.657957. Epub 2015 Jul 22.


Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells.

Hescot S, Slama A, Lombès A, Paci A, Remy H, Leboulleux S, Chadarevian R, Trabado S, Amazit L, Young J, Baudin E, Lombès M.

Endocr Relat Cancer. 2013 May 21;20(3):371-81. doi: 10.1530/ERC-12-0368. Print 2013 Jun.


A new strategy for selective targeting of progesterone receptor with passive antagonists.

Khan JA, Tikad A, Fay M, Hamze A, Fagart J, Chabbert-Buffet N, Meduri G, Amazit L, Brion JD, Alami M, Lombès M, Loosfelt H, Rafestin-Oblin ME.

Mol Endocrinol. 2013 Jun;27(6):909-24. doi: 10.1210/me.2012-1328. Epub 2013 Apr 11.


Normosmic congenital hypogonadotropic hypogonadism due to TAC3/TACR3 mutations: characterization of neuroendocrine phenotypes and novel mutations.

Francou B, Bouligand J, Voican A, Amazit L, Trabado S, Fagart J, Meduri G, Brailly-Tabard S, Chanson P, Lecomte P, Guiochon-Mantel A, Young J.

PLoS One. 2011;6(10):e25614. doi: 10.1371/journal.pone.0025614. Epub 2011 Oct 21.


p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization.

Khan JA, Amazit L, Bellance C, Guiochon-Mantel A, Lombès M, Loosfelt H.

Mol Endocrinol. 2011 Oct;25(10):1710-24. doi: 10.1210/me.2011-1042. Epub 2011 Aug 4.


Ligand-dependent degradation of SRC-1 is pivotal for progesterone receptor transcriptional activity.

Amazit L, Roseau A, Khan JA, Chauchereau A, Tyagi RK, Loosfelt H, Leclerc P, Lombès M, Guiochon-Mantel A.

Mol Endocrinol. 2011 Mar;25(3):394-408. doi: 10.1210/me.2010-0458. Epub 2011 Jan 27.


Familial glucocorticoid receptor haploinsufficiency by non-sense mediated mRNA decay, adrenal hyperplasia and apparent mineralocorticoid excess.

Bouligand J, Delemer B, Hecart AC, Meduri G, Viengchareun S, Amazit L, Trabado S, Fève B, Guiochon-Mantel A, Young J, Lombès M.

PLoS One. 2010 Oct 22;5(10):e13563. doi: 10.1371/journal.pone.0013563.


SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration.

Long W, Yi P, Amazit L, LaMarca HL, Ashcroft F, Kumar R, Mancini MA, Tsai SY, Tsai MJ, O'Malley BW.

Mol Cell. 2010 Feb 12;37(3):321-32. doi: 10.1016/j.molcel.2010.01.004.


Activation of estrogen receptor-alpha by E2 or EGF induces temporally distinct patterns of large-scale chromatin modification and mRNA transcription.

Berno V, Amazit L, Hinojos C, Zhong J, Mancini MG, Sharp ZD, Mancini MA.

PLoS One. 2008 May 28;3(5):e2286. doi: 10.1371/journal.pone.0002286.


Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.

Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW.

Mol Cell. 2008 Feb 29;29(4):465-76. doi: 10.1016/j.molcel.2007.12.030.


ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation.

Karagianni P, Amazit L, Qin J, Wong J.

Mol Cell Biol. 2008 Jan;28(2):705-17. Epub 2007 Oct 29.


Regulation of SRC-3 intercompartmental dynamics by estrogen receptor and phosphorylation.

Amazit L, Pasini L, Szafran AT, Berno V, Wu RC, Mielke M, Jones ED, Mancini MG, Hinojos CA, O'Malley BW, Mancini MA.

Mol Cell Biol. 2007 Oct;27(19):6913-32. Epub 2007 Jul 23.


Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway.

Li X, Amazit L, Long W, Lonard DM, Monaco JJ, O'Malley BW.

Mol Cell. 2007 Jun 22;26(6):831-42.


Specific amino acid residues in the basic helix-loop-helix domain of SRC-3 are essential for its nuclear localization and proteasome-dependent turnover.

Li C, Wu RC, Amazit L, Tsai SY, Tsai MJ, O'Malley BW.

Mol Cell Biol. 2007 Feb;27(4):1296-308. Epub 2006 Dec 11.


High-resolution, high-throughput microscopy analyses of nuclear receptor and coregulator function.

Berno V, Hinojos CA, Amazit L, Szafran AT, Mancini MA.

Methods Enzymol. 2006;414:188-210.


Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program.

Louet JF, Coste A, Amazit L, Tannour-Louet M, Wu RC, Tsai SY, Tsai MJ, Auwerx J, O'Malley BW.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17868-73. Epub 2006 Nov 10.


Ligand-controlled interaction of histone acetyltransferase binding to ORC-1 (HBO1) with the N-terminal transactivating domain of progesterone receptor induces steroid receptor coactivator 1-dependent coactivation of transcription.

Georgiakaki M, Chabbert-Buffet N, Dasen B, Meduri G, Wenk S, Rajhi L, Amazit L, Chauchereau A, Burger CW, Blok LJ, Milgrom E, Lombès M, Guiochon-Mantel A, Loosfelt H.

Mol Endocrinol. 2006 Sep;20(9):2122-40. Epub 2006 Apr 27.


Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells.

Grenier J, Trousson A, Chauchereau A, Amazit L, Lamirand A, Leclerc P, Guiochon-Mantel A, Schumacher M, Massaad C.

Mol Endocrinol. 2004 Dec;18(12):2866-79. Epub 2004 Aug 26.


Subcellular localization and mechanisms of nucleocytoplasmic trafficking of steroid receptor coactivator-1.

Amazit L, Alj Y, Tyagi RK, Chauchereau A, Loosfelt H, Pichon C, Pantel J, Foulon-Guinchard E, Leclerc P, Milgrom E, Guiochon-Mantel A.

J Biol Chem. 2003 Aug 22;278(34):32195-203. Epub 2003 Jun 4.


Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.

Chauchereau A, Amazit L, Quesne M, Guiochon-Mantel A, Milgrom E.

J Biol Chem. 2003 Apr 4;278(14):12335-43. Epub 2003 Jan 14.


RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone.

Roux S, Amazit L, Meduri G, Guiochon-Mantel A, Milgrom E, Mariette X.

Am J Clin Pathol. 2002 Feb;117(2):210-6.


Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate.

Tyagi RK, Amazit L, Lescop P, Milgrom E, Guiochon-Mantel A.

Mol Endocrinol. 1998 Nov;12(11):1684-95.


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