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Items: 49


Critical slowing down in biochemical networks with feedback.

Byrd TA, Erez A, Vogel RM, Peterson C, Vennettilli M, Altan-Bonnet G, Mugler A.

Phys Rev E. 2019 Aug;100(2-1):022415. doi: 10.1103/PhysRevE.100.022415.


TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors.

Guerin MV, Regnier F, Feuillet V, Vimeux L, Weiss JM, Bismuth G, Altan-Bonnet G, Guilbert T, Thoreau M, Finisguerra V, Donnadieu E, Trautmann A, Bercovici N.

Nat Commun. 2019 Sep 11;10(1):4131. doi: 10.1038/s41467-019-11998-w.


IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus.

Hemmers S, Schizas M, Azizi E, Dikiy S, Zhong Y, Feng Y, Altan-Bonnet G, Rudensky AY.

J Exp Med. 2019 Aug 21. pii: jem.20190993. doi: 10.1084/jem.20190993. [Epub ahead of print]


Monocyte recruitment and activated inflammation are associated with thyroid carcinogenesis in a mouse model.

Park S, Zhu J, Altan-Bonnet G, Cheng SY.

Am J Cancer Res. 2019 Jul 1;9(7):1439-1453. eCollection 2019.


Constitutive Activation of the B Cell Receptor Underlies Dysfunctional Signaling in Chronic Lymphocytic Leukemia.

Ziegler CGK, Kim J, Piersanti K, Oyler-Yaniv A, Argyropoulos KV, van den Brink MRM, Palomba ML, Altan-Bonnet N, Altan-Bonnet G.

Cell Rep. 2019 Jul 23;28(4):923-937.e3. doi: 10.1016/j.celrep.2019.06.069.


Quantifying the Dynamics of Hematopoiesis by In Vivo IdU Pulse-Chase, Mass Cytometry, and Mathematical Modeling.

Erez A, Mukherjee R, Altan-Bonnet G.

Cytometry A. 2019 Oct;95(10):1075-1084. doi: 10.1002/cyto.a.23799. Epub 2019 May 31.


Universality of biochemical feedback and its application to immune cells.

Erez A, Byrd TA, Vogel RM, Altan-Bonnet G, Mugler A.

Phys Rev E. 2019 Feb;99(2-1):022422. doi: 10.1103/PhysRevE.99.022422.


Cytokine-mediated communication: a quantitative appraisal of immune complexity.

Altan-Bonnet G, Mukherjee R.

Nat Rev Immunol. 2019 Apr;19(4):205-217. doi: 10.1038/s41577-019-0131-x. Review.


Modeling of cytometry data in logarithmic space: When is a bimodal distribution not bimodal?

Erez A, Vogel R, Mugler A, Belmonte A, Altan-Bonnet G.

Cytometry A. 2018 Jun;93(6):611-619. doi: 10.1002/cyto.a.23333. Epub 2018 Feb 16.


EGFR and PDGFRA co-expression and heterodimerization in glioblastoma tumor sphere lines.

Chakravarty D, Pedraza AM, Cotari J, Liu AH, Punko D, Kokroo A, Huse JT, Altan-Bonnet G, Brennan CW.

Sci Rep. 2017 Aug 22;7(1):9043. doi: 10.1038/s41598-017-08940-9.


Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation.

Oyler-Yaniv J, Oyler-Yaniv A, Shakiba M, Min NK, Chen YH, Cheng SY, Krichevsky O, Altan-Bonnet N, Altan-Bonnet G.

Mol Cell. 2017 Jun 1;66(5):635-647.e7. doi: 10.1016/j.molcel.2017.05.011.


A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System.

Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O.

Immunity. 2017 Apr 18;46(4):609-620. doi: 10.1016/j.immuni.2017.03.011. Epub 2017 Apr 4.


Correction: Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse.

Le Floc'h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonnet G, Fukui Y, Huse M.

