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Items: 1 to 50 of 222

1.

Challenges With Left Ventricular Functional Parameters: The Pediatric Heart Network Normal Echocardiogram Database.

Frommelt PC, Minich LL, Trachtenberg FL, Altmann K, Camarda J, Cohen MS, Colan SD, Dragulescu A, Frommelt MA, Johnson TR, Kovalchin JP, Lin L, Mahgerefteh J, Nutting A, Parra DA, Pearson GD, Pignatelli R, Sachdeva R, Soriano BD, Spurney C, Srivastava S, Statile CJ, Stelter J, Stylianou M, Thankavel PP, Tierney ES, van der Velde ME, Lopez L; Pediatric Heart Network Investigators.

J Am Soc Echocardiogr. 2019 Jul 24. pii: S0894-7317(19)30763-1. doi: 10.1016/j.echo.2019.05.025. [Epub ahead of print]

PMID:
31351792
2.

Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies.

Bartholomäus R, Nicolussi S, Baumann A, Rau M, Simão AC, Gertsch J, Altmann KH.

ChemMedChem. 2019 Jul 19. doi: 10.1002/cmdc.201900390. [Epub ahead of print]

PMID:
31322825
3.

Configurationally Stabilized Analogs of M. ulcerans Exotoxins Mycolactones A and B Reveal the Importance of Side Chain Geometry for Mycolactone Virulence.

Gehringer M, Mäder P, Gersbach P, Pfeiffer B, Scherr N, Dangy JP, Pluschke G, Altmann KH.

Org Lett. 2019 Aug 2;21(15):5853-5857. doi: 10.1021/acs.orglett.9b01947. Epub 2019 Jul 11.

PMID:
31295000
4.

Short- and Long-Range Mechanical and Chemical Interphases Caused by Interaction of Boehmite (γ-AlOOH) with Anhydride-Cured Epoxy Resins.

Ghasem Zadeh Khorasani M, Elert AM, Hodoroaba VD, Agudo Jácome L, Altmann K, Silbernagl D, Sturm H.

Nanomaterials (Basel). 2019 Jun 4;9(6). pii: E853. doi: 10.3390/nano9060853.

5.

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.

Balaguer FA, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián JF, Risinger AL, Sorensen EJ, Vanderwal CD, Altmann KH, Mooberry SL, Steinmetz MO, Oliva MÁ, Prota AE, Díaz JF.

Int J Mol Sci. 2019 Mar 20;20(6). pii: E1392. doi: 10.3390/ijms20061392.

6.

Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate.

Gaugaz FZ, Chicca A, Redondo-Horcajo M, Barasoain I, Díaz JF, Altmann KH.

Int J Mol Sci. 2019 Mar 5;20(5). pii: E1113. doi: 10.3390/ijms20051113.

7.

Development and testing of a fractionated filtration for sampling of microplastics in water.

Bannick CG, Szewzyk R, Ricking M, Schniegler S, Obermaier N, Barthel AK, Altmann K, Eisentraut P, Braun U.

Water Res. 2019 Feb 1;149:650-658. doi: 10.1016/j.watres.2018.10.045. Epub 2018 Oct 19.

PMID:
30641445
8.

Studies toward the Total Synthesis of the Marine Macrolide Salarin C.

Schrof R, Altmann KH.

Org Lett. 2018 Dec 7;20(23):7679-7683. doi: 10.1021/acs.orglett.8b03422. Epub 2018 Nov 26.

PMID:
30474982
9.

The challenge in preparing particle suspensions for aquatic microplastic research.

Eitzen L, Paul S, Braun U, Altmann K, Jekel M, Ruhl AS.

Environ Res. 2019 Jan;168:490-495. doi: 10.1016/j.envres.2018.09.008. Epub 2018 Sep 8.

PMID:
30318109
10.

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis.

Foo CS, Lupien A, Kienle M, Vocat A, Benjak A, Sommer R, Lamprecht DA, Steyn AJC, Pethe K, Piton J, Altmann KH, Cole ST.

MBio. 2018 Oct 9;9(5). pii: e01276-18. doi: 10.1128/mBio.01276-18.

11.

Primary resistance mechanism of the canine distemper virus fusion protein against a small-molecule membrane fusion inhibitor.

Kalbermatter D, Shrestha N, Ader-Ebert N, Herren M, Moll P, Plemper RK, Altmann KH, Langedijk JP, Gall F, Lindenmann U, Riedl R, Fotiadis D, Plattet P.

Virus Res. 2019 Jan 2;259:28-37. doi: 10.1016/j.virusres.2018.10.003. Epub 2018 Oct 5.

