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Items: 39


The Transcription Factor Function of Parkin: Breaking the Dogma.

Alves da Costa C, Duplan E, Rouland L, Checler F.

Front Neurosci. 2019 Jan 15;12:965. doi: 10.3389/fnins.2018.00965. eCollection 2018. Review.


Nuclear TP53: An unraveled function as transcriptional repressor of PINK1.

Checler F, Goiran T, Alves da Costa C.

Autophagy. 2018;14(6):1099-1101. doi: 10.1080/15548627.2018.1450022. Epub 2018 May 11.


Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation.

Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, You H, Checler F, Alves da Costa C.

Cell Death Differ. 2018 May;25(5):873-884. doi: 10.1038/s41418-017-0016-0. Epub 2018 Jan 19.


Presenilins at the crossroad of a functional interplay between PARK2/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases.

Checler F, Goiran T, Alves da Costa C.

Autophagy. 2017;13(11):2004-2005. doi: 10.1080/15548627.2017.1363950. Epub 2017 Sep 21.


β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models.

Goiran T, Duplan E, Chami M, Bourgeois A, El Manaa W, Rouland L, Dunys J, Lauritzen I, You H, Stambolic V, Biféri MG, Barkats M, Pimplikar SW, Sergeant N, Colin M, Morais VA, Pardossi-Piquard R, Checler F, Alves da Costa C.

Biol Psychiatry. 2018 Mar 1;83(5):416-427. doi: 10.1016/j.biopsych.2017.04.011. Epub 2017 May 3.


α-synuclein and p53 functional interplay in physiopathological contexts.

Alves da Costa C, Duplan E, Checler F.

Oncotarget. 2017 Feb 7;8(6):9001-9002. doi: 10.18632/oncotarget.14385. No abstract available.


Direct α-synuclein promoter transactivation by the tumor suppressor p53.

Duplan E, Giordano C, Checler F, Alves da Costa C.

Mol Neurodegener. 2016 Feb 2;11:13. doi: 10.1186/s13024-016-0079-2.


p53 in neurodegenerative diseases and brain cancers.

Checler F, Alves da Costa C.

Pharmacol Ther. 2014 Apr;142(1):99-113. doi: 10.1016/j.pharmthera.2013.11.009. Epub 2013 Nov 25. Review.


Interplay between parkin and p53 governs a physiological homeostasis that is disrupted in Parkinson's disease and cerebral cancer.

Checler F, Alves da Costa C.

Neurodegener Dis. 2014;13(2-3):118-21. doi: 10.1159/000354075. Epub 2013 Sep 4. Review.


Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity.

Viotti J, Duplan E, Caillava C, Condat J, Goiran T, Giordano C, Marie Y, Idbaih A, Delattre JY, Honnorat J, Checler F, Alves da Costa C.

Oncogene. 2014 Apr 3;33(14):1764-75. doi: 10.1038/onc.2013.124. Epub 2013 May 6.


ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.

Duplan E, Giaime E, Viotti J, Sévalle J, Corti O, Brice A, Ariga H, Qi L, Checler F, Alves da Costa C.

J Cell Sci. 2013 May 1;126(Pt 9):2124-33. doi: 10.1242/jcs.127340. Epub 2013 Feb 27.


Parkin: much more than a simple ubiquitin ligase.

Alves da Costa C, Checler F.

Neurodegener Dis. 2012;10(1-4):49-51. doi: 10.1159/000332803. Epub 2011 Dec 23. Review.


Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism?

Alves da Costa C, Checler F.

Cell Signal. 2011 Jun;23(6):963-8. doi: 10.1016/j.cellsig.2010.10.020. Epub 2010 Oct 20. Review.


p53 is regulated by and regulates members of the gamma-secretase complex.

Checler F, Dunys J, Pardossi-Piquard R, Alves da Costa C.

Neurodegener Dis. 2010;7(1-3):50-5. doi: 10.1159/000283483. Epub 2010 Feb 13. Review.


Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.

Giaime E, Sunyach C, Druon C, Scarzello S, Robert G, Grosso S, Auberger P, Goldberg MS, Shen J, Heutink P, Pouysségur J, Pagès G, Checler F, Alves da Costa C.

Cell Death Differ. 2010 Jan;17(1):158-69. doi: 10.1038/cdd.2009.116.


p53-dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex.

Pardossi-Piquard R, Dunys J, Giaime E, Guillot-Sestier MV, St George-Hyslop P, Checler F, Alves da Costa C.

J Neurochem. 2009 Apr;109(1):225-37. doi: 10.1111/j.1471-4159.2009.05952.x. Epub 2009 Feb 23.


Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2.

Dunys J, Kawarai T, Giaime E, Wilk S, Herrant M, Auberger P, St George-Hyslop P, Alves da Costa C, Checler F.

Neurodegener Dis. 2007;4(2-3):156-63.


Response to correspondence: Pardossi-Piquard et al., "Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betAAPP and APLP." Neuron 46, 541-554.

