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Items: 1 to 50 of 70

1.

Gi- and Gs-coupled GPCRs show different modes of G-protein binding.

Van Eps N, Altenbach C, Caro LN, Latorraca NR, Hollingsworth SA, Dror RO, Ernst OP, Hubbell WL.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2383-2388. doi: 10.1073/pnas.1721896115. Epub 2018 Feb 20.

2.

Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1.

Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E172-E179. doi: 10.1073/pnas.1715464115. Epub 2017 Dec 26.

3.

Exploring Structure, Dynamics, and Topology of Nitroxide Spin-Labeled Proteins Using Continuous-Wave Electron Paramagnetic Resonance Spectroscopy.

Altenbach C, López CJ, Hideg K, Hubbell WL.

Methods Enzymol. 2015;564:59-100. doi: 10.1016/bs.mie.2015.08.006. Epub 2015 Sep 8.

PMID:
26477248
4.

High-Pressure EPR and Site-Directed Spin Labeling for Mapping Molecular Flexibility in Proteins.

Lerch MT, Yang Z, Altenbach C, Hubbell WL.

Methods Enzymol. 2015;564:29-57. doi: 10.1016/bs.mie.2015.07.004. Epub 2015 Sep 9.

PMID:
26477247
5.

Saturation Recovery EPR and Nitroxide Spin Labeling for Exploring Structure and Dynamics in Proteins.

Yang Z, Bridges M, Lerch MT, Altenbach C, Hubbell WL.

Methods Enzymol. 2015;564:3-27. doi: 10.1016/bs.mie.2015.07.016. Epub 2015 Aug 15.

PMID:
26477246
6.

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling.

Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK.

Cell. 2015 May 21;161(5):1101-1111. doi: 10.1016/j.cell.2015.04.043. Epub 2015 May 14. Erratum in: Cell. 2015 Sep 10;162(6):1431.

7.

Differential dynamics of extracellular and cytoplasmic domains in denatured States of rhodopsin.

Dutta A, Altenbach C, Mangahas S, Yanamala N, Gardner E, Hubbell WL, Klein-Seetharaman J.

Biochemistry. 2014 Nov 25;53(46):7160-9. doi: 10.1021/bi401557e. Epub 2014 Nov 10.

8.

High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population.

Schredelseker J, Paz A, López CJ, Altenbach C, Leung CS, Drexler MK, Chen JN, Hubbell WL, Abramson J.

J Biol Chem. 2014 May 2;289(18):12566-77. doi: 10.1074/jbc.M113.497438. Epub 2014 Mar 13.

9.

Self-association of arrestin family members.

Chen Q, Zhuo Y, Kim M, Hanson SM, Francis DJ, Vishnivetskiy SA, Altenbach C, Klug CS, Hubbell WL, Gurevich VV.

Handb Exp Pharmacol. 2014;219:205-23. doi: 10.1007/978-3-642-41199-1_11.

10.

Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants.

López CJ, Yang Z, Altenbach C, Hubbell WL.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4306-15. doi: 10.1073/pnas.1318754110. Epub 2013 Oct 28.

11.

Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant.

Song X, Seo J, Baameur F, Vishnivetskiy SA, Chen Q, Kook S, Kim M, Brooks EK, Altenbach C, Hong Y, Hanson SM, Palazzo MC, Chen J, Hubbell WL, Gurevich EV, Gurevich VV.

Cell Signal. 2013 Dec;25(12):2613-24. doi: 10.1016/j.cellsig.2013.08.022. Epub 2013 Sep 3.

12.

Technological advances in site-directed spin labeling of proteins.

Hubbell WL, López CJ, Altenbach C, Yang Z.

Curr Opin Struct Biol. 2013 Oct;23(5):725-33. doi: 10.1016/j.sbi.2013.06.008. Epub 2013 Jul 11. Review.

13.

Structure and dynamics of an imidazoline nitroxide side chain with strongly hindered internal motion in proteins.

Toledo Warshaviak D, Khramtsov VV, Cascio D, Altenbach C, Hubbell WL.

J Magn Reson. 2013 Jul;232:53-61. doi: 10.1016/j.jmr.2013.04.013. Epub 2013 Apr 30.

14.

Genetic analysis of captive spawning strategies for the endangered Rio Grande Silvery Minnow.

Osborne MJ, Perez TL, Altenbach CS, Turner TF.

