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IL-33 and ST2 as predictors of disease severity in children with viral acute lower respiratory infection.

Portugal CAA, de Araújo Castro Í, Prates MCM, Gagliardi TB, Martins RB, de Jesus BLS, de Souza Cardoso R, da Silva MVG, Aragon DC, Arruda Neto E, Alves Filho JCF, Cunha FQ, Carlotti APCP.

Cytokine. 2020 Jan 2;127:154965. doi: 10.1016/j.cyto.2019.154965. [Epub ahead of print]


NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus.

Ferreira NS, Bruder-Nascimento T, Pereira CA, Zanotto CZ, Prado DS, Silva JF, Rassi DM, Foss-Freitas MC, Alves-Filho JC, Carlos D, Tostes RC.

Cells. 2019 Dec 8;8(12). pii: E1595. doi: 10.3390/cells8121595.


Liver X receptor activation impairs neutrophil functions and aggravates sepsis.

Souto FO, Castanheira FVS, Trevelin SC, Lima BHF, Cebinelli GCM, Turato WM, Auxiliadora-Martins M, Basile-Filho A, Alves-Filho JC, Cunha FQ.

J Infect Dis. 2019 Nov 30. pii: jiz635. doi: 10.1093/infdis/jiz635. [Epub ahead of print]


ILC2s and Basophils Team Up to Orchestrate IL-33-Induced Atopic Dermatitis.

Ryffel B, Alves-Filho JC.

J Invest Dermatol. 2019 Oct;139(10):2077-2079. doi: 10.1016/j.jid.2019.06.118.


Frontline Science: Blood-circulating leukocytes fail to infiltrate the spinal cord parenchyma after spared nerve injury.

Guimarães RM, Davoli-Ferreira M, Fonseca MM, Damasceno LEA, Santa-Cecilia FV, Kusuda R, Menezes GB, Cunha FQ, Alves-Filho JC, Cunha TM.

J Leukoc Biol. 2019 Sep;106(3):541-551. doi: 10.1002/JLB.HI1118-458R. Epub 2019 May 31.


Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice.

Borghi SM, Fattori V, Pinho-Ribeiro FA, Domiciano TP, Miranda-Sapla MM, Zaninelli TH, Casagrande R, Pinge-Filho P, Pavanelli WR, Alves-Filho JC, Cunha FQ, Cunha TM, Verri WA Jr.

J Neuroinflammation. 2019 May 28;16(1):113. doi: 10.1186/s12974-019-1496-2.


IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria.

de Menezes MN, Salles ÉM, Vieira F, Amaral EP, Zuzarte-Luís V, Cassado A, Epiphanio S, Alvarez JM, Alves-Filho JC, Mota MM, D'Império-Lima MR.

Sci Rep. 2019 May 20;9(1):7575. doi: 10.1038/s41598-019-44125-2.


Targeting nitric oxide as a key modulator of sepsis, arthritis and pain.

Spiller F, Oliveira Formiga R, Fernandes da Silva Coimbra J, Alves-Filho JC, Cunha TM, Cunha FQ.

Nitric Oxide. 2019 Aug 1;89:32-40. doi: 10.1016/j.niox.2019.04.011. Epub 2019 Apr 30. Review.


Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation.

Lourenco-Gonzalez Y, Fattori V, Domiciano TP, Rossaneis AC, Borghi SM, Zaninelli TH, Bernardy CCF, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr.

Mediators Inflamm. 2019 Mar 31;2019:6481812. doi: 10.1155/2019/6481812. eCollection 2019.


Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis.

Colón DF, Wanderley CW, Franchin M, Silva CM, Hiroki CH, Castanheira FVS, Donate PB, Lopes AH, Volpon LC, Kavaguti SK, Borges VF, Speck-Hernandez CA, Ramalho F, Carlotti AP, Carmona F, Alves-Filho JC, Liew FY, Cunha FQ.

Crit Care. 2019 Apr 8;23(1):113. doi: 10.1186/s13054-019-2407-8.


Fructose 1,6-bisphosphate inhibits osteoclastogenesis by attenuating RANKL-induced NF-κB/NFATc-1.

