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Δ9-Tetrahydrocannabinol suppresses monocyte-mediated astrocyte production of MCP-1 and IL-6 in a TLR7-stimulated human co-culture.

Rizzo MD, Crawford RB, Bach A, Sermet S, Amalfitano A, Kaminski NE.

J Pharmacol Exp Ther. 2019 Aug 5. pii: jpet.119.260661. doi: 10.1124/jpet.119.260661. [Epub ahead of print]


Imiquimod and interferon-alpha augment monocyte-mediated astrocyte secretion of MCP-1, IL-6 and IP-10 in a human co-culture system.

Rizzo MD, Crawford RB, Bach A, Sermet S, Amalfitano A, Kaminski NE.

J Neuroimmunol. 2019 Aug 15;333:576969. doi: 10.1016/j.jneuroim.2019.576969. Epub 2019 May 20.


The role of ERAP1 in autoinflammation and autoimmunity.

Pepelyayeva Y, Amalfitano A.

Hum Immunol. 2019 May;80(5):302-309. doi: 10.1016/j.humimm.2019.02.013. Epub 2019 Feb 25. Review.


A protein chimera self-assembling unit for drug delivery.

Amalfitano A, Martini C, Nocca G, Papi M, De Spirito M, Sanguinetti M, Vitali A, Bugli F, Arcovito A.

Biotechnol Prog. 2019 Mar;35(2):e2769. doi: 10.1002/btpr.2769. Epub 2018 Dec 27.


Quantitative Determination of 18-β-Glycyrrhetinic Acid in HepG2 Cell Line by High Performance Liquid Chromatography Method.

Nocca G, Callà C, Santini SA, Amalfitano A, Marigo L, Rossetti DV, Spagnuolo G, Cordaro M.

Int J Anal Chem. 2018 Nov 13;2018:5673186. doi: 10.1155/2018/5673186. eCollection 2018.


SLAMF7 Is a Critical Negative Regulator of IFN-α-Mediated CXCL10 Production in Chronic HIV Infection.

O'Connell P, Pepelyayeva Y, Blake MK, Hyslop S, Crawford RB, Rizzo MD, Pereira-Hicks C, Godbehere S, Dale L, Gulick P, Kaminski NE, Amalfitano A, Aldhamen YA.

J Immunol. 2019 Jan 1;202(1):228-238. doi: 10.4049/jimmunol.1800847. Epub 2018 Dec 10.


ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis.

Pepelyayeva Y, Rastall DPW, Aldhamen YA, O'Connell P, Raehtz S, Alyaqoub FS, Blake MK, Raedy AM, Angarita AM, Abbas AM, Pereira-Hicks CN, Roosa SG, McCabe L, Amalfitano A.

Sci Rep. 2018 Aug 20;8(1):12464. doi: 10.1038/s41598-018-30159-5.


Controlled release of 18-β-glycyrrhetic acid by nanodelivery systems increases cytotoxicity on oral carcinoma cell line.

Cacciotti I, Chronopoulou L, Palocci C, Amalfitano A, Cantiani M, Cordaro M, Lajolo C, Callà C, Boninsegna A, Lucchetti D, Gallenzi P, Sgambato A, Nocca G, Arcovito A.

Nanotechnology. 2018 Jul 13;29(28):285101. doi: 10.1088/1361-6528/aabecc. Epub 2018 Apr 17.


Compound heterozygosity for loss-of-function FARSB variants in a patient with classic features of recessive aminoacyl-tRNA synthetase-related disease.

Antonellis A, Oprescu SN, Griffin LB, Heider A, Amalfitano A, Innis JW.

Hum Mutat. 2018 Jun;39(6):834-840. doi: 10.1002/humu.23424. Epub 2018 Apr 10.


ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability.

Kady NM, Liu X, Lydic TA, Syed MH, Navitskaya S, Wang Q, Hammer SS, O'Reilly S, Huang C, Seregin SS, Amalfitano A, Chiodo VA, Boye SL, Hauswirth WW, Antonetti DA, Busik JV.

Diabetes. 2018 Apr;67(4):769-781. doi: 10.2337/db17-1034. Epub 2018 Jan 23.


Correlation Between Metabolic Syndrome, Periodontitis and Reactive Oxygen Species Production. A Pilot Study.

Patini R, Gallenzi P, Spagnuolo G, Cordaro M, Cantiani M, Amalfitano A, Arcovito A, Callà C, Mingrone G, Nocca G.

