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Items: 1 to 50 of 102

1.

β-Secretase BACE1 Is Required for Normal Cochlear Function.

Dierich M, Hartmann S, Dietrich N, Moeser P, Brede F, Johnson Chacko L, Tziridis K, Schilling A, Krauss P, Hessler S, Karch S, Schrott-Fischer A, Blumer M, Birchmeier C, Oliver D, Moser T, Schulze H, Alzheimer C, Leitner MG, Huth T.

J Neurosci. 2019 Nov 6;39(45):9013-9027. doi: 10.1523/JNEUROSCI.0028-19.2019. Epub 2019 Sep 16.

PMID:
31527119
2.

Chronic antipsychotic treatment targets GIRK current suppression, loss of long-term synaptic depression and behavioural sensitization in a mouse model of amphetamine psychosis.

Groos D, Zheng F, Rauh M, Quinger B, Kornhuber J, Müller CP, Alzheimer C.

J Psychopharmacol. 2018 Nov 29:269881118812235. doi: 10.1177/0269881118812235. [Epub ahead of print]

PMID:
30488738
3.

Doxorubicin induces caspase-mediated proteolysis of KV7.1.

Strigli A, Raab C, Hessler S, Huth T, Schuldt AJT, Alzheimer C, Friedrich T, Burridge PW, Luedde M, Schwake M.

Commun Biol. 2018 Sep 28;1:155. doi: 10.1038/s42003-018-0162-z. eCollection 2018.

4.

Nasal Spray to the Rescue of Neurons in Stroke.

Alzheimer C.

Mol Ther. 2018 Oct 3;26(10):2333-2334. doi: 10.1016/j.ymthe.2018.08.024. Epub 2018 Sep 11. No abstract available.

5.

A dopaminergic mechanism of antipsychotic drug efficacy, failure, and failure reversal: the role of the dopamine transporter.

Amato D, Canneva F, Cumming P, Maschauer S, Groos D, Dahlmanns JK, Grömer TW, Chiofalo L, Dahlmanns M, Zheng F, Kornhuber J, Prante O, Alzheimer C, von Hörsten S, Müller CP.

Mol Psychiatry. 2018 Jul 23. doi: 10.1038/s41380-018-0114-5. [Epub ahead of print]

PMID:
30038229
6.

A New Fluorogenic Small-Molecule Labeling Tool for Surface Diffusion Analysis and Advanced Fluorescence Imaging of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Based on Silicone Rhodamine: SiR-BACE1.

Karch S, Broichhagen J, Schneider J, Böning D, Hartmann S, Schmid B, Tripal P, Palmisano R, Alzheimer C, Johnsson K, Huth T.

J Med Chem. 2018 Jul 26;61(14):6121-6139. doi: 10.1021/acs.jmedchem.8b00387. Epub 2018 Jul 10.

PMID:
29939737
7.

Functional Consequences of the Postnatal Switch From Neonatal to Mutant Adult Glycine Receptor α1 Subunits in the Shaky Mouse Model of Startle Disease.

Schaefer N, Zheng F, van Brederode J, Berger A, Leacock S, Hirata H, Paige CJ, Harvey RJ, Alzheimer C, Villmann C.

Front Mol Neurosci. 2018 May 24;11:167. doi: 10.3389/fnmol.2018.00167. eCollection 2018.

8.

β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses.

Hartmann S, Zheng F, Kyncl MC, Karch S, Voelkl K, Zott B, D'Avanzo C, Lomoio S, Tesco G, Kim DY, Alzheimer C, Huth T.

J Neurosci. 2018 Apr 4;38(14):3480-3494. doi: 10.1523/JNEUROSCI.2643-17.2018. Epub 2018 Mar 5.

9.

Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease.

Schaefer N, Berger A, van Brederode J, Zheng F, Zhang Y, Leacock S, Littau L, Jablonka S, Malhotra S, Topf M, Winter F, Davydova D, Lynch JW, Paige CJ, Alzheimer C, Harvey RJ, Villmann C.

J Neurosci. 2017 Aug 16;37(33):7948-7961. doi: 10.1523/JNEUROSCI.0009-17.2017. Epub 2017 Jul 19.

10.

EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction.

Mielenz D, Reichel M, Jia T, Quinlan EB, Stöckl T, Mettang M, Zilske D, Kirmizi-Alsan E, Schönberger P, Praetner M, Huber SE, Amato D, Schwarz M, Purohit P, Brachs S, Spranger J, Hess A, Büttner C, Ekici AB, Perez-Branguli F, Winner B, Rauschenberger V, Banaschewski T, Bokde ALW, Büchel C, Conrod PJ, Desrivières S, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Martinot JL, Lemaitre H, Nees F, Paus T, Smolka MN; IMAGEN Consortium, Schambony A, Bäuerle T, Eulenburg V, Alzheimer C, Lourdusamy A, Schumann G, Müller CP.