Wilches-Buitrago L, Viacava PR, Cunha FQ, Alves-Filho JC, Fukada SY.

Inflamm Res. 2019 May;68(5):415-421. doi: 10.1007/s00011-019-01228-w. Epub 2019 Mar 29.


DMH-CBD, a cannabidiol analog with reduced cytotoxicity, inhibits TNF production by targeting NF-kB activity dependent on A2A receptor.

Silva RL, Silveira GT, Wanderlei CW, Cecilio NT, Maganin AGM, Franchin M, Marques LMM, Lopes NP, Crippa JA, Guimarães FS, Alves-Filho JCF, Cunha FQ, Cunha TM.

Toxicol Appl Pharmacol. 2019 Apr 1;368:63-71. doi: 10.1016/j.taap.2019.02.011. Epub 2019 Feb 20.


CCR5-Positive Inflammatory Monocytes are Crucial for Control of Sepsis.

Castanheira FVES, de Lima KA, Cebinelli GCM, Sônego F, Kanashiro A, Colon DF, Borges V, Czaikoski PG, Mota JM, Cunha TM, Alves-Filho JC, Liew FY, Cunha FQ.

Shock. 2019 Nov;52(5):e100-e106. doi: 10.1097/SHK.0000000000001301.


CCR2 Plays a Protective Role in Rocio Virus-Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain.

Amarilla AA, Santos-Junior NN, Figueiredo ML, Luiz JPM, Fumagalli MJ, Colón DF, Lippi V, Alfonso HL, Lima-Junior DS, Trabuco AC, Spinieli RL, Desidera AC, Leite-Panissi CRA, Lauretti F, Mendoza SES, Silva CLA, Rego EM, Galvao-Lima LJ, Bassi GS, Penharvel Martíns SLB, Manrique WG, Alves-Filho JC, Cunha FQ, Peng NYG, Modhiran N, Setoh YX, Khromykh AA, Figueiredo LTM, Aquino VH.

J Infect Dis. 2019 May 24;219(12):2015-2025. doi: 10.1093/infdis/jiz029.


CCR4-dependent reduction in the number and suppressor function of CD4+Foxp3+ cells augments IFN-γ-mediated pulmonary inflammation and aggravates tuberculosis pathogenesis.

Bertolini TB, Piñeros AR, Prado RQ, Gembre AF, Ramalho LNZ, Alves-Filho JC, Bonato VLD.

Cell Death Dis. 2018 Dec 21;10(1):11. doi: 10.1038/s41419-018-1240-3.


Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.

Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E.

Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6.


TGFβ1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism.

de Lima KA, Donate PB, Talbot J, Davoli-Ferreira M, Peres RS, Cunha TM, Alves-Filho JC, Cunha FQ.

Cell Death Dis. 2018 Nov 13;9(11):1130. doi: 10.1038/s41419-018-1107-7.


Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB.

Manchope MF, Artero NA, Fattori V, Mizokami SS, Pitol DL, Issa JPM, Fukada SY, Cunha TM, Alves-Filho JC, Cunha FQ, Casagrande R, Verri WA Jr.

Inflamm Res. 2018 Dec;67(11-12):997-1012. doi: 10.1007/s00011-018-1195-y. Epub 2018 Oct 28.


Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice.

Staurengo-Ferrari L, Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Fattori V, Zaninelli TH, Badaro-Garcia S, Borghi SM, Carvalho TT, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr.

Front Pharmacol. 2018 Oct 2;9:1123. doi: 10.3389/fphar.2018.01123. eCollection 2018.


Budlein A, a Sesquiterpene Lactone From Viguiera robusta, Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice.

Fattori V, Zarpelon AC, Staurengo-Ferrari L, Borghi SM, Zaninelli TH, Da Costa FB, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Arakawa NS, Verri WA Jr.

Front Pharmacol. 2018 Sep 25;9:1076. doi: 10.3389/fphar.2018.01076. eCollection 2018.


15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice.

Ruiz-Miyazawa KW, Staurengo-Ferrari L, Pinho-Ribeiro FA, Fattori V, Zaninelli TH, Badaro-Garcia S, Borghi SM, Andrade KC, Clemente-Napimoga JT, Alves-Filho JC, Cunha TM, Fraceto LF, Cunha FQ, Napimoga MH, Casagrande R, Verri WA Jr.