J Exp Med. 2017 Apr 3;214(4):1203. doi: 10.1084/jem.2013132403102017c. Epub 2017 Mar 14. No abstract available.


Lymphocytic division clocked up by Myc.

Erez A, Altan-Bonnet G.

Immunol Cell Biol. 2017 Feb;95(2):119-120. doi: 10.1038/icb.2016.115. Epub 2016 Dec 20. No abstract available.


Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis.

Vogel RM, Erez A, Altan-Bonnet G.

Nat Commun. 2016 Sep 30;7:12428. doi: 10.1038/ncomms12428.


JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors.

Gao SP, Chang Q, Mao N, Daly LA, Vogel R, Chan T, Liu SH, Bournazou E, Schori E, Zhang H, Brewer MR, Pao W, Morris L, Ladanyi M, Arcila M, Manova-Todorova K, de Stanchina E, Norton L, Levine RL, Altan-Bonnet G, Solit D, Zinda M, Huszar D, Lyden D, Bromberg JF.

Sci Signal. 2016 Mar 29;9(421):ra33. doi: 10.1126/scisignal.aac8460.


Clonal B cells in Waldenström's macroglobulinemia exhibit functional features of chronic active B-cell receptor signaling.

Argyropoulos KV, Vogel R, Ziegler C, Altan-Bonnet G, Velardi E, Calafiore M, Dogan A, Arcila M, Patel M, Knapp K, Mallek C, Hunter ZR, Treon SP, van den Brink MR, Palomba ML.

Leukemia. 2016 May;30(5):1116-25. doi: 10.1038/leu.2016.8. Epub 2016 Feb 12.


Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion.

Malandro N, Budhu S, Kuhn NF, Liu C, Murphy JT, Cortez C, Zhong H, Yang X, Rizzuto G, Altan-Bonnet G, Merghoub T, Wolchok JD.

Immunity. 2016 Jan 19;44(1):179-193. doi: 10.1016/j.immuni.2015.12.018.


Noise-driven causal inference in biomolecular networks.

Prill RJ, Vogel R, Cecchi GA, Altan-Bonnet G, Stolovitzky G.

PLoS One. 2015 Jun 1;10(6):e0125777. doi: 10.1371/journal.pone.0125777. eCollection 2015.


T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens.

Voisinne G, Nixon BG, Melbinger A, Gasteiger G, Vergassola M, Altan-Bonnet G.

Cell Rep. 2015 May 26;11(8):1208-19.


Phosphatidylserine vesicles enable efficient en bloc transmission of enteroviruses.

Chen YH, Du W, Hagemeijer MC, Takvorian PM, Pau C, Cali A, Brantner CA, Stempinski ES, Connelly PS, Ma HC, Jiang P, Wimmer E, Altan-Bonnet G, Altan-Bonnet N.

Cell. 2015 Feb 12;160(4):619-630. doi: 10.1016/j.cell.2015.01.032.


Computational algorithm-driven evaluation of monocytic myeloid-derived suppressor cell frequency for prediction of clinical outcomes.

Kitano S, Postow MA, Ziegler CG, Kuk D, Panageas KS, Cortez C, Rasalan T, Adamow M, Yuan J, Wong P, Altan-Bonnet G, Wolchok JD, Lesokhin AM.

Cancer Immunol Res. 2014 Aug;2(8):812-21. doi: 10.1158/2326-6066.CIR-14-0013. Epub 2014 May 20.


T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks.

Tkach KE, Barik D, Voisinne G, Malandro N, Hathorn MM, Cotari JW, Vogel R, Merghoub T, Wolchok J, Krichevsky O, Altan-Bonnet G.

Elife. 2014 Apr 9;3:e01944. doi: 10.7554/eLife.01944.


Cracking the NF-κB code.

Tkach KE, Oyler JE, Altan-Bonnet G.

Sci Signal. 2014 Feb 18;7(313):pe5. doi: 10.1126/scisignal.2005108. Review.


A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity.

