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Items: 32


NF-κB/NKILA signaling modulates the anti-cancerous effects of EZH2 inhibition.

Duan S, Chan WK, Oman A, Basile DP, Alvira CM, Buxton ILO, Iosef C.

J Cell Mol Med. 2019 Sep;23(9):6182-6192. doi: 10.1111/jcmm.14500. Epub 2019 Jul 7.


Enhancing the Development and Retention of Physician-Scientists in Academic Pediatrics: Strategies for Success.

Alvira CM, Steinhorn RH, Balistreri WF, Fineman JR, Oishi PE, Padbury JF, Kinsella JP, Abman SH.

J Pediatr. 2018 Sep;200:277-284. doi: 10.1016/j.jpeds.2018.06.019. Epub 2018 Jul 25. Review. No abstract available.


Distinct roles for IκB kinases alpha and beta in regulating pulmonary endothelial angiogenic function during late lung development.

Iosef C, Liu M, Ying L, Rao SP, Concepcion KR, Chan WK, Oman A, Alvira CM.

J Cell Mol Med. 2018 Sep;22(9):4410-4422. doi: 10.1111/jcmm.13741. Epub 2018 Jul 11.


Pulmonary artery smooth muscle cell HIF-1α regulates endothelin expression via microRNA-543.

Wang CC, Ying L, Barnes EA, Adams ES, Kim FY, Engel KW, Alvira CM, Cornfield DN.

Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L422-L431. doi: 10.1152/ajplung.00475.2017. Epub 2018 May 10.


Intrauterine growth restriction decreases NF-κB signaling in fetal pulmonary artery endothelial cells of fetal sheep.

Dodson RB, Powers KN, Gien J, Rozance PJ, Seedorf G, Astling D, Jones K, Crombleholme TM, Abman SH, Alvira CM.

Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L348-L359. doi: 10.1152/ajplung.00052.2018. Epub 2018 May 3.


β1-Subunit of the calcium-sensitive potassium channel modulates the pulmonary vascular smooth muscle cell response to hypoxia.

Barnes EA, Lee L, Barnes SL, Brenner R, Alvira CM, Cornfield DN.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L265-L275. doi: 10.1152/ajplung.00060.2018. Epub 2018 Apr 12.


Developmental differences in focal adhesion kinase expression modulate pulmonary endothelial barrier function in response to inflammation.

Ying L, Alvira CM, Cornfield DN.

Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L66-L77. doi: 10.1152/ajplung.00363.2017. Epub 2018 Mar 29.


Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?

Alvira CM, Morty RE.

J Pediatr. 2017 Nov;190:27-37. doi: 10.1016/j.jpeds.2017.08.041. Review. No abstract available.


Aberrant Pulmonary Vascular Growth and Remodeling in Bronchopulmonary Dysplasia.

Alvira CM.

Front Med (Lausanne). 2016 May 20;3:21. doi: 10.3389/fmed.2016.00021. eCollection 2016. Review.


Absence of TNF-α enhances inflammatory response in the newborn lung undergoing mechanical ventilation.

Ehrhardt H, Pritzke T, Oak P, Kossert M, Biebach L, Förster K, Koschlig M, Alvira CM, Hilgendorff A.

Am J Physiol Lung Cell Mol Physiol. 2016 May 15;310(10):L909-18. doi: 10.1152/ajplung.00367.2015. Epub 2016 Mar 25.


The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy.

Ying L, Becard M, Lyell D, Han X, Shortliffe L, Husted CI, Alvira CM, Cornfield DN.

Sci Transl Med. 2015 Dec 23;7(319):319ra204. doi: 10.1126/scitranslmed.aad0376.


Activation of the nuclear factor-κB pathway during postnatal lung inflammation preserves alveolarization by suppressing macrophage inflammatory protein-2.

Hou Y, Liu M, Husted C, Chen C, Thiagarajan K, Johns JL, Rao SP, Alvira CM.

Am J Physiol Lung Cell Mol Physiol. 2015 Sep 15;309(6):L593-604. doi: 10.1152/ajplung.00029.2015. Epub 2015 Jul 10.


Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia.

Kim FY, Barnes EA, Ying L, Chen C, Lee L, Alvira CM, Cornfield DN.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L368-77. doi: 10.1152/ajplung.00253.2014. Epub 2014 Nov 14.


Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome.

Emrich FC, Okamura H, Dalal AR, Penov K, Merk DR, Raaz U, Hennigs JK, Chin JT, Miller MO, Pedroza AJ, Craig JK, Koyano TK, Blankenberg FG, Connolly AJ, Mohr FW, Alvira CM, Rabinovitch M, Fischbein MP.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):146-54. doi: 10.1161/ATVBAHA.114.304364. Epub 2014 Oct 30.


Disrupted lung development and bronchopulmonary dysplasia: opportunities for lung repair and regeneration.

Baker CD, Alvira CM.

Curr Opin Pediatr. 2014 Jun;26(3):306-14. doi: 10.1097/MOP.0000000000000095. Review.


