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National trends and perioperative outcomes of robotic resection of thymic tumours in the United States: a propensity matching comparison with open and video-assisted thoracoscopic approaches†.

Kamel MK, Villena-Vargas J, Rahouma M, Lee B, Harrison S, Stiles BM, Abdelrahman AM, Altorki NK, Port JL.

Eur J Cardiothorac Surg. 2019 Oct 1;56(4):762-769. doi: 10.1093/ejcts/ezz111.


Do the surgical results in the National Lung Screening Trial reflect modern thoracic surgical practice?

Kamel MK, Lee B, Harrison S, Port JL, Pua B, Altorki NK, Stiles BM.

J Thorac Cardiovasc Surg. 2019 May;157(5):2038-2046.e1. doi: 10.1016/j.jtcvs.2018.11.139. Epub 2018 Dec 15.


Adjuvant Therapy for Node-Positive Esophageal Cancer After Induction and Surgery: A Multisite Study.

Semenkovich TR, Subramanian M, Yan Y, Hofstetter WL, Correa AM, Cassivi SD, Inra ML, Stiles BM, Altorki NK, Chang AC, Brescia AA, Darling GE, Allison F, Broderick SR, Etchill EW, Fernandez FG, Chihara RK, Litle VR, Muñoz-Largacha JA, Kozower BD, Puri V, Meyers BF.

Ann Thorac Surg. 2019 Sep;108(3):828-836. doi: 10.1016/j.athoracsur.2019.04.099. Epub 2019 Jun 20.


TOX is a critical regulator of tumour-specific T cell differentiation.

Scott AC, Dündar F, Zumbo P, Chandran SS, Klebanoff CA, Shakiba M, Trivedi P, Menocal L, Appleby H, Camara S, Zamarin D, Walther T, Snyder A, Femia MR, Comen EA, Wen HY, Hellmann MD, Anandasabapathy N, Liu Y, Altorki NK, Lauer P, Levy O, Glickman MS, Kaye J, Betel D, Philip M, Schietinger A.

Nature. 2019 Jul;571(7764):270-274. doi: 10.1038/s41586-019-1324-y. Epub 2019 Jun 17.


Role of wedge resection in bronchial carcinoid (BC) tumors: SEER database analysis.

Rahouma M, Kamel M, Narula N, Nasar A, Harrison S, Lee B, Stiles BM, Lau C, Altorki NK, Port JL.

J Thorac Dis. 2019 Apr;11(4):1355-1362. doi: 10.21037/jtd.2019.03.89.


Sublobar resection for node-negative lung cancer 2-5 cm in size.

Stiles BM, Mao J, Harrison S, Lee B, Port JL, Altorki NK, Sedrakyan A.

Eur J Cardiothorac Surg. 2019 Jun 5. pii: ezz146. doi: 10.1093/ejcts/ezz146. [Epub ahead of print]


Extent of lymphadenectomy is associated with oncological efficacy of sublobar resection for lung cancer ≤2 cm.

Stiles BM, Mao J, Harrison S, Lee B, Port JL, Sedrakyan A, Altorki NK.

J Thorac Cardiovasc Surg. 2019 Jun;157(6):2454-2465.e1. doi: 10.1016/j.jtcvs.2019.01.136. Epub 2019 Feb 28.


Do individual surgeon volumes affect outcomes in thoracic surgery?†.

Harrison S, Sun T, Kamel MK, Cleary C, Stiles BM, Altorki NK, Sedrakyan A.

Eur J Cardiothorac Surg. 2019 Oct 1;56(4):770-777. doi: 10.1093/ejcts/ezz095.


Sensitivity and specificity of fine needle aspiration for the diagnosis of mediastinal lesions.

Marcus A, Narula N, Kamel MK, Koizumi J, Port JL, Stiles B, Moreira A, Altorki NK, Giorgadze T.

Ann Diagn Pathol. 2019 Apr;39:69-73. doi: 10.1016/j.anndiagpath.2019.02.011. Epub 2019 Feb 10.