Shono Y, Tuckett AZ, Ouk S, Liou HC, Altan-Bonnet G, Tsai JJ, Oyler JE, Smith OM, West ML, Singer NV, Doubrovina E, Pankov D, Undhad CV, Murphy GF, Lezcano C, Liu C, O'Reilly RJ, van den Brink MR, Zakrzewski JL.

Cancer Discov. 2014 May;4(5):578-91. doi: 10.1158/2159-8290.CD-13-0585. Epub 2014 Feb 18.


Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells.

Palomba ML, Piersanti K, Ziegler CG, Decker H, Cotari JW, Bantilan K, Rijo I, Gardner JR, Heaney M, Bemis D, Balderas R, Malek SN, Seymour E, Zelenetz AD, van den Brink MR, Altan-Bonnet G.

PLoS One. 2014 Jan 29;9(1):e79987. doi: 10.1371/journal.pone.0079987. eCollection 2014.


Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse.

Le Floc'h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonnet G, Fukui Y, Huse M.

J Exp Med. 2013 Nov 18;210(12):2721-37. doi: 10.1084/jem.20131324. Epub 2013 Nov 4. Erratum in: J Exp Med. 2017 Apr 3;214(4):1203.


The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

Chang Q, Bournazou E, Sansone P, Berishaj M, Gao SP, Daly L, Wels J, Theilen T, Granitto S, Zhang X, Cotari J, Alpaugh ML, de Stanchina E, Manova K, Li M, Bonafe M, Ceccarelli C, Taffurelli M, Santini D, Altan-Bonnet G, Kaplan R, Norton L, Nishimoto N, Huszar D, Lyden D, Bromberg J.

Neoplasia. 2013 Jul;15(7):848-62.


Diversity training for signal transduction: leveraging cell-to-cell variability to dissect cellular signaling, differentiation and death.

Cotari JW, Voisinne G, Altan-Bonnet G.

Curr Opin Biotechnol. 2013 Aug;24(4):760-6. doi: 10.1016/j.copbio.2013.05.002. Epub 2013 Jun 7. Review.


Cell-to-cell variability analysis dissects the plasticity of signaling of common γ chain cytokines in T cells.

Cotari JW, Voisinne G, Dar OE, Karabacak V, Altan-Bonnet G.

Sci Signal. 2013 Mar 12;6(266):ra17. doi: 10.1126/scisignal.2003240.


Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism.

François P, Voisinne G, Siggia ED, Altan-Bonnet G, Vergassola M.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E888-97. doi: 10.1073/pnas.1300752110. Epub 2013 Feb 19.


T cell responses to antigen: hasty proposals resolved through long engagements.

Tkach K, Altan-Bonnet G.

Curr Opin Immunol. 2013 Feb;25(1):120-5. doi: 10.1016/j.coi.2012.12.001. Epub 2012 Dec 28. Review.


Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses.

Höfer T, Krichevsky O, Altan-Bonnet G.

Front Immunol. 2012 Sep 5;3:268. doi: 10.3389/fimmu.2012.00268. eCollection 2012.


Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1.

Romano E, Cotari JW, Barreira da Silva R, Betts BC, Chung DJ, Avogadri F, Fink MJ, St Angelo ET, Mehrara B, Heller G, Münz C, Altan-Bonnet G, Young JW.

Blood. 2012 May 31;119(22):5182-90. doi: 10.1182/blood-2011-09-382200. Epub 2012 Apr 17.


Nucleic acid hybridization: Robust sequence discrimination.

Altan-Bonnet G, Kramer FR.

Nat Chem. 2012 Feb 21;4(3):155-7. doi: 10.1038/nchem.1283. No abstract available.


Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses.

Gottschalk RA, Hathorn MM, Beuneu H, Corse E, Dustin ML, Altan-Bonnet G, Allison JP.

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):881-6. doi: 10.1073/pnas.1119763109. Epub 2012 Jan 5.


A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.

