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Items: 1 to 50 of 131


Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation Following Colorectal Surgery.

Gaines S, van Praagh JB, Williamson AJ, Jacobson RA, Hyoju S, Zaborin A, Mao J, Koo HY, Alpert L, Bissonnette M, Weichselbaum R, Gilbert J, Chang E, Hyman N, Zaborina O, Shogan BD, Alverdy JC.

Gastroenterology. 2019 Oct 23. pii: S0016-5085(19)41471-6. doi: 10.1053/j.gastro.2019.10.020. [Epub ahead of print]


Enterococcus faecalis exploits the human fibrinolytic system to drive excess collagenolysis: implications in gut healing and identification of druggable targets.

Jacobson RA, Wienholts K, Williamson AJ, Gaines S, Hyoju S, van Goor H, Zaborin A, Shogan BD, Zaborina O, Alverdy JC.

Am J Physiol Gastrointest Liver Physiol. 2019 Oct 11. doi: 10.1152/ajpgi.00236.2019. [Epub ahead of print]


Preparing the bowel for surgery: rethinking the strategy.

Alverdy JC, Shogan BD.

Nat Rev Gastroenterol Hepatol. 2019 Sep 23. doi: 10.1038/s41575-019-0214-y. [Epub ahead of print] No abstract available.


Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts.

Hyoju SK, Zaborin A, Keskey R, Sharma A, Arnold W, van den Berg F, Kim SM, Gottel N, Bethel C, Charnot-Katsikas A, Jianxin P, Adriaansens C, Papazian E, Gilbert JA, Zaborina O, Alverdy JC.

MBio. 2019 Jul 30;10(4). pii: e00903-19. doi: 10.1128/mBio.00903-19.


Sustained Release of Phosphates From Hydrogel Nanoparticles Suppresses Bacterial Collagenase and Biofilm Formation in vitro.

Nichols D, Pimentel MB, Borges FTP, Hyoju SK, Teymour F, Hong SH, Zaborina OY, Alverdy JC, Papavasiliou G.

Front Bioeng Biotechnol. 2019 Jun 26;7:153. doi: 10.3389/fbioe.2019.00153. eCollection 2019.


Surgeon as Basic Bench Scientist: A Play in Three Acts.

Alverdy JC.

J Surg Res. 2019 Sep;241:336-342. doi: 10.1016/j.jss.2019.04.016. Epub 2019 May 6.


The wound environment, microbial virulence and postoperative infection: Practical lessons for the surgeon.

Alverdy JC.

Cir Esp. 2018 Dec;96(10):612-619. doi: 10.1016/j.ciresp.2018.09.016. Epub 2018 Nov 27. English, Spanish.


Ionic Modulation of Bacterial Virulence and Its Role in Surgical Infection.

Alverdy JC.

Surg Infect (Larchmt). 2018 Nov/Dec;19(8):769-773. doi: 10.1089/sur.2018.224. Epub 2018 Oct 25. Review.


Novel de novo synthesized phosphate carrier compound ABA-PEG20k-Pi20 suppresses collagenase production in Enterococcus faecalis and prevents colonic anastomotic leak in an experimental model.

Wiegerinck M, Hyoju SK, Mao J, Zaborin A, Adriaansens C, Salzman E, Hyman NH, Zaborina O, van Goor H, Alverdy JC.

Br J Surg. 2018 Sep;105(10):1368-1376. doi: 10.1002/bjs.10859. Epub 2018 Apr 16.


Microbiome Medicine: This Changes Everything.

Alverdy JC.

J Am Coll Surg. 2018 May;226(5):719-729. doi: 10.1016/j.jamcollsurg.2018.02.004. Epub 2018 Mar 2. No abstract available.


Hypermetabolism and Nutritional Support in Sepsis.

Alverdy JC.

Surg Infect (Larchmt). 2018 Feb/Mar;19(2):163-167. doi: 10.1089/sur.2017.313. Epub 2018 Feb 2. Review.


De Novo Synthesis of Phosphorylated Triblock Copolymers with Pathogen Virulence-Suppressing Properties That Prevent Infection-Related Mortality.

Mao J, Zaborin A, Poroyko V, Goldfeld D, Lynd NA, Chen W, Tirrell MV, Zaborina O, Alverdy JC.

ACS Biomater Sci Eng. 2017 Sep 11;3(9):2076-2085. doi: 10.1021/acsbiomaterials.7b00373. Epub 2017 Jul 17.


Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery.

