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Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains.

Underhill SM, Hullihen PD, Chen J, Fenollar-Ferrer C, Rizzo MA, Ingram SL, Amara SG.

Mol Psychiatry. 2019 Aug 9. doi: 10.1038/s41380-019-0469-2. [Epub ahead of print]


Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats.

Bäck S, Necarsulmer J, Whitaker LR, Coke LM, Koivula P, Heathward EJ, Fortuno LV, Zhang Y, Yeh CG, Baldwin HA, Spencer MD, Mejias-Aponte CA, Pickel J, Hoffman AF, Spivak CE, Lupica CR, Underhill SM, Amara SG, Domanskyi A, Anttila JE, Airavaara M, Hope BT, Hamra FK, Richie CT, Harvey BK.

Neuron. 2019 Apr 3;102(1):105-119.e8. doi: 10.1016/j.neuron.2019.01.035. Epub 2019 Feb 18.


G protein βγ subunits play a critical role in the actions of amphetamine.

Mauna JC, Harris SS, Pino JA, Edwards CM, DeChellis-Marks MR, Bassi CD, Garcia-Olivares J, Amara SG, Guajardo FG, Sotomayor-Zarate R, Terminel M, Castañeda E, Vergara M, Baust T, Thiels E, Torres GE.

Transl Psychiatry. 2019 Feb 11;9(1):81. doi: 10.1038/s41398-019-0387-8.


Introduction to the Theme "New Therapeutic Targets".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:15-20. doi: 10.1146/annurev-pharmtox-101018-112717.


Neuronal excitatory amino acid transporter EAAT3: Emerging functions in health and disease.

Underhill SM, Ingram SL, Ahmari SE, Veenstra-VanderWeele J, Amara SG.

Neurochem Int. 2019 Feb;123:69-76. doi: 10.1016/j.neuint.2018.05.012. Epub 2018 May 22. No abstract available.


Introduction to the Theme "New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:33-36. doi: 10.1146/annurev-pharmtox-092617-121952. Epub 2017 Oct 20.


Gβγ subunit activation promotes dopamine efflux through the dopamine transporter.

Garcia-Olivares J, Baust T, Harris S, Hamilton P, Galli A, Amara SG, Torres GE.

Mol Psychiatry. 2017 Dec;22(12):1673-1679. doi: 10.1038/mp.2017.176. Epub 2017 Sep 12.


MAP Kinase Phosphatase 3 (MKP3) Preserves Norepinephrine Transporter Activity by Modulating ERK1/2 Kinase-Mediated Gene Expression.

Mortensen OV, Larsen MB, Amara SG.

Front Cell Neurosci. 2017 Aug 22;11:253. doi: 10.3389/fncel.2017.00253. eCollection 2017.


ErbB4 signaling in dopaminergic axonal projections increases extracellular dopamine levels and regulates spatial/working memory behaviors.

Skirzewski M, Karavanova I, Shamir A, Erben L, Garcia-Olivares J, Shin JH, Vullhorst D, Alvarez VA, Amara SG, Buonanno A.

Mol Psychiatry. 2018 Nov;23(11):2227-2237. doi: 10.1038/mp.2017.132. Epub 2017 Jul 20.


Glial and Neuronal Glutamate Transporters Differ in the Na+ Requirements for Activation of the Substrate-Independent Anion Conductance.

Divito CB, Borowski JE, Glasgow NG, Gonzalez-Suarez AD, Torres-Salazar D, Johnson JW, Amara SG.

Front Mol Neurosci. 2017 May 29;10:150. doi: 10.3389/fnmol.2017.00150. eCollection 2017.


Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters.

Cheng MH, Torres-Salazar D, Gonzalez-Suarez AD, Amara SG, Bahar I.

Elife. 2017 Jun 1;6. pii: e25850. doi: 10.7554/eLife.25850.


The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.

Hong WC, Yano H, Hiranita T, Chin FT, McCurdy CR, Su TP, Amara SG, Katz JL.

J Biol Chem. 2017 Jul 7;292(27):11250-11261. doi: 10.1074/jbc.M116.774075. Epub 2017 May 11.


Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons.

Li MH, Underhill SM, Reed C, Phillips TJ, Amara SG, Ingram SL.

Neuropsychopharmacology. 2017 Jun;42(7):1539-1547. doi: 10.1038/npp.2016.278. Epub 2016 Dec 15.


Introduction to the Theme "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:13-17. doi: 10.1146/annurev-pharmtox-091616-023708. Epub 2016 Oct 12.


