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Items: 44


Screening Mycobacterium tuberculosis Secreted Proteins Identifies Mpt64 as a Eukaryotic Membrane-Binding Bacterial Effector.

Stamm CE, Pasko BL, Chaisavaneeyakorn S, Franco LH, Nair VR, Weigele BA, Alto NM, Shiloh MU.

mSphere. 2019 Jun 5;4(3). pii: e00354-19. doi: 10.1128/mSphere.00354-19.


A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.

Liu Z, Mar KB, Hanners NW, Perelman SS, Kanchwala M, Xing C, Schoggins JW, Alto NM.

Nature. 2019 Apr;568(7751):249-253. doi: 10.1038/s41586-019-1041-6. Epub 2019 Mar 20.


Cooperative Immune Suppression by Escherichia coli and Shigella Effector Proteins.

de Jong MF, Alto NM.

Infect Immun. 2018 Mar 22;86(4). pii: e00560-17. doi: 10.1128/IAI.00560-17. Print 2018 Apr. Review.


A systematic exploration of the interactions between bacterial effector proteins and host cell membranes.

Weigele BA, Orchard RC, Jimenez A, Cox GW, Alto NM.

Nat Commun. 2017 Sep 14;8(1):532. doi: 10.1038/s41467-017-00700-7.


Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection.

Perelman SS, Abrams ME, Eitson JL, Chen D, Jimenez A, Mettlen M, Schoggins JW, Alto NM.

PLoS Pathog. 2016 Dec 21;12(12):e1006102. doi: 10.1371/journal.ppat.1006102. eCollection 2016 Dec.


Shigella flexneri suppresses NF-κB activation by inhibiting linear ubiquitin chain ligation.

de Jong MF, Liu Z, Chen D, Alto NM.

Nat Microbiol. 2016 May 27;1(7):16084. doi: 10.1038/nmicrobiol.2016.84.


How Bacteria Subvert Animal Cell Structure and Function.

Jimenez A, Chen D, Alto NM.

Annu Rev Cell Dev Biol. 2016 Oct 6;32:373-397. Epub 2016 May 4. Review.


STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease.

Dobbs N, Burnaevskiy N, Chen D, Gonugunta VK, Alto NM, Yan N.

Cell Host Microbe. 2015 Aug 12;18(2):157-68. doi: 10.1016/j.chom.2015.07.001. Epub 2015 Jul 30.


Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ.

Burnaevskiy N, Peng T, Reddick LE, Hang HC, Alto NM.

Mol Cell. 2015 Apr 2;58(1):110-22. doi: 10.1016/j.molcel.2015.01.040. Epub 2015 Mar 12.


Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration.

Glotfelty LG, Zahs A, Hodges K, Shan K, Alto NM, Hecht GA.

Cell Microbiol. 2014 Dec;16(12):1767-83. doi: 10.1111/cmi.12323. Epub 2014 Aug 7.


Bacteria fighting back: how pathogens target and subvert the host innate immune system.

Reddick LE, Alto NM.

Mol Cell. 2014 Apr 24;54(2):321-8. doi: 10.1016/j.molcel.2014.03.010. Review.


Selective protection of an ARF1-GTP signaling axis by a bacterial scaffold induces bidirectional trafficking arrest.

Selyunin AS, Reddick LE, Weigele BA, Alto NM.

Cell Rep. 2014 Mar 13;6(5):878-91. doi: 10.1016/j.celrep.2014.01.040. Epub 2014 Feb 27.


Thinking outside the Osp(G)--kinase activation by E2-ubiquitin.

de Jong MF, Alto NM.

EMBO J. 2014 Mar 3;33(5):403-4. doi: 10.1002/embj.201387606. Epub 2014 Jan 30.


Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ.

Burnaevskiy N, Fox TG, Plymire DA, Ertelt JM, Weigele BA, Selyunin AS, Way SS, Patrie SM, Alto NM.

Nature. 2013 Apr 4;496(7443):106-9. doi: 10.1038/nature12004. Epub 2013 Mar 27.


Express your LOV: an engineered flavoprotein as a reporter for protein expression and purification.

Gawthorne JA, Reddick LE, Akpunarlieva SN, Beckham KS, Christie JM, Alto NM, Gabrielsen M, Roe AJ.

PLoS One. 2012;7(12):e52962. doi: 10.1371/journal.pone.0052962. Epub 2012 Dec 27.


Subversion of cell signaling by pathogens.

Alto NM, Orth K.

Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a006114. doi: 10.1101/cshperspect.a006114. Review.


Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit.

Orchard RC, Kittisopikul M, Altschuler SJ, Wu LF, Süel GM, Alto NM.

Cell. 2012 Feb 17;148(4):803-15. doi: 10.1016/j.cell.2011.11.063.


Mimicking GEFs: a common theme for bacterial pathogens.

Orchard RC, Alto NM.

Cell Microbiol. 2012 Jan;14(1):10-8. doi: 10.1111/j.1462-5822.2011.01703.x. Epub 2011 Dec 1. Review.


The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.

Selyunin AS, Sutton SE, Weigele BA, Reddick LE, Orchard RC, Bresson SM, Tomchick DR, Alto NM.

