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Items: 1 to 50 of 89

1.

Hyaluronic acid binding to TLR4 promotes proliferation and blocks apoptosis in colon cancer.

Makkar S, Riehl TE, Chen B, Yan Y, Alvarado DM, Ciorba MA, Stenson WF.

Mol Cancer Ther. 2019 Sep 4. pii: molcanther.1225.2018. doi: 10.1158/1535-7163.MCT-18-1225. [Epub ahead of print]

PMID:
31484704
2.

Genomic Correlates of Exceptional Response to ErbB3 Inhibition in Head and Neck Squamous Cell Carcinoma.

Faden DL, Gomez-Casal R, Alvarado D, Duvvuri U.

JCO Precis Oncol. 2019;3. doi: 10.1200/PO.18.00174. Epub 2019 Mar 25. No abstract available.

3.

Epithelial Indoleamine 2,3-Dioxygenase 1 Modulates Aryl Hydrocarbon Receptor and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota.

Alvarado DM, Chen B, Iticovici M, Thaker AI, Dai N, VanDussen KL, Shaikh N, Lim CK, Guillemin GJ, Tarr PI, Ciorba MA.

Gastroenterology. 2019 Oct;157(4):1093-1108.e11. doi: 10.1053/j.gastro.2019.07.013. Epub 2019 Jul 17.

PMID:
31325428
4.

Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients.

Duvvuri U, George J, Kim S, Alvarado D, Neumeister VM, Chenna A, Gedrich R, Hawthorne T, LaVallee T, Grandis JR, Bauman JE.

Clin Cancer Res. 2019 Oct 1;25(19):5752-5758. doi: 10.1158/1078-0432.CCR-18-3453. Epub 2019 Jul 15.

PMID:
31308059
5.

HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma.

Meister KS, Godse NR, Khan NI, Hedberg ML, Kemp C, Kulkarni S, Alvarado D, LaVallee T, Kim S, Grandis JR, Duvvuri U.

Sci Rep. 2019 Jun 24;9(1):9130. doi: 10.1038/s41598-019-45589-y.

6.

An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma.

Sano R, Krytska K, Larmour CE, Raman P, Martinez D, Ligon GF, Lillquist JS, Cucchi U, Orsini P, Rizzi S, Pawel BR, Alvarado D, Mossé YP.

Sci Transl Med. 2019 Mar 13;11(483). pii: eaau9732. doi: 10.1126/scitranslmed.aau9732.

PMID:
30867324
7.

IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis.

Bishnupuri KS, Alvarado DM, Khouri AN, Shabsovich M, Chen B, Dieckgraefe BK, Ciorba MA.

Cancer Res. 2019 Mar 15;79(6):1138-1150. doi: 10.1158/0008-5472.CAN-18-0668. Epub 2019 Jan 24.

PMID:
30679179
8.

Bereavement, Self-Reported Sleep Disturbances, and Inflammation: Results From Project HEART.

Chirinos DA, Ong JC, Garcini LM, Alvarado D, Fagundes C.

Psychosom Med. 2019 Jan;81(1):67-73. doi: 10.1097/PSY.0000000000000645.

PMID:
30300238
9.

Lactobacillus rhamnosus GG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells.

Riehl TE, Alvarado D, Ee X, Zuckerman A, Foster L, Kapoor V, Thotala D, Ciorba MA, Stenson WF.

Gut. 2019 Jun;68(6):1003-1013. doi: 10.1136/gutjnl-2018-316226. Epub 2018 Jun 22.

PMID:
29934438
10.

Antimicrobial resistance not related to 1,2,3 integrons and Superintegron in Vibrio spp. isolated from seawater sample of Lima (Peru).

Sulca MA, Orozco R, Alvarado DE.

Mar Pollut Bull. 2018 Jun;131(Pt A):370-377. doi: 10.1016/j.marpolbul.2018.04.050. Epub 2018 Apr 23.

PMID:
29886960
11.

A morphological database for 606 Colombian bird species.

Montoya P, Gonzalez MA, Tenorio EA, López-Ordóñez JP, Pinto Gómez A, Cueva D, Acevedo Rincón AA, Angarita Yanes C, Arango Martínez HM, Armesto O, Betancur JS, Caguazango Castro A, Calderon Leyton JJ, Calpa-Anaguano EV, Cárdenas-Posada G, Castaño Díaz M, Chaparro-Herrera S, Diago-Muñoz N, Franco Espinosa L, Gómez Bernal LG, Gonzalez-Zapata FL, Gutiérrez Zamora EA, Gutiérrez-Zuluaga AM, Lizcano Jiménez RS, Lopera-Salazar A, Alvarado DM, Maya Girón AM, Medina W, Montealegre-Talero C, Parra JL, Pérez-Peña S, Ramírez Ramírez F, Reyes J, Rivera-Gutiérrez HF, Rosero Mora Y, Trujillo-Torres CM, Vidal-Maldonado CC, Salgado-Negret B.

