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Items: 1 to 50 of 170

1.

Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts.

Wagner T, Boyko A, Alzari PM, Bunik VI, Bellinzoni M.

J Struct Biol. 2019 Aug 30. pii: S1047-8477(19)30182-0. doi: 10.1016/j.jsb.2019.08.012. [Epub ahead of print]

PMID:
31476368
2.

Arabidopsis thaliana Hcc1 is a Sco-like metallochaperone for CuA assembly in Cytochrome c Oxidase.

Llases ME, Lisa MN, Morgada MN, Giannini E, Alzari PM, Vila AJ.

FEBS J. 2019 Jul 26. doi: 10.1111/febs.15016. [Epub ahead of print]

PMID:
31348612
3.

Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.

Bellinzoni M, Wehenkel AM, Durán R, Alzari PM.

Microbes Infect. 2019 Jun 26. pii: S1286-4579(19)30075-9. doi: 10.1016/j.micinf.2019.06.015. [Epub ahead of print]

PMID:
31254628
4.

Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.

Wagner T, André-Leroux G, Hindie V, Barilone N, Lisa MN, Hoos S, Raynal B, Vulliez-Le Normand B, O'Hare HM, Bellinzoni M, Alzari PM.

Sci Signal. 2019 May 7;12(580). pii: eaav9504. doi: 10.1126/scisignal.aav9504.

PMID:
31064884
5.

Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.

Bellinzoni M, Wehenkel AM, Durán R, Alzari PM.

Genes Immun. 2019 May;20(5):383-393. doi: 10.1038/s41435-019-0069-9. Epub 2019 Apr 25. Review.

PMID:
31019252
6.

Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor.

Lisa MN, Cvirkaite-Krupovic V, Richet E, André-Leroux G, Alzari PM, Haouz A, Danot O.

Nucleic Acids Res. 2019 Apr 23;47(7):3795-3810. doi: 10.1093/nar/gkz112.

7.

Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity.

Petrella S, Capton E, Raynal B, Giffard C, Thureau A, Bonneté F, Alzari PM, Aubry A, Mayer C.

Structure. 2019 Apr 2;27(4):579-589.e5. doi: 10.1016/j.str.2019.01.004. Epub 2019 Feb 7.

PMID:
30744994
8.

The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.

Palacios AR, Mojica MF, Giannini E, Taracila MA, Bethel CR, Alzari PM, Otero LH, Klinke S, Llarrull LI, Bonomo RA, Vila AJ.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01754-18. doi: 10.1128/AAC.01754-18. Print 2019 Jan.

9.

New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach.

Gil M, Lima A, Rivera B, Rossello J, Urdániz E, Cascioferro A, Carrión F, Wehenkel A, Bellinzoni M, Batthyány C, Pritsch O, Denicola A, Alvarez MN, Carvalho PC, Lisa MN, Brosch R, Piuri M, Alzari PM, Durán R.

J Proteomics. 2019 Feb 10;192:321-333. doi: 10.1016/j.jprot.2018.09.013. Epub 2018 Sep 27.

PMID:
30267874
10.

The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase.

Chen Z, Marcé P, Resende R, Alzari PM, Frasch AC, van den Elsen JMH, Crennell SJ, Watts AG.

Eur J Med Chem. 2018 Oct 5;158:25-33. doi: 10.1016/j.ejmech.2018.08.089. Epub 2018 Aug 31.

PMID:
30199703
11.

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance.

Mechaly AE, Haouz A, Sassoon N, Buschiazzo A, Betton JM, Alzari PM.

J Struct Biol. 2018 Nov;204(2):165-171. doi: 10.1016/j.jsb.2018.08.001. Epub 2018 Aug 4.

PMID:
30086390
12.

Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase.

Mechaly AE, Soto Diaz S, Sassoon N, Buschiazzo A, Betton JM, Alzari PM.

Structure. 2017 Jun 6;25(6):939-944.e3. doi: 10.1016/j.str.2017.04.011. Epub 2017 May 25.

13.

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.

Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar-Adler NR, Bottrill AR, le Chevalier F, Frigui W, Bellinzoni M, Lisa MN, Alzari PM, Nguyen L, Brosch R, Sauer U, Manganelli R, O'Hare HM.