Open Dent J. 2017 Dec 12;11:621-627. doi: 10.2174/1874210601711010621. eCollection 2017.


HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γ-inducible protein 10 levels compared with nonusing HIV patients.

Rizzo MD, Crawford RB, Henriquez JE, Aldhamen YA, Gulick P, Amalfitano A, Kaminski NE.

AIDS. 2018 Feb 20;32(4):419-429. doi: 10.1097/QAD.0000000000001704.


Current and Future Treatments for Lysosomal Storage Disorders.

Rastall DPW, Amalfitano A.

Curr Treat Options Neurol. 2017 Nov 4;19(12):45. doi: 10.1007/s11940-017-0481-2. Review.


Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality.

Rastall DPW, Alyaquob FS, O'Connell P, Pepelyayeva Y, Peters D, Godbehere-Roosa S, Pereira-Hicks C, Aldhamen YA, Amalfitano A.

Int Immunol. 2017 Jun 1;29(6):277-289. doi: 10.1093/intimm/dxx035.


Decreased Vector Gene Expression from E2b Gene-Deleted Adenovirus Serotype 5 Vaccines Intensifies Proinflammatory Immune Responses.

Quiroga D, Aldhamen YA, Godbehere S, Harding L, Amalfitano A.

Clin Vaccine Immunol. 2017 Jun 5;24(6). pii: e00061-17. doi: 10.1128/CVI.00061-17. Print 2017 Jun.


Selective delivery of doxorubicin by novel stimuli-sensitive nano-ferritins overcomes tumor refractoriness.

Fracasso G, Falvo E, Colotti G, Fazi F, Ingegnere T, Amalfitano A, Doglietto GB, Alfieri S, Boffi A, Morea V, Conti G, Tremante E, Giacomini P, Arcovito A, Ceci P.

J Control Release. 2016 Oct 10;239:10-8. doi: 10.1016/j.jconrel.2016.08.010. Epub 2016 Aug 12.


Long-term, high-level hepatic secretion of acid α-glucosidase for Pompe disease achieved in non-human primates using helper-dependent adenovirus.

Rastall DP, Seregin SS, Aldhamen YA, Kaiser LM, Mullins C, Liou A, Ing F, Pereria-Hicks C, Godbehere-Roosa S, Palmer D, Ng P, Amalfitano A.

Gene Ther. 2016 Oct;23(10):743-752. doi: 10.1038/gt.2016.53. Epub 2016 Jul 1.


CRACC-targeting Fc-fusion protein induces activation of NK cells and DCs and improves T cell immune responses to antigenic targets.

Aldhamen YA, Rastall DPW, Chen W, Seregin SS, Pereira-Hicks C, Godbehere S, Kaminski NE, Amalfitano A.

Vaccine. 2016 Jun 8;34(27):3109-3118. doi: 10.1016/j.vaccine.2016.04.068. Epub 2016 May 3.


In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens.

Alyaqoub FS, Aldhamen YA, Koestler BJ, Bruger EL, Seregin SS, Pereira-Hicks C, Godbehere S, Waters CM, Amalfitano A.

J Immunol. 2016 Feb 15;196(4):1741-52. doi: 10.4049/jimmunol.1501272. Epub 2016 Jan 20.


Recent advances in gene therapy for lysosomal storage disorders.

Rastall DP, Amalfitano A.

Appl Clin Genet. 2015 Jun 24;8:157-69. doi: 10.2147/TACG.S57682. eCollection 2015. Review.


Dexamethasone-loaded biopolymeric nanoparticles promote gingival fibroblasts differentiation.

Chronopoulou L, Amalfitano A, Palocci C, Nocca G, Callà C, Arcovito A.

Biotechnol Prog. 2015 Sep-Oct;31(5):1381-7. doi: 10.1002/btpr.2141. Epub 2015 Jul 15.


Strengthened tumor antigen immune recognition by inclusion of a recombinant Eimeria antigen in therapeutic cancer vaccination.

Quiroga D, Aldhamen YA, Appledorn DM, Godbehere S, Amalfitano A.

Cancer Immunol Immunother. 2015 Apr;64(4):479-91. doi: 10.1007/s00262-015-1659-7. Epub 2015 Feb 6.


Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.

Aldhamen YA, Pepelyayeva Y, Rastall DP, Seregin SS, Zervoudi E, Koumantou D, Aylsworth CF, Quiroga D, Godbehere S, Georgiadis D, Stratikos E, Amalfitano A.