Nuclear factor-kappa-B signaling in lung development and disease: one pathway, numerous functions.

Alvira CM.

Birth Defects Res A Clin Mol Teratol. 2014 Mar;100(3):202-16. doi: 10.1002/bdra.23233. Epub 2014 Mar 17. Review.


Chronic lung disease in the preterm infant. Lessons learned from animal models.

Hilgendorff A, Reiss I, Ehrhardt H, Eickelberg O, Alvira CM.

Am J Respir Cell Mol Biol. 2014 Feb;50(2):233-45. doi: 10.1165/rcmb.2013-0014TR. Review.


Hypoxia-inducible factor-1α in pulmonary artery smooth muscle cells lowers vascular tone by decreasing myosin light chain phosphorylation.

Kim YM, Barnes EA, Alvira CM, Ying L, Reddy S, Cornfield DN.

Circ Res. 2013 Apr 26;112(9):1230-3. doi: 10.1161/CIRCRESAHA.112.300646. Epub 2013 Mar 19.


Voltage-dependent anion channel-2 interaction with nitric oxide synthase enhances pulmonary artery endothelial cell nitric oxide production.

Alvira CM, Umesh A, Husted C, Ying L, Hou Y, Lyu SC, Nowak J, Cornfield DN.

Am J Respir Cell Mol Biol. 2012 Nov;47(5):669-78. doi: 10.1165/rcmb.2011-0436OC. Epub 2012 Jul 27.


Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization.

Iosef C, Alastalo TP, Hou Y, Chen C, Adams ES, Lyu SC, Cornfield DN, Alvira CM.

Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L1023-36. doi: 10.1152/ajplung.00230.2011. Epub 2012 Feb 24.


miR-29b participates in early aneurysm development in Marfan syndrome.

Merk DR, Chin JT, Dake BA, Maegdefessel L, Miller MO, Kimura N, Tsao PS, Iosef C, Berry GJ, Mohr FW, Spin JM, Alvira CM, Robbins RC, Fischbein MP.

Circ Res. 2012 Jan 20;110(2):312-24. doi: 10.1161/CIRCRESAHA.111.253740. Epub 2011 Nov 23.


Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells.

Ahn YT, Kim YM, Adams E, Lyu SC, Alvira CM, Cornfield DN.

Am J Physiol Lung Cell Mol Physiol. 2012 Feb 1;302(3):L352-9. doi: 10.1152/ajplung.00302.2011. Epub 2011 Nov 23.


Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions.

Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira CM, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M.

Am J Pathol. 2011 Sep;179(3):1560-72. doi: 10.1016/j.ajpath.2011.05.051. Epub 2011 Jul 19.


Inhibition of transforming growth factor β worsens elastin degradation in a murine model of Kawasaki disease.

Alvira CM, Guignabert C, Kim YM, Chen C, Wang L, Duong TT, Yeung RS, Li DY, Rabinovitch M.

Am J Pathol. 2011 Mar;178(3):1210-20. doi: 10.1016/j.ajpath.2010.11.054.


Rho kinase modulates postnatal adaptation of the pulmonary circulation through separate effects on pulmonary artery endothelial and smooth muscle cells.

Alvira CM, Sukovich DJ, Lyu SC, Cornfield DN.

Am J Physiol Lung Cell Mol Physiol. 2010 Dec;299(6):L872-8. doi: 10.1152/ajplung.00199.2010. Epub 2010 Aug 13.


Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice.

Mokres LM, Parai K, Hilgendorff A, Ertsey R, Alvira CM, Rabinovitch M, Bland RD.

Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L23-35. doi: 10.1152/ajplung.00251.2009. Epub 2009 Oct 23.


Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.

Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, Wang L, El-Bizri N, Rabinovitch M.

Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1082-90. doi: 10.1152/ajplung.00199.2009. Epub 2009 Oct 2.


LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor.

Ying L, Lau A, Alvira CM, West R, Cann GM, Zhou B, Kinnear C, Jan E, Sarnow P, Van de Rijn M, Rabinovitch M.

J Cell Sci. 2009 May 1;122(Pt 9):1441-51. doi: 10.1242/jcs.025957. Epub 2009 Apr 14.


An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.

Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M.

J Clin Invest. 2008 May;118(5):1846-57. doi: 10.1172/JCI32503.


Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin.

Spiekerkoetter E, Alvira CM, Kim YM, Bruneau A, Pricola KL, Wang L, Ambartsumian N, Rabinovitch M.

Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L276-89. Epub 2007 Dec 14.


Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development?

Bland RD, Ertsey R, Mokres LM, Xu L, Jacobson BE, Jiang S, Alvira CM, Rabinovitch M, Shinwell ES, Dixit A.

Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L3-14. Epub 2007 Oct 12.


Nuclear factor-kappaB activation in neonatal mouse lung protects against lipopolysaccharide-induced inflammation.

Alvira CM, Abate A, Yang G, Dennery PA, Rabinovitch M.

Am J Respir Crit Care Med. 2007 Apr 15;175(8):805-15. Epub 2007 Jan 25.

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