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Items: 1 to 50 of 81

1.

Feedback-Driven Assembly of the Axon Initial Segment.

Fréal A, Rai D, Tas RP, Pan X, Katrukha EA, van de Willige D, Stucchi R, Aher A, Yang C, Altelaar AFM, Vocking K, Post JA, Harterink M, Kapitein LC, Akhmanova A, Hoogenraad CC.

Neuron. 2019 Oct 23;104(2):305-321.e8. doi: 10.1016/j.neuron.2019.07.029. Epub 2019 Aug 29.

2.

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.

Vlaming H, McLean CM, Korthout T, Alemdehy MF, Hendriks S, Lancini C, Palit S, Klarenbeek S, Kwesi-Maliepaard EM, Molenaar TM, Hoekman L, Schmidlin TT, Altelaar AM, van Welsem T, Dannenberg JH, Jacobs H, van Leeuwen F.

EMBO J. 2019 Jul 15;38(14):e101564. doi: 10.15252/embj.2019101564. Epub 2019 Jun 17.

3.

MAP7 family proteins regulate kinesin-1 recruitment and activation.

Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes GJ, Peeters CAE, Katrukha EA, Ferrari L, Stucchi R, Verhagen DGF, van Riel WE, Grigoriev I, Altelaar AFM, Hoogenraad CC, Rüdiger SGD, Steinmetz MO, Kapitein LC, Akhmanova A.

J Cell Biol. 2019 Apr 1;218(4):1298-1318. doi: 10.1083/jcb.201808065. Epub 2019 Feb 15.

4.

Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites.

Stucchi R, Plucińska G, Hummel JJA, Zahavi EE, Guerra San Juan I, Klykov O, Scheltema RA, Altelaar AFM, Hoogenraad CC.

Cell Rep. 2018 Jul 17;24(3):685-700. doi: 10.1016/j.celrep.2018.06.071.

5.

A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells.

Ressa A, Bosdriesz E, de Ligt J, Mainardi S, Maddalo G, Prahallad A, Jager M, de la Fonteijne L, Fitzpatrick M, Groten S, Altelaar AFM, Bernards R, Cuppen E, Wessels L, Heck AJR.

Mol Cell Proteomics. 2018 Oct;17(10):1892-1908. doi: 10.1074/mcp.RA117.000486. Epub 2018 Jul 3.

6.

Actin from the apicomplexan Neospora caninum (NcACT) has different isoforms in 2D electrophoresis.

Baroni L, Pollo-Oliveira L, Heck AJ, Altelaar AM, Yatsuda AP.

Parasitology. 2019 Jan;146(1):33-41. doi: 10.1017/S0031182018000872. Epub 2018 Jun 6.

PMID:
29871709
7.

H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2.

Simonetta M, de Krijger I, Serrat J, Moatti N, Fortunato D, Hoekman L, Bleijerveld OB, Altelaar AFM, Jacobs JJL.

Cell Cycle. 2018;17(1):124-136. doi: 10.1080/15384101.2017.1404210. Epub 2018 Jan 2.

8.

Endogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis.

Stelloo S, Nevedomskaya E, Kim Y, Hoekman L, Bleijerveld OB, Mirza T, Wessels LFA, van Weerden WM, Altelaar AFM, Bergman AM, Zwart W.

Oncogene. 2018 Jan 18;37(3):313-322. doi: 10.1038/onc.2017.330. Epub 2017 Sep 18.

PMID:
28925401
9.

Erratum: Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.

Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Altelaar AFM, Heck AJR, Kammerer RA, Steinmetz MO, Akhmanova A.

Nat Cell Biol. 2017 Jun 29;19(7):873. doi: 10.1038/ncb3557.

PMID:
28659643
10.

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.

Brockmann M, Blomen VA, Nieuwenhuis J, Stickel E, Raaben M, Bleijerveld OB, Altelaar AFM, Jae LT, Brummelkamp TR.

Nature. 2017 Jun 8;546(7657):307-311. doi: 10.1038/nature22376. Epub 2017 May 31.

PMID:
28562590
11.

Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.

Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Altelaar AFM, Heck AJR, Kammerer RA, Steinmetz MO, Akhmanova A.

Nat Cell Biol. 2017 May;19(5):480-492. doi: 10.1038/ncb3511. Epub 2017 Apr 24. Erratum in: Nat Cell Biol. 2017 Jun 29;19(7):873.

