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Items: 1 to 50 of 114

1.

Clinical Utility of Combinatorial Pharmacogenomics-Guided Antidepressant Therapy: Evidence from Three Clinical Studies.

Altar CA, Carhart J, Allen JD, Hall-Flavin D, Winner J, Dechairo B.

Mol Neuropsychiatry. 2015 Oct;1(3):145-55. doi: 10.1159/000430915. Epub 2015 Jul 31.

2.

Combinatorial pharmacogenomic guidance for psychiatric medications reduces overall pharmacy costs in a 1 year prospective evaluation.

Winner JG, Carhart JM, Altar CA, Goldfarb S, Allen JD, Lavezzari G, Parsons KK, Marshak AG, Garavaglia S, Dechairo BM.

Curr Med Res Opin. 2015;31(9):1633-43. doi: 10.1185/03007995.2015.1063483. Epub 2015 Jul 23.

PMID:
26086890
3.

Clinical validity: Combinatorial pharmacogenomics predicts antidepressant responses and healthcare utilizations better than single gene phenotypes.

Altar CA, Carhart JM, Allen JD, Hall-Flavin DK, Dechairo BM, Winner JG.

Pharmacogenomics J. 2015 Oct;15(5):443-51. doi: 10.1038/tpj.2014.85. Epub 2015 Feb 17.

PMID:
25686762
4.

A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996-2013.

Mrazek DA, Hornberger JC, Altar CA, Degtiar I.

Psychiatr Serv. 2014 Aug 1;65(8):977-87. doi: 10.1176/appi.ps.201300059. Review.

PMID:
24789696
5.
6.

Clinical validity of cytochrome P450 metabolism and serotonin gene variants in psychiatric pharmacotherapy.

Altar CA, Hornberger J, Shewade A, Cruz V, Garrison J, Mrazek D.

Int Rev Psychiatry. 2013 Oct;25(5):509-33. doi: 10.3109/09540261.2013.825579. Review.

PMID:
24151799
7.

The social and economic burden of treatment-resistant schizophrenia: a systematic literature review.

Kennedy JL, Altar CA, Taylor DL, Degtiar I, Hornberger JC.

Int Clin Psychopharmacol. 2014 Mar;29(2):63-76. doi: 10.1097/YIC.0b013e32836508e6. Review.

PMID:
23995856
8.

Psychiatric pharmacogenomics predicts health resource utilization of outpatients with anxiety and depression.

Winner J, Allen JD, Altar CA, Spahic-Mihajlovic A.

Transl Psychiatry. 2013 Mar 19;3:e242. doi: 10.1038/tp.2013.2.

9.

The prefrontal cortex influence over subcortical and limbic regions governs antidepressant response by N=H/(M+R).

Salerian AJ, Altar CA.

Psychiatry Res. 2012 Oct 30;204(1):1-12. doi: 10.1016/j.pscychresns.2012.04.019. Epub 2012 Sep 28. Review.

PMID:
23022274
10.

Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism.

Giorgetti M, Gibbons JA, Bernales S, Alfaro IE, Drieu La Rochelle C, Cremers T, Altar CA, Wronski R, Hutter-Paier B, Protter AA.

J Pharmacol Exp Ther. 2010 Jun;333(3):748-57. doi: 10.1124/jpet.109.164491. Epub 2010 Mar 1.

PMID:
20194526
11.

Insulin, IGF-1, and muscarinic agonists modulate schizophrenia-associated genes in human neuroblastoma cells.

Altar CA, Hunt RA, Jurata LW, Webster MJ, Derby E, Gallagher P, Lemire A, Brockman J, Laeng P.

Biol Psychiatry. 2008 Dec 15;64(12):1077-87. doi: 10.1016/j.biopsych.2008.08.031. Epub 2008 Oct 30.

PMID:
18973876
12.

Target identification for CNS diseases by transcriptional profiling.

Altar CA, Vawter MP, Ginsberg SD.

Neuropsychopharmacology. 2009 Jan;34(1):18-54. doi: 10.1038/npp.2008.172. Epub 2008 Oct 15. Review.

13.

The Biomarkers Consortium: on the critical path of drug discovery.

Altar CA.

Clin Pharmacol Ther. 2008 Feb;83(2):361-4. doi: 10.1038/sj.clpt.6100471. Epub 2008 Jan 9.