J Hered. 2013 May-Jun;104(3):437-46. doi: 10.1093/jhered/est013. Epub 2013 Mar 21.

15.

Engineering visual arrestin-1 with special functional characteristics.

Vishnivetskiy SA, Chen Q, Palazzo MC, Brooks EK, Altenbach C, Iverson TM, Hubbell WL, Gurevich VV.

J Biol Chem. 2013 Feb 1;288(5):3394-405. doi: 10.1074/jbc.M112.445437. Epub 2012 Dec 17.

16.

Structural states and dynamics of the D-loop in actin.

Durer ZA, Kudryashov DS, Sawaya MR, Altenbach C, Hubbell W, Reisler E.

Biophys J. 2012 Sep 5;103(5):930-9.

17.

Site-directed spin labeling electron paramagnetic resonance study of the ORF1 protein from a mouse L1 retrotransposon.

Januszyk K, Fleissner MR, Atchabahian L, Shieh FK, Altenbach C, Martin SL, Guo F, Hubbell WL, Clubb RT.

Protein Sci. 2011 Jul;20(7):1231-43. doi: 10.1002/pro.651. Epub 2011 Jun 14.

18.

Site-directed spin labeling of a genetically encoded unnatural amino acid.

Fleissner MR, Brustad EM, Kálai T, Altenbach C, Cascio D, Peters FB, Hideg K, Peuker S, Schultz PG, Hubbell WL.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21637-42. doi: 10.1073/pnas.0912009106. Epub 2009 Dec 7. Erratum in: Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5693. Peuker, Sebastian [added].

19.

Effects of binding factors on structural elements in F-actin.

Scoville D, Stamm JD, Altenbach C, Shvetsov A, Kokabi K, Rubenstein PA, Hubbell WL, Reisler E.

Biochemistry. 2009 Jan 20;48(2):370-8. doi: 10.1021/bi801649j.

20.

High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation.

Altenbach C, Kusnetzow AK, Ernst OP, Hofmann KP, Hubbell WL.

Proc Natl Acad Sci U S A. 2008 May 27;105(21):7439-44. doi: 10.1073/pnas.0802515105. Epub 2008 May 19.

21.

Sugar binding induces an outward facing conformation of LacY.

Smirnova I, Kasho V, Choe JY, Altenbach C, Hubbell WL, Kaback HR.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16504-9. Epub 2007 Oct 9.

22.

Structure and function of the visual arrestin oligomer.

Hanson SM, Van Eps N, Francis DJ, Altenbach C, Vishnivetskiy SA, Arshavsky VY, Klug CS, Hubbell WL, Gurevich VV.

EMBO J. 2007 Mar 21;26(6):1726-36. Epub 2007 Mar 1.

23.

Hydrophobic loop dynamics and actin filament stability.

Scoville D, Stamm JD, Toledo-Warshaviak D, Altenbach C, Phillips M, Shvetsov A, Rubenstein PA, Hubbell WL, Reisler E.

Biochemistry. 2006 Nov 14;45(45):13576-84.

PMID:
17087511
24.

Conformational dynamics of loop 262-274 in G- and F-actin.

Shvetsov A, Stamm JD, Phillips M, Warshaviak D, Altenbach C, Rubenstein PA, Hideg K, Hubbell WL, Reisler E.

Biochemistry. 2006 May 23;45(20):6541-9.

PMID:
16700564
25.

Conformational states and dynamics of rhodopsin in micelles and bilayers.

Kusnetzow AK, Altenbach C, Hubbell WL.

Biochemistry. 2006 May 2;45(17):5538-50.

26.

Accessibility and dynamics of nitroxide side chains in T4 lysozyme measured by saturation recovery EPR.

Pyka J, Ilnicki J, Altenbach C, Hubbell WL, Froncisz W.

Biophys J. 2005 Sep;89(3):2059-68. Epub 2005 Jul 1.

27.

Accessibility of nitroxide side chains: absolute Heisenberg exchange rates from power saturation EPR.

Altenbach C, Froncisz W, Hemker R, McHaourab H, Hubbell WL.

Biophys J. 2005 Sep;89(3):2103-12. Epub 2005 Jul 1.

28.

Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge.

Kim JM, Altenbach C, Kono M, Oprian DD, Hubbell WL, Khorana HG.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12508-13. Epub 2004 Aug 11.

29.

Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking.

