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Items: 1 to 50 of 481

1.

PharmGKB summary: lamotrigine pathway, pharmacokinetics and pharmacodynamics.

Mitra-Ghosh T, Callisto SP, Lamba JK, Remmel RP, Birnbaum AK, Barbarino JM, Klein TE, Altman RB.

Pharmacogenet Genomics. 2020 Mar 16. doi: 10.1097/FPC.0000000000000397. [Epub ahead of print] No abstract available.

PMID:
32187155
2.

Pharmacogenomics in Asian subpopulations and impacts on commonly prescribed medications.

Lo C, Nguyen S, Yang C, Witt L, Wen A, Liao TV, Nguyen J, Lin B, Altman RB, Palaniappan L.

Clin Transl Sci. 2020 Feb 26. doi: 10.1111/cts.12771. [Epub ahead of print] Review.

PMID:
32100936
3.

Elongation factor-Tu can repetitively engage aminoacyl-tRNA within the ribosome during the proofreading stage of tRNA selection.

Morse JC, Girodat D, Burnett BJ, Holm M, Altman RB, Sanbonmatsu KY, Wieden HJ, Blanchard SC.

Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3610-3620. doi: 10.1073/pnas.1904469117. Epub 2020 Feb 5.

4.

Wiring Minds.

Kaushal A, Altman RB.

Nature. 2019 Dec;576(7787):S62-S63. doi: 10.1038/d41586-019-03849-x. No abstract available.

PMID:
31853071
5.

PharmGKB summary: sertraline pathway, pharmacokinetics.

Huddart R, Hicks JK, Ramsey LB, Strawn JR, Smith DM, Bobonis Babilonia M, Altman RB, Klein TE.

Pharmacogenet Genomics. 2020 Feb;30(2):26-33. doi: 10.1097/FPC.0000000000000392. No abstract available.

PMID:
31851125
6.

PharmGKB summary: very important pharmacogene information for CACNA1S.

Sangkuhl K, Dirksen RT, Alvarellos ML, Altman RB, Klein TE.

Pharmacogenet Genomics. 2020 Feb;30(2):34-44. doi: 10.1097/FPC.0000000000000393. No abstract available.

PMID:
31851124
7.

Pathway and network embedding methods for prioritizing psychiatric drugs.

Pershad Y, Guo M, Altman RB.

Pac Symp Biocomput. 2020;25:671-682.

8.

PGxMine: Text mining for curation of PharmGKB.

Lever J, Barbarino JM, Gong L, Huddart R, Sangkuhl K, Whaley R, Whirl-Carrillo M, Woon M, Klein TE, Altman RB.

Pac Symp Biocomput. 2020;25:611-622.

9.

A Literature-Based Knowledge Graph Embedding Method for Identifying Drug Repurposing Opportunities in Rare Diseases.

Sosa DN, Derry A, Guo M, Wei E, Brinton C, Altman RB.

Pac Symp Biocomput. 2020;25:463-474.

10.

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins.

Morgens DW, Chan C, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Zhou J, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, Bassik MC.

Elife. 2019 Nov 1;8. pii: e48434. doi: 10.7554/eLife.48434.

11.

A deep learning framework to predict binding preference of RNA constituents on protein surface.

Lam JH, Li Y, Zhu L, Umarov R, Jiang H, Héliou A, Sheong FK, Liu T, Long Y, Li Y, Fang L, Altman RB, Chen W, Huang X, Gao X.

Nat Commun. 2019 Oct 30;10(1):4941. doi: 10.1038/s41467-019-12920-0.

12.

RedMed: Extending drug lexicons for social media applications.

Lavertu A, Altman RB.

J Biomed Inform. 2019 Nov;99:103307. doi: 10.1016/j.jbi.2019.103307. Epub 2019 Oct 15.

PMID:
31627020
13.

Predicting HLA class II antigen presentation through integrated deep learning.

Chen B, Khodadoust MS, Olsson N, Wagar LE, Fast E, Liu CL, Muftuoglu Y, Sworder BJ, Diehn M, Levy R, Davis MM, Elias JE, Altman RB, Alizadeh AA.

Nat Biotechnol. 2019 Nov;37(11):1332-1343. doi: 10.1038/s41587-019-0280-2. Epub 2019 Oct 14.

PMID:
31611695
14.

Atrial Fibrillation Burden Signature and Near-Term Prediction of Stroke: A Machine Learning Analysis.

Han L, Askari M, Altman RB, Schmitt SK, Fan J, Bentley JP, Narayan SM, Turakhia MP.

Circ Cardiovasc Qual Outcomes. 2019 Oct;12(10):e005595. doi: 10.1161/CIRCOUTCOMES.118.005595. Epub 2019 Oct 15.

PMID:
31610712
15.

Graph Convolutional Neural Networks for Predicting Drug-Target Interactions.

Torng W, Altman RB.

J Chem Inf Model. 2019 Oct 28;59(10):4131-4149. doi: 10.1021/acs.jcim.9b00628. Epub 2019 Oct 16.

