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Items: 1 to 50 of 61

1.

4-Methylcatechol-induced oxidative stress induces intrinsic apoptotic pathway in metastatic melanoma cells.

Payton F, Bose R, Alworth WL, Kumar AP, Ghosh R.

Biochem Pharmacol. 2011 May 15;81(10):1211-8. doi: 10.1016/j.bcp.2011.03.005. Epub 2011 Mar 23.

2.

Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity.

Shimada T, Murajama N, Tanaka K, Takenaka S, Imai Y, Hopkins NE, Foroozesh MK, Alworth WL, Yamazaki H, Guengerich FP, Komori M.

Chem Res Toxicol. 2008 Dec;21(12):2313-23.

3.

Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells.

Ghosh R, Ganapathy M, Alworth WL, Chan DC, Kumar AP.

J Steroid Biochem Mol Biol. 2009 Jan;113(1-2):25-35. doi: 10.1016/j.jsbmb.2008.11.002. Epub 2008 Nov 21.

PMID:
19084597
4.

NMR study of the solution structure of curcumin.

Payton F, Sandusky P, Alworth WL.

J Nat Prod. 2007 Feb;70(2):143-6.

PMID:
17315954
5.

Eugenol causes melanoma growth suppression through inhibition of E2F1 transcriptional activity.

Ghosh R, Nadiminty N, Fitzpatrick JE, Alworth WL, Slaga TJ, Kumar AP.

J Biol Chem. 2005 Feb 18;280(7):5812-9. Epub 2004 Dec 1.

6.
7.

Curcumin and derivatives.

Mague JT, Alworth WL, Payton FL.

Acta Crystallogr C. 2004 Aug;60(Pt 8):o608-10. Epub 2004 Jul 31. No abstract available.

PMID:
15295200
8.

Novel reversible inactivation of cytochrome P450 2E1 T303A by tert-butyl acetylene: the role of threonine 303 in proton delivery to the active site of cytochrome P450 2E1.

Blobaum AL, Kent UM, Alworth WL, Hollenberg PF.

J Pharmacol Exp Ther. 2004 Jul;310(1):281-90. Epub 2004 Feb 26.

PMID:
14988423
9.

4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management.

Kumar AP, Garcia GE, Ghosh R, Rajnarayanan RV, Alworth WL, Slaga TJ.

Neoplasia. 2003 May-Jun;5(3):255-66. doi: 10.1016/S1476-5586(03)80057-X.

10.
11.

Differential expression of CYP102 in Bacillus megaterium by 17-beta-estradiol and 4-sec-butylphenol.

Rowley CW, Rajnarayanan RV, Hopkins NE, Alworth WL.

Biochem Biophys Res Commun. 2003 Jan 3;300(1):102-6.

PMID:
12480527
12.

Chemical inactivation of the cinnamate 4-hydroxylase allows for the accumulation of salicylic acid in elicited cells.

Schoch GA, Nikov GN, Alworth WL, Werck-Reichhart D.

Plant Physiol. 2002 Oct;130(2):1022-31.

13.
14.

Regulation of phenobarbital-mediated induction of CYP102 (cytochrome P450(BM-3)) in Bacillus megaterium by phytochemicals from soy and green tea.

Rajnarayanan RV, Rowley CW, Hopkins NE, Alworth WL.

J Agric Food Chem. 2001 Oct;49(10):4930-6.

PMID:
11600046
15.

Interactions of synthetic estrogens with human estrogen receptors.

Nikov GN, Eshete M, Rajnarayanan RV, Alworth WL.

J Endocrinol. 2001 Jul;170(1):137-45.

PMID:
11431146
16.
17.

Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity.

Alexander DL, Zhang L, Foroozesh M, Alworth WL, Jefcoate CR.

Toxicol Appl Pharmacol. 1999 Dec 1;161(2):123-39.

PMID:
10581206
18.

Identification of selective mechanism-based inactivators of cytochromes P-450 2B4 and 2B5, and determination of the molecular basis for differential susceptibility.

Strobel SM, Szklarz GD, He Y, Foroozesh M, Alworth WL, Roberts ES, Hollenberg PF, Halpert JR.

