Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 118

1.

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.

Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, Okreglicka K, Hültner L, Schneider M, Ladinig C, Kuklik-Roos C, Mysliwietz J, Janik D, Neff F, Rathkolb B, Hrabé de Angelis M, Buske C, da Silva AR, Muedder K, Conrad M, Ganz T, Kopf M, Muckenthaler MU, Bornkamm GW.

Haematologica. 2019 Jun 27. pii: haematol.2018.212977. doi: 10.3324/haematol.2018.212977. [Epub ahead of print]

2.

Gut microbiota and immunity in common variable immunodeficiency: crosstalk with pro-inflammatory cytokines.

Franza L, Carusi V, Altamura S, Gasbarrini A, Caraffa A, Kritas SK, Ronconi G, Gallenga CE, Di Virgilio F, Pandolfi F.

J Biol Regul Homeost Agents. 2019 Mar-Apr,;33(2):315-319.

PMID:
30942065
3.

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction.

Vinchi F, Porto G, Simmelbauer A, Altamura S, Passos ST, Garbowski M, Silva AMN, Spaich S, Seide SE, Sparla R, Hentze MW, Muckenthaler MU.

Eur Heart J. 2019 Mar 20. pii: ehz112. doi: 10.1093/eurheartj/ehz112. [Epub ahead of print]

PMID:
30903157
4.

Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling.

Rauner M, Baschant U, Roetto A, Pellegrino RM, Rother S, Salbach-Hirsch J, Weidner H, Hintze V, Campbell G, Petzold A, Lemaitre R, Henry I, Bellido T, Theurl I, Altamura S, Colucci S, Muckenthaler MU, Schett G, Komla Ebri D, Bassett JHD, Williams GR, Platzbecker U, Hofbauer LC.

Nat Metab. 2019 Jan;1(1):111-124. doi: 10.1038/s42255-018-0005-8. Epub 2019 Jan 7.

5.

Correction to: Regenerative therapies increase survivorship of avascular necrosis of the femoral head: a systematic review and meta-analysis.

Andriolo L, Merli G, Tobar C, Altamura SA, Kon E, Filardo G.

Int Orthop. 2019 Feb;43(2):505. doi: 10.1007/s00264-018-4183-5.

PMID:
30294752
6.

Air-blood barrier thickening and alterations of alveolar epithelial type 2 cells in mouse lungs with disrupted hepcidin/ferroportin regulatory system.

Mühlfeld C, Neves J, Brandenberger C, Hegermann J, Wrede C, Altamura S, Muckenthaler MU.

Histochem Cell Biol. 2019 Mar;151(3):217-228. doi: 10.1007/s00418-018-1737-y. Epub 2018 Oct 3.

PMID:
30280242
7.

Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model.

Artuso I, Lidonnici MR, Altamura S, Mandelli G, Pettinato M, Muckenthaler MU, Silvestri L, Ferrari G, Camaschella C, Nai A.

Blood. 2018 Nov 22;132(21):2286-2297. doi: 10.1182/blood-2018-05-852277. Epub 2018 Sep 12. Erratum in: Blood. 2019 Jul 4;134(1):94.

8.

Is Platelet-Rich Plasma Suitable for Patellar Tendinopathy? Response.

Filardo G, Andriolo L, Reale D, Altamura SA, Candrian C, Zaffagnini S.

Am J Sports Med. 2018 Sep;46(11):NP53-NP54. doi: 10.1177/0363546518788320. No abstract available.

PMID:
30169140
9.

Dietary stearic acid regulates mitochondria in vivo in humans.

Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA.

Nat Commun. 2018 Aug 7;9(1):3129. doi: 10.1038/s41467-018-05614-6.

10.

Nonsurgical Treatments of Patellar Tendinopathy: Multiple Injections of Platelet-Rich Plasma Are a Suitable Option: A Systematic Review and Meta-analysis.

Andriolo L, Altamura SA, Reale D, Candrian C, Zaffagnini S, Filardo G.

Am J Sports Med. 2019 Mar;47(4):1001-1018. doi: 10.1177/0363546518759674. Epub 2018 Mar 30.

PMID:
29601207
11.

Circulating stem cells, HIF-1, and SDF-1 in septic abdominal surgical patients: randomized controlled study protocol.

Cotoia A, Mirabella L, Altamura S, Villani R, Marchese F, Ferrara G, Mariano K, Livio T, Cinnella G.

Trials. 2018 Mar 12;19(1):179. doi: 10.1186/s13063-018-2556-0.

12.

Regenerative therapies increase survivorship of avascular necrosis of the femoral head: a systematic review and meta-analysis.

Andriolo L, Merli G, Tobar C, Altamura SA, Kon E, Filardo G.