The lung microenvironment: an important regulator of tumour growth and metastasis.

Altorki NK, Markowitz GJ, Gao D, Port JL, Saxena A, Stiles B, McGraw T, Mittal V.

Nat Rev Cancer. 2019 Jan;19(1):9-31. doi: 10.1038/s41568-018-0081-9. Review.


Perioperative mortality and morbidity after sublobar versus lobar resection for early-stage non-small-cell lung cancer: post-hoc analysis of an international, randomised, phase 3 trial (CALGB/Alliance 140503).

Altorki NK, Wang X, Wigle D, Gu L, Darling G, Ashrafi AS, Landrenau R, Miller D, Liberman M, Jones DR, Keenan R, Conti M, Wright G, Veit LJ, Ramalingam SS, Kamel M, Pass HI, Mitchell JD, Stinchcombe T, Vokes E, Kohman LJ.

Lancet Respir Med. 2018 Dec;6(12):915-924. doi: 10.1016/S2213-2600(18)30411-9. Epub 2018 Nov 12.


Neoadjuvant Therapy for Locally Advanced Esophageal Cancer Should Be Targeted to Tumor Histology.

Stiles BM, Kamel MK, Harrison SW, Rahouma M, Lee B, Nasar A, Port JL, Altorki NK.

Ann Thorac Surg. 2019 Jan;107(1):187-193. doi: 10.1016/j.athoracsur.2018.07.089. Epub 2018 Sep 29.


Segmentectomy Is Equivalent to Lobectomy in Hypermetabolic Clinical Stage IA Lung Adenocarcinomas.

Kamel MK, Rahouma M, Lee B, Harrison SW, Stiles BM, Altorki NK, Port JL.

Ann Thorac Surg. 2019 Jan;107(1):217-223. doi: 10.1016/j.athoracsur.2018.07.042. Epub 2018 Sep 19.


Lung cancer patients have the highest malignancy-associated suicide rate in USA: a population-based analysis.

Rahouma M, Kamel M, Abouarab A, Eldessouki I, Nasar A, Harrison S, Lee B, Shostak E, Morris J, Stiles B, Altorki NK, Port JL.

Ecancermedicalscience. 2018 Aug 16;12:859. doi: 10.3332/ecancer.2018.859. eCollection 2018. Review.


Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival.

Markowitz GJ, Havel LS, Crowley MJ, Ban Y, Lee SB, Thalappillil JS, Narula N, Bhinder B, Elemento O, Wong ST, Gao D, Altorki NK, Mittal V.

JCI Insight. 2018 Jul 12;3(13). pii: 96836. doi: 10.1172/jci.insight.96836.


Incidence and Prognostic Significance of Carcinoid Lymph Node Metastases.

Kneuertz PJ, Kamel MK, Stiles BM, Lee BE, Rahouma M, Harrison SW, Altorki NK, Port JL.

Ann Thorac Surg. 2018 Oct;106(4):981-988. doi: 10.1016/j.athoracsur.2018.05.044. Epub 2018 Jun 15.


Molecular Testing for Early Lung Cancer.

Altorki NK.

Arch Pathol Lab Med. 2018 Jul;142(7):794-795. doi: 10.5858/arpa.2018-0087-ED. Epub 2018 Apr 6. No abstract available.


Predictors of Survival After Treatment of Oligometastases After Esophagectomy.

Ghaly G, Harrison S, Kamel MK, Rahouma M, Nasar A, Port JL, Stiles BM, Altorki NK.

Ann Thorac Surg. 2018 Feb;105(2):357-362. doi: 10.1016/j.athoracsur.2017.10.039. Epub 2017 Dec 21.


The NeoRes trial: questioning the benefit of radiation therapy as part of neoadjuvant therapy for esophageal adenocarcinoma.

Stiles BM, Altorki NK.

J Thorac Dis. 2017 Oct;9(10):3465-3468. doi: 10.21037/jtd.2017.08.146. No abstract available.


