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Items: 37


Pre-clinical development of Listeria-based nanovaccines as immunotherapies for solid tumours: insights from melanoma.

Terán-Navarro H, Calderon-Gonzalez R, Salcines-Cuevas D, García I, Marradi M, Freire J, Salmon E, Portillo-Gonzalez M, Frande-Cabanes E, García-Castaño A, Martinez-Callejo V, Gomez-Roman J, Tobes R, Rivera F, Yañez-Diaz S, Álvarez-Domínguez C.

Oncoimmunology. 2018 Nov 10;8(2):e1541534. doi: 10.1080/2162402X.2018.1541534. eCollection 2019.


Dendritic cell therapy in melanoma.

Alvarez-Dominguez C, Calderón-Gonzalez R, Terán-Navarro H, Salcines-Cuevas D, Garcia-Castaño A, Freire J, Gomez-Roman J, Rivera F.

Ann Transl Med. 2017 Oct;5(19):386. doi: 10.21037/atm.2017.06.13. Review.


GNP-GAPDH1-22 nanovaccines prevent neonatal listeriosis by blocking microglial apoptosis and bacterial dissemination.

Calderon-Gonzalez R, Frande-Cabanes E, Teran-Navarro H, Marimon JM, Freire J, Salcines-Cuevas D, Carmen Fariñas M, Onzalez-Rico C, Marradi M, Garcia I, Alkorta-Gurrutxaga M, San Nicolas-Gomez A, Castañeda-Sampedro A, Yañez-Diaz S, Penades S, Punzon C, Gomez-Roman J, Rivera F, Fresno M, Alvarez-Dominguez C.

Oncotarget. 2017 Jul 20;8(33):53916-53934. doi: 10.18632/oncotarget.19405. eCollection 2017 Aug 15.


Gold glyconanoparticles coupled to listeriolysin O 91-99 peptide serve as adjuvant therapy against melanoma.

Calderon-Gonzalez R, Terán-Navarro H, García I, Marradi M, Salcines-Cuevas D, Yañez-Diaz S, Solis-Angulo A, Frande-Cabanes E, Fariñas MC, Garcia-Castaño A, Gomez-Roman J, Penades S, Rivera F, Freire J, Álvarez-Domínguez C.

Nanoscale. 2017 Aug 3;9(30):10721-10732. doi: 10.1039/c7nr02494k.


Biomarker Tools to Design Clinical Vaccines Determined from a Study of Annual Listeriosis Incidence in Northern Spain.

Calderon-Gonzalez R, Teran-Navarro H, Marimon JM, González-Rico C, Calvo-Montes J, Frande-Cabanes E, Alkorta-Gurrutxaga M, Fariñas MC, Martínez-Martínez L, Perez-Trallero E, Alvarez-Dominguez C.

Front Immunol. 2016 Nov 29;7:541. eCollection 2016.


Exceptional antineoplastic activity of a dendritic-cell-targeted vaccine loaded with a Listeria peptide proposed against metastatic melanoma.

Calderon-Gonzalez R, Bronchalo-Vicente L, Freire J, Frande-Cabanes E, Alaez-Alvarez L, Gomez-Roman J, Yañez-Diaz S, Alvarez-Dominguez C.

Oncotarget. 2016 Mar 29;7(13):16855-65. doi: 10.18632/oncotarget.7806.


Pregnancy Vaccination with Gold Glyco-Nanoparticles Carrying Listeria monocytogenes Peptides Protects against Listeriosis and Brain- and Cutaneous-Associated Morbidities.

Calderón-Gonzalez R, Terán-Navarro H, Frande-Cabanes E, Ferrández-Fernández E, Freire J, Penadés S, Marradi M, García I, Gomez-Román J, Yañez-Díaz S, Álvarez-Domínguez C.

Nanomaterials (Basel). 2016 Aug 19;6(8). pii: E151. doi: 10.3390/nano6080151.


Novel nanoparticle vaccines for Listeriosis.

Calderon-Gonzalez R, Marradi M, Garcia I, Petrovsky N, Alvarez-Dominguez C.

Hum Vaccin Immunother. 2015;11(10):2501-3. doi: 10.1080/21645515.2015.1063756.


Identification and characterisation of T-cell epitopes for incorporation into dendritic cell-delivered Listeria vaccines.

Calderon-Gonzalez R, Tobes R, Pareja E, Frande-Cabanes E, Petrovsky N, Alvarez-Dominguez C.

