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Items: 1 to 50 of 84

1.

Roles of Cyclooxygenase, Prostaglandin E2 and EP Receptors in Mucosal Protection and Ulcer Healing in the Gastrointestinal Tract.

Takeuchi K, Amagase K.

Curr Pharm Des. 2018;24(18):2002-2011. doi: 10.2174/1381612824666180629111227.

PMID:
29956615
2.

Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of postoperative ileus.

Matsumoto K, Kawanaka H, Hori M, Kusamori K, Utsumi D, Tsukahara T, Amagase K, Horie S, Yamamoto A, Ozaki H, Mori Y, Kato S.

Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G104-G116. doi: 10.1152/ajpgi.00305.2017. Epub 2018 Mar 22.

3.
4.

Transient receptor potential vanilloid 4 channel regulates vascular endothelial permeability during colonic inflammation in dextran sulphate sodium-induced murine colitis.

Matsumoto K, Yamaba R, Inoue K, Utsumi D, Tsukahara T, Amagase K, Tominaga M, Kato S.

Br J Pharmacol. 2018 Jan;175(1):84-99. doi: 10.1111/bph.14072. Epub 2017 Dec 3.

5.

G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells.

Tsukahara T, Hamouda N, Utsumi D, Matsumoto K, Amagase K, Kato S.

Pharmacol Res. 2017 Sep;123:27-39. doi: 10.1016/j.phrs.2017.06.009. Epub 2017 Jun 23.

PMID:
28648739
6.

Probiotic Bifidobacterium bifidum G9-1 attenuates 5-fluorouracil-induced intestinal mucositis in mice via suppression of dysbiosis-related secondary inflammatory responses.

Kato S, Hamouda N, Kano Y, Oikawa Y, Tanaka Y, Matsumoto K, Amagase K, Shimakawa M.

Clin Exp Pharmacol Physiol. 2017 Oct;44(10):1017-1025. doi: 10.1111/1440-1681.12792. Epub 2017 Aug 24.

PMID:
28590519
7.
8.

Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5-Fluorouracil-Induced Intestinal Mucositis in Mice.

Hamouda N, Sano T, Oikawa Y, Ozaki T, Shimakawa M, Matsumoto K, Amagase K, Higuchi K, Kato S.

Basic Clin Pharmacol Toxicol. 2017 Sep;121(3):159-168. doi: 10.1111/bcpt.12793. Epub 2017 May 10.

9.

NOX1/NADPH Oxidase Expressed in Colonic Macrophages Contributes to the Pathogenesis of Colonic Inflammation in Trinitrobenzene Sulfonic Acid-Induced Murine Colitis.

Yokota H, Tsuzuki A, Shimada Y, Imai A, Utsumi D, Tsukahara T, Matsumoto M, Amagase K, Iwata K, Nakamura A, Yabe-Nishimura C, Kato S.

J Pharmacol Exp Ther. 2017 Jan;360(1):192-200. Epub 2016 Oct 17.

PMID:
27754929
10.

5-HT3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis.

Utsumi D, Matsumoto K, Amagase K, Horie S, Kato S.

Br J Pharmacol. 2016 Jun;173(11):1835-49. doi: 10.1111/bph.13482. Epub 2016 Apr 21.

11.

[Glutamate as a potential protective drug in the gastrointestinal mucosa].

Amagase K, Nakamura E, Kato S, Takeuchi K.

Yakugaku Zasshi. 2015;135(6):779-82. doi: 10.1248/yakushi.14-00250-3. Review. Japanese.

12.
13.

Saireito (TJ-114), a Japanese traditional herbal medicine, reduces 5-fluorouracil-induced intestinal mucositis in mice by inhibiting cytokine-mediated apoptosis in intestinal crypt cells.

Kato S, Hayashi S, Kitahara Y, Nagasawa K, Aono H, Shibata J, Utsumi D, Amagase K, Kadowaki M.