Ecology. 2018 Jul;99(7):1693. doi: 10.1002/ecy.2368. Epub 2018 Jun 28.

PMID:
29701245
12.

A Role for Salivary Peptides in the Innate Defense Against Enterotoxigenic Escherichia coli.

Brown JW, Badahdah A, Iticovici M, Vickers TJ, Alvarado DM, Helmerhorst EJ, Oppenheim FG, Mills JC, Ciorba MA, Fleckenstein JM, Bullitt E.

J Infect Dis. 2018 Apr 11;217(9):1435-1441. doi: 10.1093/infdis/jiy032.

13.

Polyphenolic Characterization and Antioxidant Activity of Malus domestica and Prunus domestica Cultivars from Costa Rica.

Navarro M, Moreira I, Arnaez E, Quesada S, Azofeifa G, Vargas F, Alvarado D, Chen P.

Foods. 2018 Jan 30;7(2). pii: E15. doi: 10.3390/foods7020015.

14.

Flavonoids and Ellagitannins Characterization, Antioxidant and Cytotoxic Activities of Phyllanthus acuminatus Vahl.

Navarro M, Moreira I, Arnaez E, Quesada S, Azofeifa G, Vargas F, Alvarado D, Chen P.

Plants (Basel). 2017 Dec 15;6(4). pii: E62. doi: 10.3390/plants6040062.

15.

Proanthocyanidin Characterization, Antioxidant and Cytotoxic Activities of Three Plants Commonly Used in Traditional Medicine in Costa Rica: Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd.

Navarro M, Moreira I, Arnaez E, Quesada S, Azofeifa G, Alvarado D, Monagas MJ.

Plants (Basel). 2017 Oct 19;6(4). pii: E50. doi: 10.3390/plants6040050.

16.

Fractioning of Proanthocyanidins of Uncaria tomentosa. Composition and Structure-Bioactivity Relationship.

Navarro M, Zamora W, Quesada S, Azofeifa G, Alvarado D, Monagas M.

Antioxidants (Basel). 2017 Jul 28;6(3). pii: E60. doi: 10.3390/antiox6030060.

17.

ErbB activation signatures as potential biomarkers for anti-ErbB3 treatment in HNSCC.

Alvarado D, Ligon GF, Lillquist JS, Seibel SB, Wallweber G, Neumeister VM, Rimm DL, McMahon G, LaVallee TM.

PLoS One. 2017 Jul 19;12(7):e0181356. doi: 10.1371/journal.pone.0181356. eCollection 2017.

18.

Building a Personalized Cancer Treatment System.

Martinez A, López G, Bola Nos C, Alvarado D, Solano A, López M, Báez A, Quirós S, Mora R.

J Med Syst. 2017 Feb;41(2):28. doi: 10.1007/s10916-016-0678-z. Epub 2016 Dec 27.

PMID:
28028763
19.

Massively parallel single-nucleotide mutagenesis using reversibly terminated inosine.

Haller G, Alvarado D, McCall K, Mitra RD, Dobbs MB, Gurnett CA.

Nat Methods. 2016 Nov;13(11):923-924. doi: 10.1038/nmeth.4015. Epub 2016 Oct 3.

20.

Zika virus associated with sensory polyneuropathy.

Medina MT, England JD, Lorenzana I, Medina-Montoya M, Alvarado D, De Bastos M, Fontiveros S, Sierra M, Contreras F.

J Neurol Sci. 2016 Oct 15;369:271-272. doi: 10.1016/j.jns.2016.08.044. Epub 2016 Aug 21. No abstract available.

PMID:
27653905
21.

Changes in Structure and Antigenicity of HIV-1 Env Trimers Resulting from Removal of a Conserved CD4 Binding Site-Proximal Glycan.

Liang Y, Guttman M, Williams JA, Verkerke H, Alvarado D, Hu SL, Lee KK.

J Virol. 2016 Sep 29;90(20):9224-36. doi: 10.1128/JVI.01116-16. Print 2016 Oct 15.

22.

Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus.

Alvarado DM, McCall K, Hecht JT, Dobbs MB, Gurnett CA.

J Med Genet. 2016 Apr;53(4):250-5. doi: 10.1136/jmedgenet-2015-103505. Epub 2016 Jan 4.

23.

A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis.

Haller G, Alvarado D, Mccall K, Yang P, Cruchaga C, Harms M, Goate A, Willing M, Morcuende JA, Baschal E, Miller NH, Wise C, Dobbs MB, Gurnett CA.

Hum Mol Genet. 2016 Jan 1;25(1):202-9. doi: 10.1093/hmg/ddv463. Epub 2015 Nov 12.

24.

Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration.