Pardossi-Piquard R, Dunys J, Kawarai T, Sunyach C, Alves da Costa C, Vincent B, Sévalle J, Pimplikar S, St George-Hyslop P, Checler F.

Neuron. 2007 Feb 15;53(4):483-6. No abstract available.


Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

Alves da Costa C, Sunyach C, Pardossi-Piquard R, Sévalle J, Vincent B, Boyer N, Kawarai T, Girardot N, St George-Hyslop P, Checler F.

J Neurosci. 2006 Jun 7;26(23):6377-85.


Neprilysin activity and expression are controlled by nicastrin.

Pardossi-Piquard R, Dunys J, Yu G, St George-Hyslop P, Alves da Costa C, Checler F.

J Neurochem. 2006 May;97(4):1052-6. Epub 2006 Apr 5.


6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation.

Alves da Costa C, Dunys J, Brau F, Wilk S, Cappai R, Checler F.

J Biol Chem. 2006 Apr 7;281(14):9824-31. Epub 2006 Feb 7. Erratum in: J Biol Chem. 2013 Jul 19;288(29):21208.


Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins.

Dunys J, Kawarai T, Wilk S, St George-Hyslop P, Alves da Costa C, Checler F.

Biochem J. 2006 Mar 1;394(Pt 2):501-9.


JLK inhibitors: isocoumarin compounds as putative probes to selectively target the gamma-secretase pathway.

Checler F, Alves da Costa C, Ayral E, Andrau D, Dumanchin C, Farzan M, Hernandez JF, Martinez J, Lefranc-Jullien S, Marambaud P, Pasini A, Petit A, Phiel C, Robert P, St George-Hyslop P, Wilk S.

Curr Alzheimer Res. 2005 Jul;2(3):327-34. Review. Erratum in: Curr Alzheimer Res. 2005 Oct;2(4):493. Frédéric, Checler [corrected to Checler, Frédéric]; Cristine, Alves da Costa [corrected to Alves da Costa, Cristine]; Erwan, Ayral [corrected to Ayral, Erwan]; David, Andrau [corrected to Andrau, David]; Cécile, Dumanchin [corrected to Dumanchin, Céc.


Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.

Pardossi-Piquard R, Petit A, Kawarai T, Sunyach C, Alves da Costa C, Vincent B, Ring S, D'Adamio L, Shen J, Müller U, St George Hyslop P, Checler F.

Neuron. 2005 May 19;46(4):541-54.


Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.

Alves da Costa C, Ayral E, Hernandez JF, St George-Hyslop P, Checler F.

J Neurochem. 2004 Aug;90(4):800-6.


JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo.

Petit A, Pasini A, Alves Da Costa C, Ayral E, Hernandez JF, Dumanchin-Njock C, Phiel CJ, Marambaud P, Wilk S, Farzan M, Fulcrand P, Martinez J, Andrau D, Checler F.

J Neurosci Res. 2003 Nov 1;74(3):370-7.


Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels.

Paitel E, Sunyach C, Alves da Costa C, Bourdon JC, Vincent B, Checler F.

J Biol Chem. 2004 Jan 2;279(1):612-8. Epub 2003 Oct 21.


Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease.

Bihel F, Quéléver G, Lelouard H, Petit A, Alvès da Costa C, Pourquié O, Checler F, Thellend A, Pierre P, Kraus JL.

Bioorg Med Chem. 2003 Jul 17;11(14):3141-52.


Recent advances on alpha-synuclein cell biology: functions and dysfunctions.

Alves da Costa C.

Curr Mol Med. 2003 Feb;3(1):17-24. Review.


Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies.

Paitel E, Alves da Costa C, Vilette D, Grassi J, Checler F.

J Neurochem. 2002 Dec;83(5):1208-14.


Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease.

Alves Da Costa C, Paitel E, Vincent B, Checler F.

J Biol Chem. 2002 Dec 27;277(52):50980-4. Epub 2002 Oct 22.


Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.

Alves da Costa C, Paitel E, Mattson MP, Amson R, Telerman A, Ancolio K, Checler F.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4043-8. Erratum in: Proc Natl Acad Sci U S A 2002 Jun 25;99(13):9081. Mattson Marc P [corrected to Mattson Mark P].


The caspase-derived C-terminal fragment of betaAPP induces caspase-independent toxicity and triggers selective increase of Abeta42 in mammalian cells.

Dumanchin-Njock C, Alves da Costa CA, Mercken L, Pradier L, Checler F.

J Neurochem. 2001 Sep;78(5):1153-61.


New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage.

Petit A, Bihel F, Alvès da Costa C, Pourquié O, Checler F, Kraus JL.

Nat Cell Biol. 2001 May;3(5):507-11.


Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

Marambaud P, Alves da Costa C, Ancolio K, Checler F.

Biochem Biophys Res Commun. 1998 Nov 9;252(1):134-8.


[Eruption of permanent mandibular canine causing an abnormal direction].


Odontologo (Belo Horizonte). 1947 Mar-Apr;9(42):16-9. Portuguese. No abstract available.


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