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Items: 1 to 50 of 1126

1.

Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype.

Kurylo CM, Parks MM, Juette MF, Zinshteyn B, Altman RB, Thibado JK, Vincent CT, Blanchard SC.

Cell Rep. 2018 Oct 2;25(1):236-248.e6. doi: 10.1016/j.celrep.2018.08.093.

2.

Data-driven human transcriptomic modules determined by independent component analysis.

Zhou W, Altman RB.

BMC Bioinformatics. 2018 Sep 17;19(1):327. doi: 10.1186/s12859-018-2338-4.

3.

PharmGKB summary: oxycodone pathway, pharmacokinetics.

Huddart R, Clarke M, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Oct;28(10):230-237. doi: 10.1097/FPC.0000000000000351. No abstract available.

PMID:
30222708
4.

PharmGKB summary: clozapine pathway, pharmacokinetics.

Thorn CF, Müller DJ, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Sep;28(9):214-222. doi: 10.1097/FPC.0000000000000347. No abstract available.

PMID:
30134346
5.

Come Together: Molecular Details into the Synergistic Effects of Polymer-Surfactant Adsorption at the Oil/Water Interface.

Schabes BK, Altman RM, Richmond GL.

J Phys Chem B. 2018 Sep 13;122(36):8582-8590. doi: 10.1021/acs.jpcb.8b05432. Epub 2018 Sep 5.

PMID:
30113831
6.

A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta.

Hilt S, Altman R, Kálai T, Maezawa I, Gong Q, Wachsmann-Hogiu S, Jin LW, Voss JC.

Molecules. 2018 Aug 12;23(8). pii: E2010. doi: 10.3390/molecules23082010.

7.

Don't Neglect the Electrocardiogram: P-Wave Proves a Potent Predictor.

Steinberg JS, Altman RK.

JACC Clin Electrophysiol. 2018 Apr;4(4):544-546. doi: 10.1016/j.jacep.2018.01.005. No abstract available.

PMID:
30067495
8.

Computational Analysis of Kinase Inhibitor Selectivity using Structural Knowledge.

Lo YC, Liu T, Morrissey KM, Kakiuchi-Kiyota S, Johnson AR, Broccatelli F, Zhong Y, Joshi A, Altman RB.

Bioinformatics. 2018 Jul 9. doi: 10.1093/bioinformatics/bty582. [Epub ahead of print]

PMID:
29985971
9.

Is Intra-Articular Injection of Synvisc Associated with a Delay to Knee Arthroplasty in Patients with Knee Osteoarthritis?

Ong KL, Runa M, Lau E, Altman R.

Cartilage. 2018 May 1:1947603518775792. doi: 10.1177/1947603518775792. [Epub ahead of print]

PMID:
29779404
10.

Machine learning in chemoinformatics and drug discovery.

Lo YC, Rensi SE, Torng W, Altman RB.

Drug Discov Today. 2018 Aug;23(8):1538-1546. doi: 10.1016/j.drudis.2018.05.010. Epub 2018 May 8. Review.

11.

Obesity Impacts Swelling of Ankle and Foot Joints in Early Rheumatoid Arthritis Patients.

Ranganath VK, Duffy EL, Garg VK, Woodworth T, Taylor M, Paulus HE, Altman RD, Elashoff DA.

J Clin Rheumatol. 2018 Apr 16. doi: 10.1097/RHU.0000000000000799. [Epub ahead of print]

PMID:
29683839
12.

Emotional Responses to Suicidal Patients: Factor Structure, Construct, and Predictive Validity of the Therapist Response Questionnaire-Suicide Form.

Barzilay S, Yaseen ZS, Hawes M, Gorman B, Altman R, Foster A, Apter A, Rosenfield P, Galynker I.

Front Psychiatry. 2018 Apr 5;9:104. doi: 10.3389/fpsyt.2018.00104. eCollection 2018.

13.

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).

Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Déry JP, Gawaz M, Bliden K, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Simon T, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Hulot JS, Mitchell BD, Schwab M, Ritchie MD, Klein TE, Shuldiner AR; ICPC Investigators.

Am Heart J. 2018 Apr;198:152-159. doi: 10.1016/j.ahj.2017.12.010. Epub 2017 Dec 17.

PMID:
29653637
14.

Tyr1-ψ[( Z)CF═CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin.

Altman RA, Sharma KK, Rajewski LG, Toren PC, Baltezor MJ, Pal M, Karad SN.

ACS Chem Neurosci. 2018 Jul 18;9(7):1735-1742. doi: 10.1021/acschemneuro.8b00085. Epub 2018 Apr 19.

PMID:
29648788
15.

Pharmacogenomics and big genomic data: from lab to clinic and back again.

Lavertu A, McInnes G, Daneshjou R, Whirl-Carrillo M, Klein TE, Altman RB.

Hum Mol Genet. 2018 May 1;27(R1):R72-R78. doi: 10.1093/hmg/ddy116.

