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A Fungal Arrestin Protein Contributes to Cell Cycle Progression and Pathogenesis.

Telzrow CL, Nichols CB, Castro-Lopez N, Wormley FL Jr, Alspaugh JA.

MBio. 2019 Nov 19;10(6). pii: e02682-19. doi: 10.1128/mBio.02682-19.


Roles for Stress Response and Cell Wall Biosynthesis Pathways in Caspofungin Tolerance in Cryptococcus neoformans.

Pianalto KM, Billmyre RB, Telzrow CL, Alspaugh JA.

Genetics. 2019 Sep;213(1):213-227. doi: 10.1534/genetics.119.302290. Epub 2019 Jul 2.


Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp.

Dischler NM, Xu L, Li Y, Nichols CB, Alspaugh JA, Bills GF, Gloer JB.

J Nat Prod. 2019 Mar 22;82(3):532-538. doi: 10.1021/acs.jnatprod.8b00923. Epub 2019 Mar 7.


A Multi-Institution Collaboration to Define Core Content and Design Flexible Curricular Components for a Foundational Medical School Course: Implications for National Curriculum Reform.

Chen SF, Deitz J, Batten JN, DeCoste-Lopez J, Adam M, Alspaugh JA, Amieva MR, Becker P, Boslett B, Carline J, Chin-Hong P, Engle DL, Hayward KN, Nevins A, Porwal A, Pottinger PS, Schwartz BS, Smith S, Sow M, Teherani A, Prober CG.

Acad Med. 2019 Jun;94(6):819-825. doi: 10.1097/ACM.0000000000002663.


Disseminated Adenovirus Infection After Combined Liver-Kidney Transplantation.

Hemmersbach-Miller M, Bailey ES, Kappus M, Prasad VK, Gray GC, Alspaugh JA.

Front Cell Infect Microbiol. 2018 Nov 20;8:408. doi: 10.3389/fcimb.2018.00408. eCollection 2018.


A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans.

Paes HC, Derengowski LDS, Peconick LDF, Albuquerque P, Pappas GJ Jr, Nicola AM, Silva FBA, Vallim MA, Alspaugh JA, Felipe MSS, Fernandes L.

Front Cell Infect Microbiol. 2018 Nov 13;8:369. doi: 10.3389/fcimb.2018.00369. eCollection 2018.


Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition.

Esher SK, Ost KS, Kohlbrenner MA, Pianalto KM, Telzrow CL, Campuzano A, Nichols CB, Munro C, Wormley FL Jr, Alspaugh JA.

PLoS Pathog. 2018 Jun 4;14(6):e1007126. doi: 10.1371/journal.ppat.1007126. eCollection 2018 Jun.


Characterization of additional components of the environmental pH-sensing complex in the pathogenic fungus Cryptococcus neoformans.

Pianalto KM, Ost KS, Brown HE, Alspaugh JA.

J Biol Chem. 2018 Jun 29;293(26):9995-10008. doi: 10.1074/jbc.RA118.002741. Epub 2018 May 16.


Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain.

Esher SK, Zaragoza O, Alspaugh JA.

Mem Inst Oswaldo Cruz. 2018;113(7):e180057. doi: 10.1590/0074-02760180057. Epub 2018 Apr 16. Review.


HDAC genes play distinct and redundant roles in Cryptococcus neoformans virulence.

Brandão F, Esher SK, Ost KS, Pianalto K, Nichols CB, Fernandes L, Bocca AL, Poças-Fonseca MJ, Alspaugh JA.

Sci Rep. 2018 Mar 26;8(1):5209. doi: 10.1038/s41598-018-21965-y.


Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay.

Xu L, Li Y, Biggins JB, Bowman BR, Verdine GL, Gloer JB, Alspaugh JA, Bills GF.

Appl Microbiol Biotechnol. 2018 Mar;102(5):2337-2350. doi: 10.1007/s00253-018-8792-0. Epub 2018 Feb 2.


Targeting protein localization for anti-infective therapy.

Alspaugh JA.

Virulence. 2017 Oct 3;8(7):1105-1107. doi: 10.1080/21505594.2017.1342921. Epub 2017 Jun 28. No abstract available.


The role of Aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy.

Gontijo FA, de Melo AT, Pascon RC, Fernandes L, Paes HC, Alspaugh JA, Vallim MA.

PLoS One. 2017 May 25;12(5):e0177461. doi: 10.1371/journal.pone.0177461. eCollection 2017.


Rim Pathway-Mediated Alterations in the Fungal Cell Wall Influence Immune Recognition and Inflammation.

Ost KS, Esher SK, Leopold Wager CM, Walker L, Wagener J, Munro C, Wormley FL Jr, Alspaugh JA.

