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Items: 25


Constitutive Activation of STAT3 in Myeloma Cells Cultured in a Three-Dimensional, Reconstructed Bone Marrow Model.

Huang YH, Molavi O, Alshareef A, Haque M, Wang Q, Chu MP, Venner CP, Sandhu I, Peters AC, Lavasanifar A, Lai R.

Cancers (Basel). 2018 Jun 16;10(6). pii: E206. doi: 10.3390/cancers10060206.


Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma.

Wu C, Gupta N, Huang YH, Zhang HF, Alshareef A, Chow A, Lai R.

BMC Cancer. 2018 Apr 2;18(1):361. doi: 10.1186/s12885-018-4300-2.


The absence of a novel intron 19-retaining ALK transcript (ALK-I19) and MYCN amplification correlates with an excellent clinical outcome in neuroblastoma patients.

Alshareef A, Irwin MS, Gupta N, Zhang HF, Haque M, Findlay SD, Seong BKA, Lai J, Rayis M, Al-Dandan S, Lai R.

Oncotarget. 2018 Jan 12;9(12):10698-10713. doi: 10.18632/oncotarget.24216. eCollection 2018 Feb 13.


Phosphorylation of Sox2 at Threonine 116 is a Potential Marker to Identify a Subset of Breast Cancer Cells with High Tumorigenecity and Stem-Like Features.

Gupta N, Gopal K, Wu C, Alshareef A, Chow A, Wu F, Wang P, Ye X, Bigras G, Lai R.

Cancers (Basel). 2018 Feb 3;10(2). pii: E41. doi: 10.3390/cancers10020041.


High expression of β-catenin contributes to the crizotinib resistant phenotype in the stem-like cell population in neuroblastoma.

Alshareef A, Gupta N, Zhang HF, Wu C, Haque M, Lai R.

Sci Rep. 2017 Dec 4;7(1):16863. doi: 10.1038/s41598-017-17319-9.


A Novel Method for Quantifying Human In Situ Whole Brain Deformation under Rotational Loading Using Sonomicrometry.

Alshareef A, Giudice JS, Forman J, Salzar RS, Panzer MB.

J Neurotrauma. 2018 Mar 1;35(5):780-789. doi: 10.1089/neu.2017.5362. Epub 2018 Jan 29.


Novel Molecular Challenges in Targeting Anaplastic Lymphoma Kinase in ALK-Expressing Human Cancers.

Alshareef A.

Cancers (Basel). 2017 Oct 28;9(11). pii: E148. doi: 10.3390/cancers9110148. Review.


High Myc expression and transcription activity underlies intra-tumoral heterogeneity in triple-negative breast cancer.

Gupta N, Jung K, Wu C, Alshareef A, Alqahtani H, Damaraju S, Mackey JR, Ghosh S, Sabri S, Abdulkarim BS, Bigras G, Lai R.

Oncotarget. 2017 Apr 25;8(17):28101-28115. doi: 10.18632/oncotarget.15891.


Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma.

Soleimani AH, Garg SM, Paiva IM, Vakili MR, Alshareef A, Huang YH, Molavi O, Lai R, Lavasanifar A.

Drug Deliv Transl Res. 2017 Aug;7(4):571-581. doi: 10.1007/s13346-017-0369-4.


A positive feedback loop involving the Wnt/β-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subpopulation in ALK-positive anaplastic large cell lymphoma.

Wu C, Zhang HF, Gupta N, Alshareef A, Wang Q, Huang YH, Lewis JT, Douglas DN, Kneteman NM, Lai R.

J Hematol Oncol. 2016 Nov 8;9(1):120.


The use of cellular thermal shift assay (CETSA) to study Crizotinib resistance in ALK-expressing human cancers.

Alshareef A, Zhang HF, Huang YH, Wu C, Zhang JD, Wang P, El-Sehemy A, Fares M, Lai R.

Sci Rep. 2016 Sep 19;6:33710. doi: 10.1038/srep33710.


The effect of some immunomodulatory and anti-inflammatory drugs on Li-pilocarpine-induced epileptic disorders in Wistar rats.

Borham LE, Mahfoz AM, Ibrahim IAA, Shahzad N, ALrefai AA, Labib AA, Bin Sef B, Alshareef A, Khan M, Milibary A, Al Ghamdi S.

Brain Res. 2016 Oct 1;1648(Pt A):418-424. doi: 10.1016/j.brainres.2016.07.046. Epub 2016 Aug 3.


miR-200b induces cell cycle arrest and represses cell growth in esophageal squamous cell carcinoma.