PLoS Pathog. 2017 May 17;13(5):e1006399. doi: 10.1371/journal.ppat.1006399. eCollection 2017 May.

14.

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.

Lisa MN, Wagner T, Alexandre M, Barilone N, Raynal B, Alzari PM, Bellinzoni M.

FEBS J. 2017 Feb;284(4):602-614. doi: 10.1111/febs.14003. Epub 2017 Jan 29.

15.

Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.

Schulze JO, Saladino G, Busschots K, Neimanis S, Süß E, Odadzic D, Zeuzem S, Hindie V, Herbrand AK, Lisa MN, Alzari PM, Gervasio FL, Biondi RM.

Cell Chem Biol. 2016 Oct 20;23(10):1193-1205. doi: 10.1016/j.chembiol.2016.06.017. Epub 2016 Sep 29.

16.

Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria.

Rodrigo-Unzueta A, Martínez MA, Comino N, Alzari PM, Chenal A, Guerin ME.

J Biol Chem. 2016 Jul 1;291(27):13955-63. doi: 10.1074/jbc.M116.723676. Epub 2016 May 9.

17.

Modification in hydrophobic packing of HAMP domain induces a destabilization of the auto-phosphorylation site in the histidine kinase CpxA.

Martinez M, Duclert-Savatier N, Betton JM, Alzari PM, Nilges M, Malliavin TE.

Biopolymers. 2016 Oct;105(10):670-82. doi: 10.1002/bip.22864.

PMID:
27124288
18.

Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis.

East A, Mechaly AE, Huysmans GHM, Bernarde C, Tello-Manigne D, Nadeau N, Pugsley AP, Buschiazzo A, Alzari PM, Bond PJ, Francetic O.

Structure. 2016 Jan 5;24(1):92-104. doi: 10.1016/j.str.2015.10.023. Epub 2015 Dec 10.

19.

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.

Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR.

Chem Biol. 2015 Jul 23;22(7):917-27. doi: 10.1016/j.chembiol.2015.05.016. Epub 2015 Jun 18.

20.

Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis.

Lisa MN, Gil M, André-Leroux G, Barilone N, Durán R, Biondi RM, Alzari PM.

Structure. 2015 Jun 2;23(6):1039-48. doi: 10.1016/j.str.2015.04.001. Epub 2015 May 7.

21.

The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.

Wagner T, Alexandre M, Duran R, Barilone N, Wehenkel A, Alzari PM, Bellinzoni M.

Proteins. 2015 May;83(5):982-8. doi: 10.1002/prot.24754. Epub 2015 Mar 25.

22.

Secondary structure reshuffling modulates glycosyltransferase function at the membrane.

Giganti D, Albesa-Jové D, Urresti S, Rodrigo-Unzueta A, Martínez MA, Comino N, Barilone N, Bellinzoni M, Chenal A, Guerin ME, Alzari PM.

Nat Chem Biol. 2015 Jan;11(1):16-8. doi: 10.1038/nchembio.1694. Epub 2014 Nov 17.

PMID:
25402770
23.

Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.

Bellinzoni M, Haouz A, Miras I, Magnet S, André-Leroux G, Mukherjee R, Shepard W, Cole ST, Alzari PM.

J Struct Biol. 2014 Nov;188(2):156-64. doi: 10.1016/j.jsb.2014.09.003. Epub 2014 Sep 24.

PMID:
25260828
24.

A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase.

Giganti D, Bouillon A, Tawk L, Robert F, Martinez M, Crublet E, Weber P, Girard-Blanc C, Petres S, Haouz A, Hernandez JF, Mercereau-Puijalon O, Alzari PM, Barale JC.

Nat Commun. 2014 Sep 10;5:4833. doi: 10.1038/ncomms5833.

PMID:
25204226
25.

Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins).

Correa A, Pacheco S, Mechaly AE, Obal G, Béhar G, Mouratou B, Oppezzo P, Alzari PM, Pecorari F.

PLoS One. 2014 May 13;9(5):e97438. doi: 10.1371/journal.pone.0097438. eCollection 2014.

26.

Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation.

