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Items: 32


Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis.

Otsuki S, Alvarez-Garcia O, Lotz MK, Neo M.

Histol Histopathol. 2019 Sep;34(9):1051-1060. doi: 10.14670/HH-18-107. Epub 2019 Mar 29.


Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis.

Fisch KM, Gamini R, Alvarez-Garcia O, Akagi R, Saito M, Muramatsu Y, Sasho T, Koziol JA, Su AI, Lotz MK.

Osteoarthritis Cartilage. 2018 Nov;26(11):1531-1538. doi: 10.1016/j.joca.2018.07.012. Epub 2018 Aug 3.


FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.

Alvarez-Garcia O, Matsuzaki T, Olmer M, Miyata K, Mokuda S, Sakai D, Masuda K, Asahara H, Lotz MK.

Aging Cell. 2018 Oct;17(5):e12800. doi: 10.1111/acel.12800. Epub 2018 Jul 2.


FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis.

Matsuzaki T, Alvarez-Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, Miyata K, Akasaki Y, Su AI, Asahara H, Lotz MK.

Sci Transl Med. 2018 Feb 14;10(428). pii: eaan0746. doi: 10.1126/scitranslmed.aan0746.


Transthyretin deposition promotes progression of osteoarthritis.

Matsuzaki T, Akasaki Y, Olmer M, Alvarez-Garcia O, Reixach N, Buxbaum JN, Lotz MK.

Aging Cell. 2017 Dec;16(6):1313-1322. doi: 10.1111/acel.12665. Epub 2017 Sep 22.


Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration.

Alvarez-Garcia O, Matsuzaki T, Olmer M, Masuda K, Lotz MK.

J Orthop Res. 2017 Dec;35(12):2682-2691. doi: 10.1002/jor.23583. Epub 2017 May 4.


Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis.

Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, Lotz MK.

Arthritis Rheumatol. 2017 Jul;69(7):1418-1428. doi: 10.1002/art.40104. Epub 2017 Jun 2.


Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes.

Akagi R, Akatsu Y, Fisch KM, Alvarez-Garcia O, Teramura T, Muramatsu Y, Saito M, Sasho T, Su AI, Lotz MK.

Osteoarthritis Cartilage. 2017 Jun;25(6):943-951. doi: 10.1016/j.joca.2016.11.007. Epub 2016 Nov 22.


Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.

Shen T, Alvarez-Garcia O, Li Y, Olmer M, Lotz MK.

Osteoarthritis Cartilage. 2017 Feb;25(2):287-296. doi: 10.1016/j.joca.2016.09.017. Epub 2016 Sep 29.


Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy.

Alvarez-Garcia O, Olmer M, Akagi R, Akasaki Y, Fisch KM, Shen T, Su AI, Lotz MK.

Osteoarthritis Cartilage. 2016 Sep;24(9):1639-47. doi: 10.1016/j.joca.2016.04.015. Epub 2016 Apr 23.


Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage.

Alvarez-Garcia O, Fisch KM, Wineinger NE, Akagi R, Saito M, Sasho T, Su AI, Lotz MK.

Arthritis Rheumatol. 2016 Aug;68(8):1876-86. doi: 10.1002/art.39643.


Metabolic Benefit of Chronic Caloric Restriction and Activation of Hypothalamic AGRP/NPY Neurons in Male Mice Is Independent of Ghrelin.

Rogers NH, Walsh H, Alvarez-Garcia O, Park S, Gaylinn B, Thorner MO, Smith RG.

Endocrinology. 2016 Apr;157(4):1430-42. doi: 10.1210/en.2015-1745. Epub 2016 Jan 26.


MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins.

D'Adamo S, Alvarez-Garcia O, Muramatsu Y, Flamigni F, Lotz MK.

Osteoarthritis Cartilage. 2016 Jun;24(6):1082-91. doi: 10.1016/j.joca.2016.01.005. Epub 2016 Jan 19.


Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis.

Akasaki Y, Reixach N, Matsuzaki T, Alvarez-Garcia O, Olmer M, Iwamoto Y, Buxbaum JN, Lotz MK.

Arthritis Rheumatol. 2015 May;67(8):2097-107. doi: 10.1002/art.39178.


Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2.

Yamanaka Y, Faghihi MA, Magistri M, Alvarez-Garcia O, Lotz M, Wahlestedt C.

Cell Rep. 2015 May 12;11(6):967-976. doi: 10.1016/j.celrep.2015.04.011. Epub 2015 Apr 30.


FoxO transcription factors support oxidative stress resistance in human chondrocytes.

Akasaki Y, Alvarez-Garcia O, Saito M, Caramés B, Iwamoto Y, Lotz MK.

Arthritis Rheumatol. 2014 Dec;66(12):3349-58. doi: 10.1002/art.38868.


Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1.

Alvarez-Garcia O, Rogers NH, Smith RG, Lotz MK.

Arthritis Rheumatol. 2014 Jul;66(7):1779-88. doi: 10.1002/art.38399.


Growth hormone improves growth retardation induced by rapamycin without blocking its antiproliferative and antiangiogenic effects on rat growth plate.

Álvarez-García Ó, García-López E, Loredo V, Gil-Peña H, Mejía-Gaviria N, Rodríguez-Suárez J, Ordóñez FÁ, Santos F.