Transport and channel functions in EAATs: the missing link.

Torres-Salazar D, Gonzalez-Suarez AD, Amara SG.

Channels (Austin). 2016;10(2):86-7. doi: 10.1080/19336950.2015.1119631. Epub 2015 Dec 18. No abstract available.


Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine.

Wheeler DS, Underhill SM, Stolz DB, Murdoch GH, Thiels E, Romero G, Amara SG.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7138-47. doi: 10.1073/pnas.1511670112. Epub 2015 Nov 9.


Introduction to the Theme "Cancer Pharmacology".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2016;56:19-22. doi: 10.1146/annurev-pharmtox-102015-123106. Epub 2015 Nov 9. No abstract available.


A Mutation in Transmembrane Domain 7 (TM7) of Excitatory Amino Acid Transporters Disrupts the Substrate-dependent Gating of the Intrinsic Anion Conductance and Drives the Channel into a Constitutively Open State.

Torres-Salazar D, Jiang J, Divito CB, Garcia-Olivares J, Amara SG.

J Biol Chem. 2015 Sep 18;290(38):22977-90. doi: 10.1074/jbc.M115.660860. Epub 2015 Jul 22.


Identification and functional characterization of a novel arginine/ornithine transporter, a member of a cationic amino acid transporter subfamily in the Trypanosoma cruzi genome.

Henriques C, Miller MP, Catanho M, de Carvalho TM, Krieger MA, Probst CM, de Souza W, Degrave W, Amara SG.

Parasit Vectors. 2015 Jun 25;8:346. doi: 10.1186/s13071-015-0950-y.


Differential regulation of two isoforms of the glial glutamate transporter EAAT2 by DLG1 and CaMKII.

Underhill SM, Wheeler DS, Amara SG.

J Neurosci. 2015 Apr 1;35(13):5260-70. doi: 10.1523/JNEUROSCI.4365-14.2015.


Introduction to the theme "Precision medicine and prediction in pharmacology".

Insel PA, Amara SG, Blaschke TF.

Annu Rev Pharmacol Toxicol. 2015;55:11-4. doi: 10.1146/annurev-pharmtox-101714-123102. Epub 2014 Dec 17. No abstract available.


Found in translation: training the next generation of translational neuroscientists.

Jensen FE, Amara SG.

Neuron. 2014 Nov 5;84(3):542-5. doi: 10.1016/j.neuron.2014.10.043. Epub 2014 Nov 5. Review.


Cysteine transport through excitatory amino acid transporter 3 (EAAT3).

Watts SD, Torres-Salazar D, Divito CB, Amara SG.

PLoS One. 2014 Oct 2;9(10):e109245. doi: 10.1371/journal.pone.0109245. eCollection 2014.


Amphetamine modulates excitatory neurotransmission through endocytosis of the glutamate transporter EAAT3 in dopamine neurons.

Underhill SM, Wheeler DS, Li M, Watts SD, Ingram SL, Amara SG.

Neuron. 2014 Jul 16;83(2):404-416. doi: 10.1016/j.neuron.2014.05.043.


Inhibition of dopamine transporter activity by G protein βγ subunits.

Garcia-Olivares J, Torres-Salazar D, Owens WA, Baust T, Siderovski DP, Amara SG, Zhu J, Daws LC, Torres GE.

PLoS One. 2013;8(3):e59788. doi: 10.1371/journal.pone.0059788. Epub 2013 Mar 26.


A call for transparent reporting to optimize the predictive value of preclinical research.

Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT 3rd, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD.

Nature. 2012 Oct 11;490(7419):187-91. doi: 10.1038/nature11556.


A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes.

Watts SD, Suchland KL, Amara SG, Ingram SL.

PLoS One. 2012;7(4):e35373. doi: 10.1371/journal.pone.0035373. Epub 2012 Apr 10.


Large collective motions regulate the functional properties of glutamate transporter trimers.

Jiang J, Shrivastava IH, Watts SD, Bahar I, Amara SG.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15141-6. doi: 10.1073/pnas.1112216108. Epub 2011 Aug 29.


Dopamine transport by the serotonin transporter: a mechanistically distinct mode of substrate translocation.

Larsen MB, Sonders MS, Mortensen OV, Larson GA, Zahniser NR, Amara SG.

J Neurosci. 2011 Apr 27;31(17):6605-15. doi: 10.1523/JNEUROSCI.0576-11.2011.


Neuroscience in recession?

Amara SG, Grillner S, Insel T, Nutt D, Tsumoto T.