12.

The atheroma plaque secretome stimulates the mobilization of endothelial progenitor cells ex vivo.

Vega FM, Gautier V, Fernandez-Ponce CM, Extremera MJ, Altelaar AFM, Millan J, Tellez JC, Hernandez-Campos JA, Conejero R, Bolivar J, Pardal R, Garcia-Cózar FJ, Aguado E, Heck AJR, Duran-Ruiz MC.

J Mol Cell Cardiol. 2017 Apr;105:12-23. doi: 10.1016/j.yjmcc.2017.02.001. Epub 2017 Feb 20.

PMID:
28223221
13.

Quantitative Map of Proteome Dynamics during Neuronal Differentiation.

Frese CK, Mikhaylova M, Stucchi R, Gautier V, Liu Q, Mohammed S, Heck AJR, Altelaar AFM, Hoogenraad CC.

Cell Rep. 2017 Feb 7;18(6):1527-1542. doi: 10.1016/j.celrep.2017.01.025.

14.

Opposite Electron-Transfer Dissociation and Higher-Energy Collisional Dissociation Fragmentation Characteristics of Proteolytic K/R(X)n and (X)nK/R Peptides Provide Benefits for Peptide Sequencing in Proteomics and Phosphoproteomics.

Tsiatsiani L, Giansanti P, Scheltema RA, van den Toorn H, Overall CM, Altelaar AF, Heck AJ.

J Proteome Res. 2017 Feb 3;16(2):852-861. doi: 10.1021/acs.jproteome.6b00825. Epub 2016 Dec 2.

PMID:
28111955
15.

Robust, Sensitive, and Automated Phosphopeptide Enrichment Optimized for Low Sample Amounts Applied to Primary Hippocampal Neurons.

Post H, Penning R, Fitzpatrick MA, Garrigues LB, Wu W, MacGillavry HD, Hoogenraad CC, Heck AJ, Altelaar AF.

J Proteome Res. 2017 Feb 3;16(2):728-737. doi: 10.1021/acs.jproteome.6b00753. Epub 2016 Dec 6.

PMID:
28107008
16.

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.

Niklasson M, Maddalo G, Sramkova Z, Mutlu E, Wee S, Sekyrova P, Schmidt L, Fritz N, Dehnisch I, Kyriatzis G, Krafcikova M, Carson BB, Feenstra JM, Marinescu VD, Segerman A, Haraldsson M, Gustavsson AL, Hammarström LG, Jenmalm Jensen A, Uhrbom L, Altelaar AF, Linnarsson S, Uhlén P, Trantirek L, Vincent CT, Nelander S, Enger PØ, Andäng M.

Cancer Res. 2017 Apr 1;77(7):1741-1752. doi: 10.1158/0008-5472.CAN-16-2274. Epub 2017 Jan 13.

17.

Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis.

Zuko A, Oguro-Ando A, Post H, Taggenbrock RL, van Dijk RE, Altelaar AF, Heck AJ, Petrenko AG, van der Zwaag B, Shimoda Y, Pasterkamp RJ, Burbach JP.

Front Mol Neurosci. 2016 Dec 15;9:143. doi: 10.3389/fnmol.2016.00143. eCollection 2016. Erratum in: Front Mol Neurosci. 2017 Jan 19;10 :6.

18.

Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1.

Vlaming H, Molenaar TM, van Welsem T, Poramba-Liyanage DW, Smith DE, Velds A, Hoekman L, Korthout T, Hendriks S, Altelaar AFM, van Leeuwen F.

Elife. 2016 Dec 6;5. pii: e18919. doi: 10.7554/eLife.18919.

19.

Quantitative Proteomics Illuminates a Functional Interaction between mDia2 and the Proteasome.

Isogai T, van der Kammen R, Bleijerveld OB, Goerdayal SS, Argenzio E, Altelaar AF, Innocenti M.

J Proteome Res. 2016 Dec 2;15(12):4624-4637. Epub 2016 Nov 7.

PMID:
27769112
20.

Molecular Pathway of Microtubule Organization at the Golgi Apparatus.