Sci Rep. 2018 Sep 18;8(1):13979. doi: 10.1038/s41598-018-32334-0.


Galectin-3 aggravates experimental polymicrobial sepsis by impairing neutrophil recruitment to the infectious focus.

Ferreira RG, Rodrigues LC, Nascimento DC, Kanashiro A, Melo PH, Borges VF, Gozzi A, da Silva Prado D, Borges MC, Ramalho FS, Stowell SR, Cummings RD, Dias-Baruffi M, Cunha FQ, Alves-Filho JC.

J Infect. 2018 Nov;77(5):391-397. doi: 10.1016/j.jinf.2018.06.010. Epub 2018 Jul 4.


The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development.

Santa-Cecília FV, Ferreira DW, Guimaraes RM, Cecilio NT, Fonseca MM, Lopes AH, Davoli-Ferreira M, Kusuda R, Souza GR, Nachbur U, Alves-Filho JC, Teixeira MM, Zamboni DS, Cunha FQ, Cunha TM.

Pain. 2019 Jan;160(1):102-116. doi: 10.1097/j.pain.0000000000001383.


Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner.

Wanderley CW, Colón DF, Luiz JPM, Oliveira FF, Viacava PR, Leite CA, Pereira JA, Silva CM, Silva CR, Silva RL, Speck-Hernandez CA, Mota JM, Alves-Filho JC, Lima-Junior RC, Cunha TM, Cunha FQ.

Cancer Res. 2018 Oct 15;78(20):5891-5900. doi: 10.1158/0008-5472.CAN-17-3480. Epub 2018 Aug 13.


Purinergic Cooperation Between P2Y2 and P2X7 Receptors Promote Cutaneous Leishmaniasis Control: Involvement of Pannexin-1 and Leukotrienes.

Thorstenberg ML, Rangel Ferreira MV, Amorim N, Canetti C, Morrone FB, Alves Filho JC, Coutinho-Silva R.

Front Immunol. 2018 Jul 9;9:1531. doi: 10.3389/fimmu.2018.01531. eCollection 2018.


Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes.

Saraiva AL, Veras FP, Peres RS, Talbot J, de Lima KA, Luiz JP, Carballido JM, Cunha TM, Cunha FQ, Ryffel B, Alves-Filho JC.

FASEB J. 2018 Jun 12:fj201800285. doi: 10.1096/fj.201800285. [Epub ahead of print]


Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells.

Talbot J, Peres RS, Pinto LG, Oliveira RDR, Lima KA, Donate PB, Silva JR, Ryffel B, Cunha TM, Alves-Filho JC, Liew FY, Louzada-Junior P, de Queiroz Cunha F.

Arthritis Res Ther. 2018 Jun 8;20(1):119. doi: 10.1186/s13075-018-1609-9.


Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis.

Staurengo-Ferrari L, Trevelin SC, Fattori V, Nascimento DC, de Lima KA, Pelayo JS, Figueiredo F, Casagrande R, Fukada SY, Teixeira MM, Cunha TM, Liew FY, Oliveira RD, Louzada-Junior P, Cunha FQ, Alves-Filho JC, Verri WA.

Front Immunol. 2018 May 16;9:962. doi: 10.3389/fimmu.2018.00962. eCollection 2018.


Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation.

Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Borghi SM, Staurengo-Ferrari L, Fattori V, Amaral FA, Teixeira MM, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr.

J Agric Food Chem. 2018 Jun 27;66(25):6269-6280. doi: 10.1021/acs.jafc.8b00959. Epub 2018 Jun 13.


Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis.

Sisti F, Wang S, Brandt SL, Glosson-Byers N, Mayo LD, Son YM, Sturgeon S, Filgueiras L, Jancar S, Wong H, Dela Cruz CS, Andrews N, Alves-Filho JC, Cunha FQ, Serezani CH.

Sci Signal. 2018 May 1;11(528). pii: eaai9085. doi: 10.1126/scisignal.aai9085.


Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.