Mol Psychiatry. 2018 May;23(5):1303-1319. doi: 10.1038/mp.2017.63. Epub 2017 Apr 11.

11.

Erratum to: The Antidepressant Fluoxetine Mobilizes Vesicles to the Recycling Pool of Rat Hippocampal Synapses During High Activity.

Jung J, Loy K, Schilling EM, Röther M, Brauner JM, Huth T, Schlötzer-Schrehardt U, Alzheimer C, Kornhuber J, Welzel O, Groemer TW.

Mol Neurobiol. 2017 May;54(4):3117. doi: 10.1007/s12035-017-0476-8. No abstract available.

PMID:
28290148
12.

Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure.

Möller D, Banerjee A, Uzuneser TC, Skultety M, Huth T, Plouffe B, Hübner H, Alzheimer C, Friedland K, Müller CP, Bouvier M, Gmeiner P.

J Med Chem. 2017 Apr 13;60(7):2908-2929. doi: 10.1021/acs.jmedchem.6b01857. Epub 2017 Mar 22.

PMID:
28248104
13.

The terpenoids Myrtenol and Verbenol act on δ subunit-containing GABAA receptors and enhance tonic inhibition in dentate gyrus granule cells.

van Brederode J, Atak S, Kessler A, Pischetsrieder M, Villmann C, Alzheimer C.

Neurosci Lett. 2016 Aug 15;628:91-7. doi: 10.1016/j.neulet.2016.06.027. Epub 2016 Jun 14.

PMID:
27312536
14.

Ion channel regulation by β-secretase BACE1 - enzymatic and non-enzymatic effects beyond Alzheimer's disease.

Lehnert S, Hartmann S, Hessler S, Adelsberger H, Huth T, Alzheimer C.

Channels (Austin). 2016 Sep 2;10(5):365-378. Epub 2016 Jun 2. Review.

15.

Activin Signaling in the Pathogenesis and Therapy of Neuropsychiatric Diseases.

Link AS, Zheng F, Alzheimer C.

Front Mol Neurosci. 2016 May 10;9:32. doi: 10.3389/fnmol.2016.00032. eCollection 2016. Review.

16.

Activin Controls Ethanol Potentiation of Inhibitory Synaptic Transmission Through GABAA Receptors and Concomitant Behavioral Sedation.

Zheng F, Puppel A, Huber SE, Link AS, Eulenburg V, van Brederode JF, Müller CP, Alzheimer C.

Neuropsychopharmacology. 2016 Jul;41(8):2024-33. doi: 10.1038/npp.2015.372. Epub 2015 Dec 31.

17.

BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs).

Agsten M, Hessler S, Lehnert S, Volk T, Rittger A, Hartmann S, Raab C, Kim DY, Groemer TW, Schwake M, Alzheimer C, Huth T.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):335-48. doi: 10.1016/j.yjmcc.2015.10.006. Epub 2015 Oct 8.

PMID:
26454161
18.

Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors.

Eberhardt E, Havlicek S, Schmidt D, Link AS, Neacsu C, Kohl Z, Hampl M, Kist AM, Klinger A, Nau C, Schüttler J, Alzheimer C, Winkler J, Namer B, Winner B, Lampert A.

Stem Cell Reports. 2015 Sep 8;5(3):305-13. doi: 10.1016/j.stemcr.2015.07.010. Epub 2015 Aug 28.

19.

Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling.

Link AS, Kurinna S, Havlicek S, Lehnert S, Reichel M, Kornhuber J, Winner B, Huth T, Zheng F, Werner S, Alzheimer C.

Mol Neurobiol. 2016 Aug;53(6):4210-4225. doi: 10.1007/s12035-015-9363-3. Epub 2015 Jul 28.

PMID:
26215835
20.

Activin A in perinatal brain injury.

Brackmann FA, Alzheimer C, Trollmann R.

Neuropediatrics. 2015 Apr;46(2):82-7. doi: 10.1055/s-0035-1547345. Epub 2015 Mar 13. Review.

PMID:
25769120
21.

β-Secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion.

Hessler S, Zheng F, Hartmann S, Rittger A, Lehnert S, Völkel M, Nissen M, Edelmann E, Saftig P, Schwake M, Huth T, Alzheimer C.

J Neurosci. 2015 Feb 25;35(8):3298-311. doi: 10.1523/JNEUROSCI.3127-14.2015.

22.

Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression.

Malsch P, Andratsch M, Vogl C, Link AS, Alzheimer C, Brierley SM, Hughes PA, Kress M.

