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Items: 5

1.

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

Pearce LR, Alton GR, Richter DT, Kath JC, Lingardo L, Chapman J, Hwang C, Alessi DR.

Biochem J. 2010 Oct 15;431(2):245-55. doi: 10.1042/BJ20101024.

PMID:
20704563
2.

Targeting the unactivated conformations of protein kinases for small molecule drug discovery.

Alton GR, Lunney EA.

Expert Opin Drug Discov. 2008 Jun;3(6):595-605. doi: 10.1517/17460441.3.6.595.

PMID:
23506143
3.

Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma.

Christensen JG, Zou HY, Arango ME, Li Q, Lee JH, McDonnell SR, Yamazaki S, Alton GR, Mroczkowski B, Los G.

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3314-22.

4.

Assay optimization and kinetic profile of the human and the rabbit isoforms of 11beta-HSD1.

Castro A, Zhu JX, Alton GR, Rejto P, Ermolieff J.

Biochem Biophys Res Commun. 2007 Jun 1;357(2):561-6. Epub 2007 Apr 9.

PMID:
17434447

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