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The Effects of Genotype × Phenotype Interactions on Transcriptional Response to Silver Nanoparticle Toxicity in Organotypic Cultures of Murine Tracheal Epithelial Cells.

Nicholas TP, Haick AK, Bammler TK, Workman TW, Kavanagh TJ, Faustman EM, Gharib SA, Altemeier WA.

Toxicol Sci. 2019 Sep 28. pii: kfz209. doi: 10.1093/toxsci/kfz209. [Epub ahead of print]


Airway epithelium-shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling.

Altman MC, Lai Y, Nolin JD, Long S, Chen CC, Piliponsky AM, Altemeier WA, Larmore M, Frevert CW, Mulligan MS, Ziegler SF, Debley JS, Peters MC, Hallstrand TS.

J Clin Invest. 2019 Nov 1;129(11):4979-4991. doi: 10.1172/JCI126402.


The Effects of Gene × Environment Interactions on Silver Nanoparticle Toxicity in the Respiratory System.

Nicholas TP, Kavanagh TJ, Faustman EM, Altemeier WA.

Chem Res Toxicol. 2019 Jun 17;32(6):952-968. doi: 10.1021/acs.chemrestox.8b00234. Epub 2019 Jun 5.


Higher Plasma Endothelial Markers in Adults with Cystic Fibrosis Compared with Healthy Age-matched Control Subjects.

Bhatraju PK, Hisert KB, Aitken ML, Goss CH, Liles WC, Altemeier WA.

Ann Am Thorac Soc. 2019 Jun;16(6):768-771. doi: 10.1513/AnnalsATS.201812-844RL. No abstract available.


Quantum dots and mouse strain influence house dust mite-induced allergic airway disease.

Scoville DK, Nolin JD, Ogden HL, An D, Afsharinejad Z, Johnson BW, Bammler TK, Gao X, Frevert CW, Altemeier WA, Hallstrand TS, Kavanagh TJ.

Toxicol Appl Pharmacol. 2019 Apr 1;368:55-62. doi: 10.1016/j.taap.2019.01.018. Epub 2019 Jan 23.


Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia.

Mikacenic C, Moore R, Dmyterko V, West TE, Altemeier WA, Liles WC, Lood C.

Crit Care. 2018 Dec 27;22(1):358. doi: 10.1186/s13054-018-2290-8.


Quantum dot induced acute changes in lung mechanics are mouse strain dependent.

Scoville DK, White CC, Botta D, An D, Afsharinejad Z, Bammler TK, Gao X, Altemeier WA, Kavanagh TJ.

Inhal Toxicol. 2018 Aug - Aug;30(9-10):397-403. doi: 10.1080/08958378.2018.1542046. Epub 2018 Dec 7.


Function of secreted phospholipase A2 group-X in asthma and allergic disease.

Nolin JD, Murphy RC, Gelb MH, Altemeier WA, Henderson WR Jr, Hallstrand TS.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun;1864(6):827-837. doi: 10.1016/j.bbalip.2018.11.009. Epub 2018 Dec 5. Review.


Matrix metalloproteinase 28 is regulated by TRIF- and type I IFN-dependent signaling in macrophages.

Long ME, Gong KQ, Volk JS, Eddy WE, Chang MY, Frevert CW, Altemeier WA, Gale M Jr, Liles WC, Manicone AM.

Innate Immun. 2018 Aug;24(6):357-365. doi: 10.1177/1753425918791024. Epub 2018 Aug 1.


Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen.

Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS.

JCI Insight. 2017 Nov 2;2(21). pii: 94929. doi: 10.1172/jci.insight.94929.


Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs.

Chang MY, Kang I, Gale M Jr, Manicone AM, Kinsella MG, Braun KR, Wigmosta T, Parks WC, Altemeier WA, Wight TN, Frevert CW.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1069-L1086. doi: 10.1152/ajplung.00353.2017. Epub 2017 Sep 14.


Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice.

Scoville DK, Botta D, Galdanes K, Schmuck SC, White CC, Stapleton PL, Bammler TK, MacDonald JW, Altemeier WA, Hernandez M, Kleeberger SR, Chen LC, Gordon T, Kavanagh TJ.

FASEB J. 2017 Oct;31(10):4600-4611. doi: 10.1096/fj.201700187R. Epub 2017 Jul 17.