Quann EJ, Liu X, Altan-Bonnet G, Huse M.

Nat Immunol. 2011 May 22;12(7):647-54. doi: 10.1038/ni.2033.


Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response.

Feinerman O, Jentsch G, Tkach KE, Coward JW, Hathorn MM, Sneddon MW, Emonet T, Smith KA, Altan-Bonnet G.

Mol Syst Biol. 2010 Nov 30;6:437. doi: 10.1038/msb.2010.90.


Perspectives for computer modeling in the study of T cell activation.

Coward J, Germain RN, Altan-Bonnet G.

Cold Spring Harb Perspect Biol. 2010 Jun;2(6):a005538. doi: 10.1101/cshperspect.a005538. Epub 2010 May 5. Review.


Towards a rigorous assessment of systems biology models: the DREAM3 challenges.

Prill RJ, Marbach D, Saez-Rodriguez J, Sorger PK, Alexopoulos LG, Xue X, Clarke ND, Altan-Bonnet G, Stolovitzky G.

PLoS One. 2010 Feb 23;5(2):e9202. doi: 10.1371/journal.pone.0009202. Erratum in: PLoS One. 2010;5(3). doi: 10.1371/annotation/f633213a-dc4f-4bee-b6c5-72d50e7073b8.


Fluorescence correlation spectroscopy in living cells: a practical approach.

Altan-Bonnet N, Altan-Bonnet G.

Curr Protoc Cell Biol. 2009 Dec;Chapter 4:Unit 4.24. doi: 10.1002/0471143030.cb0424s45.


Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response.

Rizzuto GA, Merghoub T, Hirschhorn-Cymerman D, Liu C, Lesokhin AM, Sahawneh D, Zhong H, Panageas KS, Perales MA, Altan-Bonnet G, Wolchok JD, Houghton AN.

J Exp Med. 2009 Apr 13;206(4):849-66. doi: 10.1084/jem.20081382. Epub 2009 Mar 30.


STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease.

Lu SX, Alpdogan O, Lin J, Balderas R, Campos-Gonzalez R, Wang X, Gao GJ, Suh D, King C, Chow M, Smith OM, Hubbard VM, Bautista JL, Cabrera-Perez J, Zakrzewski JL, Kochman AA, Chow A, Altan-Bonnet G, van den Brink MR.

Blood. 2008 Dec 15;112(13):5254-8. doi: 10.1182/blood-2008-03-147322. Epub 2008 Oct 6.


Variability and robustness in T cell activation from regulated heterogeneity in protein levels.

Feinerman O, Veiga J, Dorfman JR, Germain RN, Altan-Bonnet G.

Science. 2008 Aug 22;321(5892):1081-4. doi: 10.1126/science.1158013.


Quantitative challenges in understanding ligand discrimination by alphabeta T cells.

Feinerman O, Germain RN, Altan-Bonnet G.

Mol Immunol. 2008 Feb;45(3):619-31. Epub 2007 Sep 6. Review. No abstract available.


Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction.

Castellino F, Huang AY, Altan-Bonnet G, Stoll S, Scheinecker C, Germain RN.

Nature. 2006 Apr 13;440(7086):890-5.


Modeling T cell antigen discrimination based on feedback control of digital ERK responses.

Altan-Bonnet G, Germain RN.

PLoS Biol. 2005 Nov;3(11):e356. Epub 2005 Oct 25.


Discerning aggregation in homogeneous ensembles: a general description of photon counting spectroscopy in diffusing systems.

Ren HC, Goddard NL, Altan-Bonnet G, Libchaber A.

Phys Rev E Stat Nonlin Soft Matter Phys. 2004 May;69(5 Pt 1):051916. Epub 2004 May 27.


Bubble dynamics in double-stranded DNA.

Altan-Bonnet G, Libchaber A, Krichevsky O.

Phys Rev Lett. 2003 Apr 4;90(13):138101. Epub 2003 Apr 1.


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