J Immunol Methods. 2015 Sep;424:111-9. doi: 10.1016/j.jim.2015.05.009. Epub 2015 May 29.


A novel therapy for melanoma developed in mice: transformation of melanoma into dendritic cells with Listeria monocytogenes.

Bronchalo-Vicente L, Rodriguez-Del Rio E, Freire J, Calderon-Gonzalez R, Frande-Cabanes E, Gomez-Roman JJ, Fernández-Llaca H, Yañez-Diaz S, Alvarez-Dominguez C.

PLoS One. 2015 Mar 11;10(3):e0117923. doi: 10.1371/journal.pone.0117923. eCollection 2015.


A gold glyco-nanoparticle carrying a Listeriolysin O peptide and formulated with Advax™ delta inulin adjuvant induces robust T-cell protection against listeria infection.

Rodriguez-Del Rio E, Marradi M, Calderon-Gonzalez R, Frande-Cabanes E, Penadés S, Petrovsky N, Alvarez-Dominguez C.

Vaccine. 2015 Mar 17;33(12):1465-73. doi: 10.1016/j.vaccine.2015.01.062. Epub 2015 Feb 7.


Influence of interleukin 10 promoter polymorphisms in polymyalgia rheumatica: disease susceptibility and functional consequences.

Alvarez-Rodriguez L, Carrasco-Marín E, Tripathi G, Muñoz-Cacho P, Lopez-Hoyos M, Mata C, Calvo-Alén J, Garcia-Unzueta M, Aurrecoechea E, Alvarez-Dominguez C, Martinez-Taboada VM.

Clin Exp Rheumatol. 2014 Jul-Aug;32(4):484-9. Epub 2014 Jun 30.


Cellular vaccines in listeriosis: role of the Listeria antigen GAPDH.

Calderón-González R, Frande-Cabanes E, Bronchalo-Vicente L, Lecea-Cuello MJ, Pareja E, Bosch-Martínez A, Fanarraga ML, Yañez-Díaz S, Carrasco-Marín E, Alvarez-Domínguez C.

Front Cell Infect Microbiol. 2014 Feb 21;4:22. doi: 10.3389/fcimb.2014.00022. eCollection 2014.


Dissociation of innate immune responses in microglia infected with Listeria monocytogenes.

Frande-Cabanes E, Fernandez-Prieto L, Calderon-Gonzalez R, Rodríguez-Del Río E, Yañez-Diaz S, López-Fanarraga M, Alvarez-Domínguez C.

Glia. 2014 Feb;62(2):233-46. doi: 10.1002/glia.22602. Epub 2013 Dec 6.


Phagosomes induced by cytokines function as anti-Listeria vaccines: novel role for functional compartmentalization of STAT-1 protein and cathepsin-D.

Carrasco-Marín E, Rodriguez-Del Rio E, Frande-Cabanes E, Tobes R, Pareja E, Lecea-Cuello MJ, Ruiz-Sáez M, Madrazo-Toca F, Hölscher C, Alvarez-Dominguez C.

J Biol Chem. 2012 Apr 27;287(18):14310-24. doi: 10.1074/jbc.M112.348615. Epub 2012 Feb 15.


The intact structural form of LLO in endosomes cannot protect against listeriosis.

Rodriguez-Del Rio E, Frande-Cabanes E, Tobes R, Pareja E, Lecea-Cuello MJ, Ruiz-Sáez M, Carrasco-Marín E, Alvarez-Dominguez C.

Int J Biochem Mol Biol. 2011;2(3):207-18. Epub 2011 Jul 15.


LIMP-2 links late phagosomal trafficking with the onset of the innate immune response to Listeria monocytogenes: a role in macrophage activation.

Carrasco-Marín E, Fernández-Prieto L, Rodriguez-Del Rio E, Madrazo-Toca F, Reinheckel T, Saftig P, Alvarez-Dominguez C.

J Biol Chem. 2011 Feb 4;286(5):3332-41. doi: 10.1074/jbc.M110.146761. Epub 2010 Dec 1.


The innate immunity role of cathepsin-D is linked to Trp-491 and Trp-492 residues of listeriolysin O.

Carrasco-Marín E, Madrazo-Toca F, de los Toyos JR, Cacho-Alonso E, Tobes R, Pareja E, Paradela A, Albar JP, Chen W, Gomez-Lopez MT, Alvarez-Dominguez C.