J Neurosci. 2014 Jul 23;34(30):9845-56. doi: 10.1523/JNEUROSCI.5161-13.2014.

23.

Risperidone inhibits voltage-gated sodium channels.

Brauner JM, Hessler S, Groemer TW, Alzheimer C, Huth T.

Eur J Pharmacol. 2014 Apr 5;728:100-6. doi: 10.1016/j.ejphar.2014.01.062. Epub 2014 Feb 5.

PMID:
24508524
24.

The antidepressant fluoxetine mobilizes vesicles to the recycling pool of rat hippocampal synapses during high activity.

Jung J, Loy K, Schilling EM, Röther M, Brauner JM, Huth T, Schlötzer-Schrehardt U, Alzheimer C, Kornhuber J, Welzel O, Groemer TW.

Mol Neurobiol. 2014 Apr;49(2):916-30. doi: 10.1007/s12035-013-8569-5. Epub 2013 Nov 5. Erratum in: Mol Neurobiol. 2017 May;54(4):3117.

PMID:
24190333
25.

Amplified cold transduction in native nociceptors by M-channel inhibition.

Vetter I, Hein A, Sattler S, Hessler S, Touska F, Bressan E, Parra A, Hager U, Leffler A, Boukalova S, Nissen M, Lewis RJ, Belmonte C, Alzheimer C, Huth T, Vlachova V, Reeh PW, Zimmermann K.

J Neurosci. 2013 Oct 16;33(42):16627-41. doi: 10.1523/JNEUROSCI.1473-13.2013.

26.

Axonal and synaptic failure suppress the transfer of firing rate oscillations, synchrony and information during high frequency deep brain stimulation.

Rosenbaum R, Zimnik A, Zheng F, Turner RS, Alzheimer C, Doiron B, Rubin JE.

Neurobiol Dis. 2014 Feb;62:86-99. doi: 10.1016/j.nbd.2013.09.006. Epub 2013 Sep 16.

27.

Activin A regulation under global hypoxia in developing mouse brain.

Brackmann FA, Link AS, Jung S, Richter M, Zoglauer D, Walkinshaw G, Alzheimer C, Trollmann R.

Brain Res. 2013 Sep 19;1531:65-74. doi: 10.1016/j.brainres.2013.07.039. Epub 2013 Jul 31.

PMID:
23916668
28.

Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs.

Gulbins E, Palmada M, Reichel M, Lüth A, Böhmer C, Amato D, Müller CP, Tischbirek CH, Groemer TW, Tabatabai G, Becker KA, Tripal P, Staedtler S, Ackermann TF, van Brederode J, Alzheimer C, Weller M, Lang UE, Kleuser B, Grassmé H, Kornhuber J.

Nat Med. 2013 Jul;19(7):934-8. doi: 10.1038/nm.3214. Epub 2013 Jun 16.

29.

BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.

Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY.

FASEB J. 2013 Jun;27(6):2458-67. doi: 10.1096/fj.12-214056. Epub 2013 Mar 15.

30.

Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons.

Klinger AB, Eberhardt M, Link AS, Namer B, Kutsche LK, Schuy ET, Sittl R, Hoffmann T, Alzheimer C, Huth T, Carr RW, Lampert A.

Mol Pain. 2012 Sep 15;8:69. doi: 10.1186/1744-8069-8-69.

31.

Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channel.

O'Reilly AO, Eberhardt E, Weidner C, Alzheimer C, Wallace BA, Lampert A.

PLoS One. 2012;7(7):e41667. doi: 10.1371/journal.pone.0041667. Epub 2012 Jul 27.

32.

Use-dependent inhibition of synaptic transmission by the secretion of intravesicularly accumulated antipsychotic drugs.

Tischbirek CH, Wenzel EM, Zheng F, Huth T, Amato D, Trapp S, Denker A, Welzel O, Lueke K, Svetlitchny A, Rauh M, Deusser J, Schwab A, Rizzoli SO, Henkel AW, Müller CP, Alzheimer C, Kornhuber J, Groemer TW.

Neuron. 2012 Jun 7;74(5):830-44. doi: 10.1016/j.neuron.2012.04.019.

33.

MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults.

Wefers B, Hitz C, Hölter SM, Trümbach D, Hansen J, Weber P, Pütz B, Deussing JM, de Angelis MH, Roenneberg T, Zheng F, Alzheimer C, Silva A, Wurst W, Kühn R.

PLoS One. 2012;7(4):e35035. doi: 10.1371/journal.pone.0035035. Epub 2012 Apr 18.

34.

Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current.

