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Items: 1 to 50 of 80

1.

Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.

Borsari C, Jiménez-Antón MD, Eick J, Bifeld E, Torrado JJ, Olías-Molero AI, Corral MJ, Santarem N, Baptista C, Severi L, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Witt G, Linciano P, Tait A, Costantino L, Luciani R, Tejera Nevado P, Zander-Dinse D, Franco CH, Ferrari S, Moraes CB, Cordeiro-da-Silva A, Ponterini G, Clos J, Alunda JM, Costi MP.

Eur J Med Chem. 2019 Sep 5;183:111676. doi: 10.1016/j.ejmech.2019.111676. [Epub ahead of print]

PMID:
31542713
2.

Immunization with recombinant rHc23 partially protects lambs against trickle infections by Haemonchus contortus.

González-Sánchez ME, Ndombasi-Bokuy M, Cuquerella M, Alunda JM.

BMC Vet Res. 2019 Sep 18;15(1):333. doi: 10.1186/s12917-019-2084-5.

3.

Efficient infection of hamster with Leishmania donovani by retro-orbital inoculation.

Jiménez-Antón MD, Grau M, Corral MJ, Olías-Molero AI, Alunda JM.

Virulence. 2019 Dec;10(1):711-718. doi: 10.1080/21505594.2019.1649587. No abstract available.

PMID:
31389288
4.

SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent.

Borsari C, Santarem N, Macedo S, Jiménez-Antón MD, Torrado JJ, Olías-Molero AI, Corral MJ, Tait A, Ferrari S, Costantino L, Luciani R, Ponterini G, Gul S, Kuzikov M, Ellinger B, Behrens B, Reinshagen J, Alunda JM, Cordeiro-da-Silva A, Costi MP.

ACS Med Chem Lett. 2019 Jan 29;10(4):528-533. doi: 10.1021/acsmedchemlett.8b00565. eCollection 2019 Apr 11.

PMID:
30996791
5.

Syrian Hamster as an Advanced Experimental Model for Visceral Leishmaniasis.

Jiménez-Antón MD, Grau M, Olías-Molero AI, Alunda JM.

Methods Mol Biol. 2019;1971:303-314. doi: 10.1007/978-1-4939-9210-2_17.

PMID:
30980312
6.

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.

Moraes CB, Witt G, Kuzikov M, Ellinger B, Calogeropoulou T, Prousis KC, Mangani S, Di Pisa F, Landi G, Iacono LD, Pozzi C, Freitas-Junior LH, Dos Santos Pascoalino B, Bertolacini CP, Behrens B, Keminer O, Leu J, Wolf M, Reinshagen J, Cordeiro-da-Silva A, Santarem N, Venturelli A, Wrigley S, Karunakaran D, Kebede B, Pöhner I, Müller W, Panecka-Hofman J, Wade RC, Fenske M, Clos J, Alunda JM, Corral MJ, Uliassi E, Bolognesi ML, Linciano P, Quotadamo A, Ferrari S, Santucci M, Borsari C, Costi MP, Gul S.

SLAS Discov. 2019 Mar;24(3):346-361. doi: 10.1177/2472555218823171.

7.

Superimposed visceral leishmanial infection aggravates response to Heligmosomoides polygyrus.

González-Sánchez ME, Cuquerella M, Alunda JM.

Parasit Vectors. 2018 Jul 11;11(1):404. doi: 10.1186/s13071-018-2987-1.

8.

In-Vitro Activity of Silybin and Related Flavonolignans against Leishmania infantum and L. donovani.

Olías-Molero AI, Jiménez-Antón MD, Biedermann D, Corral MJ, Alunda JM.

Molecules. 2018 Jun 27;23(7). pii: E1560. doi: 10.3390/molecules23071560.

9.

Pharmacokinetics and disposition of miltefosine in healthy mice and hamsters experimentally infected with Leishmania infantum.

Jiménez-Antón MD, García-Calvo E, Gutiérrez C, Escribano MD, Kayali N, Luque-García JL, Olías-Molero AI, Corral MJ, Costi MP, Torrado JJ, Alunda JM.

Eur J Pharm Sci. 2018 Aug 30;121:281-286. doi: 10.1016/j.ejps.2018.06.002. Epub 2018 Jun 5.

PMID:
29883726
10.

Vaccination of lambs against Haemonchus contortus with the recombinant rHc23. Effect of adjuvant and antigen dose.

González-Sánchez ME, Cuquerella M, Alunda JM.

PLoS One. 2018 Mar 7;13(3):e0193118. doi: 10.1371/journal.pone.0193118. eCollection 2018.

11.

Morphological and molecular characteristics of six Sarcocystis spp. from red deer (Cervus elaphus) in Spain, including Sarcocystis cervicanis and three new species.