Nature. 2011 Jan 6;469(7328):107-11. doi: 10.1038/nature09593. Epub 2010 Dec 19.


Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties.

Bui M, Gilady SY, Fitzsimmons RE, Benson MD, Lynes EM, Gesson K, Alto NM, Strack S, Scott JD, Simmen T.

J Biol Chem. 2010 Oct 8;285(41):31590-602. doi: 10.1074/jbc.M110.101584. Epub 2010 Jul 29.


Salmonella taking charge.

Weigele BA, Alto NM.

Cell Host Microbe. 2010 Jun 25;7(6):421-2. doi: 10.1016/j.chom.2010.06.001.


E. coli secreted protein F promotes EPEC invasion of intestinal epithelial cells via an SNX9-dependent mechanism.

Weflen AW, Alto NM, Viswanathan VK, Hecht G.

Cell Microbiol. 2010 Jul;12(7):919-29. doi: 10.1111/j.1462-5822.2010.01440.x. Epub 2010 Jan 20.


Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics.

Huang Z, Sutton SE, Wallenfang AJ, Orchard RC, Wu X, Feng Y, Chai J, Alto NM.

Nat Struct Mol Biol. 2009 Aug;16(8):853-60. doi: 10.1038/nsmb.1647. Epub 2009 Jul 20.


Tight junctions and enteropathogenic E. coli.

Weflen AW, Alto NM, Hecht GA.

Ann N Y Acad Sci. 2009 May;1165:169-74. doi: 10.1111/j.1749-6632.2009.04060.x.


Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation.

Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon JE, Chai J, Miller SI.

Cell Host Microbe. 2008 Nov 13;4(5):434-46. doi: 10.1016/j.chom.2008.08.012.


The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity.

Hodges K, Alto NM, Ramaswamy K, Dudeja PK, Hecht G.

Cell Microbiol. 2008 Aug;10(8):1735-45. doi: 10.1111/j.1462-5822.2008.01163.x. Epub 2008 Apr 21.


Analysis of Rho-GTPase mimicry by a family of bacterial type III effector proteins.

Alto NM, Dixon JE.

Methods Enzymol. 2008;439:131-43. doi: 10.1016/S0076-6879(07)00410-7.


Subversion of myosin function by E. coli.

Mattoo S, Alto NM, Dixon JE.

Dev Cell. 2008 Jan;14(1):8-10. doi: 10.1016/j.devcel.2007.12.016.


Mimicking small G-proteins: an emerging theme from the bacterial virulence arsenal.

Alto NM.

Cell Microbiol. 2008 Mar;10(3):566-75. doi: 10.1111/j.1462-5822.2007.01110.x. Epub 2008 Jan 9. Review.


The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways.

Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor SS, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE.

J Cell Biol. 2007 Sep 24;178(7):1265-78.


Identification of a bacterial type III effector family with G protein mimicry functions.

Alto NM, Shao F, Lazar CS, Brost RL, Chua G, Mattoo S, McMahon SA, Ghosh P, Hughes TR, Boone C, Dixon JE.

Cell. 2006 Jan 13;124(1):133-45.


Functions of the Yersinia effector proteins in inhibiting host immune responses.

Navarro L, Alto NM, Dixon JE.

Curr Opin Microbiol. 2005 Feb;8(1):21-7. Review.


The role of A-Kinase anchoring proteins in cAMP-mediated signal transduction pathways.

Alto NM, Scott JD.

Cell Biochem Biophys. 2004;40(3 Suppl):201-8. Review.


Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring.

Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4445-50. Epub 2003 Apr 2.


Fluid flow regulates E-selectin protein levels in human endothelial cells by inhibiting translation.

Kraiss LW, Alto NM, Dixon DA, McIntyre TM, Weyrich AS, Zimmerman GA.

J Vasc Surg. 2003 Jan;37(1):161-8.


Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics.

Alto NM, Soderling J, Scott JD.

J Cell Biol. 2002 Aug 19;158(4):659-68. Epub 2002 Aug 19.


Flow-induced DNA synthesis requires signaling to a translational control pathway.

Kraiss LW, Ennis TM, Alto NM.

J Surg Res. 2001 May 1;97(1):20-6.


Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold.

Westphal RS, Soderling SH, Alto NM, Langeberg LK, Scott JD.

EMBO J. 2000 Sep 1;19(17):4589-600.


A genetic screen for zygotic embryonic lethal mutations affecting cuticular morphology in the wasp Nasonia vitripennis.

Pultz MA, Zimmerman KK, Alto NM, Kaeberlein M, Lange SK, Pitt JN, Reeves NL, Zehrung DL.

Genetics. 2000 Mar;154(3):1213-29.


Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells.

Kraiss LW, Weyrich AS, Alto NM, Dixon DA, Ennis TM, Modur V, McIntyre TM, Prescott SM, Zimmerman GA.

Am J Physiol Heart Circ Physiol. 2000 May;278(5):H1537-44.


Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex.

Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, Scott JD.

Science. 1999 Jul 2;285(5424):93-6.


Extensive zygotic control of the anteroposterior axis in the wasp Nasonia vitripennis.

Pultz MA, Pitt JN, Alto NM.

Development. 1999 Feb;126(4):701-10.

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