J Pharmacol Exp Ther. 1999 Jul;290(1):445-51.

PMID:
10381811
19.

Mineralization of benzo[a]pyrene by Marasmiellus troyanus, a mushroom isolated from a toxic waste site.

Wunch KG, Alworth WL, Bennett JW.

Microbiol Res. 1999 May;154(1):75-9.

PMID:
10356797
21.

Catalytic properties of an expressed cytochrome P450 2B1 from a Wistar-Kyoto rat liver cDNA library.

Kobayashi Y, Strobel SM, Hopkins NE, Alworth WL, Halpert JR.

Drug Metab Dispos. 1998 Oct;26(10):1026-30.

PMID:
9763409
22.

Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1.

Shimada T, Yamazaki H, Foroozesh M, Hopkins NE, Alworth WL, Guengerich FP.

Chem Res Toxicol. 1998 Sep;11(9):1048-56.

PMID:
9760279
23.

Mechanism-based inactivation of cytochromes P450 2E1 and 2B1 by 5-phenyl-1-pentyne.

Roberts ES, Alworth WL, Hollenberg PF.

Arch Biochem Biophys. 1998 Jun 15;354(2):295-302.

PMID:
9637739
24.

Induction of CYP102 (cytochrome P450BM-3) in Bacillus megaterium by 17 beta-estradiol and 4-sec-butylphenol.

Hopkins NE, English N, Hughes V, Rowley CW, Wolf CR, Alworth WL.

Biochem Biophys Res Commun. 1998 Mar 27;244(3):868-72. Erratum in: Biochem Biophys Res Commun 1998 May 29;246(3):933.

PMID:
9535758
25.

Fatty acid signals in Bacillus megaterium are attenuated by cytochrome P-450-mediated hydroxylation.

English N, Palmer CN, Alworth WL, Kang L, Hughes V, Wolf CR.

Biochem J. 1997 Oct 15;327 ( Pt 2):363-8.

26.

Inactivation of cytochrome P450s 2B1, 2B4, 2B6, and 2B11 by arylalkynes.

Roberts ES, Hopkins NE, Foroozesh M, Alworth WL, Halpert JR, Hollenberg PF.

Drug Metab Dispos. 1997 Nov;25(11):1242-8.

PMID:
9351899
27.

Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes.

Foroozesh M, Primrose G, Guo Z, Bell LC, Alworth WL, Guengerich FP.

Chem Res Toxicol. 1997 Jan;10(1):91-102.

PMID:
9074808
28.

Mechanism-based inhibition of mouse P4502b-10 by selected arylalkynes.

Beebe LE, Roberts ES, Fornwald LW, Hollenberg PF, Alworth WL.

Biochem Pharmacol. 1996 Nov 22;52(10):1507-13.

PMID:
8937464
29.

A role for threonine 302 in the mechanism-based inactivation of P450 2B4 by 2-ethynylnaphthalene.

Roberts ES, Pernecky SJ, Alworth WL, Hollenberg PF.

Arch Biochem Biophys. 1996 Jul 15;331(2):170-6.

PMID:
8660695
30.

Mechanistic studies of 9-ethynylphenanthrene-inactivated cytochrome P450 2B1.

Roberts ES, Ballou DP, Hopkins NE, Alworth WL, Hollenberg PF.

Arch Biochem Biophys. 1995 Nov 10;323(2):303-12.

PMID:
7487092
31.

Mechanism-based inactivation of cytochrome P450 2B1 by 9-ethynylphenanthrene.

Roberts ES, Hopkins NE, Zaluzec EJ, Gage DA, Alworth WL, Hollenberg PF.

Arch Biochem Biophys. 1995 Nov 10;323(2):295-302.

PMID:
7487091
32.

Effect of dietary Aroclor 1254 exposure on lung and kidney cytochromes P450 in female rats: evidence for P4501A2 expression in kidney.

Beebe LE, Fornwald LW, Alworth WL, Dragnev KH, Lubet RA.

Chem Biol Interact. 1995 Aug 18;97(3):215-27.

PMID:
7671339
33.