J Innate Immun. 2015;7(3):275-89. doi: 10.1159/000368899. Epub 2015 Jan 14.


Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus.

Koestler BJ, Seregin SS, Rastall DP, Aldhamen YA, Godbehere S, Amalfitano A, Waters CM.

Clin Vaccine Immunol. 2014 Nov;21(11):1550-9. doi: 10.1128/CVI.00471-14. Epub 2014 Sep 17.


ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses.

Rastall DP, Aldhamen YA, Seregin SS, Godbehere S, Amalfitano A.

Int Immunol. 2014 Dec;26(12):685-95. doi: 10.1093/intimm/dxu078. Epub 2014 Aug 2.


Manipulation of EAT-2 expression promotes induction of multiple beneficial regulatory and effector functions of the human innate immune system as a novel immunomodulatory strategy.

Aldhamen YA, Seregin SS, Aylsworth CF, Godbehere S, Amalfitano A.

Int Immunol. 2014 May;26(5):291-303. doi: 10.1093/intimm/dxt061. Epub 2013 Dec 27.


Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses.

Zervoudi E, Saridakis E, Birtley JR, Seregin SS, Reeves E, Kokkala P, Aldhamen YA, Amalfitano A, Mavridis IM, James E, Georgiadis D, Stratikos E.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19890-5. doi: 10.1073/pnas.1309781110. Epub 2013 Nov 18.


Regulation of epithelial differentiation in rat intestine by intraluminal delivery of an adenoviral vector or silencing RNA coding for Schlafen 3.

Kovalenko PL, Yuan L, Sun K, Kunovska L, Seregin S, Amalfitano A, Basson MD.

PLoS One. 2013 Nov 11;8(11):e79745. doi: 10.1371/journal.pone.0079745. eCollection 2013.


Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.

Seregin SS, Rastall DP, Evnouchidou I, Aylsworth CF, Quiroga D, Kamal RP, Godbehere-Roosa S, Blum CF, York IA, Stratikos E, Amalfitano A.

Autoimmunity. 2013 Dec;46(8):497-508. doi: 10.3109/08916934.2013.819855. Epub 2013 Sep 13.


Improved cytotoxic T-lymphocyte immune responses to a tumor antigen by vaccines co-expressing the SLAM-associated adaptor EAT-2.

Aldhamen YA, Seregin SS, Kousa YA, Rastall DP, Appledorn DM, Godbehere S, Schutte BC, Amalfitano A.

Cancer Gene Ther. 2013 Oct;20(10):564-75. doi: 10.1038/cgt.2013.53. Epub 2013 Aug 16.


Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response.

Aldhamen YA, Seregin SS, Rastall DP, Aylsworth CF, Pepelyayeva Y, Busuito CJ, Godbehere-Roosa S, Kim S, Amalfitano A.

PLoS One. 2013 Jul 24;8(7):e69539. doi: 10.1371/journal.pone.0069539. Print 2013.


Activation of human natural killer cells by the novel innate immune modulator recombinant Eimeria antigen.

Aylsworth CF, Aldhamen YA, Seregin SS, Godbehere S, Amalfitano A.

Hum Immunol. 2013 Aug;74(8):916-26. doi: 10.1016/j.humimm.2013.04.035. Epub 2013 Apr 29.


Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients.

Morse MA, Chaudhry A, Gabitzsch ES, Hobeika AC, Osada T, Clay TM, Amalfitano A, Burnett BK, Devi GR, Hsu DS, Xu Y, Balcaitis S, Dua R, Nguyen S, Balint JP Jr, Jones FR, Lyerly HK.

Cancer Immunol Immunother. 2013 Aug;62(8):1293-301. doi: 10.1007/s00262-013-1400-3. Epub 2013 Apr 30.


A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.

Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M, Panayotou G, Giastas P, Petrakis O, Georgiadis D, Amalfitano A, Saridakis E, Mavridis IM, Stratikos E.

J Immunol. 2012 Sep 1;189(5):2383-92. doi: 10.4049/jimmunol.1200918. Epub 2012 Jul 25.


Vaccines expressing the innate immune modulator EAT-2 elicit potent effector memory T lymphocyte responses despite pre-existing vaccine immunity.

Aldhamen YA, Seregin SS, Schuldt NJ, Rastall DP, Liu CJ, Godbehere S, Amalfitano A.

J Immunol. 2012 Aug 1;189(3):1349-59. doi: 10.4049/jimmunol.1200736. Epub 2012 Jun 27.


