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Functional and structural comparison of the ABC exporter MsbA studied in detergent and reconstituted in nanodiscs.

Arana MR, Fiori MC, Altenberg GA.

Biochem Biophys Res Commun. 2019 May 7;512(3):448-452. doi: 10.1016/j.bbrc.2019.03.069. Epub 2019 Mar 20.


Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation.

Retamal MA, Orellana VP, Arévalo NJ, Rojas CG, Arjona RJ, Alcaíno CA, González W, Canan JG, Moraga-Amaro R, Stehberg J, Reuss L, Altenberg GA.

Nitric Oxide. 2019 May 1;86:54-62. doi: 10.1016/j.niox.2019.02.007. Epub 2019 Feb 21.


Inhibition of Connexin Hemichannels by New Amphiphilic Aminoglycosides without Antibiotic Activity.

AlFindee MN, Subedi YP, Fiori MC, Krishnan S, Kjellgren A, Altenberg GA, Chang CT.

ACS Med Chem Lett. 2018 Jun 19;9(7):697-701. doi: 10.1021/acsmedchemlett.8b00158. eCollection 2018 Jul 12.


Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria.

Fiori MC, Krishnan S, Kjellgren A, Cuello LG, Altenberg GA.

Molecules. 2017 Nov 25;22(12). pii: E2063. doi: 10.3390/molecules22122063.


Polymer Nanodiscs: Discoidal Amphiphilic Block Copolymer Membranes as a New Platform for Membrane Proteins.

Fiori MC, Jiang Y, Zheng W, Anzaldua M, Borgnia MJ, Altenberg GA, Liang H.

Sci Rep. 2017 Nov 9;7(1):15227. doi: 10.1038/s41598-017-15151-9.


ATP-binding Cassette Exporters: Structure and Mechanism with a Focus on P-glycoprotein and MRP1.

Arana MR, Altenberg GA.

Curr Med Chem. 2019;26(7):1062-1078. doi: 10.2174/0929867324666171012105143. Review.


Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer-associated P-glycoprotein during ATP hydrolysis.

Zoghbi ME, Mok L, Swartz DJ, Singh A, Fendley GA, Urbatsch IL, Altenberg GA.

J Biol Chem. 2017 Dec 15;292(50):20412-20424. doi: 10.1074/jbc.M117.814186. Epub 2017 Oct 9.


Luminescence resonance energy transfer spectroscopy of ATP-binding cassette proteins.

Zoghbi ME, Altenberg GA.

Biochim Biophys Acta Biomembr. 2018 Apr;1860(4):854-867. doi: 10.1016/j.bbamem.2017.08.005. Epub 2017 Aug 8. Review.


Polymer-encased nanodiscs with improved buffer compatibility.

Fiori MC, Jiang Y, Altenberg GA, Liang H.

Sci Rep. 2017 Aug 7;7(1):7432. doi: 10.1038/s41598-017-07110-1.


Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1).

Date SS, Fiori MC, Altenberg GA, Jansen M.

PLoS One. 2017 May 11;12(5):e0177572. doi: 10.1371/journal.pone.0177572. eCollection 2017.


A Cell-Based Assay to Assess Hemichannel Function.

Krishnan S, Fiori MC, Cuello LG, Altenberg GA.

Yale J Biol Med. 2017 Mar 29;90(1):87-95. eCollection 2017 Mar. Review.


An Escherichia coli-Based Assay to Assess the Function of Recombinant Human Hemichannels.

Krishnan S, Fiori MC, Whisenant TE, Cortes DM, Altenberg GA, Cuello LG.

SLAS Discov. 2017 Feb;22(2):135-143. doi: 10.1177/1087057116675321. Epub 2016 Oct 28.


Nucleotide dependence of the dimerization of ATP binding cassette nucleotide binding domains.

Fendley GA, Urbatsch IL, Sutton RB, Zoghbi ME, Altenberg GA.

Biochem Biophys Res Commun. 2016 Nov 11;480(2):268-272. doi: 10.1016/j.bbrc.2016.10.046. Epub 2016 Oct 17.


Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness.

Dalamon V, Fiori MC, Figueroa VA, Oliva CA, Del Rio R, Gonzalez W, Canan J, Elgoyhen AB, Altenberg GA, Retamal MA.

Pflugers Arch. 2016 May;468(5):909-18. doi: 10.1007/s00424-016-1788-7. Epub 2016 Jan 14.