Gjerde B, Luzón M, Alunda JM, de la Fuente C.

Parasitol Res. 2017 Oct;116(10):2795-2811. doi: 10.1007/s00436-017-5590-z. Epub 2017 Aug 30.

PMID:
28856431
12.

Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.

Borsari C, Santarem N, Torrado J, Olías AI, Corral MJ, Baptista C, Gul S, Wolf M, Kuzikov M, Ellinger B, Witt G, Gribbon P, Reinshagen J, Linciano P, Tait A, Costantino L, Freitas-Junior LH, Moraes CB, Bruno Dos Santos P, Alcântara LM, Franco CH, Bertolacini CD, Fontana V, Tejera Nevado P, Clos J, Alunda JM, Cordeiro-da-Silva A, Ferrari S, Costi MP.

Eur J Med Chem. 2017 Jan 27;126:1129-1135. doi: 10.1016/j.ejmech.2016.12.017. Epub 2016 Dec 9.

PMID:
28064141
13.

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.

Borsari C, Luciani R, Pozzi C, Poehner I, Henrich S, Trande M, Cordeiro-da-Silva A, Santarem N, Baptista C, Tait A, Di Pisa F, Dello Iacono L, Landi G, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Witt G, Gribbon P, Kohler M, Keminer O, Behrens B, Costantino L, Tejera Nevado P, Bifeld E, Eick J, Clos J, Torrado J, Jiménez-Antón MD, Corral MJ, Alunda JM, Pellati F, Wade RC, Ferrari S, Mangani S, Costi MP.

J Med Chem. 2016 Aug 25;59(16):7598-616. doi: 10.1021/acs.jmedchem.6b00698. Epub 2016 Aug 5.

PMID:
27411733
14.

Allicin Induces Calcium and Mitochondrial Dysregulation Causing Necrotic Death in Leishmania.

Corral MJ, Benito-Peña E, Jiménez-Antón MD, Cuevas L, Moreno-Bondi MC, Alunda JM.

PLoS Negl Trop Dis. 2016 Mar 29;10(3):e0004525. doi: 10.1371/journal.pntd.0004525. eCollection 2016 Mar.

15.

Sarcocystosis in Cervus elaphus: Comparison of diagnostic methods.

Luzón M, Domínguez-González J, Soto-Carrión AM, Alunda JM, Fuente Cde L.

Int J Parasitol Parasites Wildl. 2015 Nov 11;4(3):396-400. doi: 10.1016/j.ijppaw.2015.11.001. eCollection 2015 Dec.

16.

Vaccination of lambs with the recombinant protein rHc23 elicits significant protection against Haemonchus contortus challenge.

Fawzi EM, González-Sánchez ME, Corral MJ, Alunda JM, Cuquerella M.

Vet Parasitol. 2015 Jun 30;211(1-2):54-9. doi: 10.1016/j.vetpar.2015.04.029. Epub 2015 May 8.

PMID:
25997645
17.

Efficacy of low doses of amphotericin B plus allicin against experimental visceral leishmaniasis.

Corral MJ, Serrano DR, Moreno I, Torrado JJ, Domínguez M, Alunda JM.

J Antimicrob Chemother. 2014 Dec;69(12):3268-74. doi: 10.1093/jac/dku290. Epub 2014 Aug 4.

PMID:
25096077
18.

Vaccination of lambs against Haemonchus contortus infection with a somatic protein (Hc23) from adult helminths.

Fawzi EM, González-Sánchez ME, Corral MJ, Cuquerella M, Alunda JM.

Int J Parasitol. 2014 Jun;44(7):429-36. doi: 10.1016/j.ijpara.2014.02.009. Epub 2014 Apr 20.

PMID:
24759430
19.

LPS and inactivated Propionibacterium acnes elicit a partially protective response in primary infections of Heligmosomoides polygyrus.

González-Sánchez E, Corral MJ, Mohamed Fawzi E, Rodríguez-Bertos A, Alunda JM, Cuquerella M.

Vet Parasitol. 2014 Jun 16;203(1-2):231-6. doi: 10.1016/j.vetpar.2014.02.026. Epub 2014 Feb 22.

PMID:
24636785
20.

In vitro synergistic effect of amphotericin B and allicin on Leishmania donovani and L. infantum.

Corral MJ, González-Sánchez E, Cuquerella M, Alunda JM.

Antimicrob Agents Chemother. 2014;58(3):1596-602. doi: 10.1128/AAC.00710-13. Epub 2013 Dec 23.

21.

Intranasal immunization of lambs with serine/threonine phosphatase 2A against gastrointestinal nematodes.

Mohamed Fawzi E, Cruz Bustos T, Gómez Samblas M, González-González G, Solano J, González-Sánchez ME, De Pablos LM, Corral-Caridad MJ, Cuquerella M, Osuna A, Alunda JM.

