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Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma.

Hanaford AR, Alt J, Rais R, Wang SZ, Kaur H, Thorek DLJ, Eberhart CG, Slusher BS, Martin AM, Raabe EH.

Transl Oncol. 2019 Jul 21;12(10):1314-1322. doi: 10.1016/j.tranon.2019.05.013. [Epub ahead of print]


Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine.

Wang SZ, Poore B, Alt J, Price A, Allen SJ, Hanaford AR, Kaur H, Orr BA, Slusher BS, Eberhart CG, Raabe EH, Rubens JA.

Clin Cancer Res. 2019 Jul 12. doi: 10.1158/1078-0432.CCR-19-0189. [Epub ahead of print]


Socioeconomic status impacts postoperative productivity loss and health utility changes in refractory chronic rhinosinusitis.

Beswick DM, Mace JC, Soler ZM, Rudmik L, Alt JA, Smith KA, Detwiller KY, Ramakrishnan VR, Smith TL.

Int Forum Allergy Rhinol. 2019 Jun 27. doi: 10.1002/alr.22374. [Epub ahead of print]


Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.

Nedelcovych MT, Kim BH, Zhu X, Lovell LE, Manning AA, Kelschenbach J, Hadas E, Chao W, Prchalová E, Dash RP, Wu Y, Alt J, Thomas AG, Rais R, Kamiya A, Volsky DJ, Slusher BS.

J Neuroimmune Pharmacol. 2019 Jun 17. doi: 10.1007/s11481-019-09859-w. [Epub ahead of print]


Long-term outcomes of endoscopic sinus surgery in the management of adult chronic rhinosinusitis.

Smith TL, Schlosser RJ, Mace JC, Alt JA, Beswick DM, DeConde AS, Detwiller KY, Mattos JL, Soler ZM.

Int Forum Allergy Rhinol. 2019 Aug;9(8):831-841. doi: 10.1002/alr.22369. Epub 2019 Jun 17.


Clinical Experience of Immunotherapy Treatment: Efficacy and Toxicity Analysis of the Compassionate Use Program of Nivolumab in Patients with Advanced Squamous Cell Non-Small Cell Lung Cancer.

Krefting F, Basara N, Schütte W, Späth-Schwalbe E, Alt J, Thiel S, Kimmich M, Fischer JR, Kurz S, Griesinger F, Christoph DC.

Oncol Res Treat. 2019;42(5):243-255. doi: 10.1159/000499321. Epub 2019 Apr 17.


Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold.

Stepanek O, Hin N, Thomas AG, Dash RP, Alt J, Rais R, Rojas C, Slusher BS, Tsukamoto T.

Eur J Med Chem. 2019 May 15;170:276-289. doi: 10.1016/j.ejmech.2019.03.015. Epub 2019 Mar 9.


Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.

Tenora L, Alt J, Dash RP, Gadiano AJ, Novotná K, Veeravalli V, Lam J, Kirkpatrick QR, Lemberg KM, Majer P, Rais R, Slusher BS.

J Med Chem. 2019 Apr 11;62(7):3524-3538. doi: 10.1021/acs.jmedchem.8b02009. Epub 2019 Mar 29.


The NAAG'ing Concerns of Modeling Human Alzheimer's Disease in Mice.

Hollinger KR, Alt J, Rais R, Kaplin AI, Slusher BS.

J Alzheimers Dis. 2019;68(3):939-945. doi: 10.3233/JAD-181251.


Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A.

Neuropsychopharmacology. 2019 May;44(6):1178. doi: 10.1038/s41386-019-0354-3. Epub 2019 Mar 13.


Symptom importance, patient expectations, and satisfaction in chronic rhinosinusitis.

Mattos JL, Rudmik L, Schlosser RJ, Smith TL, Mace JC, Alt J, Soler ZM.

Int Forum Allergy Rhinol. 2019 Jun;9(6):593-600. doi: 10.1002/alr.22309. Epub 2019 Feb 12.


Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer.

Papachristofilou A, Hipp MM, Klinkhardt U, Früh M, Sebastian M, Weiss C, Pless M, Cathomas R, Hilbe W, Pall G, Wehler T, Alt J, Bischoff H, Geißler M, Griesinger F, Kallen KJ, Fotin-Mleczek M, Schröder A, Scheel B, Muth A, Seibel T, Stosnach C, Doener F, Hong HS, Koch SD, Gnad-Vogt U, Zippelius A.

J Immunother Cancer. 2019 Feb 8;7(1):38. doi: 10.1186/s40425-019-0520-5.


Correlation between systemic inflammatory response and quality of life in patients with chronic rhinosinusitis.

Orb Q, Pulsipher A, Smith KA, Ashby S, Alt JA.