Hubbell WL, Altenbach C, Hubbell CM, Khorana HG.

Adv Protein Chem. 2003;63:243-90. Review. No abstract available.

PMID:
12629973
30.

A model for the structure of the Escherichia coli SOS-regulated UmuD2 protein.

Sutton MD, Guzzo A, Narumi I, Costanzo M, Altenbach C, Ferentz AE, Hubbell WL, Walker GC.

DNA Repair (Amst). 2002 Jan 22;1(1):77-93.

PMID:
12509298
31.

Arrangement of subunits and ordering of beta-strands in an amyloid sheet.

Serag AA, Altenbach C, Gingery M, Hubbell WL, Yeates TO.

Nat Struct Biol. 2002 Oct;9(10):734-9. Erratum in: Nat Struct Biol. 2003 Jan;10(1):70.

PMID:
12219081
32.

Site-directed spin labeling of a bacterial chemoreceptor reveals a dynamic, loosely packed transmembrane domain.

Barnakov A, Altenbach C, Barnakova L, Hubbell WL, Hazelbauer GL.

Protein Sci. 2002 Jun;11(6):1472-81.

35.

Estimation of inter-residue distances in spin labeled proteins at physiological temperatures: experimental strategies and practical limitations.

Altenbach C, Oh KJ, Trabanino RJ, Hideg K, Hubbell WL.

Biochemistry. 2001 Dec 25;40(51):15471-82.

PMID:
11747422
38.

Identification of a subunit interface in transthyretin amyloid fibrils: evidence for self-assembly from oligomeric building blocks.

Serag AA, Altenbach C, Gingery M, Hubbell WL, Yeates TO.

Biochemistry. 2001 Aug 7;40(31):9089-96.

PMID:
11478875
39.

Binding of spin-labeled galactosides to the lactose permease of Escherichia coli.

Zhao M, Kálai T, Hideg K, Altenbach C, Hubbell WL, Kaback HR.

Biochemistry. 2000 Sep 19;39(37):11381-8.

PMID:
10985783
40.

Identifying conformational changes with site-directed spin labeling.

Hubbell WL, Cafiso DS, Altenbach C.

Nat Struct Biol. 2000 Sep;7(9):735-9. Review.

PMID:
10966640
41.

Site-directed spin labeling of proteins. Applications to diphtheria toxin.

Oh KJ, Altenbach C, Collier RJ, Hubbell WL.

Methods Mol Biol. 2000;145:147-69. No abstract available.

PMID:
10820721
42.

Nitroxide scanning electron paramagnetic resonance of helices IV and V and the intervening loop in the lactose permease of Escherichia coli.

Zhao M, Zen KC, Hernandez-Borrell J, Altenbach C, Hubbell WL, Kaback HR.

Biochemistry. 1999 Nov 30;38(48):15970-7.

PMID:
10625464
43.

Side chain mobility and ligand interactions of the G strand of tear lipocalins by site-directed spin labeling.

Glasgow BJ, Gasymov OK, Abduragimov AR, Yusifov TN, Altenbach C, Hubbell WL.

Biochemistry. 1999 Oct 12;38(41):13707-16.

PMID:
10521278
44.

Conformation of the diphtheria toxin T domain in membranes: a site-directed spin-labeling study of the TH8 helix and TL5 loop.

Oh KJ, Zhan H, Cui C, Altenbach C, Hubbell WL, Collier RJ.

Biochemistry. 1999 Aug 10;38(32):10336-43.

PMID:
10441127
45.

Structure of the KcsA potassium channel from Streptomyces lividans: a site-directed spin labeling study of the second transmembrane segment.

Gross A, Columbus L, Hideg K, Altenbach C, Hubbell WL.

Biochemistry. 1999 Aug 10;38(32):10324-35.

PMID:
10441126
46.

Structural features and light-dependent changes in the sequence 59-75 connecting helices I and II in rhodopsin: a site-directed spin-labeling study.

Altenbach C, Klein-Seetharaman J, Hwa J, Khorana HG, Hubbell WL.

Biochemistry. 1999 Jun 22;38(25):7945-9.

PMID:
10387037
50.

Structural features of the C-terminal domain of bovine rhodopsin: a site-directed spin-labeling study.

Langen R, Cai K, Altenbach C, Khorana HG, Hubbell WL.

Biochemistry. 1999 Jun 22;38(25):7918-24.

PMID:
10387033

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