Lee S, Greenlee EB, Amick JR, Ligon GF, Lillquist JS, Natoli EJ Jr, Hadari Y, Alvarado D, Schlessinger J.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13225-30. doi: 10.1073/pnas.1518361112. Epub 2015 Oct 12.

25.

Genetic Risk for Aortic Aneurysm in Adolescent Idiopathic Scoliosis.

Haller G, Alvarado DM, Willing MC, Braverman AC, Bridwell KH, Kelly M, Lenke LG, Luhmann SJ, Gurnett CA, Dobbs MB.

J Bone Joint Surg Am. 2015 Sep 2;97(17):1411-7. doi: 10.2106/JBJS.O.00290.

26.

Butyrate and Mucosal Inflammation: New Scientific Evidence Supports Clinical Observation.

Cushing K, Alvarado DM, Ciorba MA.

Clin Transl Gastroenterol. 2015 Aug 27;6:e108. doi: 10.1038/ctg.2015.34. No abstract available.

27.

Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer.

Santhanam S, Alvarado DM, Ciorba MA.

Transl Res. 2016 Jan;167(1):67-79. doi: 10.1016/j.trsl.2015.07.003. Epub 2015 Aug 3. Review.

28.

Ligand regulation of a constitutively dimeric EGF receptor.

Freed DM, Alvarado D, Lemmon MA.

Nat Commun. 2015 Jun 10;6:7380. doi: 10.1038/ncomms8380.

29.

Comparison of Saccharomyces cerevisiae F-BAR domain structures reveals a conserved inositol phosphate binding site.

Moravcevic K, Alvarado D, Schmitz KR, Kenniston JA, Mendrola JM, Ferguson KM, Lemmon MA.

Structure. 2015 Feb 3;23(2):352-63. doi: 10.1016/j.str.2014.12.009. Epub 2015 Jan 22.

30.

Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.

Murray PB, Lax I, Reshetnyak A, Ligon GF, Lillquist JS, Natoli EJ Jr, Shi X, Folta-Stogniew E, Gunel M, Alvarado D, Schlessinger J.

Sci Signal. 2015 Jan 20;8(360):ra6. doi: 10.1126/scisignal.2005916.

PMID:
25605972
31.

[National survey of blindness and avoidable visual impairment in Honduras].

Alvarado D, Rivera B, Lagos L, Ochoa M, Starkman I, Castillo M, Flores E, Lansingh VC, Limburg H, Silva JC.

Rev Panam Salud Publica. 2014 Nov;36(5):300-5. Spanish.

PMID:
25604099
32.

Emerging Receptor Tyrosine Kinase Drug Targets: Implications for Antibody-Based Therapies for Oncology and Immunologic Disorders.

LaVallee TM, Alvarado D, Garton AJ, Trombetta ES, Gedrich R, McMahon G.

Crit Rev Oncog. 2015;20(5-6):485-508. doi: 10.1615/CritRevOncog.v20.i5-6.170. Review.

PMID:
27279243
33.

Exome sequencing identifies a rare HSPG2 variant associated with familial idiopathic scoliosis.

Baschal EE, Wethey CI, Swindle K, Baschal RM, Gowan K, Tang NL, Alvarado DM, Haller GE, Dobbs MB, Taylor MR, Gurnett CA, Jones KL, Miller NH.

G3 (Bethesda). 2014 Dec 12;5(2):167-74. doi: 10.1534/g3.114.015669.

34.

A survey of scholarly literature describing the field of bioinformatics education and bioinformatics educational research.

Magana AJ, Taleyarkhan M, Alvarado DR, Kane M, Springer J, Clase K.

CBE Life Sci Educ. 2014 Winter;13(4):607-23. doi: 10.1187/cbe.13-10-0193. Review.

35.

Kinesin family member 6 (kif6) is necessary for spine development in zebrafish.

Buchan JG, Gray RS, Gansner JM, Alvarado DM, Burgert L, Gitlin JD, Gurnett CA, Goldsmith MI.

Dev Dyn. 2014 Dec;243(12):1646-57. doi: 10.1002/dvdy.24208. Epub 2014 Oct 20.

36.

Killed Saccharomyces cerevisiae protects against lethal challenge of Cryptococcus grubii.

Majumder T, Liu M, Chen V, Martinez M, Alvarado D, Clemons KV, Stevens DA.

Mycopathologia. 2014 Oct;178(3-4):189-95. doi: 10.1007/s11046-014-9798-5. Epub 2014 Aug 15.

PMID:
25118873
37.

Are copy number variants associated with adolescent idiopathic scoliosis?

Buchan JG, Alvarado DM, Haller G, Aferol H, Miller NH, Dobbs MB, Gurnett CA.

Clin Orthop Relat Res. 2014 Oct;472(10):3216-25. doi: 10.1007/s11999-014-3766-8. Epub 2014 Jul 9.