Mechaly AE, Sassoon N, Betton JM, Alzari PM.

PLoS Biol. 2014 Jan 28;12(1):e1001776. doi: 10.1371/journal.pbio.1001776. eCollection 2014 Jan.

27.

Structure-function relationships of membrane-associated GT-B glycosyltransferases.

Albesa-Jové D, Giganti D, Jackson M, Alzari PM, Guerin ME.

Glycobiology. 2014 Feb;24(2):108-24. doi: 10.1093/glycob/cwt101. Epub 2013 Nov 18. Review.

28.

A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase).

Wagner T, Barilone N, Alzari PM, Bellinzoni M.

Biochem J. 2014 Feb 1;457(3):425-34. doi: 10.1042/BJ20131142. Erratum in: Biochem J. 2014 Mar 1;458(2):419.

PMID:
24171907
29.

GarA is an essential regulator of metabolism in Mycobacterium tuberculosis.

Ventura M, Rieck B, Boldrin F, Degiacomi G, Bellinzoni M, Barilone N, Alzaidi F, Alzari PM, Manganelli R, O'Hare HM.

Mol Microbiol. 2013 Oct;90(2):356-66. doi: 10.1111/mmi.12368. Epub 2013 Sep 8.

30.

Inhibition of Mycobacterium tuberculosis PknG by non-catalytic rubredoxin domain specific modification: reaction of an electrophilic nitro-fatty acid with the Fe-S center.

Gil M, Graña M, Schopfer FJ, Wagner T, Denicola A, Freeman BA, Alzari PM, Batthyány C, Durán R.

Free Radic Biol Med. 2013 Dec;65:150-161. doi: 10.1016/j.freeradbiomed.2013.06.021. Epub 2013 Jun 20.

31.

Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins.

Béhar G, Bellinzoni M, Maillasson M, Paillard-Laurance L, Alzari PM, He X, Mouratou B, Pecorari F.

Protein Eng Des Sel. 2013 Apr;26(4):267-75. doi: 10.1093/protein/gzs106. Epub 2013 Jan 11.

PMID:
23315487
32.

Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus.

Albanesi D, Reh G, Guerin ME, Schaeffer F, Debarbouille M, Buschiazzo A, Schujman GE, de Mendoza D, Alzari PM.

PLoS Pathog. 2013 Jan;9(1):e1003108. doi: 10.1371/journal.ppat.1003108. Epub 2013 Jan 3.

33.

Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site.

Busschots K, Lopez-Garcia LA, Lammi C, Stroba A, Zeuzem S, Piiper A, Alzari PM, Neimanis S, Arencibia JM, Engel M, Schulze JO, Biondi RM.

Chem Biol. 2012 Sep 21;19(9):1152-63. doi: 10.1016/j.chembiol.2012.07.017.

34.

Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.

Urresti S, Albesa-Jové D, Schaeffer F, Pham HT, Kaur D, Gest P, van der Woerd MJ, Carreras-González A, López-Fernández S, Alzari PM, Brennan PJ, Jackson M, Guerin ME.

J Biol Chem. 2012 Jul 13;287(29):24649-61. doi: 10.1074/jbc.M112.368191. Epub 2012 May 25.

35.

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

Mechaly AE, Haouz A, Miras I, Barilone N, Weber P, Shepard W, Alzari PM, Bellinzoni M.

FEBS Lett. 2012 Jun 4;586(11):1606-11. doi: 10.1016/j.febslet.2012.04.034. Epub 2012 May 3.

36.

Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket.

Lopez-Garcia LA, Schulze JO, Fröhner W, Zhang H, Süss E, Weber N, Navratil J, Amon S, Hindie V, Zeuzem S, Jørgensen TJ, Alzari PM, Neimanis S, Engel M, Biondi RM.

Chem Biol. 2011 Nov 23;18(11):1463-73. doi: 10.1016/j.chembiol.2011.08.010.

37.

Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism.

Wagner T, Bellinzoni M, Wehenkel A, O'Hare HM, Alzari PM.

Chem Biol. 2011 Aug 26;18(8):1011-20. doi: 10.1016/j.chembiol.2011.06.004.

38.