Gaines S, Shao C, Hyman N, Alverdy JC.

Br J Surg. 2018 Jan;105(2):e131-e141. doi: 10.1002/bjs.10760. Review.


Media from macrophages co-incubated with Enterococcus faecalis induces epithelial cell monolayer reassembly and altered cell morphology.

Belogortseva N, Krezalek M, Guyton K, Labno C, Poroyko V, Zaborina O, Alverdy JC.

PLoS One. 2017 Aug 9;12(8):e0182825. doi: 10.1371/journal.pone.0182825. eCollection 2017.


Preparing the Bowel for Surgery: Learning from the Past and Planning for the Future.

Alverdy JC, Hyman N, Gilbert J, Luo JN, Krezalek M.

J Am Coll Surg. 2017 Aug;225(2):324-332. doi: 10.1016/j.jamcollsurg.2017.05.005. Epub 2017 May 19. Review. No abstract available.


Fecal Micobiota Transplantation to Treat Sepsis of Unclear Etiology.

Gaines S, Alverdy JC.

Crit Care Med. 2017 Jun;45(6):1106-1107. doi: 10.1097/CCM.0000000000002382. No abstract available.


Optimum Operating Room Environment for the Prevention of Surgical Site Infections.

Gaines S, Luo JN, Gilbert J, Zaborina O, Alverdy JC.

Surg Infect (Larchmt). 2017 May/Jun;18(4):503-507. doi: 10.1089/sur.2017.020. Epub 2017 Apr 12.


Stochasticity among Antibiotic-Resistance Profiles of Common Burn-Related Pathogens over a Six-Year Period.

Collier ZJ, Gottlieb LJ, Alverdy JC.

Surg Infect (Larchmt). 2017 Apr;18(3):327-335. doi: 10.1089/sur.2016.191. Epub 2017 Feb 24.


The Influence of Host Stress on the Mechanism of Infection: Lost Microbiomes, Emergent Pathobiomes, and the Role of Interkingdom Signaling.

Alverdy JC, Luo JN.

Front Microbiol. 2017 Mar 2;8:322. doi: 10.3389/fmicb.2017.00322. eCollection 2017.


Smoking and Postoperative Surgical Site Infection: Where There's Smoke, There's Fire.

Alverdy JC, Prachand V.

JAMA Surg. 2017 May 1;152(5):484. doi: 10.1001/jamasurg.2016.5706. No abstract available.


Can Methicillin-resistant Staphylococcus aureus Silently Travel From the Gut to the Wound and Cause Postoperative Infection? Modeling the "Trojan Horse Hypothesis".

Krezalek MA, Hyoju S, Zaborin A, Okafor E, Chandrasekar L, Bindokas V, Guyton K, Montgomery CP, Daum RS, Zaborina O, Boyle-Vavra S, Alverdy JC.

Ann Surg. 2018 Apr;267(4):749-758. doi: 10.1097/SLA.0000000000002173.


Oral Polyphosphate Suppresses Bacterial Collagenase Production and Prevents Anastomotic Leak Due to Serratia marcescens and Pseudomonas aeruginosa.

Hyoju SK, Klabbers RE, Aaron M, Krezalek MA, Zaborin A, Wiegerinck M, Hyman NH, Zaborina O, Van Goor H, Alverdy JC.

Ann Surg. 2018 Jun;267(6):1112-1118. doi: 10.1097/SLA.0000000000002167.


The gut microbiome and the mechanism of surgical infection.

Alverdy JC, Hyoju SK, Weigerinck M, Gilbert JA.

Br J Surg. 2017 Jan;104(2):e14-e23. doi: 10.1002/bjs.10405. Review.


Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis.

Alverdy JC, Krezalek MA.

Crit Care Med. 2017 Feb;45(2):337-347. doi: 10.1097/CCM.0000000000002172.


Modeling Acinetobacter baumannii wound infections: The critical role of iron.

Fleming ID, Krezalek MA, Belogortseva N, Zaborin A, Defazio J, Chandrasekar L, Actis LA, Zaborina O, Alverdy JC.

J Trauma Acute Care Surg. 2017 Mar;82(3):557-565. doi: 10.1097/TA.0000000000001338.


Influence of nutrition therapy on the intestinal microbiome.

Krezalek MA, Yeh A, Alverdy JC, Morowitz M.

Curr Opin Clin Nutr Metab Care. 2017 Mar;20(2):131-137. doi: 10.1097/MCO.0000000000000348. Review.


Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress.