MBio. 2017 Jan 31;8(1). pii: e02290-16. doi: 10.1128/mBio.02290-16.


Discovery of Ibomycin, a Potent Antifungal Weapon.

Alspaugh JA.

Cell Chem Biol. 2016 Nov 17;23(11):1321-1322. doi: 10.1016/j.chembiol.2016.11.001.


New Horizons in Antifungal Therapy.

Pianalto KM, Alspaugh JA.

J Fungi (Basel). 2016 Oct 2;2(4). pii: E26. doi: 10.3390/jof2040026. Review.


Relative Contributions of Prenylation and Postprenylation Processing in Cryptococcus neoformans Pathogenesis.

Esher SK, Ost KS, Kozubowski L, Yang DH, Kim MS, Bahn YS, Alspaugh JA, Nichols CB.

mSphere. 2016 Mar 30;1(2). pii: e00084-15. doi: 10.1128/mSphere.00084-15. eCollection 2016 Mar-Apr.


Unveiling Protein Kinase A Targets in Cryptococcus neoformans Capsule Formation.

Alspaugh JA.

MBio. 2016 Feb 9;7(1):e00021-16. doi: 10.1128/mBio.00021-16.


Rapid mapping of insertional mutations to probe cell wall regulation in Cryptococcus neoformans.

Esher SK, Granek JA, Alspaugh JA.

Fungal Genet Biol. 2015 Sep;82:9-21. doi: 10.1016/j.fgb.2015.06.003. Epub 2015 Jun 23.


Impact of Protein Palmitoylation on the Virulence Potential of Cryptococcus neoformans.

Nichols CB, Ost KS, Grogan DP, Pianalto K, Hasan S, Alspaugh JA.

Eukaryot Cell. 2015 Jul;14(7):626-35. doi: 10.1128/EC.00010-15. Epub 2015 Apr 10.


The Cryptococcus neoformans alkaline response pathway: identification of a novel rim pathway activator.

Ost KS, O'Meara TR, Huda N, Esher SK, Alspaugh JA.

PLoS Genet. 2015 Apr 10;11(4):e1005159. doi: 10.1371/journal.pgen.1005159. eCollection 2015 Apr.


Fungal morphogenesis.

Lin X, Alspaugh JA, Liu H, Harris S.

Cold Spring Harb Perspect Med. 2014 Nov 3;5(2):a019679. doi: 10.1101/cshperspect.a019679. Review.


Virulence mechanisms and Cryptococcus neoformans pathogenesis.

Alspaugh JA.

Fungal Genet Biol. 2015 May;78:55-8. doi: 10.1016/j.fgb.2014.09.004. Epub 2014 Sep 23. Review.


The role of the de novo pyrimidine biosynthetic pathway in Cryptococcus neoformans high temperature growth and virulence.

de Gontijo FA, Pascon RC, Fernandes L, Machado J Jr, Alspaugh JA, Vallim MA.

Fungal Genet Biol. 2014 Sep;70:12-23. doi: 10.1016/j.fgb.2014.06.003. Epub 2014 Jul 7.


Hostile takeover: fungal protein promotes host cell invasion.

Alspaugh JA.

J Clin Invest. 2014 Jan;124(1):74-6. doi: 10.1172/JCI73585. Epub 2013 Dec 20.


The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host.

O'Meara TR, Xu W, Selvig KM, O'Meara MJ, Mitchell AP, Alspaugh JA.

Mol Cell Biol. 2014 Feb;34(4):673-84. doi: 10.1128/MCB.01359-13. Epub 2013 Dec 9.


Restricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence.

Selvig K, Ballou ER, Nichols CB, Alspaugh JA.

Eukaryot Cell. 2013 Nov;12(11):1462-71. doi: 10.1128/EC.00193-13. Epub 2013 Sep 6.


Ras1 acts through duplicated Cdc42 and Rac proteins to regulate morphogenesis and pathogenesis in the human fungal pathogen Cryptococcus neoformans.

Ballou ER, Kozubowski L, Nichols CB, Alspaugh JA.

PLoS Genet. 2013;9(8):e1003687. doi: 10.1371/journal.pgen.1003687. Epub 2013 Aug 8.


Two Rac paralogs regulate polarized growth in the human fungal pathogen Cryptococcus neoformans.

Ballou ER, Selvig K, Narloch JL, Nichols CB, Alspaugh JA.

Fungal Genet Biol. 2013 Aug;57:58-75. doi: 10.1016/j.fgb.2013.05.006. Epub 2013 Jun 5.


Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses.

O'Meara TR, Holmer SM, Selvig K, Dietrich F, Alspaugh JA.

