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Items: 31


Medullary thymic epithelial cells: Deciphering the functional diversity beyond promiscuous gene expression.

Ribeiro C, Alves NL, Ferreirinha P.

Immunol Lett. 2019 Mar 7. pii: S0165-2478(19)30007-0. doi: 10.1016/j.imlet.2019.01.012. [Epub ahead of print]


FoxN1-dependent thymic epithelial cells promote T-cell leukemia development.

Ghezzo MN, Fernandes MT, Pacheco-Leyva I, Rodrigues PM, Machado RS, Araújo MAS, Kalathur RK, Futschik ME, Alves NL, Dos Santos NR.

Carcinogenesis. 2018 Dec 31;39(12):1463-1476. doi: 10.1093/carcin/bgy127.


Intrathymic Deletion of IL-7 Reveals a Contribution of the Bone Marrow to Thymic Rebound Induced by Androgen Blockade.

Rodrigues PM, Ribeiro AR, Serafini N, Meireles C, Di Santo JP, Alves NL.

J Immunol. 2018 Feb 15;200(4):1389-1398. doi: 10.4049/jimmunol.1701112. Epub 2018 Jan 10.


Setting Up the Perimeter of Tolerance: Insights into mTEC Physiology.

Rodrigues PM, Peterson P, Alves NL.

Trends Immunol. 2018 Jan;39(1):2-5. doi: 10.1016/ Epub 2017 Nov 24. Review.


Innate IFN-γ-Producing Cells Developing in the Absence of IL-2 Receptor Common γ-Chain.

Resende M, Cardoso MS, Ribeiro AR, Flórido M, Borges M, Castro AG, Alves NL, Cooper AM, Appelberg R.

J Immunol. 2017 Aug 15;199(4):1429-1439. doi: 10.4049/jimmunol.1601701. Epub 2017 Jul 7.


Thymic epithelial cells require p53 to support their long-term function in thymopoiesis in mice.

Rodrigues PM, Ribeiro AR, Perrod C, Landry JJM, Araújo L, Pereira-Castro I, Benes V, Moreira A, Xavier-Ferreira H, Meireles C, Alves NL.

Blood. 2017 Jul 27;130(4):478-488. doi: 10.1182/blood-2016-12-758961. Epub 2017 May 30.


Thymic crosstalk restrains the pool of cortical thymic epithelial cells with progenitor properties.

Meireles C, Ribeiro AR, Pinto RD, Leitão C, Rodrigues PM, Alves NL.

Eur J Immunol. 2017 Jun;47(6):958-969. doi: 10.1002/eji.201746922. Epub 2017 Apr 13.


Thymus medulla under construction: Time and space oddities.

Alves NL, Ribeiro AR.

Eur J Immunol. 2016 Apr;46(4):829-33. doi: 10.1002/eji.201646329. Epub 2016 Mar 21.


Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype.

Fernandes MT, Ghezzo MN, Silveira AB, Kalathur RK, Póvoa V, Ribeiro AR, Brandalise SR, Dejardin E, Alves NL, Ghysdael J, Barata JT, Yunes JA, dos Santos NR.

Br J Haematol. 2015 Dec;171(5):736-51. doi: 10.1111/bjh.13760. Epub 2015 Oct 12. Erratum in: Br J Haematol. 2016 Jun;173(5):804.


Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function.

Remmerswaal EB, Klarenbeek PL, Alves NL, Doorenspleet ME, van Schaik BD, Esveldt RE, Idu MM, van Leeuwen EM, van der Bom-Baylon N, van Kampen AH, Koch SD, Pircher H, Bemelman FJ, Ten Brinke A, Baas F, Ten Berge IJ, van Lier RA, de Vries N.

J Virol. 2015 Jan;89(1):568-80. doi: 10.1128/JVI.02003-14. Epub 2014 Oct 22.


Intermediate expression of CCRL1 reveals novel subpopulations of medullary thymic epithelial cells that emerge in the postnatal thymus.

Ribeiro AR, Meireles C, Rodrigues PM, Alves NL.

Eur J Immunol. 2014 Oct;44(10):2918-24. doi: 10.1002/eji.201444585. Epub 2014 Sep 5. Erratum in: Eur J Immunol. 2014 Dec;44(12):3768.


Serial progression of cortical and medullary thymic epithelial microenvironments.

Alves NL, Takahama Y, Ohigashi I, Ribeiro AR, Baik S, Anderson G, Jenkinson WE.

Eur J Immunol. 2014 Jan;44(1):16-22. doi: 10.1002/eji.201344110. Epub 2013 Dec 4. Review. Erratum in: Eur J Immunol. 2014 Jul;44(7):2197.


Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo.

Ribeiro AR, Rodrigues PM, Meireles C, Di Santo JP, Alves NL.

J Immunol. 2013 Aug 1;191(3):1200-9. doi: 10.4049/jimmunol.1203042. Epub 2013 Jun 21.


Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice.

Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Plet A, Weijer K, Jacques Y, Spits H, Di Santo JP.

Eur J Immunol. 2011 Oct;41(10):2883-93. doi: 10.1002/eji.201141586. Epub 2011 Aug 30.


Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1.

Wensveen FM, Alves NL, Derks IA, Reedquist KA, Eldering E.

Apoptosis. 2011 Jul;16(7):708-21. doi: 10.1007/s10495-011-0599-8.


IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo.

Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Mention JJ, Plet A, Weijer K, Jacques Y, Becker PD, Guzman C, Soussan P, Kremsdorf D, Spits H, Di Santo JP.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6217-22. doi: 10.1073/pnas.1019167108. Epub 2011 Mar 28.


Cutting Edge: a thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivo.

Alves NL, Huntington ND, Mention JJ, Richard-Le Goff O, Di Santo JP.

J Immunol. 2010 Jun 1;184(11):5949-53. doi: 10.4049/jimmunol.1000601. Epub 2010 May 3.


CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism.

Lalanne AI, Moraga I, Hao Y, Pereira JP, Alves NL, Huntington ND, Freitas AA, Cumano A, Vieira P.

J Immunol. 2010 May 15;184(10):5678-85. doi: 10.4049/jimmunol.0903854. Epub 2010 Apr 16.


Thymic epithelial cells: the multi-tasking framework of the T cell "cradle".

Alves NL, Huntington ND, Rodewald HR, Di Santo JP.

Trends Immunol. 2009 Oct;30(10):468-74. doi: 10.1016/ Epub 2009 Sep 24.


Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.

Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL.

Int Immunol. 2009 Jun;21(6):715-25. doi: 10.1093/intimm/dxp043. Epub 2009 May 19.


Characterization of the thymic IL-7 niche in vivo.

Alves NL, Richard-Le Goff O, Huntington ND, Sousa AP, Ribeiro VS, Bordack A, Vives FL, Peduto L, Chidgey A, Cumano A, Boyd R, Eberl G, Di Santo JP.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1512-7. doi: 10.1073/pnas.0809559106. Epub 2009 Jan 21.


IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.

Huntington ND, Legrand N, Alves NL, Jaron B, Weijer K, Plet A, Corcuff E, Mortier E, Jacques Y, Spits H, Di Santo JP.

J Exp Med. 2009 Jan 16;206(1):25-34. doi: 10.1084/jem.20082013. Epub 2008 Dec 22.


Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling.

Alves NL, van Leeuwen EM, Derks IA, van Lier RA.

J Immunol. 2008 Apr 15;180(8):5201-10.


Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection.

Hallaert DY, Spijker R, Jak M, Derks IA, Alves NL, Wensveen FM, de Boer JP, de Jong D, Green SR, van Oers MH, Eldering E.

Cell Death Differ. 2007 Nov;14(11):1958-67. Epub 2007 Aug 17.


A new subset of human naive CD8+ T cells defined by low expression of IL-7R alpha.

Alves NL, van Leeuwen EM, Remmerswaal EB, Vrisekoop N, Tesselaar K, Roosnek E, ten Berge IJ, van Lier RA.

J Immunol. 2007 Jul 1;179(1):221-8.


Common gamma chain cytokines: dissidence in the details.

Alves NL, Arosa FA, van Lier RA.

Immunol Lett. 2007 Feb 15;108(2):113-20. Epub 2006 Dec 18. Review.


Withdrawal symptoms on display: Bcl-2 members under investigation.

Alves NL, van Lier RA, Eldering E.

Trends Immunol. 2007 Jan;28(1):26-32. Epub 2006 Nov 28.


The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells.

Alves NL, Derks IA, Berk E, Spijker R, van Lier RA, Eldering E.

Immunity. 2006 Jun;24(6):703-16.


IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells.

Alves NL, Arosa FA, van Lier RA.

J Immunol. 2005 Jul 15;175(2):755-62.


Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells.

Gimeno R, Weijer K, Voordouw A, Uittenbogaart CH, Legrand N, Alves NL, Wijnands E, Blom B, Spits H.

Blood. 2004 Dec 15;104(13):3886-93. Epub 2004 Aug 19.


IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro.

Alves NL, Hooibrink B, Arosa FA, van Lier RA.

Blood. 2003 Oct 1;102(7):2541-6. Epub 2003 Jun 12.

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