Sittl R, Lampert A, Huth T, Schuy ET, Link AS, Fleckenstein J, Alzheimer C, Grafe P, Carr RW.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6704-9. doi: 10.1073/pnas.1118058109. Epub 2012 Apr 9.

35.

M2 muscarinic acetylcholine receptors regulate long-term potentiation at hippocampal CA3 pyramidal cell synapses in an input-specific fashion.

Zheng F, Wess J, Alzheimer C.

J Neurophysiol. 2012 Jul;108(1):91-100. doi: 10.1152/jn.00740.2011. Epub 2012 Apr 4.

36.

Voltage-dependent Na+ channels as targets of BACE1 - implications for neuronal firing and beyond.

Huth T, Alzheimer C.

Curr Alzheimer Res. 2012 Feb;9(2):184-8.

PMID:
22455479
37.

Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model.

Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM.

J Mol Neurosci. 2011 Nov;45(3):432-7. doi: 10.1007/s12031-011-9604-5. Epub 2011 Aug 6.

PMID:
21822709
38.

More than being protective: functional roles for TGF-β/activin signaling pathways at central synapses.

Krieglstein K, Zheng F, Unsicker K, Alzheimer C.

Trends Neurosci. 2011 Aug;34(8):421-9. doi: 10.1016/j.tins.2011.06.002. Review.

PMID:
21742388
39.

Axonal failure during high frequency stimulation of rat subthalamic nucleus.

Zheng F, Lammert K, Nixdorf-Bergweiler BE, Steigerwald F, Volkmann J, Alzheimer C.

J Physiol. 2011 Jun 1;589(Pt 11):2781-93. doi: 10.1113/jphysiol.2011.205807. Epub 2011 Apr 11.

40.

Layer-specific processing of excitatory signals in CA1 interneurons depends on postsynaptic M₂ muscarinic receptors.

Zheng F, Seeger T, Nixdorf-Bergweiler BE, Alzheimer C.

Neurosci Lett. 2011 May 2;494(3):217-21. doi: 10.1016/j.neulet.2011.03.016. Epub 2011 Mar 21.

PMID:
21396982
41.

Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM.

J Neurosci. 2011 Feb 16;31(7):2511-25. doi: 10.1523/JNEUROSCI.5245-10.2011.

42.

β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current.

Huth T, Rittger A, Saftig P, Alzheimer C.

Pflugers Arch. 2011 Mar;461(3):355-71. doi: 10.1007/s00424-010-0913-2. Epub 2011 Jan 19.

PMID:
21246381
43.

Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function.

Huth T, Schmidt-Neuenfeldt K, Rittger A, Saftig P, Reiss K, Alzheimer C.

Neurobiol Dis. 2009 Feb;33(2):282-9. doi: 10.1016/j.nbd.2008.10.015. Epub 2008 Nov 8.

PMID:
19056495
44.
45.

Four-mode gating model of fast inactivation of sodium channel Nav1.2a.

Huth T, Schmidtmayer J, Alzheimer C, Hansen UP.

Pflugers Arch. 2008 Oct;457(1):103-19. doi: 10.1007/s00424-008-0500-y. Epub 2008 Apr 19.

PMID:
18425532
46.

Unexpected suppression of neuronal G protein-activated, inwardly rectifying K+ current by common phospholipase C inhibitor.

Sickmann T, Klose A, Huth T, Alzheimer C.

Neurosci Lett. 2008 May 9;436(2):102-6. doi: 10.1016/j.neulet.2008.02.067. Epub 2008 Mar 5.

PMID:
18358607
47.

Activin tunes GABAergic neurotransmission and modulates anxiety-like behavior.

Zheng F, Adelsberger H, Müller MR, Fritschy JM, Werner S, Alzheimer C.

Mol Psychiatry. 2009 Mar;14(3):332-46. doi: 10.1038/sj.mp.4002131. Epub 2008 Jan 8.

PMID:
18180762
48.

M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes.

Gautam D, Duttaroy A, Cui Y, Han SJ, Deng C, Seeger T, Alzheimer C, Wess J.

J Mol Neurosci. 2006;30(1-2):157-60.

PMID:
17192665
49.

Cholinergic modulation of periaqueductal grey neurons: does it contribute to epileptogenesis after organophosphorus nerve agent intoxication?

Sanada M, Zheng F, Huth T, Alzheimer C.

Toxicology. 2007 Apr 20;233(1-3):199-208. Epub 2006 Aug 22.

PMID:
16996672
50.

Transgenic mice expressing dominant-negative activin receptor IB in forebrain neurons reveal novel functions of activin at glutamatergic synapses.

Müller MR, Zheng F, Werner S, Alzheimer C.

J Biol Chem. 2006 Sep 29;281(39):29076-84. Epub 2006 Aug 2.

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