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Items: 1 to 50 of 143

1.

Heme and sensory neuropathy: insights from novel mutations in the heme exporter FLVCR1.

Bertino F, Firestone K, Bellacchio E, Jackson KE, Asamoah A, Hersh J, Fiorito V, Destefanis F, Gonser R, Tucker ME, Altruda F, Tolosano E, Chiabrando D.

Pain. 2019 Aug 10. doi: 10.1097/j.pain.0000000000001675. [Epub ahead of print]

PMID:
31408049
2.

Investigating the Connection Between Endogenous Heme Accumulation and COX2 Activity in Cancer Cells.

Destefanis F, Fiorito V, Altruda F, Tolosano E.

Front Oncol. 2019 Mar 19;9:162. doi: 10.3389/fonc.2019.00162. eCollection 2019.

3.

Mice harbouring a SCA28 patient mutation in AFG3L2 develop late-onset ataxia associated with enhanced mitochondrial proteotoxicity.

Mancini C, Hoxha E, Iommarini L, Brussino A, Richter U, Montarolo F, Cagnoli C, Parolisi R, Gondor Morosini DI, Nicolò V, Maltecca F, Muratori L, Ronchi G, Geuna S, Arnaboldi F, Donetti E, Giorgio E, Cavalieri S, Di Gregorio E, Pozzi E, Ferrero M, Riberi E, Casari G, Altruda F, Turco E, Gasparre G, Battersby BJ, Porcelli AM, Ferrero E, Brusco A, Tempia F.

Neurobiol Dis. 2019 Apr;124:14-28. doi: 10.1016/j.nbd.2018.10.018. Epub 2018 Oct 30.

PMID:
30389403
4.

Characterization of Human Mesenchymal Stem Cells Isolated from the Testis.

De Chiara L, Famulari ES, Fagoonee S, van Daalen SKM, Buttiglieri S, Revelli A, Tolosano E, Silengo L, van Pelt AMM, Altruda F.

Stem Cells Int. 2018 Sep 3;2018:4910304. doi: 10.1155/2018/4910304. eCollection 2018.

5.

Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis.

Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, Mussano F, Carossa S, Silengo L, Altruda F, Merlo GR, Munaron L, Tolosano E.

Cell Death Differ. 2018 Mar;25(3):573-588. doi: 10.1038/s41418-017-0001-7. Epub 2017 Dec 11.

6.

The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis.

Fusella F, Seclì L, Busso E, Krepelova A, Moiso E, Rocca S, Conti L, Annaratone L, Rubinetto C, Mello-Grand M, Singh V, Chiorino G, Silengo L, Altruda F, Turco E, Morotti A, Oliviero S, Castellano I, Cavallo F, Provero P, Tarone G, Brancaccio M.

Nat Commun. 2017 Nov 21;8(1):1636. doi: 10.1038/s41467-017-01829-1.

7.

Data demonstrating the anti-oxidant role of hemopexin in the heart.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Data Brief. 2017 May 13;13:69-76. doi: 10.1016/j.dib.2017.05.026. eCollection 2017 Aug.

8.

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Free Radic Biol Med. 2017 Jul;108:452-464. doi: 10.1016/j.freeradbiomed.2017.04.003. Epub 2017 Apr 8.

9.

The RNA-binding protein ESRP1 promotes human colorectal cancer progression.

Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfò I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F.

Oncotarget. 2017 Feb 7;8(6):10007-10024. doi: 10.18632/oncotarget.14318.

10.

Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception.

Chiabrando D, Castori M, di Rocco M, Ungelenk M, Gießelmann S, Di Capua M, Madeo A, Grammatico P, Bartsch S, Hübner CA, Altruda F, Silengo L, Tolosano E, Kurth I.

PLoS Genet. 2016 Dec 6;12(12):e1006461. doi: 10.1371/journal.pgen.1006461. eCollection 2016 Dec.

11.

Helicobacter pylori infection and ischemic heart disease: could experimental data lead to clinical studies?

Ribaldone DG, Fagoonee S, Hickman I, Altruda F, Saracco GM, Pellicano R.

Minerva Cardioangiol. 2016 Dec;64(6):686-96. Epub 2016 Sep 7. Review.

PMID:
27603552
12.

Endoscopic imaging in the management of gastroenteropancreatic neuroendocrine tumors.

Pellicano R, Fagoonee S, Altruda F, Bruno M, Saracco GM, De Angelis C.

Minerva Endocrinol. 2016 Dec;41(4):490-8. Review.

