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Items: 12


Long-Acting β2-Adrenoceptor Agonists Enhance Glucocorticoid Receptor (GR)-Mediated Transcription by Gene-Specific Mechanisms Rather Than Generic Effects via GR.

Rider CF, Altonsy MO, Mostafa MM, Shah SV, Sasse S, Manson ML, Yan D, Kärrman-Mårdh C, Miller-Larsson A, Gerber AN, Giembycz MA, Newton R.

Mol Pharmacol. 2018 Sep;94(3):1031-1046. doi: 10.1124/mol.118.112755. Epub 2018 Jun 29.


Glucocorticoid and cytokine crosstalk: Feedback, feedforward, and co-regulatory interactions determine repression or resistance.

Newton R, Shah S, Altonsy MO, Gerber AN.

J Biol Chem. 2017 Apr 28;292(17):7163-7172. doi: 10.1074/jbc.R117.777318. Epub 2017 Mar 10. Review.


Long-acting β2-agonists promote glucocorticoid-mediated repression of NF-κB by enhancing expression of the feedback regulator TNFAIP3.

Altonsy MO, Mostafa MM, Gerber AN, Newton R.

Am J Physiol Lung Cell Mol Physiol. 2017 Mar 1;312(3):L358-L370. doi: 10.1152/ajplung.00426.2016. Epub 2016 Dec 29.


DUSP1 Maintains IRF1 and Leads to Increased Expression of IRF1-dependent Genes: A MECHANISM PROMOTING GLUCOCORTICOID INSENSITIVITY.

Shah S, King EM, Mostafa MM, Altonsy MO, Newton R.

J Biol Chem. 2016 Oct 7;291(41):21802-21816. Epub 2016 Aug 22.


Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression.

Sasse SK, Altonsy MO, Kadiyala V, Cao G, Panettieri RA Jr, Gerber AN.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L421-32. doi: 10.1152/ajplung.00179.2016. Epub 2016 Jul 1.


Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-κB Orchestrates Anti-inflammatory Effects.

Kadiyala V, Sasse SK, Altonsy MO, Berman R, Chu HW, Phang TL, Gerber AN.

J Biol Chem. 2016 Jun 10;291(24):12673-87. doi: 10.1074/jbc.M116.721217. Epub 2016 Apr 13.


Cistrome Analysis of Glucocorticoid Receptor Activity in Bronchial Epithelial Cells Defines Novel Mechanisms of Steroid Efficacy.

Kadiyala V, Sasse SK, Altonsy MO, Phang TL, Gerber AN.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S103. doi: 10.1513/AnnalsATS.201508-534MG. No abstract available.


The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry.

Sasse SK, Mailloux CM, Barczak AJ, Wang Q, Altonsy MO, Jain MK, Haldar SM, Gerber AN.

Mol Cell Biol. 2013 Jun;33(11):2104-15. doi: 10.1128/MCB.01474-12. Epub 2013 Mar 18.


Diallyl disulfide-induced apoptosis in a breast-cancer cell line (MCF-7) may be caused by inhibition of histone deacetylation.

Altonsy MO, Habib TN, Andrews SC.

Nutr Cancer. 2012;64(8):1251-60. doi: 10.1080/01635581.2012.721156.


Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enteropathogenic bacteria: mediation by the mitochondrial pathway.

Altonsy MO, Andrews SC, Tuohy KM.

Int J Food Microbiol. 2010 Feb 28;137(2-3):190-203. doi: 10.1016/j.ijfoodmicro.2009.11.015. Epub 2009 Dec 5.


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