Matrix Metalloproteinase-28 Is a Key Contributor to Emphysema Pathogenesis.

Manicone AM, Gharib SA, Gong KQ, Eddy WE, Long ME, Frevert CW, Altemeier WA, Parks WC, Houghton AM.

Am J Pathol. 2017 Jun;187(6):1288-1300. doi: 10.1016/j.ajpath.2017.02.008. Epub 2017 Apr 8.


Transcriptional Signatures of Sleep Duration Discordance in Monozygotic Twins.

Watson NF, Buchwald D, Delrow JJ, Altemeier WA, Vitiello MV, Pack AI, Bamshad M, Noonan C, Gharib SA.

Sleep. 2017 Jan 1;40(1). doi: 10.1093/sleep/zsw019.


Lung pericyte-like cells are functional interstitial immune sentinel cells.

Hung CF, Mittelsteadt KL, Brauer R, McKinney BL, Hallstrand TS, Parks WC, Chen P, Schnapp LM, Liles WC, Duffield JS, Altemeier WA.

Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L556-L567. doi: 10.1152/ajplung.00349.2016. Epub 2017 Feb 10.


Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.

Leaf IA, Nakagawa S, Johnson BG, Cha JJ, Mittelsteadt K, Guckian KM, Gomez IG, Altemeier WA, Duffield JS.

J Clin Invest. 2017 Jan 3;127(1):321-334. doi: 10.1172/JCI87532. Epub 2016 Nov 21.


Ablation of Pericyte-Like Cells in Lungs by Oropharyngeal Aspiration of Diphtheria Toxin.

Hung CF, Chow YH, Liles WC, Altemeier WA, Schnapp LM.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):160-167. doi: 10.1165/rcmb.2016-0083MA.


The pulmonary inflammatory response to multiwalled carbon nanotubes is influenced by gender and glutathione synthesis.

Cartwright MM, Schmuck SC, Corredor C, Wang B, Scoville DK, Chisholm CR, Wilkerson HW, Afsharinejad Z, Bammler TK, Posner JD, Shutthanandan V, Baer DR, Mitra S, Altemeier WA, Kavanagh TJ.

Redox Biol. 2016 Oct;9:264-275. doi: 10.1016/j.redox.2016.08.009. Epub 2016 Aug 21.


Modified High-Molecular-Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance.

Gebe JA, Yadava K, Ruppert SM, Marshall P, Hill P, Falk BA, Sweere JM, Han H, Kaber G, Harten IA, Medina C, Mikecz K, Ziegler SF, Balaji S, Keswani SG, Perez VA, Butte MJ, Nadeau K, Altemeier WA, Fanger N, Bollyky PL.

Am J Respir Cell Mol Biol. 2017 Jan;56(1):109-120. doi: 10.1165/rcmb.2016-0111OC. Erratum in: Am J Respir Cell Mol Biol. 2017 Aug;57(2):259.


Identification of Epithelial Phospholipase A2 Receptor 1 as a Potential Target in Asthma.

Nolin JD, Ogden HL, Lai Y, Altemeier WA, Frevert CW, Bollinger JG, Naika GS, Kicic A, Stick SM, Lambeau G, Henderson WR Jr, Gelb MH, Hallstrand TS.

Am J Respir Cell Mol Biol. 2016 Dec;55(6):825-836.


Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma.

Hondowicz BD, An D, Schenkel JM, Kim KS, Steach HR, Krishnamurty AT, Keitany GJ, Garza EN, Fraser KA, Moon JJ, Altemeier WA, Masopust D, Pepper M.

Immunity. 2016 Jan 19;44(1):155-166. doi: 10.1016/j.immuni.2015.11.004. Epub 2015 Dec 29.



Gharib SA, Mar D, Bomsztyk K, Denisenko O, Dhanireddy S, Liles WC, Altemeier WA.

Shock. 2016 Feb;45(2):148-56. doi: 10.1097/SHK.0000000000000507. Erratum in: Shock. 2016 Apr;45(4):469. Shock. 2016 Feb 12;:.


Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils.

Hallstrand TS, Lai Y, Hooper KA, Oslund RC, Altemeier WA, Matute-Bello G, Gelb MH.

J Allergy Clin Immunol. 2016 Jan;137(1):268-277.e8. doi: 10.1016/j.jaci.2015.05.026. Epub 2015 Jun 30.


Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction.