T1N0 oesophageal cancer: patterns of care and outcomes over 25 years.

Kamel MK, Lee B, Rahouma M, Harrison S, Nguyen AB, Port JL, Altorki NK, Stiles BM.

Eur J Cardiothorac Surg. 2018 May 1;53(5):952-959. doi: 10.1093/ejcts/ezx430.


Pulmonary sarcomatoid carcinoma: an analysis of a rare cancer from the Surveillance, Epidemiology, and End Results database.

Rahouma M, Kamel M, Narula N, Nasar A, Harrison S, Lee B, Stiles B, Altorki NK, Port JL.

Eur J Cardiothorac Surg. 2018 Apr 1;53(4):828-834. doi: 10.1093/ejcts/ezx417.


Never smokers with resected lung cancer: different demographics, similar survival.

Stiles BM, Rahouma M, Hussein MK, Nasar A, Nguyen AB, Harrison S, Lee B, Port JL, Altorki NK.

Eur J Cardiothorac Surg. 2018 Apr 1;53(4):842-848. doi: 10.1093/ejcts/ezx390.


Robotic Thymectomy Is Feasible for Large Thymomas: A Propensity-Matched Comparison.

Kneuertz PJ, Kamel MK, Stiles BM, Lee BE, Rahouma M, Nasar A, Altorki NK, Port JL.

Ann Thorac Surg. 2017 Nov;104(5):1673-1678. doi: 10.1016/j.athoracsur.2017.05.074. Epub 2017 Sep 19.


Variation by stage in the effects of prediagnosis weight loss on mortality in a prospective cohort of esophageal cancer patients.

Shen S, Araujo JL, Altorki NK, Sonett JR, Rodriguez A, Sungur-Stasik K, Spinelli CF, Neugut AI, Abrams JA.

Dis Esophagus. 2017 Sep 1;30(9):1-7. doi: 10.1093/dote/dox073.


Fischer et al. reply.

Fischer KR, Altorki NK, Mittal V, Gao D.

Nature. 2017 Jul 5;547(7661):E5-E6. doi: 10.1038/nature22817. No abstract available.


Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake.

Beg M, Abdullah N, Thowfeik FS, Altorki NK, McGraw TE.

Elife. 2017 Jun 7;6. pii: e26896. doi: 10.7554/eLife.26896.


Clinical Predictors of Nodal Metastases in Peripherally Clinical T1a N0 Non-Small Cell Lung Cancer.

Ghaly G, Rahouma M, Kamel MK, Nasar A, Harrison S, Nguyen AB, Port J, Stiles BM, Altorki NK, Lee PC.

Ann Thorac Surg. 2017 Oct;104(4):1153-1158. doi: 10.1016/j.athoracsur.2017.02.074. Epub 2017 May 24.


The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.

Chen M, Nowak DG, Narula N, Robinson B, Watrud K, Ambrico A, Herzka TM, Zeeman ME, Minderer M, Zheng W, Ebbesen SH, Plafker KS, Stahlhut C, Wang VM, Wills L, Nasar A, Castillo-Martin M, Cordon-Cardo C, Wilkinson JE, Powers S, Sordella R, Altorki NK, Mittal V, Stiles BM, Plafker SM, Trotman LC.

J Cell Biol. 2017 Mar 6;216(3):641-656. doi: 10.1083/jcb.201604025. Epub 2017 Feb 13.


Robotic Thymectomy: Learning Curve and Associated Perioperative Outcomes.

Kamel MK, Rahouma M, Stiles BM, Nasar A, Altorki NK, Port JL.

J Laparoendosc Adv Surg Tech A. 2017 Jul;27(7):685-690. doi: 10.1089/lap.2016.0553. Epub 2017 Jan 25.


Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor.

Stawowczyk M, Wellenstein MD, Lee SB, Yomtoubian S, Durrans A, Choi H, Narula N, Altorki NK, Gao D, Mittal V.

Neoplasia. 2017 Feb;19(2):55-64. doi: 10.1016/j.neo.2016.11.005. Epub 2016 Dec 23.