Zhang HF, Alshareef A, Wu C, Jiao JW, Sorensen PH, Lai R, Xu LY, Li EM.

Carcinogenesis. 2016 Sep;37(9):858-869. doi: 10.1093/carcin/bgw079. Epub 2016 Aug 4.


The PI3K/AKT/c-MYC Axis Promotes the Acquisition of Cancer Stem-Like Features in Esophageal Squamous Cell Carcinoma.

Zhang HF, Wu C, Alshareef A, Gupta N, Zhao Q, Xu XE, Jiao JW, Li EM, Xu LY, Lai R.

Stem Cells. 2016 Aug;34(8):2040-51. doi: 10.1002/stem.2395. Epub 2016 May 23.


Oxidative stress induces the acquisition of cancer stem-like phenotype in breast cancer detectable by using a Sox2 regulatory region-2 (SRR2) reporter.

Gopal K, Gupta N, Zhang H, Alshareef A, Alqahtani H, Bigras G, Lewis J, Douglas D, Kneteman N, Lavasanifar A, Lai R.

Oncotarget. 2016 Jan 19;7(3):3111-27. doi: 10.18632/oncotarget.6630.


DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer.

Alqahtani H, Gopal K, Gupta N, Jung K, Alshareef A, Ye X, Wu F, Li L, Lai R.

Cell Signal. 2016 Feb;28(2):42-50. doi: 10.1016/j.cellsig.2015.11.004. Epub 2015 Nov 10.


The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma.

Zhang HF, Chen Y, Wu C, Wu ZY, Tweardy DJ, Alshareef A, Liao LD, Xue YJ, Wu JY, Chen B, Xu XE, Gopal K, Gupta N, Li EM, Xu LY, Lai R.

Clin Cancer Res. 2016 Feb 1;22(3):691-703. doi: 10.1158/1078-0432.CCR-15-1253. Epub 2015 Sep 24.


Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin β1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism.

Zhang HF, Alshareef A, Wu C, Li S, Jiao JW, Cao HH, Lai R, Xu LY, Li EM.

Oncotarget. 2015 Oct 6;6(30):28949-60. doi: 10.18632/oncotarget.5027.


STAT1 is phosphorylated and downregulated by the oncogenic tyrosine kinase NPM-ALK in ALK-positive anaplastic large-cell lymphoma.

Wu C, Molavi O, Zhang H, Gupta N, Alshareef A, Bone KM, Gopal K, Wu F, Lewis JT, Douglas DN, Kneteman NM, Lai R.

Blood. 2015 Jul 16;126(3):336-45. doi: 10.1182/blood-2014-10-603738. Epub 2015 Apr 28.


Triple negative breast cancers comprise a highly tumorigenic cell subpopulation detectable by its high responsiveness to a Sox2 regulatory region 2 (SRR2) reporter.

Jung K, Gupta N, Wang P, Lewis JT, Gopal K, Wu F, Ye X, Alshareef A, Abdulkarim BS, Douglas DN, Kneteman NM, Lai R.

Oncotarget. 2015 Apr 30;6(12):10366-73.


Profiling gene promoter occupancy of Sox2 in two phenotypically distinct breast cancer cell subsets using chromatin immunoprecipitation and genome-wide promoter microarrays.

Jung K, Wang P, Gupta N, Gopal K, Wu F, Ye X, Alshareef A, Bigras G, McMullen TP, Abdulkarim BS, Lai R.

Breast Cancer Res. 2014 Nov 8;16(6):470. doi: 10.1186/s13058-014-0470-2.


Effect of spinal cord compression on local vascular blood flow and perfusion capacity.

Alshareef M, Krishna V, Ferdous J, Alshareef A, Kindy M, Kolachalama VB, Shazly T.

PLoS One. 2014 Sep 30;9(9):e108820. doi: 10.1371/journal.pone.0108820. eCollection 2014.


Extracranial glioblastoma in transplant recipients.

Jimsheleishvili S, Alshareef AT, Papadimitriou K, Bregy A, Shah AH, Graham RM, Ferraro N, Komotar RJ.

J Cancer Res Clin Oncol. 2014 May;140(5):801-7. doi: 10.1007/s00432-014-1625-3. Epub 2014 Mar 5.


Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma.

Hegazy SA, Alshareef A, Gelebart P, Anand M, Armanious H, Ingham RJ, Lai R.

Cell Signal. 2013 Jan;25(1):295-307. doi: 10.1016/j.cellsig.2012.09.027. Epub 2012 Sep 28.


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