Int Forum Allergy Rhinol. 2019 May;9(5):458-465. doi: 10.1002/alr.22289. Epub 2019 Jan 18.


An analysis of RUC methodology for determining the RVU valuation of sinus surgery.

Smith KA, Oakley G, Alt JA, Orlandi RR.

Int Forum Allergy Rhinol. 2019 May;9(5):479-485. doi: 10.1002/alr.22283. Epub 2019 Jan 17.


Long-term revision rates for endoscopic sinus surgery.

Smith KA, Orlandi RR, Oakley G, Meeks H, Curtin K, Alt JA.

Int Forum Allergy Rhinol. 2019 Apr;9(4):402-408. doi: 10.1002/alr.22264. Epub 2018 Dec 20.


Characterization of Drosophila Nidogen/entactin reveals roles in basement membrane stability, barrier function and nervous system patterning.

Wolfstetter G, Dahlitz I, Pfeifer K, Töpfer U, Alt JA, Pfeifer DC, Lakes-Harlan R, Baumgartner S, Palmer RH, Holz A.

Development. 2019 Jan 16;146(2). pii: dev168948. doi: 10.1242/dev.168948.


Socioeconomic factors impact quality of life outcomes and olfactory measures in chronic rhinosinusitis.

Beswick DM, Mace JC, Rudmik L, Soler ZM, Alt JA, Smith KA, Detwiller KY, Smith TL.

Int Forum Allergy Rhinol. 2019 Mar;9(3):231-239. doi: 10.1002/alr.22256. Epub 2018 Dec 10.


Appropriateness Criteria for Surgery in the Management of Adult Recurrent Acute Rhinosinusitis.

Rudmik L, Beswick DM, Alt JA, Bhattacharyya N, Chester AC, Gray ST, Poetker DM, Stewart MG, Smith TL.

Laryngoscope. 2019 Jan;129(1):37-44. doi: 10.1002/lary.27438. Epub 2018 Oct 3.


Impact of chronic rhinosinusitis on sleep: a controlled clinical study.

Alt JA, Ramakrishnan VR, Platt MP, Schlosser RJ, Storck T, Soler ZM.

Int Forum Allergy Rhinol. 2019 Jan;9(1):16-22. doi: 10.1002/alr.22212. Epub 2018 Oct 3.


[Epidemiological Study of the Effects of Gender, Age, Mobility and Time of Injury on Proximal Femoral Fractures].

Zelenka L, Alt J, Knížková I, Kunc P, Lukešová D.

Acta Chir Orthop Traumatol Cech. 2018;85(1):40-45. Czech.


A synthetic glycosaminoglycan reduces sinonasal inflammation in a murine model of chronic rhinosinusitis.

Alt JA, Lee WY, Davis BM, Savage JR, Kennedy TP, Prestwich GD, Pulsipher A.

PLoS One. 2018 Sep 25;13(9):e0204709. doi: 10.1371/journal.pone.0204709. eCollection 2018.


Efficacy and safety analysis of the German expanded access program of osimertinib in patients with advanced, T790M-positive non-small cell lung cancer.

Stratmann JA, Michels S, Hornetz S, Christoph DC, Sackmann S, Spengler W, Bischoff H, Schäfer M, Alt J, Müller A, Laack E, Kimmich M, Griesinger F, Sebastian M.

J Cancer Res Clin Oncol. 2018 Dec;144(12):2457-2463. doi: 10.1007/s00432-018-2754-x. Epub 2018 Sep 22.


Inhibition of mTORC1 in pediatric low-grade glioma depletes glutathione and therapeutically synergizes with carboplatin.

Poore B, Yuan M, Arnold A, Price A, Alt J, Rubens JA, Slusher BS, Eberhart CG, Raabe EH.

Neuro Oncol. 2019 Feb 14;21(2):252-263. doi: 10.1093/neuonc/noy150.


Does Medical Therapy Improve SinoNasal Outcomes Test-22 Domain Scores? An Analysis of Clinically Important Differences.

Chowdhury NI, Mace JC, Bodner TE, Alt JA, Deconde AS, Levy JM, Smith TL.

Laryngoscope. 2019 Jan;129(1):31-36. doi: 10.1002/lary.27470. Epub 2018 Sep 12.


Does Delaying Endoscopic Sinus Surgery Adversely Impact Quality-of-Life Outcomes?

Alt JA, Orlandi RR, Mace JC, Soler ZM, Smith TL.

Laryngoscope. 2019 Feb;129(2):303-311. doi: 10.1002/lary.27473. Epub 2018 Sep 12.


JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A.