Immunogenicity when utilizing adenovirus serotype 4 and 5 vaccines expressing circumsporozoite protein in naïve and adenovirus (Ad5) immune mice.

Schuldt NJ, Aldhamen YA, Godbehere-Roosa S, Seregin SS, Kousa YA, Amalfitano A.

Malar J. 2012 Jun 21;11:209. doi: 10.1186/1475-2875-11-209.


Malaria vaccines: focus on adenovirus based vectors.

Schuldt NJ, Amalfitano A.

Vaccine. 2012 Jul 27;30(35):5191-8. doi: 10.1016/j.vaccine.2012.05.048. Epub 2012 Jun 7. Review.


Persistence of high sustained antibodies to enzyme replacement therapy despite extensive immunomodulatory therapy in an infant with Pompe disease: need for agents to target antibody-secreting plasma cells.

Banugaria SG, Patel TT, Mackey J, Das S, Amalfitano A, Rosenberg AS, Charrow J, Chen YT, Kishnani PS.

Mol Genet Metab. 2012 Apr;105(4):677-80. doi: 10.1016/j.ymgme.2012.01.019. Epub 2012 Jan 28.


Adenovirus-based vaccination against Clostridium difficile toxin A allows for rapid humoral immunity and complete protection from toxin A lethal challenge in mice.

Seregin SS, Aldhamen YA, Rastall DP, Godbehere S, Amalfitano A.

Vaccine. 2012 Feb 14;30(8):1492-501. doi: 10.1016/j.vaccine.2011.12.064. Epub 2011 Dec 23.


Improving adenovirus based gene transfer: strategies to accomplish immune evasion.

Seregin SS, Amalfitano A.

Viruses. 2010 Sep;2(9):2013-36. doi: 10.3390/v2092013. Epub 2010 Sep 24.


Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses.

Schuldt NJ, Aldhamen YA, Appledorn DM, Seregin SS, Kousa Y, Godbehere S, Amalfitano A.

PLoS One. 2011;6(8):e24147. doi: 10.1371/journal.pone.0024147. Epub 2011 Aug 30.


Gene therapy for lysosomal storage diseases: progress, challenges and future prospects.

Seregin SS, Amalfitano A.

Curr Pharm Des. 2011;17(24):2558-74. Review.


TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo.

Seregin SS, Aldhamen YA, Appledorn DM, Aylsworth CF, Godbehere S, Liu CJ, Quiroga D, Amalfitano A.

PLoS One. 2011;6(7):e22064. doi: 10.1371/journal.pone.0022064. Epub 2011 Jul 8.


Use of DAF-displaying adenovirus vectors reduces induction of transgene- and vector-specific adaptive immune responses in mice.

Seregin SS, Aldhamen YA, Appledorn DM, Zehnder J, Voss T, Godbehere S, Amalfitano A.

Hum Gene Ther. 2011 Sep;22(9):1083-94. doi: 10.1089/hum.2010.218. Epub 2011 Apr 18.


Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme.

Evnouchidou I, Kamal RP, Seregin SS, Goto Y, Tsujimoto M, Hattori A, Voulgari PV, Drosos AA, Amalfitano A, York IA, Stratikos E.

J Immunol. 2011 Feb 15;186(4):1909-13. doi: 10.4049/jimmunol.1003337. Epub 2011 Jan 17.


Immune recognition of gene transfer vectors: focus on adenovirus as a paradigm.

Aldhamen YA, Seregin SS, Amalfitano A.

Front Immunol. 2011 Sep 6;2:40. doi: 10.3389/fimmu.2011.00040. eCollection 2011.


Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens.

Aldhamen YA, Appledorn DM, Seregin SS, Liu CJ, Schuldt NJ, Godbehere S, Amalfitano A.

J Immunol. 2011 Jan 15;186(2):722-32. doi: 10.4049/jimmunol.1002105. Epub 2010 Dec 13.


G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice.

Patial S, Shahi S, Saini Y, Lee T, Packiriswamy N, Appledorn DM, Lapres JJ, Amalfitano A, Parameswaran N.

J Cell Physiol. 2011 May;226(5):1323-33. doi: 10.1002/jcp.22460.


Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice.

Patial S, Saini Y, Parvataneni S, Appledorn DM, Dorn GW 2nd, Lapres JJ, Amalfitano A, Senagore P, Parameswaran N.

J Cell Physiol. 2011 Mar;226(3):627-37. doi: 10.1002/jcp.22384.

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