PLoS One. 2015 Jan 7;10(1):e0116213. doi: 10.1371/journal.pone.0116213. eCollection 2015.

14.

Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats.

Takeuchi K, Takayama S, Hashimoto E, Itayama M, Amagase K, Izuhara C.

J Gastroenterol Hepatol. 2014 Dec;29 Suppl 4:37-46. doi: 10.1111/jgh.12774.

PMID:
25521732
15.

Importance of cyclooxygenase-1/prostacyclin in modulating gastric mucosal integrity under stress conditions.

Amagase K, Izumi N, Takahira Y, Wada T, Takeuchi K.

J Gastroenterol Hepatol. 2014 Dec;29 Suppl 4:3-10. doi: 10.1111/jgh.12767.

PMID:
25521725
16.

Distribution of transient receptor potential cation channel subfamily V member 1-expressing nerve fibers in mouse esophagus.

Matsumoto K, Hosoya T, Ishikawa E, Tashima K, Amagase K, Kato S, Murayama T, Horie S.

Histochem Cell Biol. 2014 Dec;142(6):635-44. doi: 10.1007/s00418-014-1246-6. Epub 2014 Jul 8.

PMID:
25002127
17.

Lubiprostone prevents nonsteroidal anti-inflammatory drug-induced small intestinal damage by suppressing the expression of inflammatory mediators via EP4 receptors.

Hayashi S, Kurata N, Yamaguchi A, Amagase K, Takeuchi K.

J Pharmacol Exp Ther. 2014 Jun;349(3):470-9. doi: 10.1124/jpet.114.213991. Epub 2014 Apr 8.

PMID:
24713141
18.

Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats.

Satoh H, Amagase K, Takeuchi K.

J Pharmacol Exp Ther. 2014 Feb;348(2):227-35. doi: 10.1124/jpet.113.208991. Epub 2013 Nov 19.

PMID:
24254524
19.

Cinacalcet, a calcimimetic, prevents nonsteroidal antiinflammatory drug-induced small intestinal damage in rats.

Hayashi S, Kurata N, Kitahirachi E, Nishimura Y, Amagase K, Yano T, Takeuchi K.

J Physiol Pharmacol. 2013 Aug;64(4):453-63.

20.

Roles of pro-angiogenic and anti-angiogenic factors as well as matrix metalloproteinases in healing of NSAID-induced small intestinal ulcers in rats.

Gyenge M, Amagase K, Kunimi S, Matsuoka R, Takeuchi K.

Life Sci. 2013 Oct 6;93(12-14):441-7. doi: 10.1016/j.lfs.2013.07.021. Epub 2013 Jul 27.

PMID:
23900029
21.

Prophylactic effect of monosodium glutamate on NSAID-induced enteropathy in rats.

Amagase K, Kimura Y, Wada A, Yukishige T, Murakami T, Nakamura E, Takeuchi K.

Curr Pharm Des. 2014;20(16):2783-90. Review.

PMID:
23886378
22.

Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs.

Takeuchi K, Izuhara C, Takayama S, Momode T, Kojo M, Hara D, Amagase K.

Curr Pharm Des. 2014;20(7):1139-48.

PMID:
23782140
23.

The role of food for the formation and prevention of gastrointestinal lesions induced by aspirin in cats.

Satoh H, Amagase K, Takeuchi K.

Dig Dis Sci. 2013 Oct;58(10):2840-9. doi: 10.1007/s10620-013-2725-7. Epub 2013 Jun 14.

PMID:
23765256
25.

Effects of Helicobacter pylori infection on gastric parietal cells and E-cadherin in Mongolian gerbils.

Murakami M, Fukuzawa M, Yamamoto M, Hamaya K, Tamura Y, Sugiyama A, Takahashi R, Murakami T, Amagase K, Takeuchi K.

J Pharmacol Sci. 2013;121(4):305-11. Epub 2013 Mar 30.

26.

5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells.