Neuropsychopharmacology. 2019 Mar;44(4):683-694. doi: 10.1038/s41386-018-0177-7. Epub 2018 Aug 13. Erratum in: Neuropsychopharmacology. 2019 May;44(6):1178.


Operative time and cost variability for functional endoscopic sinus surgery.

Thomas AJ, Smith KA, Newberry CI, Cardon B, Davis B, Ou Z, Presson AP, Meier JD, Alt JA.

Int Forum Allergy Rhinol. 2019 Jan;9(1):23-29. doi: 10.1002/alr.22198. Epub 2018 Aug 17.


Biologics in Chronic Rhinosinusitis: An Update and Thoughts for Future Directions.

Smith KA, Pulsipher A, Gabrielsen DA, Alt JA.

Am J Rhinol Allergy. 2018 Sep;32(5):412-423. doi: 10.1177/1945892418787132. Epub 2018 Jul 19. Review.


Calgranulin C (S100A12) Is Differentially Expressed in Subtypes of Chronic Rhinosinusitis.

Pulsipher A, Davis BM, Smith KA, Ashby S, Qin X, Firpo M, Orlandi RR, Alt JA.

Am J Rhinol Allergy. 2018 Sep;32(5):380-387. doi: 10.1177/1945892418782238. Epub 2018 Jun 26.


Sensing of Substrate Vibrations in the Adult Cicada Okanagana rimosa (Hemiptera: Cicadidae).

Alt JA, Lakes-Harlan R.

J Insect Sci. 2018 May 1;18(3). doi: 10.1093/jisesa/iey029.


The Diversity of Chemoprotective Glucosinolates in Moringaceae (Moringa spp.).

Fahey JW, Olson ME, Stephenson KK, Wade KL, Chodur GM, Odee D, Nouman W, Massiah M, Alt J, Egner PA, Hubbard WC.

Sci Rep. 2018 May 22;8(1):7994. doi: 10.1038/s41598-018-26058-4.


Comparing ex vivo and in vitro translocation of silver nanoparticles and ions through human nasal epithelium.

Falconer JL, Alt JA, Grainger DW.

Biomaterials. 2018 Jul;171:97-106. doi: 10.1016/j.biomaterials.2018.04.013. Epub 2018 Apr 14.


The price of pain in chronic rhinosinusitis.

Smith KA, Ashby S, Orlandi RR, Oakley G, Alt JA.

Int Forum Allergy Rhinol. 2018 Apr 12. doi: 10.1002/alr.22128. [Epub ahead of print]


Time, Resident Involvement, and Supply Drive Cost Variability in Septoplasty with Turbinate Reduction.

Quinn NA, Alt JA, Ashby S, Orlandi RR.

Otolaryngol Head Neck Surg. 2018 Aug;159(2):310-314. doi: 10.1177/0194599818765099. Epub 2018 Mar 27.


Independent suboesophageal neuronal innervation of the defense gland and longitudinal muscles in the stick insect (Peruphasma schultei) prothorax.

Stolz K, Strauß J, Alt JA, Lakes-Harlan R.

Arthropod Struct Dev. 2018 Mar;47(2):162-172. doi: 10.1016/j.asd.2018.02.003. Epub 2018 Feb 17.


International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.

Wise SK, Lin SY, Toskala E, Orlandi RR, Akdis CA, Alt JA, Azar A, Baroody FM, Bachert C, Canonica GW, Chacko T, Cingi C, Ciprandi G, Corey J, Cox LS, Creticos PS, Custovic A, Damask C, DeConde A, DelGaudio JM, Ebert CS, Eloy JA, Flanagan CE, Fokkens WJ, Franzese C, Gosepath J, Halderman A, Hamilton RG, Hoffman HJ, Hohlfeld JM, Houser SM, Hwang PH, Incorvaia C, Jarvis D, Khalid AN, Kilpeläinen M, Kingdom TT, Krouse H, Larenas-Linnemann D, Laury AM, Lee SE, Levy JM, Luong AU, Marple BF, McCoul ED, McMains KC, Melén E, Mims JW, Moscato G, Mullol J, Nelson HS, Patadia M, Pawankar R, Pfaar O, Platt MP, Reisacher W, Rondón C, Rudmik L, Ryan M, Sastre J, Schlosser RJ, Settipane RA, Sharma HP, Sheikh A, Smith TL, Tantilipikorn P, Tversky JR, Veling MC, Wang Y, Westman M, Wickman M, Zacharek M.

Int Forum Allergy Rhinol. 2018 Feb;8(2):108-352. doi: 10.1002/alr.22073.


[Intramedullary injection with tethered cord : Case report of a rare complication during spinal anesthesia].

Vogt L, Rodermond B, Post P, Iborra S, Stickeler E, Schiefer J, Alt JP, Rossaint R, Röhl A.