Bomsztyk K, Mar D, An D, Sharifian R, Mikula M, Gharib SA, Altemeier WA, Liles WC, Denisenko O.

Crit Care. 2015 May 11;19:225. doi: 10.1186/s13054-015-0943-4.


CYR61 (CCN1) overexpression induces lung injury in mice.

Grazioli S, Gil S, An D, Kajikawa O, Farnand AW, Hanson JF, Birkland T, Chen P, Duffield J, Schnapp LM, Altemeier WA, Matute-Bello G.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L759-65. doi: 10.1152/ajplung.00190.2014. Epub 2015 Feb 20.


Management of Acute Myeloid Leukemia in the Intensive Care Setting.

Cowan AJ, Altemeier WA, Johnston C, Gernsheimer T, Becker PS.

J Intensive Care Med. 2015 Oct;30(7):375-84. doi: 10.1177/0885066614530959. Epub 2014 Apr 22. Review.


Airway epithelial regulation of pulmonary immune homeostasis and inflammation.

Hallstrand TS, Hackett TL, Altemeier WA, Matute-Bello G, Hansbro PM, Knight DA.

Clin Immunol. 2014 Mar;151(1):1-15. doi: 10.1016/j.clim.2013.12.003. Epub 2013 Dec 14. Review.


Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33.

Lai Y, Altemeier WA, Vandree J, Piliponsky AM, Johnson B, Appel CL, Frevert CW, Hyde DM, Ziegler SF, Smith DE, Henderson WR Jr, Gelb MH, Hallstrand TS.

J Allergy Clin Immunol. 2014 May;133(5):1448-55. doi: 10.1016/j.jaci.2013.08.052. Epub 2013 Nov 9.


Ischemia-reperfusion lung injury is attenuated in MyD88-deficient mice.

Altemeier WA, Liles WC, Villagra-Garcia A, Matute-Bello G, Glenny RW.

PLoS One. 2013 Oct 11;8(10):e77123. doi: 10.1371/journal.pone.0077123. eCollection 2013.


Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis.

Hung C, Linn G, Chow YH, Kobayashi A, Mittelsteadt K, Altemeier WA, Gharib SA, Schnapp LM, Duffield JS.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):820-30. doi: 10.1164/rccm.201212-2297OC.


TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury.

Campanholle G, Mittelsteadt K, Nakagawa S, Kobayashi A, Lin SL, Gharib SA, Heinecke JW, Hamerman JA, Altemeier WA, Duffield JS.

PLoS One. 2013 Jul 3;8(7):e68640. doi: 10.1371/journal.pone.0068640. Print 2013.


Role of cells and mediators in exercise-induced bronchoconstriction.

Hallstrand TS, Altemeier WA, Aitken ML, Henderson WR Jr.

Immunol Allergy Clin North Am. 2013 Aug;33(3):313-28, vii. doi: 10.1016/j.iac.2013.02.003. Epub 2013 Mar 29. Review.


Regulation and function of epithelial secreted phospholipase A2 group X in asthma.

Hallstrand TS, Lai Y, Altemeier WA, Appel CL, Johnson B, Frevert CW, Hudkins KL, Bollinger JG, Woodruff PG, Hyde DM, Henderson WR Jr, Gelb MH.

Am J Respir Crit Care Med. 2013 Jul 1;188(1):42-50. doi: 10.1164/rccm.201301-0084OC.


Epithelial regulation of eicosanoid production in asthma.

Hallstrand TS, Lai Y, Henderson WR Jr, Altemeier WA, Gelb MH.

Pulm Pharmacol Ther. 2012 Dec;25(6):432-7. Review.


Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells.

Gharib SA, Altemeier WA, Van Winkle LS, Plopper CG, Schlesinger SY, Buell CA, Brauer R, Lee V, Parks WC, Chen P.

Am J Respir Cell Mol Biol. 2013 Mar;48(3):390-6. doi: 10.1165/rcmb.2012-0083OC. Epub 2012 Dec 20.


Lipopolysaccharide-induced lung injury is independent of serum vitamin D concentration.

Klaff LS, Gill SE, Wisse BE, Mittelsteadt K, Matute-Bello G, Chen P, Altemeier WA.

PLoS One. 2012;7(11):e49076. doi: 10.1371/journal.pone.0049076. Epub 2012 Nov 19.