PMID:
29635477
16.

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.

Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W.

Elife. 2018 Mar 21;7. pii: e34271. doi: 10.7554/eLife.34271.

17.

Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.

Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT.

Front Psychiatry. 2018 Mar 6;9:65. doi: 10.3389/fpsyt.2018.00065. eCollection 2018.

18.

PharmGKB summary: clobazam pathway, pharmacokinetics.

Huddart R, Leeder JS, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Apr;28(4):110-115. doi: 10.1097/FPC.0000000000000327. No abstract available.

PMID:
29517622
19.

PharmGKB summary: atazanavir pathway, pharmacokinetics/pharmacodynamics.

Alvarellos M, Guillemette C, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 May;28(5):127-137. doi: 10.1097/FPC.0000000000000331. No abstract available.

PMID:
29517518
20.

Stepwise O-Atom Transfer in Heme-Based Tryptophan Dioxygenase: Role of Substrate Ammonium in Epoxide Ring Opening.

Shin I, Ambler BR, Wherritt D, Griffith WP, Maldonado AC, Altman RA, Liu A.

J Am Chem Soc. 2018 Mar 28;140(12):4372-4379. doi: 10.1021/jacs.8b00262. Epub 2018 Mar 15.

21.

Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: A systematic review.

Altman R, Hackel J, Niazi F, Shaw P, Nicholls M.

Semin Arthritis Rheum. 2018 Jan 31. pii: S0049-0172(17)30650-9. doi: 10.1016/j.semarthrit.2018.01.009. [Epub ahead of print] Review.

22.

A global network of biomedical relationships derived from text.

Percha B, Altman RB.

Bioinformatics. 2018 Aug 1;34(15):2614-2624. doi: 10.1093/bioinformatics/bty114.

23.

Reversals and limitations on high-intensity, life-sustaining treatments.

Chavez G, Richman IB, Kaimal R, Bentley J, Yasukawa LA, Altman RB, Periyakoil VS, Chen JH.

PLoS One. 2018 Feb 28;13(2):e0190569. doi: 10.1371/journal.pone.0190569. eCollection 2018.

24.

PharmGKB: A worldwide resource for pharmacogenomic information.

Barbarino JM, Whirl-Carrillo M, Altman RB, Klein TE.

Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. doi: 10.1002/wsbm.1417. Epub 2018 Feb 23. Review.

25.

Mendelian Disease Associations Reveal Novel Insights into Inflammatory Bowel Disease.

Han L, Maciejewski M, Brockel C, Afzelius L, Altman RB.

Inflamm Bowel Dis. 2018 Feb 15;24(3):471-481. doi: 10.1093/ibd/izx087.

PMID:
29462399
26.

Anti-Inflammatory Effects of Intra-Articular Hyaluronic Acid: A Systematic Review.

Altman R, Bedi A, Manjoo A, Niazi F, Shaw P, Mease P.

Cartilage. 2018 Feb 1:1947603517749919. doi: 10.1177/1947603517749919. [Epub ahead of print]

PMID:
29429372
27.

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.

Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29.

28.

Expanding a radiology lexicon using contextual patterns in radiology reports.

Percha B, Zhang Y, Bozkurt S, Rubin D, Altman RB, Langlotz CP.

J Am Med Inform Assoc. 2018 Jun 1;25(6):679-685. doi: 10.1093/jamia/ocx152.

PMID:
29329435
29.

Systematic target function annotation of human transcription factors.

Li YF, Altman RB.

BMC Biol. 2018 Jan 10;16(1):4. doi: 10.1186/s12915-017-0469-0.

30.

Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development.

Wagner JA, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP.

Clin Transl Sci. 2018 Mar;11(2):166-174. doi: 10.1111/cts.12531. Epub 2017 Dec 22.

31.

A dynamic map for learning, communicating, navigating and improving therapeutic development.

Wagner J, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP.

Nat Rev Drug Discov. 2018 Feb;17(2):150. doi: 10.1038/nrd.2017.217. Epub 2017 Dec 22. No abstract available.

PMID:
29269942
32.

Review of the Mechanism of Action for Supartz FX in Knee Osteoarthritis.

Altman RD, Dasa V, Takeuchi J.

Cartilage. 2018 Jan;9(1):11-20. doi: 10.1177/1947603516684588. Epub 2016 Dec 29. Review.

33.

GeneDive: A gene interaction search and visualization tool to facilitate precision medicine.

Previde P, Thomas B, Wong M, Mallory EK, Petkovic D, Altman RB, Kulkarni A.

Pac Symp Biocomput. 2018;23:590-601.

34.

Improving the explainability of Random Forest classifier - user centered approach.

Petkovic D, Altman R, Wong M, Vigil A.

Pac Symp Biocomput. 2018;23:204-215.

35.

Chemical reaction vector embeddings: towards predicting drug metabolism in the human gut microbiome.