PMID:
18183037
14.

A prototypical process for creating evidentiary standards for biomarkers and diagnostics.

Altar CA, Amakye D, Bounos D, Bloom J, Clack G, Dean R, Devanarayan V, Fu D, Furlong S, Hinman L, Girman C, Lathia C, Lesko L, Madani S, Mayne J, Meyer J, Raunig D, Sager P, Williams SA, Wong P, Zerba K.

Clin Pharmacol Ther. 2008 Feb;83(2):368-71. Epub 2007 Dec 19.

PMID:
18091762
15.

Altered expression of hippocampal dentate granule neuron genes in a mouse model of human 22q11 deletion syndrome.

Jurata LW, Gallagher P, Lemire AL, Charles V, Brockman JA, Illingworth EL, Altar CA.

Schizophr Res. 2006 Dec;88(1-3):251-9. Epub 2006 Sep 26.

PMID:
17008057
16.

Aripiprazole blocks reinstatement of cocaine seeking in an animal model of relapse.

Feltenstein MW, Altar CA, See RE.

Biol Psychiatry. 2007 Mar 1;61(5):582-90. Epub 2006 Jun 27.

PMID:
16806092
17.

Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts.

Altar CA, Jurata LW, Charles V, Lemire A, Liu P, Bukhman Y, Young TA, Bullard J, Yokoe H, Webster MJ, Knable MB, Brockman JA.

Biol Psychiatry. 2005 Jul 15;58(2):85-96.

PMID:
16038679
18.

Increased adult hippocampal brain-derived neurotrophic factor and normal levels of neurogenesis in maternal separation rats.

Greisen MH, Altar CA, Bolwig TG, Whitehead R, Wörtwein G.

J Neurosci Res. 2005 Mar 15;79(6):772-8.

PMID:
15690366
19.

The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells.

Laeng P, Pitts RL, Lemire AL, Drabik CE, Weiner A, Tang H, Thyagarajan R, Mallon BS, Altar CA.

J Neurochem. 2004 Oct;91(1):238-51.

20.

Mechanism of action of aripiprazole predicts clinical efficacy and a favourable side-effect profile.

Hirose T, Uwahodo Y, Yamada S, Miwa T, Kikuchi T, Kitagawa H, Burris KD, Altar CA, Nabeshima T.

J Psychopharmacol. 2004 Sep;18(3):375-83.

PMID:
15358981
21.

Comparison of microarray-based mRNA profiling technologies for identification of psychiatric disease and drug signatures.

Jurata LW, Bukhman YV, Charles V, Capriglione F, Bullard J, Lemire AL, Mohammed A, Pham Q, Laeng P, Brockman JA, Altar CA.

J Neurosci Methods. 2004 Sep 30;138(1-2):173-88.

PMID:
15325126
22.

Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways.

Altar CA, Laeng P, Jurata LW, Brockman JA, Lemire A, Bullard J, Bukhman YV, Young TA, Charles V, Palfreyman MG.

J Neurosci. 2004 Mar 17;24(11):2667-77.

23.

In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function.

Jordan S, Koprivica V, Dunn R, Tottori K, Kikuchi T, Altar CA.

Eur J Pharmacol. 2004 Jan 1;483(1):45-53.

PMID:
14709325
24.

Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain.

Altar CA, Whitehead RE, Chen R, Wörtwein G, Madsen TM.

Biol Psychiatry. 2003 Oct 1;54(7):703-9.

PMID:
14512210
25.

Diminished catalepsy and dopamine metabolism distinguish aripiprazole from haloperidol or risperidone.

Nakai S, Hirose T, Uwahodo Y, Imaoka T, Okazaki H, Miwa T, Nakai M, Yamada S, Dunn B, Burris KD, Molinoff PB, Tottori K, Altar CA, Kikuchi T.

Eur J Pharmacol. 2003 Jul 4;472(1-2):89-97.

PMID:
12860477
26.

Novel directions in antipsychotic target identification using gene arrays.

Palfreyman MG, Hook DJ, Klimczak LJ, Brockman JA, Evans DM, Altar CA.

Curr Drug Targets CNS Neurol Disord. 2002 Apr;1(2):227-38. Review.

PMID:
12769629
27.

The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor.