Wu J, de Heus C, Liu Q, Bouchet BP, Noordstra I, Jiang K, Hua S, Martin M, Yang C, Grigoriev I, Katrukha EA, Altelaar AFM, Hoogenraad CC, Qi RZ, Klumperman J, Akhmanova A.

Dev Cell. 2016 Oct 10;39(1):44-60. doi: 10.1016/j.devcel.2016.08.009. Epub 2016 Sep 22.

21.

Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.

Bouchet BP, Gough RE, Ammon YC, van de Willige D, Post H, Jacquemet G, Altelaar AM, Heck AJ, Goult BT, Akhmanova A.

Elife. 2016 Jul 13;5. pii: e18124. doi: 10.7554/eLife.18124.

22.

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.

Kemper K, Krijgsman O, Kong X, Cornelissen-Steijger P, Shahrabi A, Weeber F, van der Velden DL, Bleijerveld OB, Kuilman T, Kluin RJC, Sun C, Voest EE, Ju YS, Schumacher TNM, Altelaar AFM, McDermott U, Adams DJ, Blank CU, Haanen JB, Peeper DS.

Cell Rep. 2016 Jun 28;16(1):263-277. doi: 10.1016/j.celrep.2016.05.064. Epub 2016 Jun 16.

23.

Assessment of SRM, MRM(3) , and DIA for the targeted analysis of phosphorylation dynamics in non-small cell lung cancer.

Schmidlin T, Garrigues L, Lane CS, Mulder TC, van Doorn S, Post H, de Graaf EL, Lemeer S, Heck AJ, Altelaar AF.

Proteomics. 2016 Aug;16(15-16):2193-205. doi: 10.1002/pmic.201500453. Epub 2016 Jun 27.

PMID:
27219855
24.

Monitoring light/dark association dynamics of multi-protein complexes in cyanobacteria using size exclusion chromatography-based proteomics.

Guerreiro AC, Penning R, Raaijmakers LM, Axman IM, Heck AJ, Altelaar AF.

J Proteomics. 2016 Jun 16;142:33-44. doi: 10.1016/j.jprot.2016.04.030. Epub 2016 Apr 29.

PMID:
27142972
25.

Differential proteomics reveals the hallmarks of seed development in common bean (Phaseolus vulgaris L.).

Parreira JR, Bouraada J, Fitzpatrick MA, Silvestre S, Bernardes da Silva A, Marques da Silva J, Almeida AM, Fevereiro P, Altelaar AFM, Araújo SS.

J Proteomics. 2016 Jun 30;143:188-198. doi: 10.1016/j.jprot.2016.03.002. Epub 2016 Mar 3.

PMID:
26945737
26.

TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays.

van Beuningen SFB, Will L, Harterink M, Chazeau A, van Battum EY, Frias CP, Franker MAM, Katrukha EA, Stucchi R, Vocking K, Antunes AT, Slenders L, Doulkeridou S, Sillevis Smitt P, Altelaar AFM, Post JA, Akhmanova A, Pasterkamp RJ, Kapitein LC, de Graaff E, Hoogenraad CC.

Neuron. 2015 Dec 16;88(6):1208-1226. doi: 10.1016/j.neuron.2015.11.012. Epub 2015 Dec 6.

27.

Myc coordinates transcription and translation to enhance transformation and suppress invasiveness.

Elkon R, Loayza-Puch F, Korkmaz G, Lopes R, van Breugel PC, Bleijerveld OB, Altelaar AF, Wolf E, Lorenzin F, Eilers M, Agami R.

EMBO Rep. 2015 Dec;16(12):1723-36. doi: 10.15252/embr.201540717. Epub 2015 Nov 4.

28.

Diet-induced neuropeptide expression: feasibility of quantifying extended and highly charged endogenous peptide sequences by selected reaction monitoring.

Schmidlin T, Boender AJ, Frese CK, Heck AJ, Adan RA, Altelaar AF.

Anal Chem. 2015 Oct 6;87(19):9966-73. doi: 10.1021/acs.analchem.5b03334.

PMID:
26376940
29.

PhosphoPath: Visualization of Phosphosite-centric Dynamics in Temporal Molecular Networks.

Raaijmakers LM, Giansanti P, Possik PA, Mueller J, Peeper DS, Heck AJ, Altelaar AF.

J Proteome Res. 2015 Oct 2;14(10):4332-41. doi: 10.1021/acs.jproteome.5b00529. Epub 2015 Sep 8.