PMID:
27600643
13.

Prospects for Adult Stem Cells in the Treatment of Liver Diseases.

Fagoonee S, Famulari ES, Silengo L, Camussi G, Altruda F.

Stem Cells Dev. 2016 Oct;25(20):1471-1482. Epub 2016 Sep 7.

14.

APL-1, an altered peptide ligand derived from heat-shock protein, alone or combined with methotrexate attenuates murine collagen-induced arthritis.

Lorenzo N, Altruda F, Silengo L, Del Carmen Dominguez M.

Clin Exp Med. 2017 May;17(2):209-216. doi: 10.1007/s10238-016-0412-7. Epub 2016 May 9.

PMID:
27160252
15.

Oncogenic ALK regulates EMT in non-small cell lung carcinoma through repression of the epithelial splicing regulatory protein 1.

Voena C, Varesio LM, Zhang L, Menotti M, Poggio T, Panizza E, Wang Q, Minero VG, Fagoonee S, Compagno M, Altruda F, Monti S, Chiarle R.

Oncotarget. 2016 May 31;7(22):33316-30. doi: 10.18632/oncotarget.8955.

16.

Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors.

Voena C, Menotti M, Mastini C, Di Giacomo F, Longo DL, Castella B, Merlo MEB, Ambrogio C, Wang Q, Minero VG, Poggio T, Martinengo C, D'Amico L, Panizza E, Mologni L, Cavallo F, Altruda F, Butaney M, Capelletti M, Inghirami G, Jänne PA, Chiarle R.

Cancer Immunol Res. 2015 Dec;3(12):1333-1343. doi: 10.1158/2326-6066.CIR-15-0089. Epub 2015 Sep 29.

17.

Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells.

Fagoonee S, Famulari ES, Silengo L, Tolosano E, Altruda F.

PLoS One. 2015 Aug 31;10(8):e0136762. doi: 10.1371/journal.pone.0136762. eCollection 2015.

18.

Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.

Breveglieri G, Mancini I, Bianchi N, Lampronti I, Salvatori F, Fabbri E, Zuccato C, Cosenza LC, Montagner G, Borgatti M, Altruda F, Fagoonee S, Carandina G, Rubini M, Aiello V, Breda L, Rivella S, Gambari R, Finotti A.

Biomed Res Int. 2015;2015:687635. doi: 10.1155/2015/687635. Epub 2015 May 4.

19.

Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis.

Fiorito V, Forni M, Silengo L, Altruda F, Tolosano E.

Antioxid Redox Signal. 2015 Dec 20;23(18):1410-23. doi: 10.1089/ars.2014.6216. Epub 2015 Jul 20.

20.

Alteration of heme metabolism in a cellular model of Diamond-Blackfan anemia.

Mercurio S, Aspesi A, Silengo L, Altruda F, Dianzani I, Chiabrando D.

Eur J Haematol. 2016 Apr;96(4):367-74. doi: 10.1111/ejh.12599. Epub 2015 Jun 25.

PMID:
26058344
21.

The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation.

Mercurio S, Petrillo S, Chiabrando D, Bassi ZI, Gays D, Camporeale A, Vacaru A, Miniscalco B, Valperga G, Silengo L, Altruda F, Baron MH, Santoro MM, Tolosano E.

Haematologica. 2015 Jun;100(6):720-9. doi: 10.3324/haematol.2014.114488. Epub 2015 Mar 20.

22.

Gastric cancer as a stem-cell disease: data and hypotheses.

Fagoonee S, Li H, Zhang H, Altruda F, Pellicano R.

Panminerva Med. 2014;56(4):289-300. Review.

23.

A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms.

Antonini D, Sirico A, Aberdam E, Ambrosio R, Campanile C, Fagoonee S, Altruda F, Aberdam D, Brissette JL, Missero C.

Nucleic Acids Res. 2015 Jan;43(2):862-74. doi: 10.1093/nar/gku1396. Epub 2015 Jan 7.

24.

Helicobacter pylori infection and dementia: can actual data reinforce the hypothesis of a causal association?

Adriani A, Fagoonee S, De Angelis C, Altruda F, Pellicano R.

Panminerva Med. 2014 Sep;56(3):195-9. Review.

PMID:
25056243
25.

LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy.

Rusconi F, Paganini L, Braida D, Ponzoni L, Toffolo E, Maroli A, Landsberger N, Bedogni F, Turco E, Pattini L, Altruda F, De Biasi S, Sala M, Battaglioli E.

