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Items: 17

1.

A Small-Molecule Inhibitor of trans-Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides To Impair Survival of Staphylococcus aureus.

Huang Y, Alumasa JN, Callaghan LT, Baugh RS, Rae CD, Keiler KC, McGillivray SM.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02362-18. doi: 10.1128/AAC.02362-18. Print 2019 Apr.

2.

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells.

Alumasa JN, Manzanillo PS, Peterson ND, Lundrigan T, Baughn AD, Cox JS, Keiler KC.

ACS Infect Dis. 2017 Sep 8;3(9):634-644. doi: 10.1021/acsinfecdis.7b00028. Epub 2017 Aug 7.

3.

Tetrazole-Based trans-Translation Inhibitors Kill Bacillus anthracis Spores To Protect Host Cells.

Alumasa JN, Goralski TDP, Keiler KC.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01199-17. doi: 10.1128/AAC.01199-17. Print 2017 Oct.

4.

Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication.

Goralski TD, Dewan KK, Alumasa JN, Avanzato V, Place DE, Markley RL, Katkere B, Rabadi SM, Bakshi CS, Keiler KC, Kirimanjeswara GS.

Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82. doi: 10.1128/AAC.03089-15. Print 2016 Jun.

5.

Clicking on trans-translation drug targets.

Alumasa JN, Keiler KC.

Front Microbiol. 2015 May 19;6:498. doi: 10.3389/fmicb.2015.00498. eCollection 2015. No abstract available.

6.

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay.

El-Mowafi SA, Sineva E, Alumasa JN, Nicoloff H, Tomsho JW, Ades SE, Keiler KC.

Antimicrob Agents Chemother. 2015 Jan;59(1):193-205. doi: 10.1128/AAC.03979-14. Epub 2014 Oct 20.

7.

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway.

El-Mowafi SA, Alumasa JN, Ades SE, Keiler KC.

Antimicrob Agents Chemother. 2014 Sep;58(9):5500-9. doi: 10.1128/AAC.03311-14. Epub 2014 Jul 7.

8.

The potential of trans-translation inhibitors as antibiotics.

Keiler KC, Alumasa JN.

Future Microbiol. 2013 Oct;8(10):1235-7. doi: 10.2217/fmb.13.110. No abstract available.

PMID:
24059913
9.

Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity.

Ramadoss NS, Alumasa JN, Cheng L, Wang Y, Li S, Chambers BS, Chang H, Chatterjee AK, Brinker A, Engels IH, Keiler KC.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10282-7. doi: 10.1073/pnas.1302816110. Epub 2013 Jun 3.

10.

Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth.

Gorka AP, Alumasa JN, Sherlach KS, Jacobs LM, Nickley KB, Brower JP, de Dios AC, Roepe PD.

Antimicrob Agents Chemother. 2013 Jan;57(1):356-64. doi: 10.1128/AAC.01709-12. Epub 2012 Oct 31.

11.

Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics.

McGillivray SM, Tran DN, Ramadoss NS, Alumasa JN, Okumura CY, Sakoulas G, Vaughn MM, Zhang DX, Keiler KC, Nizet V.

Antimicrob Agents Chemother. 2012 Apr;56(4):1854-61. doi: 10.1128/AAC.05131-11. Epub 2012 Jan 17.

12.

Antiplasmodial and antiproliferative pseudoguaianolides of Athroisma proteiforme from the Madagascar Dry Forest.

Pan E, Gorka AP, Alumasa JN, Slebodnick C, Harinantenaina L, Brodie PJ, Roepe PD, Randrianaivo R, Birkinshaw C, Kingston DG.

J Nat Prod. 2011 Oct 28;74(10):2174-80. doi: 10.1021/np200499d. Epub 2011 Oct 13.

13.

The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex.

Alumasa JN, Gorka AP, Casabianca LB, Comstock E, de Dios AC, Roepe PD.

J Inorg Biochem. 2011 Mar;105(3):467-75. doi: 10.1016/j.jinorgbio.2010.08.011. Epub 2010 Sep 22.

14.

Antiproliferative and antimalarial anthraquinones of Scutia myrtina from the Madagascar forest.

Hou Y, Cao S, Brodie PJ, Callmander MW, Ratovoson F, Rakotobe EA, Rasamison VE, Ratsimbason M, Alumasa JN, Roepe PD, Kingston DG.

Bioorg Med Chem. 2009 Apr 1;17(7):2871-6. doi: 10.1016/j.bmc.2009.02.022. Epub 2009 Feb 20.

15.

Antimalarial drugs and heme in detergent micelles: An NMR study.

Casabianca LB, Kallgren JB, Natarajan JK, Alumasa JN, Roepe PD, Wolf C, de Dios AC.

J Inorg Biochem. 2009 May;103(5):745-8. doi: 10.1016/j.jinorgbio.2009.01.013. Epub 2009 Jan 27.

16.

Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium.

Casabianca LB, An D, Natarajan JK, Alumasa JN, Roepe PD, Wolf C, de Dios AC.

Inorg Chem. 2008 Jul 7;47(13):6077-81. doi: 10.1021/ic800440d. Epub 2008 Jun 6.

17.

4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.

Natarajan JK, Alumasa JN, Yearick K, Ekoue-Kovi KA, Casabianca LB, de Dios AC, Wolf C, Roepe PD.

J Med Chem. 2008 Jun 26;51(12):3466-79. doi: 10.1021/jm701478a.

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