PMID:
26317507
30.

Signal Transduction Reaction Monitoring Deciphers Site-Specific PI3K-mTOR/MAPK Pathway Dynamics in Oncogene-Induced Senescence.

de Graaf EL, Kaplon J, Mohammed S, Vereijken LA, Duarte DP, Redondo Gallego L, Heck AJ, Peeper DS, Altelaar AF.

J Proteome Res. 2015 Jul 2;14(7):2906-14. doi: 10.1021/acs.jproteome.5b00236. Epub 2015 Jun 2.

PMID:
26011226
31.

Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

Stulemeijer IJ, De Vos D, van Harten K, Joshi OK, Blomberg O, van Welsem T, Terweij M, Vlaming H, de Graaf EL, Altelaar AF, Bakker BM, van Leeuwen F.

Sci Rep. 2015 May 12;5:9824. doi: 10.1038/srep09824.

32.

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division.

Gray AN, Egan AJ, Van't Veer IL, Verheul J, Colavin A, Koumoutsi A, Biboy J, Altelaar AF, Damen MJ, Huang KC, Simorre JP, Breukink E, den Blaauwen T, Typas A, Gross CA, Vollmer W.

Elife. 2015 May 7;4. doi: 10.7554/eLife.07118.

33.

Benchmarking multiple fragmentation methods on an orbitrap fusion for top-down phospho-proteoform characterization.

Brunner AM, Lössl P, Liu F, Huguet R, Mullen C, Yamashita M, Zabrouskov V, Makarov A, Altelaar AF, Heck AJ.

Anal Chem. 2015 Apr 21;87(8):4152-8. doi: 10.1021/acs.analchem.5b00162. Epub 2015 Apr 8.

PMID:
25803405
34.

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.

Vogel CJ, Smit MA, Maddalo G, Possik PA, Sparidans RW, van der Burg SH, Verdegaal EM, Heck AJ, Samatar AA, Beijnen JH, Altelaar AF, Peeper DS.

Pigment Cell Melanoma Res. 2015 May;28(3):307-17. doi: 10.1111/pcmr.12364. Epub 2015 Apr 6.

PMID:
25728708
35.

Proteomic analyses uncover a new function and mode of action for mouse homolog of Diaphanous 2 (mDia2).

Isogai T, van der Kammen R, Goerdayal SS, Heck AJ, Altelaar AF, Innocenti M.

Mol Cell Proteomics. 2015 Apr;14(4):1064-78. doi: 10.1074/mcp.M114.043885. Epub 2015 Feb 14.

36.

ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma.

Smit MA, Maddalo G, Greig K, Raaijmakers LM, Possik PA, van Breukelen B, Cappadona S, Heck AJ, Altelaar AF, Peeper DS.

Mol Syst Biol. 2014 Dec 23;10:772. doi: 10.15252/msb.20145450.

37.

Protein acetylation affects acetate metabolism, motility and acid stress response in Escherichia coli.

Castaño-Cerezo S, Bernal V, Post H, Fuhrer T, Cappadona S, Sánchez-Díaz NC, Sauer U, Heck AJ, Altelaar AF, Cánovas M.

Mol Syst Biol. 2014 Nov 27;10:762. doi: 10.15252/msb.20145227.

38.

Identification of putative substrates for the periplasmic chaperone YfgM in Escherichia coli using quantitative proteomics.

Götzke H, Muheim C, Altelaar AF, Heck AJ, Maddalo G, Daley DO.

Mol Cell Proteomics. 2015 Jan;14(1):216-26. doi: 10.1074/mcp.M114.043216. Epub 2014 Nov 17.

39.

Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo.

Vlaming H, van Welsem T, de Graaf EL, Ontoso D, Altelaar AF, San-Segundo PA, Heck AJ, van Leeuwen F.

EMBO Rep. 2014 Oct;15(10):1077-84. doi: 10.15252/embr.201438793. Epub 2014 Aug 20. Erratum in: EMBO Rep. 2014 Nov;15(11):1220-1.

40.

Similar is not the same: differences in the function of the (hemi-)cellulolytic regulator XlnR (Xlr1/Xyr1) in filamentous fungi.

Klaubauf S, Narang HM, Post H, Zhou M, Brunner K, Mach-Aigner AR, Mach RL, Heck AJR, Altelaar AFM, de Vries RP.