Clin Vaccine Immunol. 2013 Sep;20(9):1352-9. doi: 10.1128/CVI.00336-13. Epub 2013 Jun 12. Erratum in: Clin Vaccine Immunol. 2014 Jul;21(7):1019. Dosage error in article text.

22.

Improvement of 96-well microplate assay for estimation of cell growth and inhibition of Leishmania with Alamar Blue.

Corral MJ, González E, Cuquerella M, Alunda JM.

J Microbiol Methods. 2013 Aug;94(2):111-116. doi: 10.1016/j.mimet.2013.05.012. Epub 2013 May 23.

PMID:
23707202
23.

Effect of allicin on promastigotes and intracellular amastigotes of Leishmania donovani and L. infantum.

Jesús Corral-Caridad M, Moreno I, Toraño A, Domínguez M, Alunda JM.

Exp Parasitol. 2012 Dec;132(4):475-82. doi: 10.1016/j.exppara.2012.08.016. Epub 2012 Sep 17.

PMID:
22995646
24.

Toxicity of betulin derivatives and in vitro effect on promastigotes and amastigotes of Leishmania infantum and L. donovani.

Wert L, Alakurtti S, Corral MJ, Sánchez-Fortún S, Yli-Kauhaluoma J, Alunda JM.

J Antibiot (Tokyo). 2011 Jul;64(7):475-81. doi: 10.1038/ja.2011.34. Epub 2011 Apr 27.

PMID:
21522160
25.

Immunization against Lamb Haemonchosis with a Recombinant Somatic Antigen of Haemonchus contortus (rHcp26/23).

García-Coiradas L, Angulo-Cubillán F, Valladares B, Martínez E, de la Fuente C, Alunda JM, Cuquerella M.

Vet Med Int. 2010;2010:852146. doi: 10.4061/2010/852146. Epub 2010 Jun 29.

26.

Biological characterization and pathogenicity of three Haemonchus contortus isolates in primary infections in lambs.

Angulo-Cubillán FJ, García-Coiradas L, Alunda JM, Cuquerella M, de la Fuente C.

Vet Parasitol. 2010 Jul 15;171(1-2):99-105. doi: 10.1016/j.vetpar.2010.03.004. Epub 2010 Mar 10.

PMID:
20363563
27.

Leishmania infantum: antiproliferative effect of recombinant plant cystatins on promastigotes and intracellular amastigotes estimated by direct counting and real-time PCR.

Ordóñez-Gutiérrez L, Martínez M, Rubio-Somoza I, Díaz I, Mendez S, Alunda JM.

Exp Parasitol. 2009 Dec;123(4):341-6. doi: 10.1016/j.exppara.2009.08.015. Epub 2009 Aug 31.

PMID:
19723520
28.

Immunobiological characterization of Graphidium strigosum experimental infection in rabbits (Oryctolagus cuniculus).

Cuquerella M, Alunda JM.

Parasitol Res. 2009 Jan;104(2):371-6. doi: 10.1007/s00436-008-1206-y. Epub 2008 Oct 1.

PMID:
18830629
29.

Isolation and immunolocalization of a putative protective antigen (p26/23) from adult Haemonchus contortus.

García-Coiradas L, Angulo-Cubillán F, Méndez S, Larraga V, de la Fuente C, Cuquerella M, Alunda JM.

Parasitol Res. 2009 Jan;104(2):363-9. doi: 10.1007/s00436-008-1204-0. Epub 2008 Sep 30.

PMID:
18825413
30.

Age distribution and seasonal dynamics of abomasal helminths in wild red deer from central Spain.

Santín-Durán M, Alunda JM, Hoberg EP, de la Fuente C.

J Parasitol. 2008 Oct;94(5):1031-7. doi: 10.1645/GE-1109.1.

31.

HPLC assay for determination of amphotericin B in biological samples.

Espada R, Josa JM, Valdespina S, Dea MA, Ballesteros MP, Alunda JM, Torrado JJ.

Biomed Chromatogr. 2008 Apr;22(4):402-7.

PMID:
18059059
32.

In vitro effect of new formulations of amphotericin B on amastigote and promastigote forms of Leishmania infantum.

Ordóñez-Gutiérrez L, Espada-Fernández R, Dea-Ayuela MA, Torrado JJ, Bolás-Fernandez F, Alunda JM.

Int J Antimicrob Agents. 2007 Oct;30(4):325-9. Epub 2007 Jul 13.

PMID:
17631982
33.

The use of an excreted superoxide dismutase in an ELISA and Western blotting for the diagnosis of Leishmania (Leishmania) infantum naturally infected dogs.