The Lipid Bilayer Modulates the Structure and Function of an ATP-binding Cassette Exporter.

Zoghbi ME, Cooper RS, Altenberg GA.

J Biol Chem. 2016 Feb 26;291(9):4453-61. doi: 10.1074/jbc.M115.698498. Epub 2016 Jan 2.


Functional hemichannels formed by human connexin 26 expressed in bacteria.

Fiori MC, Krishnan S, Cortes DM, Retamal MA, Reuss L, Altenberg GA, Cuello LG.

Biosci Rep. 2015 Mar 18;35(2). pii: e00177. doi: 10.1042/BSR20140089.


Carbon monoxide (CO) is a novel inhibitor of connexin hemichannels.

León-Paravic CG, Figueroa VA, Guzmán DJ, Valderrama CF, Vallejos AA, Fiori MC, Altenberg GA, Reuss L, Retamal MA.

J Biol Chem. 2014 Dec 26;289(52):36150-7. doi: 10.1074/jbc.M114.602243. Epub 2014 Nov 10.


Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance.

Swartz DJ, Mok L, Botta SK, Singh A, Altenberg GA, Urbatsch IL.

Biosci Rep. 2014 Jun 25;34(3). pii: e00116. doi: 10.1042/BSR20140062.


Functional analysis and regulation of purified connexin hemichannels.

Fiori MC, Reuss L, Cuello LG, Altenberg GA.

Front Physiol. 2014 Feb 25;5:71. doi: 10.3389/fphys.2014.00071. eCollection 2014. Review.


ATP binding to two sites is necessary for dimerization of nucleotide-binding domains of ABC proteins.

Zoghbi ME, Altenberg GA.

Biochem Biophys Res Commun. 2014 Jan 3;443(1):97-102. doi: 10.1016/j.bbrc.2013.11.050. Epub 2013 Nov 19.


Hydrolysis at one of the two nucleotide-binding sites drives the dissociation of ATP-binding cassette nucleotide-binding domain dimers.

Zoghbi ME, Altenberg GA.

J Biol Chem. 2013 Nov 22;288(47):34259-65. doi: 10.1074/jbc.M113.500371. Epub 2013 Oct 15.


Association/dissociation of the nucleotide-binding domains of the ATP-binding cassette protein MsbA measured during continuous hydrolysis.

Cooper RS, Altenberg GA.

J Biol Chem. 2013 Jul 19;288(29):20785-96. doi: 10.1074/jbc.M113.477976. Epub 2013 May 30.


Permeation of calcium through purified connexin 26 hemichannels.

Fiori MC, Figueroa V, Zoghbi ME, Saéz JC, Reuss L, Altenberg GA.

J Biol Chem. 2012 Nov 23;287(48):40826-34. doi: 10.1074/jbc.M112.383281. Epub 2012 Oct 9.


Dissociation of ATP-binding cassette nucleotide-binding domain dimers into monomers during the hydrolysis cycle.

Zoghbi ME, Krishnan S, Altenberg GA.

J Biol Chem. 2012 Apr 27;287(18):14994-5000. doi: 10.1074/jbc.M112.340281. Epub 2012 Mar 8.


Kinetics of the association/dissociation cycle of an ATP-binding cassette nucleotide-binding domain.

Zoghbi ME, Fuson KL, Sutton RB, Altenberg GA.

J Biol Chem. 2012 Feb 3;287(6):4157-64. doi: 10.1074/jbc.M111.318378. Epub 2011 Dec 9.


A pyrene maleimide with a flexible linker for sampling of longer inter-thiol distances by excimer formation.

Niwayama S, Kassar AS, Zhao T, Sutton RB, Altenberg GA.

PLoS One. 2011;6(10):e26691. doi: 10.1371/journal.pone.0026691. Epub 2011 Oct 20.


Altered intracellular pH regulation in cells with high levels of P-glycoprotein expression.

Young G, Reuss L, Altenberg GA.

Int J Biochem Mol Biol. 2011;2(3):219-27. Epub 2010 Jun 3.


Biphasic effect of linoleic acid on connexin 46 hemichannels.

Retamal MA, Evangelista-Martínez F, León-Paravic CG, Altenberg GA, Reuss L.

Pflugers Arch. 2011 Jun;461(6):635-43. doi: 10.1007/s00424-011-0936-3. Epub 2011 Mar 1.


Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization.