PMID:
31580672
16.

Examining the Use of Real-World Evidence in the Regulatory Process.

Beaulieu-Jones BK, Finlayson SG, Yuan W, Altman RB, Kohane IS, Prasad V, Yu KH.

Clin Pharmacol Ther. 2020 Apr;107(4):843-852. doi: 10.1002/cpt.1658. Epub 2019 Nov 14. Review.

PMID:
31562770
17.

Pharmacogenomics Clinical Annotation Tool (PharmCAT).

Sangkuhl K, Whirl-Carrillo M, Whaley RM, Woon M, Lavertu A, Altman RB, Carter L, Verma A, Ritchie MD, Klein TE.

Clin Pharmacol Ther. 2020 Jan;107(1):203-210. doi: 10.1002/cpt.1568. Epub 2019 Sep 17.

18.

PathFXweb: a web application for identifying drug safety and efficacy phenotypes.

Wilson JL, Wong M, Chalke A, Stepanov N, Petkovic D, Altman RB.

Bioinformatics. 2019 Nov 1;35(21):4504-4506. doi: 10.1093/bioinformatics/btz419.

19.

High precision protein functional site detection using 3D convolutional neural networks.

Torng W, Altman RB.

Bioinformatics. 2019 May 1;35(9):1503-1512. doi: 10.1093/bioinformatics/bty813.

20.

Pharmacogenomics in dermatology: tools for understanding gene-drug associations.

Daneshjou R, Huddart R, Klein TE, Altman RB.

Semin Cutan Med Surg. 2019 Mar 1;38(1):E19-E24. doi: 10.12788/j.sder.2019.009. Review.

21.

PharmGKB summary: methylphenidate pathway, pharmacokinetics/pharmacodynamics.

Stevens T, Sangkuhl K, Brown JT, Altman RB, Klein TE.

Pharmacogenet Genomics. 2019 Aug;29(6):136-154. doi: 10.1097/FPC.0000000000000376. No abstract available.

PMID:
30950912
22.

Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site.

Lo YC, Cormier O, Liu T, Nettles KW, Katzenellenbogen JA, Stearns T, Altman RB.

Nat Commun. 2019 Mar 4;10(1):1033. doi: 10.1038/s41467-019-08965-w.

23.

Research Projects Supported by the University of California, San Francisco-Stanford Center of Excellence in Regulatory Science and Innovation.

Giacomini KM, Lin L, Altman RB.

Clin Pharmacol Ther. 2019 Apr;105(4):815-818. doi: 10.1002/cpt.1308. Epub 2019 Feb 17. No abstract available.

PMID:
30773618
24.

PharmGKB summary: Ondansetron and tropisetron pathways, pharmacokinetics and pharmacodynamics.

Huddart R, Altman RB, Klein TE.

Pharmacogenet Genomics. 2019 Jun;29(4):91-97. doi: 10.1097/FPC.0000000000000369. No abstract available.

PMID:
30672837
25.

The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression.

Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT.

J Neural Transm (Vienna). 2019 Jan;126(1):35-45. doi: 10.1007/s00702-018-01966-x. Epub 2019 Jan 4.

PMID:
30610379
26.

Standardized Biogeographic Grouping System for Annotating Populations in Pharmacogenetic Research.

Huddart R, Fohner AE, Whirl-Carrillo M, Wojcik GL, Gignoux CR, Popejoy AB, Bustamante CD, Altman RB, Klein TE.

Clin Pharmacol Ther. 2019 May;105(5):1256-1262. doi: 10.1002/cpt.1322. Epub 2019 Jan 21.

PMID:
30506572
27.

ERASE: a novel surface reconditioning strategy for single-molecule experiments.

Broadwater DWB, Altman RB, Blanchard SC, Kim HD.

Nucleic Acids Res. 2019 Feb 20;47(3):e14. doi: 10.1093/nar/gky1168.

28.

Essential Characteristics of Pharmacogenomics Study Publications.

Thorn CF, Whirl-Carrillo M, Hachad H, Johnson JA, McDonagh EM, Ratain MJ, Relling MV, Scott SA, Altman RB, Klein TE.

Clin Pharmacol Ther. 2019 Jan;105(1):86-91. doi: 10.1002/cpt.1279. Review.

29.

The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond.

Devchand PR, Liu T, Altman RB, FitzGerald GA, Schadt EE.

Front Pharmacol. 2018 Oct 4;9:1093. doi: 10.3389/fphar.2018.01093. eCollection 2018. Review.

30.

Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype.

Kurylo CM, Parks MM, Juette MF, Zinshteyn B, Altman RB, Thibado JK, Vincent CT, Blanchard SC.

Cell Rep. 2018 Oct 2;25(1):236-248.e6. doi: 10.1016/j.celrep.2018.08.093.

31.

Data-driven human transcriptomic modules determined by independent component analysis.

Zhou W, Altman RB.