PMID:
30296457
12.

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model.

Häfliger P, Graff J, Rubin M, Stooss A, Dettmer MS, Altmann KH, Gertsch J, Charles RP.

J Exp Clin Cancer Res. 2018 Sep 21;37(1):234. doi: 10.1186/s13046-018-0907-z.

13.

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.

Menchon G, Prota AE, Lucena-Agell D, Bucher P, Jansen R, Irschik H, Müller R, Paterson I, Díaz JF, Altmann KH, Steinmetz MO.

Nat Commun. 2018 May 29;9(1):2106. doi: 10.1038/s41467-018-04535-8.

14.

Tumor Targeting with Small Molecule-Drug Conjugates (SMDCs) - Can They be Better than ADCs?

Altmann KH.

Chimia (Aarau). 2018 Mar 30;72(3):154-155. doi: 10.2533/chimia.2018.154. No abstract available.

PMID:
29631670
15.

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.

Jackson SM, Manolaridis I, Kowal J, Zechner M, Taylor NMI, Bause M, Bauer S, Bartholomaeus R, Bernhardt G, Koenig B, Buschauer A, Stahlberg H, Altmann KH, Locher KP.

Nat Struct Mol Biol. 2018 Apr;25(4):333-340. doi: 10.1038/s41594-018-0049-1. Epub 2018 Apr 2.

PMID:
29610494
16.

Total Synthesis of Ripostatin B and Structure-Activity Relationship Studies on Ripostatin Analogs.

Glaus F, Dedić D, Tare P, Nagaraja V, Rodrigues L, Aínsa JA, Kunze J, Schneider G, Hartkoorn RC, Cole ST, Altmann KH.

J Org Chem. 2018 Jul 6;83(13):7150-7172. doi: 10.1021/acs.joc.8b00193. Epub 2018 Mar 29.

PMID:
29542926
17.

Embedding the photon with its relativistic mass as a particle into the electromagnetic wave.

Altmann K.

Opt Express. 2018 Jan 22;26(2):1375-1389. doi: 10.1364/OE.26.001375.

PMID:
29402012
18.

Reproducibility of Left Ventricular Dimension Versus Area Versus Volume Measurements in Pediatric Patients With Dilated Cardiomyopathy.

Selamet Tierney ES, Hollenbeck-Pringle D, Lee CK, Altmann K, Dunbar-Masterson C, Golding F, Lu M, Miller SG, Molina K, Natarajan S, Taylor CL, Trachtenberg F, Colan SD; Pediatric Heart Network Investigators.

Circ Cardiovasc Imaging. 2017 Nov;10(11). pii: e006007. doi: 10.1161/CIRCIMAGING.116.006007.

19.

Drugs from the Oceans: Marine Natural Products as Leads for Drug Discovery.

Altmann KH.

Chimia (Aarau). 2017 Oct 25;71(10):646-652. doi: 10.2533/chimia.2017.646. Review.

PMID:
29070409
20.

Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites.

Field JJ, Pera B, Gallego JE, Calvo E, Rodríguez-Salarichs J, Sáez-Calvo G, Zuwerra D, Jordi M, Andreu JM, Prota AE, Ménchon G, Miller JH, Altmann KH, Díaz JF.

J Nat Prod. 2018 Mar 23;81(3):494-505. doi: 10.1021/acs.jnatprod.7b00704. Epub 2017 Oct 12.

PMID:
29023132
21.

The chemistry and biology of mycolactones.

Gehringer M, Altmann KH.

Beilstein J Org Chem. 2017 Aug 11;13:1596-1660. doi: 10.3762/bjoc.13.159. eCollection 2017. Review.

22.

Rational Design of Membrane-Pore-Forming Peptides.

Pillong M, Hiss JA, Schneider P, Lin YC, Posselt G, Pfeiffer B, Blatter M, Müller AT, Bachler S, Neuhaus CS, Dittrich PS, Altmann KH, Wessler S, Schneider G.

Small. 2017 Oct;13(40). doi: 10.1002/smll.201701316. Epub 2017 Aug 11.

PMID:
28799716
23.

Peptide-Membrane Interaction between Targeting and Lysis.

Stutz K, Müller AT, Hiss JA, Schneider P, Blatter M, Pfeiffer B, Posselt G, Kanfer G, Kornmann B, Wrede P, Altmann KH, Wessler S, Schneider G.

ACS Chem Biol. 2017 Sep 15;12(9):2254-2259. doi: 10.1021/acschembio.7b00504. Epub 2017 Aug 8.