Fungal Genet Biol. 2014 Nov;72:73-81. doi: 10.1016/j.fgb.2014.07.007. Epub 2014 Jul 23.

PMID:
25064064
41.

Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence.

de Graaf EL, Kaplon J, Zhou H, Heck AJ, Peeper DS, Altelaar AF.

Mol Cell Proteomics. 2014 Aug;13(8):2089-100. doi: 10.1074/mcp.M113.035436. Epub 2014 Jun 24.

42.

Single-step enrichment by Ti4+-IMAC and label-free quantitation enables in-depth monitoring of phosphorylation dynamics with high reproducibility and temporal resolution.

de Graaf EL, Giansanti P, Altelaar AF, Heck AJ.

Mol Cell Proteomics. 2014 Sep;13(9):2426-34. doi: 10.1074/mcp.O113.036608. Epub 2014 May 21.

43.

Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.

Jiang K, Hua S, Mohan R, Grigoriev I, Yau KW, Liu Q, Katrukha EA, Altelaar AF, Heck AJ, Hoogenraad CC, Akhmanova A.

Dev Cell. 2014 Feb 10;28(3):295-309. doi: 10.1016/j.devcel.2014.01.001. Epub 2014 Jan 30.

44.

Unravelling the Neospora caninum secretome through the secreted fraction (ESA) and quantification of the discharged tachyzoite using high-resolution mass spectrometry-based proteomics.

Pollo-Oliveira L, Post H, Acencio ML, Lemke N, van den Toorn H, Tragante V, Heck AJ, Altelaar AF, Yatsuda AP.

Parasit Vectors. 2013 Nov 23;6(1):335. doi: 10.1186/1756-3305-6-335.

45.

Characterization of electron transfer dissociation in the Orbitrap Velos HCD cell.

Frese CK, Nolting D, Altelaar AF, Griep-Raming J, Mohammed S, Heck AJ.

J Am Soc Mass Spectrom. 2013 Nov;24(11):1663-70. doi: 10.1007/s13361-013-0618-9. Epub 2013 Apr 20.

PMID:
23605687
46.

Profiling of diet-induced neuropeptide changes in rat brain by quantitative mass spectrometry.

Frese CK, Boender AJ, Mohammed S, Heck AJ, Adan RA, Altelaar AF.

Anal Chem. 2013 May 7;85(9):4594-604. doi: 10.1021/ac400232y. Epub 2013 Apr 26.

PMID:
23581470
47.

A central role for TFIID in the pluripotent transcription circuitry.

Pijnappel WW, Esch D, Baltissen MP, Wu G, Mischerikow N, Bergsma AJ, van der Wal E, Han DW, Bruch Hv, Moritz S, Lijnzaad P, Altelaar AF, Sameith K, Zaehres H, Heck AJ, Holstege FC, Schöler HR, Timmers HT.

Nature. 2013 Mar 28;495(7442):516-9. doi: 10.1038/nature11970. Epub 2013 Mar 17.

PMID:
23503660
48.

Imaging mass spectrometry-based molecular histology differentiates microscopically identical and heterogeneous tumors.

Jones EA, Schmitz N, Waaijer CJ, Frese CK, van Remoortere A, van Zeijl RJ, Heck AJ, Hogendoorn PC, Deelder AM, Altelaar AF, Bovée JV, McDonnell LA.

J Proteome Res. 2013 Apr 5;12(4):1847-55. doi: 10.1021/pr301190g. Epub 2013 Mar 25.

PMID:
23480610
49.

Deletion of flbA results in increased secretome complexity and reduced secretion heterogeneity in colonies of Aspergillus niger.

Krijgsheld P, Nitsche BM, Post H, Levin AM, Müller WH, Heck AJ, Ram AF, Altelaar AF, Wösten HA.

J Proteome Res. 2013 Apr 5;12(4):1808-19. doi: 10.1021/pr301154w. Epub 2013 Mar 22.

PMID:
23461488
50.

Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway.

Meijer LA, Zhou H, Chan OY, Altelaar AF, Hennrich ML, Mohammed S, Bos JL, Heck AJ.

Mol Biosyst. 2013 Apr 5;9(4):732-49. doi: 10.1039/c3mb25524g.

PMID:
23403867

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