Nat Rev Neurosci. 2011 May;12(5):297-302. doi: 10.1038/nrn3023. Review.


New views of glutamate transporter structure and function: advances and challenges.

Jiang J, Amara SG.

Neuropharmacology. 2011 Jan;60(1):172-81. doi: 10.1016/j.neuropharm.2010.07.019. Epub 2010 Aug 12. Review.


Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding.

Hong WC, Amara SG.

J Biol Chem. 2010 Oct 15;285(42):32616-26. doi: 10.1074/jbc.M110.150565. Epub 2010 Aug 5.


Close encounters of the oily kind: regulation of transporters by lipids.

Divito CB, Amara SG.

Mol Interv. 2009 Oct;9(5):252-62. doi: 10.1124/mi.9.5.8. Review.


Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin.

Fontana AC, Sonders MS, Pereira-Junior OS, Knight M, Javitch JA, Rodrigues V, Amara SG, Mortensen OV.

Eur J Pharmacol. 2009 Aug 15;616(1-3):48-57. doi: 10.1016/j.ejphar.2009.06.023. Epub 2009 Jun 21.


Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter.

Gu Y, Shrivastava IH, Amara SG, Bahar I.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2589-94. doi: 10.1073/pnas.0812299106. Epub 2009 Feb 6.


Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter.

Shrivastava IH, Jiang J, Amara SG, Bahar I.

J Biol Chem. 2008 Oct 17;283(42):28680-90. doi: 10.1074/jbc.M800889200. Epub 2008 Aug 4.


Genetic complementation screen identifies a mitogen-activated protein kinase phosphatase, MKP3, as a regulator of dopamine transporter trafficking.

Mortensen OV, Larsen MB, Prasad BM, Amara SG.

Mol Biol Cell. 2008 Jul;19(7):2818-29. doi: 10.1091/mbc.E07-09-0980. Epub 2008 Apr 23.


Chloride finds its place in the transport cycle.

Amara SG.

Nat Struct Mol Biol. 2007 Sep;14(9):792-4. No abstract available.


Enhancing glutamate transport: mechanism of action of Parawixin1, a neuroprotective compound from Parawixia bistriata spider venom.

Fontana AC, de Oliveira Beleboni R, Wojewodzic MW, Ferreira Dos Santos W, Coutinho-Netto J, Grutle NJ, Watts SD, Danbolt NC, Amara SG.

Mol Pharmacol. 2007 Nov;72(5):1228-37. Epub 2007 Jul 23.


Glutamate and monoamine transporters: new visions of form and function.

Torres GE, Amara SG.

Curr Opin Neurobiol. 2007 Jun;17(3):304-12. Epub 2007 May 16. Review.


Effects of Tityus serrulatus scorpion venom and its toxin TsTX-V on neurotransmitter uptake in vitro.

Cecchini AL, Vasconcelos F, Amara SG, Giglio JR, Arantes EC.

Toxicol Appl Pharmacol. 2006 Dec 1;217(2):196-203. Epub 2006 Sep 12.


Structural rearrangements at the translocation pore of the human glutamate transporter, EAAT1.

Leighton BH, Seal RP, Watts SD, Skyba MO, Amara SG.

J Biol Chem. 2006 Oct 6;281(40):29788-96. Epub 2006 Jul 28.


Distinct proteomic profiles of amphetamine self-administration transitional states.

Freeman WM, Brebner K, Amara SG, Reed MS, Pohl J, Phillips AG.

Pharmacogenomics J. 2005;5(3):203-14.


Differential regulation of GLAST immunoreactivity and activity by protein kinase C: evidence for modification of amino and carboxyl termini.

Susarla BT, Seal RP, Zelenaia O, Watson DJ, Wolfe JH, Amara SG, Robinson MB.

J Neurochem. 2004 Dec;91(5):1151-63.


Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters.

Shimamoto K, Sakai R, Takaoka K, Yumoto N, Nakajima T, Amara SG, Shigeri Y.

Mol Pharmacol. 2004 Apr;65(4):1008-15.


Dynamic regulation of the dopamine transporter.

Mortensen OV, Amara SG.

Eur J Pharmacol. 2003 Oct 31;479(1-3):159-70. Review.


Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake.

Fontana AC, Guizzo R, de Oliveira Beleboni R, Meirelles E Silva AR, Coimbra NC, Amara SG, dos Santos WF, Coutinho-Netto J.

Br J Pharmacol. 2003 Aug;139(7):1297-309.

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