PMID:
28763193
24.

Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake.

Chicca A, Nicolussi S, Bartholomäus R, Blunder M, Aparisi Rey A, Petrucci V, Reynoso-Moreno IDC, Viveros-Paredes JM, Dalghi Gens M, Lutz B, Schiöth HB, Soeberdt M, Abels C, Charles RP, Altmann KH, Gertsch J.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E5006-E5015. doi: 10.1073/pnas.1704065114. Epub 2017 Jun 5.

25.

RNA polymerase motions during promoter melting.

Feklistov A, Bae B, Hauver J, Lass-Napiorkowska A, Kalesse M, Glaus F, Altmann KH, Heyduk T, Landick R, Darst SA.

Science. 2017 May 26;356(6340):863-866. doi: 10.1126/science.aam7858.

26.

The Effect of the Superior Cavopulmonary Anastomosis on Ventricular Remodeling in Infants with Single Ventricle.

Margossian R, Zak V, Shillingford AJ, Hlavacek AM, Cnota JF, Puchalski MD, Levine JC, McCrindle BW, Cohen MS, Altmann K, Barker PC, Hsu DT, Colan SD; Pediatric Heart Network Investigators.

J Am Soc Echocardiogr. 2017 Jul;30(7):699-707.e1. doi: 10.1016/j.echo.2017.03.005. Epub 2017 May 10.

27.

Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.

Field JJ, Northcote PT, Paterson I, Altmann KH, Díaz JF, Miller JH.

Int J Mol Sci. 2017 May 3;18(5). pii: E971. doi: 10.3390/ijms18050971.

28.

The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR.

Bieri R, Scherr N, Ruf MT, Dangy JP, Gersbach P, Gehringer M, Altmann KH, Pluschke G.

ACS Chem Biol. 2017 May 19;12(5):1297-1307. doi: 10.1021/acschembio.7b00053. Epub 2017 Mar 27.

PMID:
28294596
29.

Translating clinical trials into clinical practice: a survey assessing the potential impact of the Pediatric Heart Network Infant Single Ventricle Trial.

Zak V, Hsu DT, Pemberton VL, Levine JC, Atz AM, Cnota JF, Ravishankar C, Barker P, Lambert LM, McCrindle BW, Frommelt MA, Altmann K, Chen S, Williams RV; Pediatric Heart Network Investigators.

Cardiol Young. 2017 Sep;27(7):1265-1270. doi: 10.1017/S104795111600295X. Epub 2017 Feb 10.

30.

Recent developments in natural product-based drug discovery for tuberculosis.

Dong M, Pfeiffer B, Altmann KH.

Drug Discov Today. 2017 Mar;22(3):585-591. doi: 10.1016/j.drudis.2016.11.015. Epub 2016 Nov 24. Review.

PMID:
27890820
31.

Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide.

Schneider G, Reker D, Chen T, Hauenstein K, Schneider P, Altmann KH.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12408-11. doi: 10.1002/anie.201605707. Epub 2016 Sep 8.

PMID:
27605391
32.

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).

Jantsch A, Nieto L, Gertsch J, Rodríguez-Salarichs J, Matesanz R, Jiménez-Barbero J, Díaz JF, Canales Á, Altmann KH.

Molecules. 2016 Aug 3;21(8). pii: E1010. doi: 10.3390/molecules21081010.

33.

Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans.

Dangy JP, Scherr N, Gersbach P, Hug MN, Bieri R, Bomio C, Li J, Huber S, Altmann KH, Pluschke G.

PLoS Negl Trop Dis. 2016 Jun 28;10(6):e0004808. doi: 10.1371/journal.pntd.0004808. eCollection 2016 Jun.

34.

Systolic-diastolic functional coupling in healthy children and in those with dilated cardiomyopathy.

Friedberg MK, Margossian R, Lu M, Mercer-Rosa L, Henderson HT, Nutting A, Friedman K, Molina KM, Altmann K, Canter C, Sleeper LA, Colan SD; Pediatric Heart Network Investigators.

J Appl Physiol (1985). 2016 Jun 1;120(11):1301-18. doi: 10.1152/japplphysiol.00635.2015. Epub 2016 Mar 3.

35.

Contradiction within wave optics and its solution within a particle picture: reply.

Altmann K.

Opt Express. 2016 Feb 8;24(3):2108. doi: 10.1364/OE.24.002108.

PMID:
26906786
36.

Muscle mass, strength and functional outcomes in critically ill patients after cardiothoracic surgery: does neuromuscular electrical stimulation help? The Catastim 2 randomized controlled trial.