Silva MC, Davoli-Ferreira M, Medina TS, Sesti-Costa R, Silva GK, Lopes CD, Cardozo LE, Gava FN, Lyroni K, Dias FC, Frade AF, Baron M, Nakaya HI, Figueiredo F, Alves-Filho JC, Cunha FQ, Tsatsanis C, Chevillard C, Cunha-Neto E, Hirsch E, Silva JS, Cunha TM.

Nat Commun. 2018 Apr 17;9(1):1513. doi: 10.1038/s41467-018-03986-3.


The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis.

Castanheira FVES, Borges V, Sônego F, Kanashiro A, Donate PB, Melo PH, Pallas K, Russo RC, Amaral FA, Teixeira MM, Ramalho FS, Cunha TM, Liew FY, Alves-Filho JC, Graham GJ, Cunha FQ.

Shock. 2018 Jun;49(6):682-689. doi: 10.1097/SHK.0000000000000969.


The host control of a clinical isolate strain of P. aeruginosa infection is independent of Nod-1 but depends on MyD88.

Sônego F, Castanheira FVS, Horta CV, Kanashiro A, Czaikoski PG, Zamboni DS, Alves-Filho JC, Cunha FQ.

Inflamm Res. 2018 May;67(5):435-443. doi: 10.1007/s00011-018-1135-x. Epub 2018 Feb 15.


TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis.

Peres RS, Donate PB, Talbot J, Cecilio NT, Lobo PR, Machado CC, Lima KWA, Oliveira RD, Carregaro V, Nakaya HI, Cunha TM, Alves-Filho JC, Liew FY, Louzada-Junior P, Cunha FQ.

J Autoimmun. 2018 Jun;90:49-58. doi: 10.1016/j.jaut.2018.01.004. Epub 2018 Feb 14.


Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis.

Soares FS, Amaral FC, Silva NLC, Valente MR, Santos LKR, Yamashiro LH, Scheffer MC, Castanheira FVES, Ferreira RG, Gehrke L, Alves-Filho JC, Silva LP, Báfica A, Spiller F.

Front Immunol. 2017 Dec 22;8:1890. doi: 10.3389/fimmu.2017.01890. eCollection 2017.


Pericytes modulate myelination in the central nervous system.

Azevedo PO, Sena IFG, Andreotti JP, Carvalho-Tavares J, Alves-Filho JC, Cunha TM, Cunha FQ, Mintz A, Birbrair A.

J Cell Physiol. 2018 Aug;233(8):5523-5529. doi: 10.1002/jcp.26348. Epub 2018 Mar 1.


Targeting IL-33/ST2 signaling: regulation of immune function and analgesia.

Fattori V, Hohmann MSN, Rossaneis AC, Manchope MF, Alves-Filho JC, Cunha TM, Cunha FQ, Verri WA Jr.

Expert Opin Ther Targets. 2017 Dec;21(12):1141-1152. doi: 10.1080/14728222.2017.1398734. Epub 2017 Nov 5. Review.


SOCS1 is a negative regulator of metabolic reprogramming during sepsis.

Piñeros Alvarez AR, Glosson-Byers N, Brandt S, Wang S, Wong H, Sturgeon S, McCarthy BP, Territo PR, Alves-Filho JC, Serezani CH.

JCI Insight. 2017 Jul 6;2(13). pii: 92530. doi: 10.1172/jci.insight.92530. eCollection 2017 Jul 6.


Diosmin reduces chronic constriction injury-induced neuropathic pain in mice.

Bertozzi MM, Rossaneis AC, Fattori V, Longhi-Balbinot DT, Freitas A, Cunha FQ, Alves-Filho JC, Cunha TM, Casagrande R, Verri WA Jr.

Chem Biol Interact. 2017 Aug 1;273:180-189. doi: 10.1016/j.cbi.2017.06.014. Epub 2017 Jun 15.


Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia.

Silva JR, Lopes AH, Talbot J, Cecilio NT, Rossato MF, Silva RL, Souza GR, Silva CR, Lucas G, Fonseca BA, Arruda E, Alves-Filho JC, Cunha FQ, Cunha TM.