Schalper KA, Sánchez HA, Lee SC, Altenberg GA, Nathanson MH, Sáez JC.

Am J Physiol Cell Physiol. 2010 Dec;299(6):C1504-15. doi: 10.1152/ajpcell.00015.2010. Epub 2010 Sep 29.


Voltage-dependent facilitation of Cx46 hemichannels.

Retamal MA, Yin S, Altenberg GA, Reuss L.

Am J Physiol Cell Physiol. 2010 Jan;298(1):C132-9. doi: 10.1152/ajpcell.00258.2009. Epub 2009 Nov 4.


Modulation of Cx46 hemichannels by nitric oxide.

Retamal MA, Yin S, Altenberg GA, Reuss L.

Am J Physiol Cell Physiol. 2009 Jun;296(6):C1356-63. doi: 10.1152/ajpcell.00054.2009. Epub 2009 Apr 8.


Molecular modeling and mutagenesis of gap junction channels.

Kovacs JA, Baker KA, Altenberg GA, Abagyan R, Yeager M.

Prog Biophys Mol Biol. 2007 May-Jun;94(1-2):15-28. Epub 2007 Mar 23. Review.


Change in permeant size selectivity by phosphorylation of connexin 43 gap-junctional hemichannels by PKC.

Bao X, Lee SC, Reuss L, Altenberg GA.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4919-24. Epub 2007 Mar 8.


The multidrug resistance protein P-glycoprotein and the regulation of chloride channels.

Altenberg GA.

Leuk Res. 2005 Sep;29(9):983-4. Epub 2005 Mar 16. No abstract available.


Mechanism of the defect in gap-junctional communication by expression of a connexin 26 mutant associated with dominant deafness.

Chen Y, Deng Y, Bao X, Reuss L, Altenberg GA.

FASEB J. 2005 Sep;19(11):1516-8. Epub 2005 Jul 11.


Membrane transport proteins with complete replacement of transmembrane helices with polyalanine sequences remain functional.

Bao X, Chen Y, Lee SH, Lee SC, Reuss L, Altenberg GA.

J Biol Chem. 2005 Mar 11;280(10):8647-50. Epub 2004 Dec 13.


Potentiation of effect of PKA stimulation of Xenopus CFTR by activation of PKC: role of NBD2.

Chen Y, Button B, Altenberg GA, Reuss L.

Am J Physiol Cell Physiol. 2004 Nov;287(5):C1436-44. Epub 2004 Jul 28.


Mechanism of activation of Xenopus CFTR by stimulation of PKC.

Chen Y, Altenberg GA, Reuss L.

Am J Physiol Cell Physiol. 2004 Nov;287(5):C1256-63. Epub 2004 Jun 30.


Regulation of purified and reconstituted connexin 43 hemichannels by protein kinase C-mediated phosphorylation of Serine 368.

Bao X, Reuss L, Altenberg GA.

J Biol Chem. 2004 May 7;279(19):20058-66. Epub 2004 Feb 17.


Structure of multidrug-resistance proteins of the ATP-binding cassette (ABC) superfamily.

Altenberg GA.

Curr Med Chem Anticancer Agents. 2004 Jan;4(1):53-62. Review.


Functional expression in Xenopus oocytes of gap-junctional hemichannels formed by a cysteine-less connexin 43.

Bao X, Chen Y, Reuss L, Altenberg GA.

J Biol Chem. 2004 Mar 12;279(11):9689-92. Epub 2003 Dec 14.


Mechanism of regulation of the gap junction protein connexin 43 by protein kinase C-mediated phosphorylation.

Bao X, Altenberg GA, Reuss L.

Am J Physiol Cell Physiol. 2004 Mar;286(3):C647-54. Epub 2003 Nov 5.


The engine of ABC proteins.

Altenberg GA.

News Physiol Sci. 2003 Oct;18:191-5. Review. No abstract available.


Nucleotide triphosphatase activity of the N-terminal nucleotide-binding domains of the multidrug resistance proteins P-glycoprotein and MRP1.

Wilkes DM, Wang C, Aristimuño PC, Castro AF, Altenberg GA.

Biochem Biophys Res Commun. 2002 Aug 16;296(2):388-94.


Cell-volume changes and ion conductances in amphibian gallbladder epithelium.

Reuss L, Vanoye CA, Altenberg GA, Vergara L, Subramaniam M, Torres R.

Cell Physiol Biochem. 2000;10(5-6):385-92. Review.


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