Zaborin A, Krezalek M, Hyoju S, Defazio JR, Setia N, Belogortseva N, Bindokas VP, Guo Q, Zaborina O, Alverdy JC.

Am J Physiol Gastrointest Liver Physiol. 2017 Feb 1;312(2):G112-G122. doi: 10.1152/ajpgi.00294.2016. Epub 2016 Dec 15.


The gut microbiota and gastrointestinal surgery.

Guyton K, Alverdy JC.

Nat Rev Gastroenterol Hepatol. 2017 Jan;14(1):43-54. doi: 10.1038/nrgastro.2016.139. Epub 2016 Oct 12. Review.


De Novo Synthesis and Functional Analysis of Polyphosphate-Loaded Poly(Ethylene) Glycol Hydrogel Nanoparticles Targeting Pyocyanin and Pyoverdin Production in Pseudomonas aeruginosa as a Model Intestinal Pathogen.

Yin Y, Papavasiliou G, Zaborina OY, Alverdy JC, Teymour F.

Ann Biomed Eng. 2017 Apr;45(4):1058-1068. doi: 10.1007/s10439-016-1740-1. Epub 2016 Oct 19.


Morphine Promotes Colonization of Anastomotic Tissues with Collagenase - Producing Enterococcus faecalis and Causes Leak.

Shakhsheer BA, Versten LA, Luo JN, Defazio JR, Klabbers R, Christley S, Zaborin A, Guyton KL, Krezalek M, Smith DP, Ajami NJ, Petrosino JF, Fleming ID, Belogortseva N, Zaborina O, Alverdy JC.

J Gastrointest Surg. 2016 Oct;20(10):1744-51. doi: 10.1007/s11605-016-3237-5. Epub 2016 Aug 16.


Prevention of Perioperative Anastomotic Healing Complications: Anastomotic Stricture and Anastomotic Leak.

Guyton KL, Hyman NH, Alverdy JC.

Adv Surg. 2016 Sep;50(1):129-41. doi: 10.1016/j.yasu.2016.03.011. Epub 2016 Jun 29. Review. No abstract available.


The intestinal microbiome and surgical disease.

Krezalek MA, Skowron KB, Guyton KL, Shakhsheer B, Hyoju S, Alverdy JC.

Curr Probl Surg. 2016 Jun;53(6):257-93. doi: 10.1067/j.cpsurg.2016.06.001. Epub 2016 Jun 14. Review. No abstract available.


The role of the microbiota in surgical recovery.

Krezalek MA, Alverdy JC.

Curr Opin Clin Nutr Metab Care. 2016 Sep;19(5):347-352. doi: 10.1097/MCO.0000000000000299.


Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.

Ward MA, Pierre JF, Leal RF, Huang Y, Shogan B, Dalal SR, Weber CR, Leone VA, Musch MW, An GC, Rao MC, Rubin DT, Raffals LE, Antonopoulos DA, Sogin ML, Hyman NH, Alverdy JC, Chang EB.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G973-88. doi: 10.1152/ajpgi.00017.2016. Epub 2016 Apr 14.


A Video Is Worth a Thousand Words.

Alverdy JC.

JAMA Surg. 2016 Jun 15;151(6):e160476. doi: 10.1001/jamasurg.2016.0476. Epub 2016 Jun 15. No abstract available.


The Shift of an Intestinal "Microbiome" to a "Pathobiome" Governs the Course and Outcome of Sepsis Following Surgical Injury.

Krezalek MA, DeFazio J, Zaborina O, Zaborin A, Alverdy JC.

Shock. 2016 May;45(5):475-82. doi: 10.1097/SHK.0000000000000534. Review.


C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype.

Kanteti R, Dhanasingh I, El-Hashani E, Riehm JJ, Stricker T, Nagy S, Zaborin A, Zaborina O, Biron D, Alverdy JC, Im HK, Siddiqui S, Padilla PA, Salgia R.

Cancer Biol Ther. 2016;17(1):91-103. doi: 10.1080/15384047.2015.1108495.


Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak.

Shogan BD, Belogortseva N, Luong PM, Zaborin A, Lax S, Bethel C, Ward M, Muldoon JP, Singer M, An G, Umanskiy K, Konda V, Shakhsheer B, Luo J, Klabbers R, Hancock LE, Gilbert J, Zaborina O, Alverdy JC.

Sci Transl Med. 2015 May 6;7(286):286ra68. doi: 10.1126/scitranslmed.3010658.


Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact.