Fischer A, Spiegl M, Altmann K, Winkler A, Salamon A, Themessl-Huber M, Mouhieddine M, Strasser EM, Schiferer A, Paternostro-Sluga T, Hiesmayr M.

Crit Care. 2016 Jan 29;20:30. doi: 10.1186/s13054-016-1199-3.

37.

Actin-binding doliculide causes premature senescence in p53 wild type cells.

Foerster F, Chen T, Altmann KH, Vollmar AM.

Bioorg Med Chem. 2016 Jan 15;24(2):123-9. doi: 10.1016/j.bmc.2015.11.042. Epub 2015 Nov 30.

PMID:
26692350
38.

Total Synthesis and Biological Assessment of Mandelalide A.

Brütsch TM, Bucher P, Altmann KH.

Chemistry. 2016 Jan 22;22(4):1292-300. doi: 10.1002/chem.201504230. Epub 2015 Dec 7.

PMID:
26639765
39.

Xenicane Natural Products: Biological Activity and Total Synthesis.

Betschart L, Altmann KH.

Curr Pharm Des. 2015;21(38):5467-88. Review.

PMID:
26429717
40.

High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells.

Pera B, Calvo-Vidal MN, Ambati S, Jordi M, Kahn A, Díaz JF, Fang W, Altmann KH, Cerchietti L, Moore MAS.

Cancer Lett. 2015 Nov 1;368(1):97-104. doi: 10.1016/j.canlet.2015.07.038. Epub 2015 Aug 12.

41.

Multidimensional Design of Anticancer Peptides.

Lin YC, Lim YF, Russo E, Schneider P, Bolliger L, Edenharter A, Altmann KH, Halin C, Hiss JA, Schneider G.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10370-4. doi: 10.1002/anie.201504018. Epub 2015 Jun 26.

PMID:
26119906
42.

Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor of Helicobacter Pylori HtrA.

Perna AM, Rodrigues T, Schmidt TP, Böhm M, Stutz K, Reker D, Pfeiffer B, Altmann KH, Backert S, Wessler S, Schneider G.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10244-8. doi: 10.1002/anie.201504035. Epub 2015 Jun 9.

43.
44.

Contradiction within wave optics and its solution within a particle picture.

Altmann K.

Opt Express. 2015 Feb 9;23(3):3731-50. doi: 10.1364/OE.23.003731.

PMID:
25836226
45.

Generation and identification of anti-inflammatory peptides from bovine β-casein using enzyme preparations from cod and hog.

Altmann K, Wutkowski A, Klempt M, Clawin-Rädecker I, Meisel H, Lorenzen PC.

J Sci Food Agric. 2016 Feb;96(3):868-77. doi: 10.1002/jsfa.7159. Epub 2015 Apr 23.

PMID:
25754585
46.

The reproducibility and absolute values of echocardiographic measurements of left ventricular size and function in children are algorithm dependent.

Margossian R, Chen S, Sleeper LA, Tani LY, Shirali G, Golding F, Selamet Tierney ES, Altmann K, Campbell MJ, Szwast A, Sharkey A, Radojewski E, Colan SD; Pediatric Heart Network Investigators.

J Am Soc Echocardiogr. 2015 May;28(5):549-558.e1. doi: 10.1016/j.echo.2015.01.014. Epub 2015 Feb 27.

47.

Total synthesis of the tiacumicin B (lipiarmycin A3/fidaxomicin) aglycone.

Glaus F, Altmann KH.

Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1937-40. doi: 10.1002/anie.201409510. Epub 2014 Dec 15.

PMID:
25510439
48.

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.

Prota AE, Bargsten K, Diaz JF, Marsh M, Cuevas C, Liniger M, Neuhaus C, Andreu JM, Altmann KH, Steinmetz MO.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21. doi: 10.1073/pnas.1408124111. Epub 2014 Aug 11.

49.

The impact of cyclopropane configuration on the biological activity of cyclopropyl-epothilones.

Gaugaz FZ, Redondo-Horcajo M, Barasoain I, Díaz JF, Cobos-Correa A, Kaufmann M, Altmann KH.

ChemMedChem. 2014 Oct;9(10):2227-32. doi: 10.1002/cmdc.201402129. Epub 2014 Jul 8.

PMID:
25045073
50.

The cytoskeleton and its interactions with small molecules.

Altmann KH.

Bioorg Med Chem. 2014 Sep 15;22(18):5038-9. doi: 10.1016/j.bmc.2014.06.037. Epub 2014 Jun 21. No abstract available.

PMID:
25023542

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