Adenovirus Protein E4-ORF1 Activation of PI3 Kinase Reveals Differential Regulation of Downstream Effector Pathways in Adipocytes.

Chaudhary N, Gonzalez E, Chang SH, Geng F, Rafii S, Altorki NK, McGraw TE.

Cell Rep. 2016 Dec 20;17(12):3305-3318. doi: 10.1016/j.celrep.2016.11.082.


The importance of lymph node dissection accompanying wedge resection for clinical stage IA lung cancer.

Stiles BM, Kamel MK, Nasar A, Harrison S, Nguyen AB, Lee P, Port JL, Altorki NK.

Eur J Cardiothorac Surg. 2017 Mar 1;51(3):511-517. doi: 10.1093/ejcts/ezw343.


Video-Assisted Thoracoscopic Lobectomy Is the Preferred Approach Following Induction Chemotherapy.

Kamel MK, Nasar A, Stiles BM, Altorki NK, Port JL.

J Laparoendosc Adv Surg Tech A. 2017 May;27(5):495-500. doi: 10.1089/lap.2016.0540. Epub 2016 Dec 20.


Prediagnosis aspirin use and outcomes in a prospective cohort of esophageal cancer patients.

Araujo JL, Altorki NK, Sonett JR, Rodriguez A, Sungur-Stasik K, Spinelli CF, Neugut AI, Abrams JA.

Therap Adv Gastroenterol. 2016 Nov;9(6):806-814. Epub 2016 Jul 15.


Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma.

Wang D, Narula N, Azzopardi S, Smith RS, Nasar A, Altorki NK, Mittal V, Somwar R, Stiles BM, Du YN.

Oncotarget. 2016 Jun 28;7(26):39957-39969. doi: 10.18632/oncotarget.9554.


Anatomical Segmentectomy and Wedge Resections Are Associated with Comparable Outcomes for Patients with Small cT1N0 Non-Small Cell Lung Cancer.

Altorki NK, Kamel MK, Narula N, Ghaly G, Nasar A, Rahouma M, Lee PC, Port JL, Stiles BM.

J Thorac Oncol. 2016 Nov;11(11):1984-1992. doi: 10.1016/j.jtho.2016.06.031. Epub 2016 Aug 3.


Predictors of Pleural Implants in Patients With Thymic Tumors.

Kamel MK, Stiles BM, Ghaly G, Rahouma M, Nasar A, Port JL, Lee PC, Altorki NK.

Ann Thorac Surg. 2016 Nov;102(5):1647-1652. doi: 10.1016/j.athoracsur.2016.04.026. Epub 2016 Jun 18.


Clinical Predictors of Persistent Mediastinal Nodal Disease After Induction Therapy for Stage IIIA N2 Non-Small Cell Lung Cancer.

Kamel MK, Rahouma M, Ghaly G, Nasar A, Port JL, Stiles BM, Nguyen AB, Altorki NK, Lee PC.

Ann Thorac Surg. 2017 Jan;103(1):281-286. doi: 10.1016/j.athoracsur.2016.06.061. Epub 2016 Sep 9.


Surgery is the Optimum Local Therapeutic Modality for Second Primary Lung Cancer.

Port JL, Kamel MK, Altorki NK.

Semin Thorac Cardiovasc Surg. 2016 Spring;28(1):201-2. doi: 10.1053/j.semtcvs.2016.04.013. Epub 2016 Apr 27. No abstract available.


Screening for Lung Cancer.

Stiles BM, Pua B, Altorki NK.

Surg Oncol Clin N Am. 2016 Jul;25(3):469-79. doi: 10.1016/j.soc.2016.02.002. Review.


Computed Tomography Screening for Lung Cancer: Mediastinal Lymph Node Resection in Stage IA Nonsmall Cell Lung Cancer Manifesting as Subsolid and Solid Nodules.