J Neurosci. 2017 Jul 5;37(27):6408-6422. doi: 10.1523/JNEUROSCI.2233-16.2017. Epub 2017 Jun 2.


Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production.

Zucoloto AZ, Manchope MF, Staurengo-Ferrari L, Pinho-Ribeiro FA, Zarpelon AC, Saraiva ALL, Cecílio NT, Alves-Filho JC, Cunha TM, Menezes GB, Cunha FQ, Casagrande R, Verri WA Jr.

Eur J Pharmacol. 2017 Aug 15;809:52-63. doi: 10.1016/j.ejphar.2017.05.016. Epub 2017 May 10.


Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis.

Souza MC, Fonseca DM, Kanashiro A, Benevides L, Medina TS, Dias MS, Andrade WA, Bonfá G, Silva MAB, Gozzi A, Borges MC, Gazzinelli RT, Alves-Filho JC, Cunha FQ, Silva JS.

Front Cell Infect Microbiol. 2017 Apr 7;7:116. doi: 10.3389/fcimb.2017.00116. eCollection 2017.


Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects.

Zucoloto AZ, Manchope MF, Staurengo-Ferrari L, Alves-Filho JC, Cunha TM, Antunes MM, Menezes GB, Cunha FQ, Casagrande R, Verri WA Jr.

Inflamm Res. 2017 Jul;66(7):591-602. doi: 10.1007/s00011-017-1040-8. Epub 2017 Apr 6.


IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population.

Nascimento DC, Melo PH, Piñeros AR, Ferreira RG, Colón DF, Donate PB, Castanheira FV, Gozzi A, Czaikoski PG, Niedbala W, Borges MC, Zamboni DS, Liew FY, Cunha FQ, Alves-Filho JC.

Nat Commun. 2017 Apr 4;8:14919. doi: 10.1038/ncomms14919.


Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis.

Peres RS, Santos GB, Cecilio NT, Jabor VA, Niehues M, Torres BG, Buqui G, Silva CH, Costa TD, Lopes NP, Nonato MC, Ramalho FS, Louzada-Júnior P, Cunha TM, Cunha FQ, Emery FS, Alves-Filho JC.

Arthritis Res Ther. 2017 Mar 7;19(1):47. doi: 10.1186/s13075-017-1236-x.


M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection.

Piñeros AR, Campos LW, Fonseca DM, Bertolini TB, Gembre AF, Prado RQ, Alves-Filho JC, Ramos SG, Russo M, Bonato VL.

Sci Rep. 2017 Jan 27;7:41240. doi: 10.1038/srep41240.


Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis.

Kanashiro A, Sônego F, Ferreira RG, Castanheira FV, Leite CA, Borges VF, Nascimento DC, Cólon DF, Alves-Filho JC, Ulloa L, Cunha FQ.

Pharmacol Res. 2017 Mar;117:1-8. doi: 10.1016/j.phrs.2016.12.014. Epub 2016 Dec 12. Review.


Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.

Massis LM, Assis-Marques MA, Castanheira FV, Capobianco YJ, Balestra AC, Escoll P, Wood RE, Manin GZ, Correa VM, Alves-Filho JC, Cunha FQ, Buchrieser C, Borges MC, Newton HJ, Zamboni DS.

J Infect Dis. 2017 Feb 1;215(3):440-451. doi: 10.1093/infdis/jiw560.


NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular Damage.

Bruder-Nascimento T, Ferreira NS, Zanotto CZ, Ramalho F, Pequeno IO, Olivon VC, Neves KB, Alves-Lopes R, Campos E, Silva CA, Fazan R, Carlos D, Mestriner FL, Prado D, Pereira FV, Braga T, Luiz JP, Cau SB, Elias PC, Moreira AC, Câmara NO, Zamboni DS, Alves-Filho JC, Tostes RC.

Circulation. 2016 Dec 6;134(23):1866-1880. Epub 2016 Nov 1.


Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice.

Fattori V, Serafim KG, Zarpelon AC, Borghi SM, Pinho-Ribeiro FA, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr.

J Drug Target. 2017 Mar;25(3):264-274. doi: 10.1080/1061186X.2016.1245308. Epub 2016 Oct 24.


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