PLoS One. 2012;7(4):e34788. doi: 10.1371/journal.pone.0034788. Epub 2012 Apr 6.


The impact of sirolimus on sex hormones in male adolescent kidney recipients.

González D, Álvarez-García O, Santos F.

Pediatr Transplant. 2012 Jun;16(4):310-1. doi: 10.1111/j.1399-3046.2012.01681.x. Epub 2012 Apr 4. No abstract available.


Sirolimus and growth.

Santos F, Alvarez-García O, González D.

Pediatr Transplant. 2011 Sep;15(6):546-7. doi: 10.1111/j.1399-3046.2011.01552.x. Epub 2011 Jul 15. No abstract available.


Rapamycin induces growth retardation by disrupting angiogenesis in the growth plate.

Alvarez-García O, García-López E, Loredo V, Gil-Peña H, Rodríguez-Suárez J, Ordóñez FA, Carbajo-Pérez E, Santos F.

Kidney Int. 2010 Sep;78(6):561-8. doi: 10.1038/ki.2010.173. Epub 2010 Jun 16.


Longitudinal growth in chronic hypokalemic disorders.

Gil-Peña H, Mejia N, Alvarez-Garcia O, Loredo V, Santos F.

Pediatr Nephrol. 2010 Apr;25(4):733-7. doi: 10.1007/s00467-009-1330-7. Epub 2009 Nov 10. Review.


Alterations of growth plate and abnormal insulin-like growth factor I metabolism in growth-retarded hypokalemic rats: effect of growth hormone treatment.

Gil-Peña H, Garcia-Lopez E, Alvarez-Garcia O, Loredo V, Carbajo-Perez E, Ordoñez FA, Rodriguez-Suarez J, Santos F.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F639-45. doi: 10.1152/ajprenal.00188.2009. Epub 2009 Jul 8.


Differential gene expression induced by growth hormone treatment in the uremic rat growth plate.

Gil H, Lozano JJ, Alvarez-García O, Secades-Vázquez P, Rodríguez-Suárez J, García-López E, Carbajo-Pérez E, Santos F.

Growth Horm IGF Res. 2008 Aug;18(4):353-9. doi: 10.1016/j.ghir.2008.01.009. Epub 2008 Mar 10.


Rapamycin retards growth and causes marked alterations in the growth plate of young rats.

Alvarez-Garcia O, Carbajo-Pérez E, Garcia E, Gil H, Molinos I, Rodriguez J, Ordoñez FA, Santos F.

Pediatr Nephrol. 2007 Jul;22(7):954-61. Epub 2007 Mar 17.


Administration of ghrelin to young uraemic rats increases food intake transiently, stimulates growth hormone secretion and does not improve longitudinal growth.

Alvarez-García O, García-López E, Rodríguez J, Gil-Peña H, Molinos I, Carbajo-Pérez E, Santos F.

Nephrol Dial Transplant. 2007 May;22(5):1309-13. Epub 2007 Feb 22.


Oxidative damage in the livers of senescence-accelerated mice: a gender-related response.

Tomás-Zapico C, Alvarez-García O, Sierra V, Vega-Naredo I, Caballero B, Joaquín García J, Acuña-Castroviejo D, Rodríguez MI, Tolivia D, Rodríguez-Colunga MJ, Coto-Montes A.

Can J Physiol Pharmacol. 2006 Feb;84(2):213-20.


Elevated oxidative stress in the brain of senescence-accelerated mice at 5 months of age.

Alvarez-García O, Vega-Naredo I, Sierra V, Caballero B, Tomás-Zapico C, Camins A, García JJ, Pallàs M, Coto-Montes A.

Biogerontology. 2006 Feb;7(1):43-52.


Inverse correlation between endogenous melatonin levels and oxidative damage in some tissues of SAM P8 mice.

Lardone PJ, Alvarez-García O, Carrillo-Vico A, Vega-Naredo I, Caballero B, Guerrero JM, Coto-Montes A.

J Pineal Res. 2006 Mar;40(2):153-7.


Survival mechanisms in a physiological oxidative stress model.

Tomás-Zapico C, Caballero B, Sierra V, Vega-Naredo I, Alvarez-García O, Tolivia D, Rodríguez-Colunga MJ, Coto-Montes A.

FASEB J. 2005 Dec;19(14):2066-8. Epub 2005 Sep 26.


Melatonin neutralizes neurotoxicity induced by quinolinic acid in brain tissue culture.

Vega-Naredo I, Poeggeler B, Sierra-Sánchez V, Caballero B, Tomás-Zapico C, Alvarez-García O, Tolivia D, Rodríguez-Colunga MJ, Coto-Montes A.

J Pineal Res. 2005 Oct;39(3):266-75.


Coexpression of MT1 and RORalpha1 melatonin receptors in the Syrian hamster Harderian gland.

Tomás-Zapico C, Antonio Boga J, Caballero B, Vega-Naredo I, Sierra V, Alvarez-García O, Tolivia D, Josefa Rodríguez-Colunga M, Coto-Montes A.

J Pineal Res. 2005 Aug;39(1):21-6.


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