38.

Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.

Alvarado DM, Coulombe PA.

J Biol Chem. 2014 Jul 11;289(28):19435-47. doi: 10.1074/jbc.M114.553867. Epub 2014 May 27.

39.

[Development of a professional social responsibility questionnaire for physicians].

Alvarado DF, Pérez CV, Navarro GS.

Rev Med Chil. 2014 Jan;142(1):90-7. doi: 10.4067/S0034-98872014000100014. Spanish.

40.

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

Buchan JG, Alvarado DM, Haller GE, Cruchaga C, Harms MB, Zhang T, Willing MC, Grange DK, Braverman AC, Miller NH, Morcuende JA, Tang NL, Lam TP, Ng BK, Cheng JC, Dobbs MB, Gurnett CA.

Hum Mol Genet. 2014 Oct 1;23(19):5271-82. doi: 10.1093/hmg/ddu224. Epub 2014 May 15.

41.

Multiplexed direct genomic selection (MDiGS): a pooled BAC capture approach for highly accurate CNV and SNP/INDEL detection.

Alvarado DM, Yang P, Druley TE, Lovett M, Gurnett CA.

Nucleic Acids Res. 2014 Jun;42(10):e82. doi: 10.1093/nar/gku218. Epub 2014 Mar 20.

42.

Genome-wide association study identifies new disease loci for isolated clubfoot.

Zhang TX, Haller G, Lin P, Alvarado DM, Hecht JT, Blanton SH, Stephens Richards B, Rice JP, Dobbs MB, Gurnett CA.

J Med Genet. 2014 May;51(5):334-9. doi: 10.1136/jmedgenet-2014-102303. Epub 2014 Mar 25.

PMID:
24667120
43.

MYBPC1 mutations impair skeletal muscle function in zebrafish models of arthrogryposis.

Ha K, Buchan JG, Alvarado DM, McCall K, Vydyanath A, Luther PK, Goldsmith MI, Dobbs MB, Gurnett CA.

Hum Mol Genet. 2013 Dec 15;22(24):4967-77. doi: 10.1093/hmg/ddt344. Epub 2013 Jul 19.

44.

BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma.

Dahiya S, Haydon DH, Alvarado D, Gurnett CA, Gutmann DH, Leonard JR.

Acta Neuropathol. 2013 Jun;125(6):901-10. doi: 10.1007/s00401-013-1120-y. Epub 2013 Apr 23.

PMID:
23609006
45.

Copy number analysis of 413 isolated talipes equinovarus patients suggests role for transcriptional regulators of early limb development.

Alvarado DM, Buchan JG, Frick SL, Herzenberg JE, Dobbs MB, Gurnett CA.

Eur J Hum Genet. 2013 Apr;21(4):373-80. doi: 10.1038/ejhg.2012.177. Epub 2012 Aug 15.

46.

Exome-sequencing confirms DNAJC5 mutations as cause of adult neuronal ceroid-lipofuscinosis.

Benitez BA, Alvarado D, Cai Y, Mayo K, Chakraverty S, Norton J, Morris JC, Sands MS, Goate A, Cruchaga C.

PLoS One. 2011;6(11):e26741. doi: 10.1371/journal.pone.0026741. Epub 2011 Nov 4.

47.

Saccharomyces as a vaccine against systemic aspergillosis: 'the friend of man' a friend again?

Liu M, Capilla J, Johansen ME, Alvarado D, Martinez M, Chen V, Clemons KV, Stevens DA.

J Med Microbiol. 2011 Oct;60(Pt 10):1423-32. doi: 10.1099/jmm.0.033290-0. Epub 2011 Aug 8.

PMID:
21825307
48.

Pitx1 haploinsufficiency causes clubfoot in humans and a clubfoot-like phenotype in mice.

Alvarado DM, McCall K, Aferol H, Silva MJ, Garbow JR, Spees WM, Patel T, Siegel M, Dobbs MB, Gurnett CA.

Hum Mol Genet. 2011 Oct 15;20(20):3943-52. doi: 10.1093/hmg/ddr313. Epub 2011 Jul 20.

49.

Exome sequencing identifies an MYH3 mutation in a family with distal arthrogryposis type 1.

Alvarado DM, Buchan JG, Gurnett CA, Dobbs MB.

J Bone Joint Surg Am. 2011 Jun 1;93(11):1045-50. doi: 10.2106/JBJS.J.02004.

50.

An RNA interference-based screen of transcription factor genes identifies pathways necessary for sensory regeneration in the avian inner ear.

Alvarado DM, Hawkins RD, Bashiardes S, Veile RA, Ku YC, Powder KE, Spriggs MK, Speck JD, Warchol ME, Lovett M.

J Neurosci. 2011 Mar 23;31(12):4535-43. doi: 10.1523/JNEUROSCI.5456-10.2011.

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