3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.

Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M, Alzari PM.

J Biol Chem. 2011 Aug 5;286(31):27399-405. doi: 10.1074/jbc.M111.253260. Epub 2011 Jun 1.

39.

Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity.

Oppezzo P, Obal G, Baraibar MA, Pritsch O, Alzari PM, Buschiazzo A.

Biochim Biophys Acta. 2011 Sep;1814(9):1154-61. doi: 10.1016/j.bbapap.2011.04.012. Epub 2011 Apr 30.

PMID:
21570497
40.

Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria.

Guerin ME, Korduláková J, Alzari PM, Brennan PJ, Jackson M.

J Biol Chem. 2010 Oct 29;285(44):33577-83. doi: 10.1074/jbc.R110.168328. Epub 2010 Aug 27. Review.

41.

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.

Manina G, Bellinzoni M, Pasca MR, Neres J, Milano A, Ribeiro AL, Buroni S, Skovierová H, Dianišková P, Mikušová K, Marák J, Makarov V, Giganti D, Haouz A, Lucarelli AP, Degiacomi G, Piazza A, Chiarelli LR, De Rossi E, Salina E, Cole ST, Alzari PM, Riccardi G.

Mol Microbiol. 2010 Sep;77(5):1172-85. doi: 10.1111/j.1365-2958.2010.07277.x.

42.

A novel role of malonyl-ACP in lipid homeostasis.

Martinez MA, Zaballa ME, Schaeffer F, Bellinzoni M, Albanesi D, Schujman GE, Vila AJ, Alzari PM, de Mendoza D.

Biochemistry. 2010 Apr 13;49(14):3161-7. doi: 10.1021/bi100136n.

PMID:
20201588
43.

Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria.

Graña M, Bellinzoni M, Bellalou J, Haouz A, Miras I, Buschiazzo A, Winter N, Alzari PM.

Proteins. 2010 Feb 15;78(3):769-72. doi: 10.1002/prot.22603. No abstract available.

PMID:
19899167
44.

Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria.

Graña M, Bellinzoni M, Miras I, Fiez-Vandal C, Haouz A, Shepard W, Buschiazzo A, Alzari PM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt 10):972-7. doi: 10.1107/S1744309109035027. Epub 2009 Sep 18.

45.

Structural plasticity and distinct drug-binding modes of LfrR, a mycobacterial efflux pump regulator.

Bellinzoni M, Buroni S, Schaeffer F, Riccardi G, De Rossi E, Alzari PM.

J Bacteriol. 2009 Dec;191(24):7531-7. doi: 10.1128/JB.00631-09. Epub 2009 Oct 9.

46.

Structural plasticity and catalysis regulation of a thermosensor histidine kinase.

Albanesi D, Martín M, Trajtenberg F, Mansilla MC, Haouz A, Alzari PM, de Mendoza D, Buschiazzo A.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16185-90. doi: 10.1073/pnas.0906699106. Epub 2009 Sep 4.

47.

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.

Hindie V, Stroba A, Zhang H, Lopez-Garcia LA, Idrissova L, Zeuzem S, Hirschberg D, Schaeffer F, Jørgensen TJ, Engel M, Alzari PM, Biondi RM.

Nat Chem Biol. 2009 Oct;5(10):758-64. doi: 10.1038/nchembio.208. Epub 2009 Aug 30.

PMID:
19718043
48.

Mechanisms determining cell membrane expression of different gammadelta TCR chain pairings.

Boucontet L, Grana M, Alzari PM, Pereira P.

Eur J Immunol. 2009 Jul;39(7):1937-46. doi: 10.1002/eji.200939345.

49.

Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis.

Guerin ME, Schaeffer F, Chaffotte A, Gest P, Giganti D, Korduláková J, van der Woerd M, Jackson M, Alzari PM.

J Biol Chem. 2009 Aug 7;284(32):21613-25. doi: 10.1074/jbc.M109.003947. Epub 2009 Jun 11.

50.

Bacterial metabolism under FHA control.

Bellinzoni M, Alzari PM.

Structure. 2009 Apr 15;17(4):487-8. doi: 10.1016/j.str.2009.03.004. No abstract available.

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