Int Orthop. 2018 Jul;42(7):1689-1704. doi: 10.1007/s00264-018-3787-0. Epub 2018 Feb 6. Erratum in: Int Orthop. 2018 Oct 8;:.

PMID:
29411077
13.

Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice.

Wiedenmann T, Dietrich N, Fleming T, Altamura S, Deelman LE, Henning RH, Muckenthaler MU, Nawroth PP, Hammes HP, Wagner AH, Hecker M.

J Diabetes Complications. 2018 Feb;32(2):130-138. doi: 10.1016/j.jdiacomp.2017.11.007. Epub 2017 Nov 22.

PMID:
29223856
14.

Integrins: Integrating the Biology and Therapy of Cell-cell Interactions.

Pandolfi F, Franza L, Altamura S, Mandolini C, Cianci R, Ansari A, Kurnick JT.

Clin Ther. 2017 Dec;39(12):2420-2436. doi: 10.1016/j.clinthera.2017.11.002. Epub 2017 Dec 6. Review.

PMID:
29203050
15.

Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome.

Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, Baldini A.

Hum Mol Genet. 2017 Nov 15;26(22):4540. doi: 10.1093/hmg/ddx353. No abstract available.

16.

Uncoupled iron homeostasis in type 2 diabetes mellitus.

Altamura S, Kopf S, Schmidt J, Müdder K, da Silva AR, Nawroth P, Muckenthaler MU.

J Mol Med (Berl). 2017 Dec;95(12):1387-1398. doi: 10.1007/s00109-017-1596-3. Epub 2017 Oct 3.

PMID:
28971221
17.

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).

Bresciani A, Missineo A, Gallo M, Cerretani M, Fezzardi P, Tomei L, Cicero DO, Altamura S, Santoprete A, Ingenito R, Bianchi E, Pacifici R, Dominguez C, Munoz-Sanjuan I, Harper S, Toledo-Sherman L, Park LC.

Arch Biochem Biophys. 2017 Oct 1;631:31-41. doi: 10.1016/j.abb.2017.08.003. Epub 2017 Aug 8. Review.

PMID:
28801166
18.

Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease.

Neves J, Leitz D, Kraut S, Brandenberger C, Agrawal R, Weissmann N, Mühlfeld C, Mall MA, Altamura S, Muckenthaler MU.

EBioMedicine. 2017 Jun;20:230-239. doi: 10.1016/j.ebiom.2017.04.036. Epub 2017 Apr 29.

19.

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.

Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A.

Cell. 2017 May 18;169(5):807-823.e19. doi: 10.1016/j.cell.2017.04.018. Epub 2017 May 4.

20.

Identification by High-Throughput Screening of Pseudomonas Acyl-Coenzyme A Synthetase Inhibitors.

Turcano L, Visaggio D, Frangipani E, Missineo A, Andreini M, Altamura S, Visca P, Bresciani A.

SLAS Discov. 2017 Aug;22(7):897-905. doi: 10.1177/2472555216689283. Epub 2017 Jan 31.

PMID:
28346095
21.

Cdk6 contributes to cytoskeletal stability in erythroid cells.

Uras IZ, Scheicher RM, Kollmann K, Glösmann M, Prchal-Murphy M, Tigan AS, Fux DA, Altamura S, Neves J, Muckenthaler MU, Bennett KL, Kubicek S, Hinds PW, von Lindern M, Sexl V.

Haematologica. 2017 Jun;102(6):995-1005. doi: 10.3324/haematol.2016.159947. Epub 2017 Mar 2.

22.

Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome.

Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, Baldini A.

Hum Mol Genet. 2016 Oct 15;25(20):4369-4375. doi: 10.1093/hmg/ddw267. Erratum in: Hum Mol Genet. 2017 Nov 15;26(22):4540.

23.

Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.

Ontoria JM, Paonessa G, Ponzi S, Ferrigno F, Nizi E, Biancofiore I, Malancona S, Graziani R, Roberts D, Willis P, Bresciani A, Gennari N, Cecchetti O, Monteagudo E, Orsale MV, Veneziano M, Di Marco A, Cellucci A, Laufer R, Altamura S, Summa V, Harper S.

ACS Med Chem Lett. 2016 Mar 5;7(5):454-9. doi: 10.1021/acsmedchemlett.5b00468. eCollection 2016 May 12.

24.

Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes.

Chen S, Feng T, Vujić Spasić M, Altamura S, Breitkopf-Heinlein K, Altenöder J, Weiss TS, Dooley S, Muckenthaler MU.

J Biol Chem. 2016 Jun 17;291(25):13160-74. doi: 10.1074/jbc.M115.691543. Epub 2016 Apr 27.

25.

Key Role of DAMP in Inflammation, Cancer, and Tissue Repair.