Yasuda M, Kato S, Yamanaka N, Iimori M, Matsumoto K, Utsumi D, Kitahara Y, Amagase K, Horie S, Takeuchi K.

Br J Pharmacol. 2013 Mar;168(6):1388-400. doi: 10.1111/bph.12019.

27.

Cyclooxygenase (COX)-1 and COX-2 both play an important role in the protection of the duodenal mucosa in cats.

Satoh H, Amagase K, Ebara S, Akiba Y, Takeuchi K.

J Pharmacol Exp Ther. 2013 Jan;344(1):189-95. doi: 10.1124/jpet.112.199182. Epub 2012 Sep 24.

PMID:
23008503
28.

Irsogladine: overview of the mechanisms of mucosal protective and healing- promoting actions in the gastrointestinal tract.

Akagi M, Amagase K, Murakami T, Takeuchi K.

Curr Pharm Des. 2013;19(1):106-14. Review.

PMID:
22950502
29.

Evaluation of gastric ulcerogenic and healing impairment effects of bisphosphonates: adverse gastric reactions of bisphosphonate.

Takeuchi K, Amagase K.

Curr Protoc Toxicol. 2012 Aug;Chapter 21:Unit 21.10.1-29. doi: 10.1002/0471140856.tx2110s53.

PMID:
22896009
30.

Exacerbation of nonsteroidal anti-inflammatory drug-induced small intestinal lesions by antisecretory drugs in rats: the role of intestinal motility.

Satoh H, Amagase K, Takeuchi K.

J Pharmacol Exp Ther. 2012 Nov;343(2):270-7. doi: 10.1124/jpet.112.197475. Epub 2012 Aug 1.

PMID:
22854201
31.

Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors.

Kato S, Matsuda N, Matsumoto K, Wada M, Onimaru N, Yasuda M, Amagase K, Horie S, Takeuchi K.

Pharmacol Res. 2012 Sep;66(3):226-34. doi: 10.1016/j.phrs.2012.06.002. Epub 2012 Jun 12.

PMID:
22699012
32.

[Development of NSAID-induced small intestinal lesions - pathogenic role of COX inhibition].

Takeuchi K, Tanaka A, Kato S, Amagase K.

Nihon Yakurigaku Zasshi. 2012 Mar;139(3):103-8. Review. Japanese. No abstract available.

PMID:
22451464
33.

Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice.

Yasuda M, Kato S, Yamanaka N, Iimori M, Utsumi D, Kitahara Y, Iwata K, Matsuno K, Amagase K, Yabe-Nishimura C, Takeuchi K.

Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1133-42. doi: 10.1152/ajpgi.00535.2011. Epub 2012 Mar 8.

34.

Gastric ulcerogenic and healing impairment effects of risedronate, a nitrogen-containing bisphosphonate in rats. Comparison with alendronate and minodronate.

Amagase K, Inaba A, Senta T, Ishikawa Y, Nukui K, Murakami T, Takeuchi K.

J Physiol Pharmacol. 2011 Dec;62(6):609-18.

35.

New therapeutic strategy for amino acid medicine: prophylactic and healing promoting effect of monosodium glutamate against NSAID-induced enteropathy.

Amagase K, Ochi A, Kojo A, Mizunoe A, Taue M, Kinoshita N, Nakamura E, Takeuchi K.

J Pharmacol Sci. 2012;118(2):131-7. Epub 2012 Jan 27. Review.

36.

[Prophylactic effect of glutamate on gastrointestinal damage].

Amagase K, Nakamura E, Kato S, Takeuchi K.

Yakugaku Zasshi. 2011;131(12):1711-9. Review. Japanese.

37.

Role of macrophage colony-stimulating factor (M-CSF)-dependent macrophages in gastric ulcer healing in mice.

Kawahara Y, Nakase Y, Isomoto Y, Matsuda N, Amagase K, Kato S, Takeuchi K.