Kim M, Christley S, Khodarev NN, Fleming I, Huang Y, Chang E, Zaborina O, Alverdy JC.

J Trauma Acute Care Surg. 2015 Apr;78(4):823-9. doi: 10.1097/TA.0000000000000574.


The opposing forces of the intestinal microbiome and the emerging pathobiome.

Defazio J, Fleming ID, Shakhsheer B, Zaborina O, Alverdy JC.

Surg Clin North Am. 2014 Dec;94(6):1151-61. doi: 10.1016/j.suc.2014.08.002. Epub 2014 Oct 7. Review.


Valuable heartburn data that may be difficult to swallow.

Alverdy JC.

Surg Obes Relat Dis. 2015 Jan-Feb;11(1):229. doi: 10.1016/j.soard.2014.05.017. Epub 2014 May 22. No abstract available.


Intestinal anastomotic injury alters spatially defined microbiome composition and function.

Shogan BD, Smith DP, Christley S, Gilbert JA, Zaborina O, Alverdy JC.

Microbiome. 2014 Sep 15;2:35. doi: 10.1186/2049-2618-2-35. eCollection 2014.


Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness.

Zaborin A, Smith D, Garfield K, Quensen J, Shakhsheer B, Kade M, Tirrell M, Tiedje J, Gilbert JA, Zaborina O, Alverdy JC.

MBio. 2014 Sep 23;5(5):e01361-14. doi: 10.1128/mBio.01361-14.


Proceedings of the first international summit on intestinal anastomotic leak, Chicago, Illinois, October 4-5, 2012.

Shogan BD, An GC, Schardey HM, Matthews JB, Umanskiy K, Fleshman JW Jr, Hoeppner J, Fry DE, Garcia-Granereo E, Jeekel H, van Goor H, Dellinger EP, Konda V, Gilbert JA, Auner GW, Alverdy JC.

Surg Infect (Larchmt). 2014 Oct;15(5):479-89. doi: 10.1089/sur.2013.114. Epub 2014 Sep 12.


The Hospital Microbiome Project: Meeting report for the 2nd Hospital Microbiome Project, Chicago, USA, January 15(th), 2013.

Shogan BD, Smith DP, Packman AI, Kelley ST, Landon EM, Bhangar S, Vora GJ, Jones RM, Keegan K, Stephens B, Ramos T, Kirkup BC Jr, Levin H, Rosenthal M, Foxman B, Chang EB, Siegel J, Cobey S, An G, Alverdy JC, Olsiewski PJ, Martin MO, Marrs R, Hernandez M, Christley S, Morowitz M, Weber S, Gilbert J.

Stand Genomic Sci. 2013 Jul 25;8(3):571-9. doi: 10.4056/sigs.4187859. eCollection 2013 Jul 30. No abstract available.


Localization of DING proteins on PstS-containing outer-surface appendages of Pseudomonas aeruginosa.

Shah M, Zaborin A, Alverdy JC, Scott K, Zaborina O.

FEMS Microbiol Lett. 2014 Mar;352(1):54-61. doi: 10.1111/1574-6968.12368. Epub 2014 Jan 21.


Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens.

Zaborin A, Defazio JR, Kade M, Kaiser BL, Belogortseva N, Camp DG 2nd, Smith RD, Adkins JN, Kim SM, Alverdy A, Goldfeld D, Firestone MA, Collier JH, Jabri B, Tirrell M, Zaborina O, Alverdy JC.

Antimicrob Agents Chemother. 2014;58(2):966-77. doi: 10.1128/AAC.02183-13. Epub 2013 Nov 25.


Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF.

Luong PM, Shogan BD, Zaborin A, Belogortseva N, Shrout JD, Zaborina O, Alverdy JC.

J Bacteriol. 2014 Jan;196(2):504-13. doi: 10.1128/JB.01050-13. Epub 2013 Nov 15.


Do we really know why colorectal anastomoses leak?

Shogan BD, Carlisle EM, Alverdy JC, Umanskiy K.

J Gastrointest Surg. 2013 Sep;17(9):1698-707. doi: 10.1007/s11605-013-2227-0. Epub 2013 May 21. Review.


High molecular weight polyethylene glycol (PEG 15-20) maintains mucosal microbial barrier function during intestinal graft preservation.

Valuckaite V, Seal J, Zaborina O, Tretiakova M, Testa G, Alverdy JC.

J Surg Res. 2013 Aug;183(2):869-75. doi: 10.1016/j.jss.2013.02.035. Epub 2013 Mar 14.

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