Identification of active-site peptides from 3H-labeled 2-ethynylnaphthalene-inactivated P450 2B1 and 2B4 using amino acid sequencing and mass spectrometry.

Roberts ES, Hopkins NE, Zaluzec EJ, Gage DA, Alworth WL, Hollenberg PF.

Biochemistry. 1994 Mar 29;33(12):3766-71.

PMID:
8142377
34.

Cytochrome P4501A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat and human.

Tai HL, McReynolds JH, Goldstein JA, Eugster HP, Sengstag C, Alworth WL, Olson JR.

Toxicol Appl Pharmacol. 1993 Nov;123(1):34-42.

PMID:
8236259
35.
36.

Mechanism-based inactivation of cytochrome P450 2B1 by 2-ethynylnaphthalene: identification of an active-site peptide.

Roberts ES, Hopkins NE, Alworth WL, Hollenberg PF.

Chem Res Toxicol. 1993 Jul-Aug;6(4):470-9.

PMID:
8374044
37.

Modification of cytochrome P450 1A2 enzymes by the mechanism-based inactivator 2-ethynylnaphthalene and the photoaffinity label 4-azidobiphenyl.

Yun CH, Hammons GJ, Jones G, Martin MV, Hopkins NE, Alworth WL, Guengerich FP.

Biochemistry. 1992 Nov 3;31(43):10556-63.

PMID:
1420171
38.

Suicide inhibitors of cytochrome P450 1A1 and P450 2B1.

Hopkins NE, Foroozesh MK, Alworth WL.

Biochem Pharmacol. 1992 Aug 18;44(4):787-96.

PMID:
1510726
39.

Potent inhibitory effects of suicide inhibitors of P450 isozymes on 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene initiated skin tumors.

Alworth WL, Viaje A, Sandoval A, Warren BS, Slaga TJ.

Carcinogenesis. 1991 Jul;12(7):1209-15.

PMID:
1906378
40.

Inhibition of the binding of 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene to DNA in mouse skin epidermis by 1-ethynylpyrene.

Viaje A, Lu JY, Hopkins NE, Nettikumara AN, DiGiovanni J, Alworth WL, Slaga TJ.

Carcinogenesis. 1990 Jul;11(7):1139-43.

PMID:
2115405
41.

Effects of 1-ethynylpyrene and related inhibitors of P450 isozymes upon benzo[a]pyrene metabolism by liver microsomes.

Hall M, Parker DK, Grover PL, Lu JY, Hopkins NE, Alworth WL.

Chem Biol Interact. 1990;76(2):181-92.

PMID:
2225228
42.

2-ethynylnaphthalene as a mechanism-based inactivator of the cytochrome P-450 catalyzed N-oxidation of 2-naphthylamine.

Hammons GJ, Alworth WL, Hopkins NE, Guengerich FP, Kadlubar FF.

Chem Res Toxicol. 1989 Nov-Dec;2(6):367-74.

PMID:
2519725
43.

Effects of acetylenic and olefinic pyrenes upon cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes.

Gan LS, Lu JY, Hershkowitz DM, Alworth WL.

Biochem Biophys Res Commun. 1985 Jun 14;129(2):591-6.

PMID:
4015648
45.
46.

Biological chemistry.

Alworth WL.

Science. 1983 Mar 4;219(4588):1060-1. No abstract available.

PMID:
17811743
47.
48.

Stimulation of mammalian epoxide hydrase activity by flavones.

Alworth WL, Dang CC, Ching LM, Viswanathan T.

Xenobiotica. 1980 Jun;10(6):395-400.

PMID:
7415221
49.

Epoxide hydrase: structure-activity relationships of in vitro stimulators of the microsomal activity.

Ganu VS, Alworth WL.

Biochemistry. 1978 Jul 11;17(14):2876-81. No abstract available.

PMID:
687567
50.

Improved syntheses of substrates for radiometric assays of microsomal monooxygenase (arylhydrocarbon hydroxylase) and epoxide hydratase.

Ganu VS, Nelson SO, Verlander L, Alworth WL.

Anal Biochem. 1977 Apr;78(2):451-8. No abstract available.

PMID:
851218

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