Cereb Cortex. 2015 Sep;25(9):2729-40. doi: 10.1093/cercor/bhu070. Epub 2014 Apr 15.

PMID:
24735673
26.

Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity.

Maccarinelli F, Gammella E, Asperti M, Regoni M, Biasiotto G, Turco E, Altruda F, Lonardi S, Cornaghi L, Donetti E, Recalcati S, Poli M, Finazzi D, Arosio P, Cairo G.

J Mol Med (Berl). 2014 Aug;92(8):859-69. doi: 10.1007/s00109-014-1147-0. Epub 2014 Apr 13.

27.

Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.

Fiorito V, Neri F, Pala V, Silengo L, Oliviero S, Altruda F, Tolosano E.

Biochim Biophys Acta. 2014;1839(4):259-64. doi: 10.1016/j.bbagrm.2014.02.010. Epub 2014 Feb 24.

28.

Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.

Vinchi F, Ingoglia G, Chiabrando D, Mercurio S, Turco E, Silengo L, Altruda F, Tolosano E.

Gastroenterology. 2014 May;146(5):1325-38. doi: 10.1053/j.gastro.2014.01.053. Epub 2014 Jan 31.

29.

APL-2, an altered peptide ligand derived from heat-shock protein 60, induces interleukin-10 in peripheral blood mononuclear cell derived from juvenile idiopathic arthritis patients and downregulates the inflammatory response in collagen-induced arthritis model.

Lorenzo N, Cantera D, Barberá A, Alonso A, Chall E, Franco L, Ancizar J, Nuñez Y, Altruda F, Silengo L, Padrón G, Del Carmen Dominguez M.

Clin Exp Med. 2015 Feb;15(1):31-9. doi: 10.1007/s10238-014-0273-x. Epub 2014 Jan 29.

30.

Alumina-zirconia composites functionalized with laminin-1 and laminin-5 for dentistry: effect of protein adsorption on cellular response.

Vallée A, Faga MG, Mussano F, Catalano F, Tolosano E, Carossa S, Altruda F, Martra G.

Colloids Surf B Biointerfaces. 2014 Feb 1;114:284-93. doi: 10.1016/j.colsurfb.2013.09.053. Epub 2013 Oct 17.

PMID:
24216619
31.

Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development.

Rolla S, Ingoglia G, Bardina V, Silengo L, Altruda F, Novelli F, Tolosano E.

J Immunol. 2013 Dec 1;191(11):5451-9. doi: 10.4049/jimmunol.1203076. Epub 2013 Oct 23.

32.

Renal cells from spermatogonial germline stem cells protect against kidney injury.

De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F.

J Am Soc Nephrol. 2014 Feb;25(2):316-28. doi: 10.1681/ASN.2013040367. Epub 2013 Oct 17.

33.

The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells.

Fagoonee S, Bearzi C, Di Cunto F, Clohessy JG, Rizzi R, Reschke M, Tolosano E, Provero P, Pandolfi PP, Silengo L, Altruda F.

PLoS One. 2013 Aug 27;8(8):e72300. doi: 10.1371/journal.pone.0072300. eCollection 2013.

34.

Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake.

Fiorito V, Geninatti Crich S, Silengo L, Aime S, Altruda F, Tolosano E.

PLoS One. 2013 Jun 27;8(6):e68146. doi: 10.1371/journal.pone.0068146. Print 2013.

35.

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.

Vinchi F, De Franceschi L, Ghigo A, Townes T, Cimino J, Silengo L, Hirsch E, Altruda F, Tolosano E.

Circulation. 2013 Mar 26;127(12):1317-29. doi: 10.1161/CIRCULATIONAHA.112.130179. Epub 2013 Feb 27.

36.

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation.

Chiabrando D, Marro S, Mercurio S, Giorgi C, Petrillo S, Vinchi F, Fiorito V, Fagoonee S, Camporeale A, Turco E, Merlo GR, Silengo L, Altruda F, Pinton P, Tolosano E.

J Clin Invest. 2012 Dec;122(12):4569-79. doi: 10.1172/JCI62422. Epub 2012 Nov 26.

37.

Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.

Chiabrando D, Fiorito V, Marro S, Silengo L, Altruda F, Tolosano E.

Blood Cells Mol Dis. 2013 Jan;50(1):25-30. doi: 10.1016/j.bcmd.2012.08.002. Epub 2012 Aug 24.

38.