Jordan S, Koprivica V, Chen R, Tottori K, Kikuchi T, Altar CA.

Eur J Pharmacol. 2002 Apr 26;441(3):137-40.

PMID:
12063084
28.

Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation.

Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, Kambayashi J, Sun B, Tandon NN.

Thromb Haemost. 2002 Apr;87(4):728-34.

PMID:
12008958
30.

Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury.

Calingasan NY, Erdely HA, Altar CA.

Neurobiol Aging. 2002 Jan-Feb;23(1):31-9.

PMID:
11755016
31.

Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523.

Tottori K, Miwa T, Uwahodo Y, Yamada S, Nakai M, Oshiro Y, Kikuchi T, Altar CA.

Neuropharmacology. 2001 Dec;41(8):976-88.

PMID:
11747902
32.

Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor.

Nakahashi T, Fujimura H, Altar CA, Li J, Kambayashi J, Tandon NN, Sun B.

FEBS Lett. 2000 Mar 24;470(2):113-7.

33.

BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain.

Mamounas LA, Altar CA, Blue ME, Kaplan DR, Tessarollo L, Lyons WE.

J Neurosci. 2000 Jan 15;20(2):771-82.

34.

Neurotrophins and depression.

Altar CA.

Trends Pharmacol Sci. 1999 Feb;20(2):59-61. Review.

PMID:
10101965
35.

Neurotrophin trafficking by anterograde transport.

Altar CA, DiStefano PS.

Trends Neurosci. 1998 Oct;21(10):433-7. Review.

PMID:
9786341
36.
37.
38.

Anterograde transport of brain-derived neurotrophic factor and its role in the brain.

Altar CA, Cai N, Bliven T, Juhasz M, Conner JM, Acheson AL, Lindsay RM, Wiegand SJ.

Nature. 1997 Oct 23;389(6653):856-60.

PMID:
9349818
39.
40.

Effects of BDNF and NT-4/5 on striatonigral neuropeptides or nigral GABA neurons in vivo.

Arenas E, Akerud P, Wong V, Boylan C, Persson H, Lindsay RM, Altar CA.

Eur J Neurosci. 1996 Aug;8(8):1707-17.

PMID:
8921261
42.

Local infusion of brain-derived neurotrophic factor modifies the firing pattern of dorsal raphé serotonergic neurons.

Celada P, Siuciak JA, Tran TM, Altar CA, Tepper JM.

Brain Res. 1996 Mar 18;712(2):293-8.

PMID:
8814905
43.

Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration.

Galpern WR, Frim DM, Tatter SB, Altar CA, Beal MF, Isacson O.

Cell Transplant. 1996 Mar-Apr;5(2):225-32.

PMID:
8689033
44.

BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration.

Siuciak JA, Boylan C, Fritsche M, Altar CA, Lindsay RM.

Brain Res. 1996 Feb 26;710(1-2):11-20.

PMID:
8963648
45.

A continuous striatal infusion of 6-hydroxydopamine produces a terminal axotomy and delayed behavioral effects.

Jones BE, Boylan CB, Fritsche M, Juhasz M, Jackson C, Wiegand SJ, Hyman C, Lindsay RM, Altar CA.

Brain Res. 1996 Feb 19;709(2):275-84.

PMID:
8833764
46.
47.

Neurotrophin-4/5 maintains the cholinergic phenotype of axotomized septal neurons.

Alderson RF, Wiegand SJ, Anderson KD, Cai N, Cho JY, Lindsay RM, Altar CA.

Eur J Neurosci. 1996 Feb;8(2):282-90.

PMID:
8714699
48.

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain.

Mamounas LA, Blue ME, Siuciak JA, Altar CA.

J Neurosci. 1995 Dec;15(12):7929-39.

49.

Differential distribution of exogenous BDNF, NGF, and NT-3 in the brain corresponds to the relative abundance and distribution of high-affinity and low-affinity neurotrophin receptors.

Anderson KD, Alderson RF, Altar CA, DiStefano PS, Corcoran TL, Lindsay RM, Wiegand SJ.

J Comp Neurol. 1995 Jun 26;357(2):296-317.

PMID:
7665731
50.

BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine.

Shults CW, Kimber T, Altar CA.

Neuroreport. 1995 May 30;6(8):1109-12.

PMID:
7662888

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