Pandolfi F, Altamura S, Frosali S, Conti P.

Clin Ther. 2016 May;38(5):1017-28. doi: 10.1016/j.clinthera.2016.02.028. Epub 2016 Mar 25. Review.

PMID:
27021609
26.

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause.

Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A.

Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033.

27.

Mice with hepcidin-resistant ferroportin accumulate iron in the retina.

Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze M, Muckenthaler MU, Dunaief JL.

FASEB J. 2016 Feb;30(2):813-23. doi: 10.1096/fj.15-276758. Epub 2015 Oct 27.

28.

Efficacy and safety of deferasirox in non-thalassemic patients with elevated ferritin levels after allogeneic hematopoietic stem cell transplantation.

Jaekel N, Lieder K, Albrecht S, Leismann O, Hubert K, Bug G, Kröger N, Platzbecker U, Stadler M, de Haas K, Altamura S, Muckenthaler MU, Niederwieser D, Al-Ali HK.

Bone Marrow Transplant. 2016 Jan;51(1):89-95. doi: 10.1038/bmt.2015.204. Epub 2015 Sep 14.

PMID:
26367238
29.

Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin.

Finotti A, Gasparello J, Breveglieri G, Cosenza LC, Montagner G, Bresciani A, Altamura S, Bianchi N, Martini E, Gallerani E, Borgatti M, Gambari R.

Exp Hematol. 2015 Dec;43(12):1062-1071.e3. doi: 10.1016/j.exphem.2015.08.011. Epub 2015 Sep 3.

30.

Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E.

Díaz V, Peinado AB, Barba-Moreno L, Altamura S, Butragueño J, González-Gross M, Alteheld B, Stehle P, Zapico AG, Muckenthaler MU, Gassmann M.

Physiol Rep. 2015 Aug;3(8). pii: e12475. doi: 10.14814/phy2.12475.

31.

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia.

Guida C, Altamura S, Klein FA, Galy B, Boutros M, Ulmer AJ, Hentze MW, Muckenthaler MU.

Blood. 2015 Apr 2;125(14):2265-75. doi: 10.1182/blood-2014-08-595256. Epub 2015 Feb 6.

32.

Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni.

Lalli C, Guidi A, Gennari N, Altamura S, Bresciani A, Ruberti G.

PLoS Negl Trop Dis. 2015 Jan 30;9(1):e0003484. doi: 10.1371/journal.pntd.0003484. eCollection 2015 Jan.

33.

Increased hepcidin levels in high-altitude pulmonary edema.

Altamura S, Bärtsch P, Dehnert C, Maggiorini M, Weiss G, Theurl I, Muckenthaler MU, Mairbäurl H.

J Appl Physiol (1985). 2015 Feb 1;118(3):292-8. doi: 10.1152/japplphysiol.00940.2014. Epub 2014 Dec 18.

34.

Peptide nucleic acids targeting β-globin mRNAs selectively inhibit hemoglobin production in murine erythroleukemia cells.

Montagner G, Gemmo C, Fabbri E, Manicardi A, Accardo I, Bianchi N, Finotti A, Breveglieri G, Salvatori F, Borgatti M, Lampronti I, Bresciani A, Altamura S, Corradini R, Gambari R.

Int J Mol Med. 2015 Jan;35(1):51-8. doi: 10.3892/ijmm.2014.2005. Epub 2014 Nov 14.

35.

Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload.

Altamura S, Kessler R, Gröne HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU.

Cell Metab. 2014 Aug 5;20(2):359-67. doi: 10.1016/j.cmet.2014.07.007.

36.

Reply: To PMID 22334511.

Ryan JD, Altamura S, Muckenthaler M, Crowe J.

Hepatology. 2014 Apr;59(4):1648-9. doi: 10.1002/hep.26764. Epub 2014 Feb 14. No abstract available.

PMID:
24122806
37.

Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome.

Cozzi A, Santambrogio P, Privitera D, Broccoli V, Rotundo LI, Garavaglia B, Benz R, Altamura S, Goede JS, Muckenthaler MU, Levi S.

J Exp Med. 2013 Aug 26;210(9):1779-91. doi: 10.1084/jem.20130315. Epub 2013 Aug 12.

38.

Identification and characterization of new molecular partners for the protein arginine methyltransferase 6 (PRMT6).

Lo Sardo A, Altamura S, Pegoraro S, Maurizio E, Sgarra R, Manfioletti G.

PLoS One. 2013;8(1):e53750. doi: 10.1371/journal.pone.0053750. Epub 2013 Jan 10. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/37947ebc-7ddb-4500-8441-8a4804b0fb5e.

39.

Administration of recombinant erythropoietin alone does not improve the phenotype in iron refractory iron deficiency anemia patients.