J Physiol Pharmacol. 2011 Aug;62(4):441-8.

38.

Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.

Takeuchi K, Tanaka A, Nukui K, Kojo A, Gyenge M, Amagase K.

J Pharmacol Exp Ther. 2011 Sep;338(3):850-9. doi: 10.1124/jpet.111.183293. Epub 2011 Jun 24.

PMID:
21705613
39.

Dopamine D₂-receptor antagonists ameliorate indomethacin-induced small intestinal ulceration in mice by activating α7 nicotinic acetylcholine receptors.

Yasuda M, Kawahara R, Hashimura H, Yamanaka N, Iimori M, Amagase K, Kato S, Takeuchi K.

J Pharmacol Sci. 2011;116(3):274-82. Epub 2011 Jun 18.

40.
41.

Carbon monoxide involved in modulating HCO3- secretion in rat duodenum.

Takasuka H, Hayashi S, Koyama M, Yasuda M, Aihara E, Amagase K, Takeuchi K.

J Pharmacol Exp Ther. 2011 Apr;337(1):293-300. doi: 10.1124/jpet.110.175216. Epub 2011 Jan 19.

PMID:
21248067
42.

[Pathogenic mechanism of aspirin-induced gastric ulceration and its characteristics].

Takeuchi K, Amagase K, Abe N, Kojo A.

Nihon Rinsho. 2010 Nov;68(11):1962-5. Japanese. No abstract available.

PMID:
21061516
43.

Prostaglandin EP receptors involved in modulating gastrointestinal mucosal integrity.

Takeuchi K, Kato S, Amagase K.

J Pharmacol Sci. 2010;114(3):248-61. Epub 2010 Oct 28. Review.

44.

Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice.

Kawahara R, Yasuda M, Hashimura H, Amagase K, Kato S, Takeuchi K.

Eur J Pharmacol. 2011 Jan 10;650(1):411-7. doi: 10.1016/j.ejphar.2010.10.031. Epub 2010 Oct 20.

PMID:
20969854
45.

Endogenous prostaglandin E2 accelerates healing of indomethacin-induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptors.

Takeuchi K, Tanigami M, Amagase K, Ochi A, Okuda S, Hatazawa R.

J Gastroenterol Hepatol. 2010 May;25 Suppl 1:S67-74. doi: 10.1111/j.1440-1746.2010.06222.x.

PMID:
20586869
46.

New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin.

Nonoyama K, Nakagawa K, Amagase K, Takeuchi K, Nakamura M, Okabe S.

J Gastroenterol Hepatol. 2010 May;25 Suppl 1:S15-22. doi: 10.1111/j.1440-1746.2010.06227.x.

PMID:
20586859
47.

Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats.

Amagase K, Ochi A, Sugihara T, Kato S, Takeuchi K.

J Gastroenterol Hepatol. 2010 May;25 Suppl 1:S111-8. doi: 10.1111/j.1440-1746.2010.06223.x.

PMID:
20586851
48.

Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1.

Yoda Y, Amagase K, Kato S, Tokioka S, Murano M, Kakimoto K, Nishio H, Umegaki E, Takeuchi K, Higuchi K.

J Physiol Pharmacol. 2010 Jun;61(3):287-94.

49.

New frontiers in gut nutrient sensor research: prophylactic effect of glutamine against Helicobacter pylori-induced gastric diseases in Mongolian gerbils.

Amagase K, Nakamura E, Endo T, Hayashi S, Hasumura M, Uneyama H, Torii K, Takeuchi K.

J Pharmacol Sci. 2010;112(1):25-32.

50.

The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease.

Sugihara T, Kobori A, Imaeda H, Tsujikawa T, Amagase K, Takeuchi K, Fujiyama Y, Andoh A.

Clin Exp Immunol. 2010 Jun;160(3):386-93. doi: 10.1111/j.1365-2249.2010.04093.x. Epub 2010 Jan 19.

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