Flores RM, Nicastri D, Bauer T, Aye R, Andaz S, Kohman L, Sheppard B, Mayfield W, Thurer R, Korst R, Straznicka M, Grannis F, Pass H, Connery C, Yip R, Smith JP, Yankelevitz DF, Henschke CI, Altorki NK; Writing committee for the I-ELCAP Investigators.

Ann Surg. 2017 May;265(5):1025-1033. doi: 10.1097/SLA.0000000000001802.


Preoperative Chemoradiation Therapy Versus Chemotherapy in Patients Undergoing Modified En Bloc Esophagectomy for Locally Advanced Esophageal Adenocarcinoma: Is Radiotherapy Beneficial?

Spicer JD, Stiles BM, Sudarshan M, Correa AM, Ferri LE, Altorki NK, Hofstetter WL.

Ann Thorac Surg. 2016 Apr;101(4):1262-9; discussion 1969-70. doi: 10.1016/j.athoracsur.2015.11.070. Epub 2016 Feb 23.


Variability in length of stay after uncomplicated pulmonary lobectomy: is length of stay a quality metric or a patient metric?†.

Giambrone GP, Smith MC, Wu X, Gaber-Baylis LK, Bhat AU, Zabih R, Altorki NK, Fleischut PM, Stiles BM.

Eur J Cardiothorac Surg. 2016 Apr;49(4):e65-71. doi: 10.1093/ejcts/ezv476. Epub 2016 Jan 27.


Incidence and implications of postoperative supraventricular tachycardia after pulmonary lobectomy.

Giambrone GP, Wu X, Gaber-Baylis LK, Bhat AU, Zabih R, Altorki NK, Fleischut PM, Stiles BM.

J Thorac Cardiovasc Surg. 2016 Apr;151(4):982-8. doi: 10.1016/j.jtcvs.2015.11.057. Epub 2015 Dec 12.


Incidence and Factors Associated With Hospital Readmission After Pulmonary Lobectomy.

Stiles BM, Poon A, Giambrone GP, Gaber-Baylis LK, Wu X, Lee PC, Port JL, Paul S, Bhat AU, Zabih R, Altorki NK, Fleischut PM.

Ann Thorac Surg. 2016 Feb;101(2):434-42; diacussion 442-3. doi: 10.1016/j.athoracsur.2015.10.001. Epub 2015 Dec 22.


The Microenvironment of Lung Cancer and Therapeutic Implications.

Mittal V, El Rayes T, Narula N, McGraw TE, Altorki NK, Barcellos-Hoff MH.

Adv Exp Med Biol. 2016;890:75-110. doi: 10.1007/978-3-319-24932-2_5. Review.


Clinical Issues in the Surgical Management of Screen-Identified Lung Cancers.

Kamel M, Stiles B, Altorki NK.

Oncology (Williston Park). 2015 Dec;29(12):944-9, 951. Review.


Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1.

El Rayes T, Catena R, Lee S, Stawowczyk M, Joshi N, Fischbach C, Powell CA, Dannenberg AJ, Altorki NK, Gao D, Mittal V.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):16000-5. doi: 10.1073/pnas.1507294112. Epub 2015 Dec 14.


Lobectomy for Non-Small Cell Lung Cancer by Video-Assisted Thoracic Surgery: Effects of Cumulative Institutional Experience on Adequacy of Lymphadenectomy.

Lee PC, Kamel M, Nasar A, Ghaly G, Port JL, Paul S, Stiles BM, Andrews WG, Altorki NK.

Ann Thorac Surg. 2016 Mar;101(3):1116-22. doi: 10.1016/j.athoracsur.2015.09.073. Epub 2015 Dec 2.


Locally advanced esophageal cancer: What becomes of 5-year survivors?

Ghaly G, Kamel M, Nasar A, Paul S, Lee PC, Port JL, Christos PJ, Stiles BM, Altorki NK.

J Thorac Cardiovasc Surg. 2016 Mar;151(3):726-732. doi: 10.1016/j.jtcvs.2015.10.096. Epub 2015 Oct 30.

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