Therapeutic effect of an altered peptide ligand derived from heat-shock protein 60 by suppressing of inflammatory cytokines secretion in two animal models of rheumatoid arthritis.

Lorenzo N, Barberá A, Domínguez MC, Torres AM, Hernandez MV, Hernandez I, Gil R, Ancizar J, Garay H, Reyes O, Altruda F, Silengo L, Padrón G.

Autoimmunity. 2012 Sep;45(6):449-59. doi: 10.3109/08916934.2012.697592. Epub 2012 Jul 20.

PMID:
22686732
39.

Functional antagonism between Sall4 and Plzf defines germline progenitors.

Hobbs RM, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, Chai L, Pandolfi PP.

Cell Stem Cell. 2012 Mar 2;10(3):284-98. doi: 10.1016/j.stem.2012.02.004.

40.

Assessment of iron absorption in mice by ICP-MS measurements of (57)Fe levels.

Fiorito V, Geninatti Crich S, Silengo L, Altruda F, Aime S, Tolosano E.

Eur J Nutr. 2012 Oct;51(7):783-9. Epub 2011 Oct 19.

41.

A role for hemopexin in oligodendrocyte differentiation and myelin formation.

Morello N, Bianchi FT, Marmiroli P, Tonoli E, Rodriguez Menendez V, Silengo L, Cavaletti G, Vercelli A, Altruda F, Tolosano E.

PLoS One. 2011;6(5):e20173. doi: 10.1371/journal.pone.0020173. Epub 2011 May 25.

42.

Potential applications of germline cell-derived pluripotent stem cells in organ regeneration.

Fagoonee S, Pellicano R, Silengo L, Altruda F.

Organogenesis. 2011 Apr-Jun;7(2):116-22. doi: 10.4161/org.7.2.16284. Epub 2011 Apr 1. Review.

43.

The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions.

Costa C, Germena G, Martin-Conte EL, Molineris I, Bosco E, Marengo S, Azzolino O, Altruda F, Ranieri VM, Hirsch E.

Blood. 2011 Jul 28;118(4):1099-108. doi: 10.1182/blood-2010-12-324756. Epub 2011 May 6.

44.

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E.

Mol Cell. 2011 Apr 8;42(1):84-95. doi: 10.1016/j.molcel.2011.01.030.

45.

High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice.

Ognibene M, Barbieri O, Vanni C, Mastracci L, Astigiano S, Emionite L, Salani B, Fedele M, Resaz R, Tenca C, Fais F, Sabatini F, De Santanna A, Altruda F, Varesio L, Hirsch E, Eva A.

J Mol Med (Berl). 2011 May;89(5):493-504. doi: 10.1007/s00109-010-0712-4. Epub 2011 Jan 11.

PMID:
21221514
46.

Clinical, pathological and immunological features of psoriatic-like lesions affecting keratin 14-vascular endothelial growth factor transgenic mice.

Canavese M, Altruda F, Silengo L, Castiglioni V, Scanziani E, Radaelli E.

Histol Histopathol. 2011 Mar;26(3):285-96. doi: 10.14670/HH-26.285.

PMID:
21210341
47.

Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice.

Spiller F, Costa C, Souto FO, Vinchi F, Mestriner FL, Laure HJ, Alves-Filho JC, Freitas A, Rosa JC, Ferreira SH, Altruda F, Hirsch E, Greene LJ, Tolosano E, Cunha FQ.

Am J Respir Crit Care Med. 2011 Apr 1;183(7):922-31. doi: 10.1164/rccm.201002-0223OC. Epub 2010 Oct 22.

PMID:
20971829
48.

Stem cell world 2010: crucial questions from clinicians to biologists.

Fagoonee S, Pellicano R, Altruda F.

Panminerva Med. 2010 Jun;52(2):95-6. No abstract available.

49.

Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis--a possible target for novel therapies?

Canavese M, Altruda F, Ruzicka T, Schauber J.

J Dermatol Sci. 2010 Jun;58(3):171-6. doi: 10.1016/j.jdermsci.2010.03.023. Epub 2010 Apr 9. Review.

PMID:
20430590
50.

Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro.

Fagoonee S, Hobbs RM, De Chiara L, Cantarella D, Piro RM, Tolosano E, Medico E, Provero P, Pandolfi PP, Silengo L, Altruda F.

Stem Cells Dev. 2010 Aug;19(8):1183-94. doi: 10.1089/scd.2009.0496.

PMID:
20331356

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