Marín C, Longoni SS, Mateo H, de Diego JA, Alunda JM, Minaya G, Sánchez-Moreno M.

Parasitol Res. 2007 Aug;101(3):801-8. Epub 2007 May 12.

PMID:
17497171
34.

Anti-Leishmania humoral and cellular immune responses in naturally infected symptomatic and asymptomatic dogs.

Cardoso L, Schallig HD, Cordeiro-da-Silva A, Cabral M, Alunda JM, Rodrigues M.

Vet Immunol Immunopathol. 2007 May 15;117(1-2):35-41. Epub 2007 Jan 31.

PMID:
17321602
35.

Setting new immunobiological parameters in the hamster model of visceral leishmaniasis for in vivo testing of antileishmanial compounds.

Dea-Ayuela MA, Rama-Iñiguez S, Alunda JM, Bolás-Fernandez F.

Vet Res Commun. 2007 Aug;31(6):703-17. Epub 2007 Jan 19.

PMID:
17237986
36.

Identification of New World Leishmania species from Peru by biochemical techniques and multiplex PCR assay.

Rodríguez-González I, Marín C, Longoni SS, Mateo H, Alunda JM, Minaya G, Gutiérrez-Sánchez R, Vargas F, Sánchez-Moreno M.

FEMS Microbiol Lett. 2007 Feb;267(1):9-16.

37.

Real-time reverse transcription-PCR quantification of cytokine mRNA expression in golden Syrian hamster infected with Leishmania infantum and treated with a new amphotericin B formulation.

Rama Iñiguez S, Dea-Ayuela MA, Sanchez-Brunete JA, Torrado JJ, Alunda JM, Bolas-Fernández F.

Antimicrob Agents Chemother. 2006 Apr;50(4):1195-201.

38.

Identification and biochemical characterization of Leishmania strains isolated in Peru, Mexico, and Spain.

Rodríguez-González I, Marín C, Vargas F, Córdova O, Barrera M, Gutiérrez-Sánchez R, Alunda JM, Sánchez-Moreno M.

Exp Parasitol. 2006 Jan;112(1):44-51. Epub 2005 Nov 11.

PMID:
16289175
39.

Influence of the vehicle on the properties and efficacy of microparticles containing amphotericin B.

Sánchez-Brunete JA, Dea MA, Rama S, Bolás F, Alunda JM, Torrado-Santiago S, Torrado JJ.

J Drug Target. 2005 May;13(4):225-33.

PMID:
16051534
41.

Amphotericin B molecular organization as an essential factor to improve activity/toxicity ratio in the treatment of visceral leishmaniasis.

Sánchez-Brunete JA, Dea MA, Rama S, Bolás F, Alunda JM, Torrado-Santiago S, Torrado JJ.

J Drug Target. 2004;12(7):453-60.

PMID:
15621670
42.

Anti-leishmanial activity of a new formulation of amphotericin B.

Dea-Ayuela MA, Rama-Iñiguez S, Sánchez-Brunete JA, Torrado JJ, Alunda JM, Bolás-Fernández F.

Trop Med Int Health. 2004 Sep;9(9):981-90.

43.

Treatment of experimental visceral leishmaniasis with amphotericin B in stable albumin microspheres.

Sánchez-Brunete JA, Dea MA, Rama S, Bolás F, Alunda JM, Raposo R, Méndez MT, Torrado-Santiago S, Torrado JJ.

Antimicrob Agents Chemother. 2004 Sep;48(9):3246-52.

44.
45.

Immunization against ovine haemonchosis with three low molecular weight somatic antigens of adult Haemonchus contortus.

Alunda JM, Angulo-Cubillán F, Cuquerella M.

J Vet Med B Infect Dis Vet Public Health. 2003 Mar;50(2):70-4.

PMID:
12675897
46.
47.

Diagnostic techniques to detect cryptic leishmaniasis in dogs.

Iniesta L, Fernández-Barredo S, Bulle B, Gómez MT, Piarroux R, Gállego M, Alunda JM, Portús M.

Clin Diagn Lab Immunol. 2002 Sep;9(5):1137-41.

48.

Practical approach for typing strains of Leishmania infantum by microsatellite analysis.

Bulle B, Millon L, Bart JM, Gállego M, Gambarelli F, Portús M, Schnur L, Jaffe CL, Fernandez-Barredo S, Alunda JM, Piarroux R.

J Clin Microbiol. 2002 Sep;40(9):3391-7.

50.

Correlation between in vitro and in vivo infectivity of Leishmania infantum clones.

Méndez S, Fernández-Pérez FJ, Santín M, De La Fuente C, Cuquerella M, Gómez-Muñoz MT, Alunda JM.

J Eukaryot Microbiol. 2001 Nov-Dec;48(6):616-21.

PMID:
11831769

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