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Items: 21


Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus.

Reeve SM, Si D, Krucinska J, Yan Y, Viswanathan K, Wang S, Holt GT, Frenkel MS, Ojewole AA, Estrada A, Agabiti SS, Alverson JB, Gibson ND, Priestley ND, Wiemer AJ, Donald BR, Wright DL.

ACS Infect Dis. 2019 Oct 15. doi: 10.1021/acsinfecdis.9b00222. [Epub ahead of print]


Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates.

Lombardo MN, G-Dayanandan N, Keshipeddy S, Zhou W, Si D, Reeve SM, Alverson J, Barney P, Walker L, Hoody J, Priestley ND, Obach RS, Wright DL.

Drug Metab Dispos. 2019 Sep;47(9):995-1003. doi: 10.1124/dmd.119.086504. Epub 2019 Jun 14.


A Controlled Antibiotic Release System for the Development of Single-Application Otitis Externa Therapeutics.

Serban BA, Stipe KT, Alverson JB, Johnston ER, Priestley ND, Serban MA.

Gels. 2017 May 17;3(2). pii: E19. doi: 10.3390/gels3020019.


The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture.

Stierle AA, Stierle DB, Decato D, Priestley ND, Alverson JB, Hoody J, McGrath K, Klepacki D.

J Nat Prod. 2017 Apr 28;80(4):1150-1160. doi: 10.1021/acs.jnatprod.7b00133. Epub 2017 Mar 22.


Pharmaceutical analysis of a novel propargyl-linked antifolate antibiotic in the mouse.

Hoody J, Alverson JB, Keshipeddy S, Barney PA, Walker L, Anderson AC, Wright DL, Priestley ND.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Apr 15;1051:54-59. doi: 10.1016/j.jchromb.2017.02.026. Epub 2017 Mar 6.


Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.

Scocchera E, Reeve SM, Keshipeddy S, Lombardo MN, Hajian B, Sochia AE, Alverson JB, Priestley ND, Anderson AC, Wright DL.

ACS Med Chem Lett. 2016 May 5;7(7):692-6. doi: 10.1021/acsmedchemlett.6b00120. eCollection 2016 Jul 14.


Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.

Lamb KM, Lombardo MN, Alverson J, Priestley ND, Wright DL, Anderson AC.

Antimicrob Agents Chemother. 2014 Dec;58(12):7484-91. doi: 10.1128/AAC.03555-14. Epub 2014 Oct 6.


De novo macrolide-glycolipid macrolactone hybrids: Synthesis, structure and antibiotic activity of carbohydrate-fused macrocycles.

Desmond RT, Magpusao AN, Lorenc C, Alverson JB, Priestley N, Peczuh MW.

Beilstein J Org Chem. 2014 Sep 17;10:2215-21. doi: 10.3762/bjoc.10.229. eCollection 2014.


Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata.

G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC.

J Med Chem. 2014 Mar 27;57(6):2643-56. doi: 10.1021/jm401916j. Epub 2014 Mar 6.


Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes.

Viswanathan K, Frey KM, Scocchera EW, Martin BD, Swain Iii PW, Alverson JB, Priestley ND, Anderson AC, Wright DL.

PLoS One. 2012;7(2):e29434. doi: 10.1371/journal.pone.0029434. Epub 2012 Feb 7.


Prion gene (PRNP) haplotype variation in United States goat breeds (Open Access publication).

White S, Herrmann-Hoesing L, O'rourke K, Waldron D, Rowe J, Alverson J.

Genet Sel Evol. 2008 Sep-Oct;40(5):553-61. doi: 10.1051/gse:2008021. Epub 2008 Aug 12.


Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie.

Schneider DA, Yan H, Fry LM, Alverson J, White SN, O'Rourke KI.

Acta Neuropathol. 2008 Jun;115(6):651-61. doi: 10.1007/s00401-008-0374-2. Epub 2008 Apr 22.


PrPSc accumulation in fetal cotyledons of scrapie-resistant lambs is influenced by fetus location in the uterus.

Alverson J, O'Rourke KI, Baszler TV.

J Gen Virol. 2006 Apr;87(Pt 4):1035-41.


Fewer PrPc myeloid-based cells in sheep with the prion-resistant genotype.

Herrmann LM, Baszler TV, O'Rourke KI, Suarez CE, Bakko M, Alverson J, Knowles DP.

Neuroreport. 2006 Feb 6;17(2):125-9.


Histamine as an aid to biopsy of third eyelid lymphoid tissue in sheep.

Bender S, Alverson J, Herrmann LM, O'Rourke KI.

Vet Rec. 2004 May 22;154(21):662-3. No abstract available. Erratum in: Vet Rec. 2004 Jun 26;154(26):813.


Transcriptional regulation of the ospAB and ospC promoters from Borrelia burgdorferi.

Alverson J, Bundle SF, Sohaskey CD, Lybecker MC, Samuels DS.

Mol Microbiol. 2003 Jun;48(6):1665-77.


Effects of mycotoxins, kojic acid and oxalic acid, on biological fitness of Lygus hesperus (Heteroptera: Miridae).

Alverson J.

J Invertebr Pathol. 2003 May;83(1):60-2. No abstract available.


groEL expression in gyrB mutants of Borrelia burgdorferi.

Alverson J, Samuels DS.

J Bacteriol. 2002 Nov;184(21):6069-72.


Effect of antifungal agents on biological fitness of Lygus hesperus (Heteroptera: Miridae).

Alverson J, Cohen AC.

J Econ Entomol. 2002 Apr;95(2):256-60.


Performance of the ImmunoCard STAT! E. coli O157:H7 test for detection of Escherichia coli O157:H7 in stools.

Mackenzie A, Orrbine E, Hyde L, Benoit M, Chan F, Park C, Alverson J, Lembke A, Hoban D, Kennedy W.

J Clin Microbiol. 2000 May;38(5):1866-8.


Variable expression of leukocyte cytosolic broad-specificity beta-glucosidase activity.

Forsyth GW, Romero KM, Alverson J, VanderJagt DJ, Glew RH.

Clin Chim Acta. 1993 Jul 16;216(1-2):11-21.


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