Anaesthesist. 2018 Feb;67(2):131-134. doi: 10.1007/s00101-017-0400-7. Epub 2017 Dec 21. German.


Investigating the minimal clinically important difference for SNOT-22 symptom domains in surgically managed chronic rhinosinusitis.

Chowdhury NI, Mace JC, Bodner TE, Alt JA, Deconde AS, Levy JM, Smith TL.

Int Forum Allergy Rhinol. 2017 Dec;7(12):1149-1155. doi: 10.1002/alr.22028. Epub 2017 Oct 20.


Bladder pain in an LL-37 interstitial cystitis and painful bladder syndrome model.

Jia W, Schults AJ, Jensen MM, Ye X, Alt JA, Prestwich GD, Oottamasathien S.

Am J Clin Exp Urol. 2017 Sep 1;5(2):10-17. eCollection 2017.


Familial clustering of oropharyngeal squamous cell carcinoma in the Utah population.

Monroe MM, Hashibe M, Orb Q, Alt J, Buchmann L, Hunt J, Cannon-Albright LA.

Head Neck. 2018 Feb;40(2):384-393. doi: 10.1002/hed.24971. Epub 2017 Oct 11.


Environmental contributions to otitis media requiring tympanostomy tubes.

Padia R, Alt JA, Curtin K, Muntz HR, Orlandi RR, Berger J, Meier JD.

Int J Pediatr Otorhinolaryngol. 2017 Oct;101:97-101. doi: 10.1016/j.ijporl.2017.07.035. Epub 2017 Jul 27.


Comparison of surgical outcomes between patients with unilateral and bilateral chronic rhinosinusitis.

Beswick DM, Mace JC, Chowdhury NI, Alt JA, Hwang PH, DeConde AS, Smith TL.

Int Forum Allergy Rhinol. 2017 Dec;7(12):1162-1169. doi: 10.1002/alr.22020. Epub 2017 Sep 22.


Single-Blinded Prospective Implementation of a Preoperative Imaging Checklist for Endoscopic Sinus Surgery.

Error M, Ashby S, Orlandi RR, Alt JA.

Otolaryngol Head Neck Surg. 2018 Jan;158(1):177-180. doi: 10.1177/0194599817731740. Epub 2017 Sep 19.


Pillars Article: M-1/M-2 Macrophages and the Th1/Th2 Paradigm. J. Immunol. 2000. 164: 6166-6173.

Mills CD, Kincaid K, Alt JM, Heilman MJ, Hill AM.

J Immunol. 2017 Oct 1;199(7):2194-2201. doi: 10.4049/jimmunol.1701141. No abstract available.


LL-37 causes cell death of human nasal epithelial cells, which is inhibited with a synthetic glycosaminoglycan.

Thomas AJ, Pulsipher A, Davis BM, Alt JA.

PLoS One. 2017 Aug 24;12(8):e0183542. doi: 10.1371/journal.pone.0183542. eCollection 2017.


Analysis of factors associated with electing endoscopic sinus surgery.

DeConde AS, Mace JC, Ramakrishnan VR, Alt JA, Smith TL.

Laryngoscope. 2018 Feb;128(2):304-310. doi: 10.1002/lary.26788. Epub 2017 Aug 4.


Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs.

Nedelcovych M, Dash RP, Tenora L, Zimmermann SC, Gadiano AJ, Garrett C, Alt J, Hollinger KR, Pommier E, Jančařík A, Rojas C, Thomas AG, Wu Y, Wozniak K, Majer P, Slusher BS, Rais R.

Mol Pharm. 2017 Oct 2;14(10):3248-3257. doi: 10.1021/acs.molpharmaceut.7b00231. Epub 2017 Aug 31.


N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.

Nedelcovych MT, Tenora L, Kim BH, Kelschenbach J, Chao W, Hadas E, Jančařík A, Prchalová E, Zimmermann SC, Dash RP, Gadiano AJ, Garrett C, Furtmüller G, Oh B, Brandacher G, Alt J, Majer P, Volsky DJ, Rais R, Slusher BS.

J Med Chem. 2017 Aug 24;60(16):7186-7198. doi: 10.1021/acs.jmedchem.7b00966. Epub 2017 Aug 14.


Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain.

Rais R, Vávra J, Tichý T, Dash RP, Gadiano AJ, Tenora L, Monincová L, Bařinka C, Alt J, Zimmermann SC, Slusher CE, Wu Y, Wozniak K, Majer P, Tsukamoto T, Slusher BS.

J Med Chem. 2017 Sep 28;60(18):7799-7809. doi: 10.1021/acs.jmedchem.7b00825. Epub 2017 Sep 18.

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