Mol Microbiol. 2009 May;72(3):668-82. doi: 10.1111/j.1365-2958.2009.06673.x.


Characterization of a Listeria monocytogenes protein interfering with Rab5a.

Alvarez-Dominguez C, Madrazo-Toca F, Fernandez-Prieto L, Vandekerckhove J, Pareja E, Tobes R, Gomez-Lopez MT, Del Cerro-Vadillo E, Fresno M, Leyva-Cobián F, Carrasco-Marín E.

Traffic. 2008 Mar;9(3):325-37. Epub 2007 Dec 7.


Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth.

del Cerro-Vadillo E, Madrazo-Toca F, Carrasco-Marín E, Fernandez-Prieto L, Beck C, Leyva-Cobián F, Saftig P, Alvarez-Dominguez C.

J Immunol. 2006 Feb 1;176(3):1321-5.


Inhibition of Rab5a exchange activity is a key step for Listeria monocytogenes survival.

Prada-Delgado A, Carrasco-Marín E, Peña-Macarro C, Del Cerro-Vadillo E, Fresno-Escudero M, Leyva-Cobián F, Alvarez-Dominguez C.

Traffic. 2005 Mar;6(3):252-65.


Interferon-gamma listericidal action is mediated by novel Rab5a functions at the phagosomal environment.

Prada-Delgado A, Carrasco-Marin E, Bokoch GM, Alvarez-Dominguez C.

J Biol Chem. 2001 Jun 1;276(22):19059-65. Epub 2001 Mar 21.


Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a.

Barbieri MA, Roberts RL, Gumusboga A, Highfield H, Alvarez-Dominguez C, Wells A, Stahl PD.

J Cell Biol. 2000 Oct 30;151(3):539-50.


Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells.

Alvarez-Dominguez C, Stahl PD.

J Biol Chem. 1998 Dec 18;273(51):33901-4.


Oxidation of defined antigens allows protein unfolding and increases both proteolytic processing and exposes peptide epitopes which are recognized by specific T cells.

Carrasco-Marín E, Paz-Miguel JE, López-Mato P, Alvarez-Domínguez C, Leyva-Cobián F.

Immunology. 1998 Nov;95(3):314-21.


The consequences of the intracellular retention of pathogen-derived T-cell-independent antigens on protein presentation to T cells.

Leyva-Cobián F, Outschoorn IM, Carrasco-Marín E, Alvarez-Domínguez C.

Clin Immunol Immunopathol. 1997 Oct;85(1):1-15. Review.


Internalized Listeria monocytogenes modulates intracellular trafficking and delays maturation of the phagosome.

Alvarez-Dominguez C, Roberts R, Stahl PD.

J Cell Sci. 1997 Mar;110 ( Pt 6):731-43.


Inhibitory effects of thymus-independent type 2 antigens on MHC class II-restricted antigen presentation: comparative analysis of carbohydrate structures and the antigen presenting cell.

González-Fernández M, Carrasco-Marín E, Alvarez-Domínguez C, Outschoorn IM, Leyva-Cobián F.

Cell Immunol. 1997 Feb 25;176(1):1-13.


Vesicular transport of microorganisms in macrophages.

Alvarez-Dominguez C.

Biocell. 1996 Dec;20(3):355-65. Review. No abstract available.


Iron salts and iron-containing porphyrins block presentation of protein antigens by macrophages to MHC class II-restricted T cells.

Carrasco-Marín E, Alvarez-Domínguez C, López-Mato P, Martínez-Palencia R, Leyva-Cobián F.

Cell Immunol. 1996 Aug 1;171(2):173-85.


Phagocytosed live Listeria monocytogenes influences Rab5-regulated in vitro phagosome-endosome fusion.

Alvarez-Dominguez C, Barbieri AM, Berón W, Wandinger-Ness A, Stahl PD.

J Biol Chem. 1996 Jun 7;271(23):13834-43.


Membrane trafficking along the phagocytic pathway.

Berón W, Alvarez-Dominguez C, Mayorga L, Stahl PD.

Trends Cell Biol. 1995 Mar;5(3):100-4.


Role of complement component C1q in phagocytosis of Listeria monocytogenes by murine macrophage-like cell lines.

Alvarez-Dominguez C, Carrasco-Marin E, Leyva-Cobian F.

Infect Immun. 1993 Sep;61(9):3664-72.

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