Mallory EK, Acharya A, Rensi SE, Turnbaugh PJ, Bright RA, Altman RB.

Pac Symp Biocomput. 2018;23:56-67.

36.

Aminoglycoside interactions and impacts on the eukaryotic ribosome.

Prokhorova I, Altman RB, Djumagulov M, Shrestha JP, Urzhumtsev A, Ferguson A, Chang CT, Yusupov M, Blanchard SC, Yusupova G.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10899-E10908. doi: 10.1073/pnas.1715501114. Epub 2017 Dec 5.

37.

Biomarkers: Delivering on the expectation of molecularly driven, quantitative health.

Wilson JL, Altman RB.

Exp Biol Med (Maywood). 2018 Feb;243(3):313-322. doi: 10.1177/1535370217744775. Epub 2017 Dec 3. Review.

PMID:
29199461
38.

Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans.

Gottlieb A, Daneshjou R, DeGorter M, Bourgeois S, Svensson PJ, Wadelius M, Deloukas P, Montgomery SB, Altman RB.

Genome Med. 2017 Nov 24;9(1):98. doi: 10.1186/s13073-017-0495-0.

39.

Association of Omics Features with Histopathology Patterns in Lung Adenocarcinoma.

Yu KH, Berry GJ, Rubin DL, Ré C, Altman RB, Snyder M.

Cell Syst. 2017 Dec 27;5(6):620-627.e3. doi: 10.1016/j.cels.2017.10.014. Epub 2017 Nov 15.

PMID:
29153840
40.

Dynamics of P-type ATPase transport revealed by single-molecule FRET.

Dyla M, Terry DS, Kjaergaard M, Sørensen TL, Lauwring Andersen J, Andersen JP, Rohde Knudsen C, Altman RB, Nissen P, Blanchard SC.

Nature. 2017 Nov 16;551(7680):346-351. doi: 10.1038/nature24296. Epub 2017 Nov 8.

41.

Challenges for Training Translational Researchers in the Era of Ubiquitous Data.

Altman RB.

Clin Pharmacol Ther. 2018 Feb;103(2):171-173. doi: 10.1002/cpt.918. Epub 2017 Nov 14.

PMID:
29134624
42.

Should the force be with us?

Steinberg JS, Altman RK.

Heart Rhythm. 2018 Feb;15(2):209-210. doi: 10.1016/j.hrthm.2017.10.040. Epub 2017 Oct 28. No abstract available.

PMID:
29107698
43.

Letter to the Editor on "The AAHKS Clinical Research Award: What Are the Costs of Knee Osteoarthritis in the Year Prior to Total Knee Arthroplasty?"

Altman RD.

J Arthroplasty. 2018 Jan;33(1):305-306. doi: 10.1016/j.arth.2017.10.003. Epub 2017 Oct 10. No abstract available.

PMID:
29066247
44.

A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease.

Han L, Maciejewski M, Brockel C, Gordon W, Snapper SB, Korzenik JR, Afzelius L, Altman RB.

Bioinformatics. 2018 Mar 15;34(6):985-993. doi: 10.1093/bioinformatics/btx651.

45.

Practical considerations when analyzing discrete survival times using the grouped relative risk model.

Altman RM, Henrey A.

Lifetime Data Anal. 2018 Jul;24(3):532-547. doi: 10.1007/s10985-017-9410-7. Epub 2017 Oct 11.

PMID:
29022153
46.

Biological and functional relevance of CASP predictions.

Liu T, Ish-Shalom S, Torng W, Lafita A, Bock C, Mort M, Cooper DN, Bliven S, Capitani G, Mooney SD, Altman RB.

Proteins. 2018 Mar;86 Suppl 1:374-386. doi: 10.1002/prot.25396. Epub 2017 Oct 17.

47.

PharmGKB summary: very important pharmacogene information for ABCG2.

Fohner AE, Brackman DJ, Giacomini KM, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Nov;27(11):420-427. doi: 10.1097/FPC.0000000000000305. Review. No abstract available.

PMID:
28858993
48.

Shallow Representation Learning via Kernel PCA Improves QSAR Modelability.

Rensi SE, Altman RB.

J Chem Inf Model. 2017 Aug 28;57(8):1859-1867. doi: 10.1021/acs.jcim.6b00694. Epub 2017 Aug 7.

49.

PharmGKB summary: pazopanib pathway, pharmacokinetics.

Thorn CF, Sharma MR, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Aug;27(8):307-312. doi: 10.1097/FPC.0000000000000292. Review. No abstract available.

50.

Glucose consumption in carbohydrate mixtures by phosphotransferase-system mutants of Escherichia coli.

Xia T, Sriram N, Lee SA, Altman R, Urbauer JL, Altman E, Eiteman MA.

Microbiology. 2017 Jun;163(6):866-877. doi: 10.1099/mic.0.000480. Epub 2017 Jun 22.

PMID:
28640743

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