BMC Bioinformatics. 2018 Sep 17;19(1):327. doi: 10.1186/s12859-018-2338-4.

32.

PharmGKB summary: oxycodone pathway, pharmacokinetics.

Huddart R, Clarke M, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Oct;28(10):230-237. doi: 10.1097/FPC.0000000000000351. No abstract available.

33.

PharmGKB summary: clozapine pathway, pharmacokinetics.

Thorn CF, Müller DJ, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Sep;28(9):214-222. doi: 10.1097/FPC.0000000000000347. No abstract available.

34.

Computational analysis of kinase inhibitor selectivity using structural knowledge.

Lo YC, Liu T, Morrissey KM, Kakiuchi-Kiyota S, Johnson AR, Broccatelli F, Zhong Y, Joshi A, Altman RB.

Bioinformatics. 2019 Jan 15;35(2):235-242. doi: 10.1093/bioinformatics/bty582.

35.

Machine learning in chemoinformatics and drug discovery.

Lo YC, Rensi SE, Torng W, Altman RB.

Drug Discov Today. 2018 Aug;23(8):1538-1546. doi: 10.1016/j.drudis.2018.05.010. Epub 2018 May 8. Review.

36.

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).

Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Déry JP, Gawaz M, Bliden K, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Simon T, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Hulot JS, Mitchell BD, Schwab M, Ritchie MD, Klein TE, Shuldiner AR; ICPC Investigators.

Am Heart J. 2018 Apr;198:152-159. doi: 10.1016/j.ahj.2017.12.010. Epub 2017 Dec 17. Review.

37.

Pharmacogenomics and big genomic data: from lab to clinic and back again.

Lavertu A, McInnes G, Daneshjou R, Whirl-Carrillo M, Klein TE, Altman RB.

Hum Mol Genet. 2018 May 1;27(R1):R72-R78. doi: 10.1093/hmg/ddy116. Review.

38.

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.

Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W.

Elife. 2018 Mar 21;7. pii: e34271. doi: 10.7554/eLife.34271.

39.

Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.

Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT.

Front Psychiatry. 2018 Mar 6;9:65. doi: 10.3389/fpsyt.2018.00065. eCollection 2018.

40.

PharmGKB summary: clobazam pathway, pharmacokinetics.

Huddart R, Leeder JS, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Apr;28(4):110-115. doi: 10.1097/FPC.0000000000000327. No abstract available.

41.

PharmGKB summary: atazanavir pathway, pharmacokinetics/pharmacodynamics.

Alvarellos M, Guillemette C, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 May;28(5):127-137. doi: 10.1097/FPC.0000000000000331. No abstract available.

42.

A global network of biomedical relationships derived from text.

Percha B, Altman RB.

Bioinformatics. 2018 Aug 1;34(15):2614-2624. doi: 10.1093/bioinformatics/bty114.

43.

Reversals and limitations on high-intensity, life-sustaining treatments.

Chavez G, Richman IB, Kaimal R, Bentley J, Yasukawa LA, Altman RB, Periyakoil VS, Chen JH.

PLoS One. 2018 Feb 28;13(2):e0190569. doi: 10.1371/journal.pone.0190569. eCollection 2018.

44.

PharmGKB: A worldwide resource for pharmacogenomic information.

Barbarino JM, Whirl-Carrillo M, Altman RB, Klein TE.

Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. doi: 10.1002/wsbm.1417. Epub 2018 Feb 23. Review.

45.

Mendelian Disease Associations Reveal Novel Insights into Inflammatory Bowel Disease.

Han L, Maciejewski M, Brockel C, Afzelius L, Altman RB.

Inflamm Bowel Dis. 2018 Feb 15;24(3):471-481. doi: 10.1093/ibd/izx087.

46.

Expanding a radiology lexicon using contextual patterns in radiology reports.

Percha B, Zhang Y, Bozkurt S, Rubin D, Altman RB, Langlotz CP.

J Am Med Inform Assoc. 2018 Jun 1;25(6):679-685. doi: 10.1093/jamia/ocx152.

47.

Systematic target function annotation of human transcription factors.

Li YF, Altman RB.

BMC Biol. 2018 Jan 10;16(1):4. doi: 10.1186/s12915-017-0469-0.

48.

Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development.

Wagner JA, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP.

Clin Transl Sci. 2018 Mar;11(2):166-174. doi: 10.1111/cts.12531. Epub 2017 Dec 22.

49.

A dynamic map for learning, communicating, navigating and improving therapeutic development.

Wagner J, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP.

Nat Rev Drug Discov. 2018 Feb;17(2):150. doi: 10.1038/nrd.2017.217. Epub 2017 Dec 22. No abstract available.

PMID:
29269942
50.

GeneDive: A gene interaction search and visualization tool to facilitate precision medicine.

Previde P, Thomas B, Wong M, Mallory EK, Petkovic D, Altman RB, Kulkarni A.

Pac Symp Biocomput. 2018;23:590-601.

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