Lehmberg K, Grosse R, Muckenthaler MU, Altamura S, Nielsen P, Schmid H, Graubner U, Oyen F, Zeller W, Schneppenheim R, Janka GE.

Ann Hematol. 2013 Mar;92(3):387-94. doi: 10.1007/s00277-012-1618-8. Epub 2012 Nov 20.

PMID:
23180434
40.

Pegylated interferon-α induced hypoferremia is associated with the immediate response to treatment in hepatitis C.

Ryan JD, Altamura S, Devitt E, Mullins S, Lawless MW, Muckenthaler MU, Crowe J.

Hepatology. 2012 Aug;56(2):492-500. doi: 10.1002/hep.25666. Epub 2012 Jun 11.

PMID:
22334511
41.

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 1.

Malancona S, Altamura S, Filocamo G, Kinzel O, Hernando JI, Rowley M, Scarpelli R, Steinkühler C, Jones P.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4422-8. doi: 10.1016/j.bmcl.2011.06.024. Epub 2011 Jun 16.

PMID:
21737272
42.

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2.

Kinzel O, Alfieri A, Altamura S, Brunetti M, Bufali S, Colaceci F, Ferrigno F, Filocamo G, Fonsi M, Gallinari P, Malancona S, Hernando JI, Monteagudo E, Orsale MV, Palumbi MC, Pucci V, Rowley M, Sasso R, Scarpelli R, Steinkühler C, Jones P.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4429-35. doi: 10.1016/j.bmcl.2011.06.023. Epub 2011 Jun 16.

PMID:
21737263
43.

Growth differentiation factor 15 in patients with congenital dyserythropoietic anaemia (CDA) type II.

Casanovas G, Swinkels DW, Altamura S, Schwarz K, Laarakkers CM, Gross HJ, Wiesneth M, Heimpel H, Muckenthaler MU.

J Mol Med (Berl). 2011 Aug;89(8):811-6. doi: 10.1007/s00109-011-0751-5. Epub 2011 Apr 8.

PMID:
21475976
44.

2,3-Dihydro-1,2-Diphenyl-substituted 4H-Pyridinone derivatives as new anti Flaviviridae inhibitors.

Peduto A, Massa A, Di Mola A, de Caprariis P, La Colla P, Loddo R, Altamura S, Maga G, Filosa R.

Chem Biol Drug Des. 2011 Jun;77(6):441-9. doi: 10.1111/j.1747-0285.2011.01102.x. Epub 2011 Mar 17.

PMID:
21414145
45.

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice.

Castoldi M, Vujic Spasic M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU.

J Clin Invest. 2011 Apr;121(4):1386-96. doi: 10.1172/JCI44883.

46.

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.

Narjes F, Crescenzi B, Ferrara M, Habermann J, Colarusso S, Ferreira Mdel R, Stansfield I, Mackay AC, Conte I, Ercolani C, Zaramella S, Palumbi MC, Meuleman P, Leroux-Roels G, Giuliano C, Fiore F, Di Marco S, Baiocco P, Koch U, Migliaccio G, Altamura S, Laufer R, De Francesco R, Rowley M.

J Med Chem. 2011 Jan 13;54(1):289-301. doi: 10.1021/jm1013105. Epub 2010 Dec 8.

PMID:
21141896
47.

A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA.

Altamura S, D'Alessio F, Selle B, Muckenthaler MU.

Biochem J. 2010 Nov 1;431(3):363-71. doi: 10.1042/BJ20100668.

48.

Synthesis and anti-hepatitis C virus activity of novel ethyl 1H-indole-3-carboxylates in vitro.

Sellitto G, Faruolo A, de Caprariis P, Altamura S, Paonessa G, Ciliberto G.

Bioorg Med Chem. 2010 Aug 15;18(16):6143-8. doi: 10.1016/j.bmc.2010.06.058. Epub 2010 Jun 22.

PMID:
20638289
49.

Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.

Ontoria JM, Altamura S, Di Marco A, Ferrigno F, Laufer R, Muraglia E, Palumbi MC, Rowley M, Scarpelli R, Schultz-Fademrecht C, Serafini S, Steinkühler C, Jones P.

J Med Chem. 2009 Nov 12;52(21):6782-9. doi: 10.1021/jm900555u.

PMID:
19888759
50.

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.

Ontoria JM, Rydberg EH, Di Marco S, Tomei L, Attenni B, Malancona S, Martin Hernando JI, Gennari N, Koch U, Narjes F, Rowley M, Summa V, Carroll SS, Olsen DB, De Francesco R, Altamura S, Migliaccio G, Carfì A.

J Med Chem. 2009 Aug 27;52(16):5217-27. doi: 10.1021/jm900517t.

PMID:
19877603

Supplemental Content

Loading ...
Support Center