MBio. 2013 Jan 15;4(1). pii: e00522-12. doi: 10.1128/mBio.00522-12.


pH Response Pathways in Fungi: Adapting to Host-derived and Environmental Signals.

Selvig K, Alspaugh JA.

Mycobiology. 2011 Dec;39(4):249-56. doi: 10.5941/MYCO.2011.39.4.249. Epub 2011 Dec 7.


The Cryptococcus neoformans capsule: a sword and a shield.

O'Meara TR, Alspaugh JA.

Clin Microbiol Rev. 2012 Jul;25(3):387-408. doi: 10.1128/CMR.00001-12. Review.


Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans.

Shen G, Zhou E, Alspaugh JA, Wang P.

Eukaryot Cell. 2012 Apr;11(4):471-81. doi: 10.1128/EC.00011-12. Epub 2012 Feb 10.


Pedicure-associated rapidly growing mycobacterial infection: an endemic disease.

Stout JE, Gadkowski LB, Rath S, Alspaugh JA, Miller MB, Cox GM.

Clin Infect Dis. 2011 Oct;53(8):787-92. doi: 10.1093/cid/cir539.


Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli.

Okagaki LH, Wang Y, Ballou ER, O'Meara TR, Bahn YS, Alspaugh JA, Xue C, Nielsen K.

Eukaryot Cell. 2011 Oct;10(10):1306-16. doi: 10.1128/EC.05179-11. Epub 2011 Aug 5.


Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens.

Hast MA, Nichols CB, Armstrong SM, Kelly SM, Hellinga HW, Alspaugh JA, Beese LS.

J Biol Chem. 2011 Oct 7;286(40):35149-62. doi: 10.1074/jbc.M111.250506. Epub 2011 Aug 4.


Heterothallic mating in Mucor irregularis and first isolate of the species outside of Asia.

Schell WA, O'Donnell K, Alspaugh JA.

Med Mycol. 2011 Oct;49(7):714-23. doi: 10.3109/13693786.2011.568975. Epub 2011 Apr 1. Erratum in: Med Mycol. 2011 Oct;49(7):723.


Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host.

O'Meara TR, Hay C, Price MS, Giles S, Alspaugh JA.

Eukaryot Cell. 2010 Aug;9(8):1193-202. doi: 10.1128/EC.00098-10. Epub 2010 Jun 25.


Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule.

O'Meara TR, Norton D, Price MS, Hay C, Clements MF, Nichols CB, Alspaugh JA.

PLoS Pathog. 2010 Feb 19;6(2):e1000776. doi: 10.1371/journal.ppat.1000776.


Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions.

Ballou ER, Nichols CB, Miglia KJ, Kozubowski L, Alspaugh JA.

Mol Microbiol. 2010 Feb;75(3):763-80. doi: 10.1111/j.1365-2958.2009.07019.x. Epub 2009 Dec 16.


Characterization of the PMT gene family in Cryptococcus neoformans.

Willger SD, Ernst JF, Alspaugh JA, Lengeler KB.

PLoS One. 2009 Jul 27;4(7):e6321. doi: 10.1371/journal.pone.0006321.


Subcellular localization directs signaling specificity of the Cryptococcus neoformans Ras1 protein.

Nichols CB, Ferreyra J, Ballou ER, Alspaugh JA.

Eukaryot Cell. 2009 Feb;8(2):181-9. doi: 10.1128/EC.00351-08. Epub 2008 Dec 19.


Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.

Fortwendel JR, Juvvadi PR, Pinchai N, Perfect BZ, Alspaugh JA, Perfect JR, Steinbach WJ.

Antimicrob Agents Chemother. 2009 Feb;53(2):476-82. doi: 10.1128/AAC.01154-08. Epub 2008 Nov 17.


The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence.

Price MS, Nichols CB, Alspaugh JA.

Infect Immun. 2008 Dec;76(12):5729-37. doi: 10.1128/IAI.00896-08. Epub 2008 Sep 8.


Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans.

Olson GM, Fox DS, Wang P, Alspaugh JA, Buchanan KL.

Eukaryot Cell. 2007 Feb;6(2):222-34. Epub 2006 Dec 1.


The Cryptococcus neoformans catalase gene family and its role in antioxidant defense.

Giles SS, Stajich JE, Nichols C, Gerrald QD, Alspaugh JA, Dietrich F, Perfect JR.

Eukaryot Cell. 2006 Sep;5(9):1447-59.


Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans.

Cramer KL, Gerrald QD, Nichols CB, Price MS, Alspaugh JA.

Eukaryot Cell. 2006 Jul;5(7):1147-56.


Non-comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation.

Alexander BD, Dodds Ashley ES, Addison RM, Alspaugh JA, Chao NJ, Perfect JR.

Transpl Infect Dis. 2006 Mar;8(1):13-20.


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