Fas-deficient mice have impaired alveolar neutrophil recruitment and decreased expression of anti-KC autoantibody:KC complexes in a model of acute lung injury.

Gil S, Farnand AW, Altemeier WA, Gill SE, Kurdowska A, Krupa A, Florence JM, Matute-Bello G.

Respir Res. 2012 Oct 9;13:91. doi: 10.1186/1465-9921-13-91.


Transmembrane and extracellular domains of syndecan-1 have distinct functions in regulating lung epithelial migration and adhesion.

Altemeier WA, Schlesinger SY, Buell CA, Brauer R, Rapraeger AC, Parks WC, Chen P.

J Biol Chem. 2012 Oct 12;287(42):34927-35. doi: 10.1074/jbc.M112.376814. Epub 2012 Aug 30.


Syndecan-1 controls cell migration by activating Rap1 to regulate focal adhesion disassembly.

Altemeier WA, Schlesinger SY, Buell CA, Parks WC, Chen P.

J Cell Sci. 2012 Nov 1;125(Pt 21):5188-95. doi: 10.1242/jcs.109884. Epub 2012 Aug 16.


Role of urokinase plasminogen activator receptor-associated protein in mouse lung.

Bundesmann MM, Wagner TE, Chow YH, Altemeier WA, Steinbach T, Schnapp LM.

Am J Respir Cell Mol Biol. 2012 Feb;46(2):233-9. doi: 10.1165/rcmb.2010-0485OC. Epub 2011 Sep 22.


Role of the Fas/FasL system in a model of RSV infection in mechanically ventilated mice.

van den Berg E, van Woensel JB, Bos AP, Bem RA, Altemeier WA, Gill SE, Martin TR, Matute-Bello G.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L451-60. doi: 10.1152/ajplung.00368.2010. Epub 2011 Jul 8.


Fas activation in alveolar epithelial cells induces KC (CXCL1) release by a MyD88-dependent mechanism.

Farnand AW, Eastman AJ, Herrero R, Hanson JF, Mongovin S, Altemeier WA, Matute-Bello G.

Am J Respir Cell Mol Biol. 2011 Sep;45(3):650-8. doi: 10.1165/rcmb.2010-0153OC. Epub 2011 Jan 21.


PKR-dependent CHOP induction limits hyperoxia-induced lung injury.

Lozon TI, Eastman AJ, Matute-Bello G, Chen P, Hallstrand TS, Altemeier WA.

Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L422-9. doi: 10.1152/ajplung.00166.2010. Epub 2010 Dec 24.


Mechanical ventilation modulates Toll-like receptor-3-induced lung inflammation via a MyD88-dependent, TLR4-independent pathway: a controlled animal study.

Chun CD, Liles WC, Frevert CW, Glenny RW, Altemeier WA.

BMC Pulm Med. 2010 Nov 19;10:57. doi: 10.1186/1471-2466-10-57.


Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X.

Lai Y, Oslund RC, Bollinger JG, Henderson WR Jr, Santana LF, Altemeier WA, Gelb MH, Hallstrand TS.

J Biol Chem. 2010 Dec 31;285(53):41491-500. doi: 10.1074/jbc.M110.153338. Epub 2010 Oct 25.


Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes.

Hallstrand TS, Wurfel MM, Lai Y, Ni Z, Gelb MH, Altemeier WA, Beyer RP, Aitken ML, Henderson WR.

PLoS One. 2010 Jan 5;5(1):e8583. doi: 10.1371/journal.pone.0008583.


Of mice and men: comparative proteomics of bronchoalveolar fluid.

Gharib SA, Nguyen E, Altemeier WA, Shaffer SA, Doneanu CE, Goodlett DR, Schnapp LM.

Eur Respir J. 2010 Jun;35(6):1388-95. doi: 10.1183/09031936.00089409. Epub 2009 Dec 23.


How can early, intensive training help a genetic disorder?

Altemeier WA, Altemeier LE.

Pediatr Ann. 2009 Mar;38(3):167-70, 172. Review.


Positive end-expiratory pressure alters the severity and spatial heterogeneity of ventilator-induced lung injury: an argument for cyclical airway collapse.

Sinclair SE, Chi E, Lin HI, Altemeier WA.

J Crit Care. 2009 Jun;24(2):206-11. doi: 10.1016/j.jcrc.2008.04.005. Epub 2008 Jul 21.

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