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Items: 9


The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis.

Althof N, Goetzke CC, Kespohl M, Voss K, Heuser A, Pinkert S, Kaya Z, Klingel K, Beling A.

EMBO Mol Med. 2018 Feb;10(2):200-218. doi: 10.15252/emmm.201708089.


Inhibition of chymotryptic-like standard proteasome activity exacerbates doxorubicin-induced cytotoxicity in primary cardiomyocytes.

Spur EM, Althof N, Respondek D, Klingel K, Heuser A, Overkleeft HS, Voigt A.

Toxicology. 2016 Apr 15;353-354:34-47. doi: 10.1016/j.tox.2016.04.010. Epub 2016 May 4.


Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity.

Gast M, Schroen B, Voigt A, Haas J, Kuehl U, Lassner D, Skurk C, Escher F, Wang X, Kratzer A, Michalik K, Papageorgiou A, Peters T, Loebel M, Wilk S, Althof N, Prasanth KV, Katus H, Meder B, Nakagawa S, Scheibenbogen C, Schultheiss HP, Landmesser U, Dimmeler S, Heymans S, Poller W.

J Mol Cell Biol. 2016 Apr;8(2):178-81. doi: 10.1093/jmcb/mjw003. Epub 2016 Jan 27. No abstract available.


The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3.

Paeschke A, Possehl A, Klingel K, Voss M, Voss K, Kespohl M, Sauter M, Overkleeft HS, Althof N, Garlanda C, Voigt A.

Eur J Immunol. 2016 Mar;46(3):619-33. doi: 10.1002/eji.201545892. Epub 2015 Dec 28.


Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy.

Rahnefeld A, Klingel K, Schuermann A, Diny NL, Althof N, Lindner A, Bleienheuft P, Savvatis K, Respondek D, Opitz E, Ketscher L, Sauter M, Seifert U, Tschöpe C, Poller W, Knobeloch KP, Voigt A.

Circulation. 2014 Oct 28;130(18):1589-600. doi: 10.1161/CIRCULATIONAHA.114.009847. Epub 2014 Aug 27.


In vivo ablation of type I interferon receptor from cardiomyocytes delays coxsackieviral clearance and accelerates myocardial disease.

Althof N, Harkins S, Kemball CC, Flynn CT, Alirezaei M, Whitton JL.

J Virol. 2014 May;88(9):5087-99. doi: 10.1128/JVI.00184-14. Epub 2014 Feb 26.


Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors.

Althof N, Whitton JL.

J Virol. 2013 Mar;87(5):2823-34. doi: 10.1128/JVI.03004-12. Epub 2012 Dec 26.


Inhibition of nuclear factor kappa B activation reduces Coxsackievirus B3 replication in lymphoid cells.

Sobotta K, Wilsky S, Althof N, Wiesener N, Wutzler P, Henke A.

Virus Res. 2012 Feb;163(2):495-502. doi: 10.1016/j.virusres.2011.11.014. Epub 2011 Nov 25.


Inhibition of fatty acid synthase by amentoflavone reduces coxsackievirus B3 replication.

Wilsky S, Sobotta K, Wiesener N, Pilas J, Althof N, Munder T, Wutzler P, Henke A.

Arch Virol. 2012 Feb;157(2):259-69. doi: 10.1007/s00705-011-1164-z. Epub 2011 Nov 11.


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