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Items: 42


Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei.

Collett CF, Kitson C, Baker N, Steele-Stallard HB, Santrot MV, Hutchinson S, Horn D, Alsford S.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00795-19. doi: 10.1128/AAC.00795-19. Print 2019 Aug.


Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.

Thomas JA, Baker N, Hutchinson S, Dominicus C, Trenaman A, Glover L, Alsford S, Horn D.

PLoS Negl Trop Dis. 2018 Nov 26;12(11):e0006980. doi: 10.1371/journal.pntd.0006980. eCollection 2018 Nov.


Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1.

Currier RB, Cooper A, Burrell-Saward H, MacLeod A, Alsford S.

PLoS Pathog. 2018 Jan 18;14(1):e1006855. doi: 10.1371/journal.ppat.1006855. eCollection 2018 Jan.


Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs.

Meredith EL, Kumar A, Konno A, Szular J, Alsford S, Seifert K, Horn D, Wilkinson SR.

Mol Microbiol. 2017 Oct;106(2):207-222. doi: 10.1111/mmi.13767. Epub 2017 Aug 31.


Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei.

Stortz JA, Serafim TD, Alsford S, Wilkes J, Fernandez-Cortes F, Hamilton G, Briggs E, Lemgruber L, Horn D, Mottram JC, McCulloch R.

PLoS Pathog. 2017 Jul 24;13(7):e1006477. doi: 10.1371/journal.ppat.1006477. eCollection 2017 Jul.


Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei.

Macedo JP, Currier RB, Wirdnam C, Horn D, Alsford S, Rentsch D.

FASEB J. 2017 Oct;31(10):4649-4660. doi: 10.1096/fj.201700311R. Epub 2017 Jul 5.


Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.

Maishman L, Obado SO, Alsford S, Bart JM, Chen WM, Ratushny AV, Navarro M, Horn D, Aitchison JD, Chait BT, Rout MP, Field MC.

Nucleic Acids Res. 2016 Dec 15;44(22):10554-10570. Epub 2016 Sep 12.


Subverting lysosomal function in Trypanosoma brucei.

Alsford S.

Microb Cell. 2015 Aug;2(8):259-261.


VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes.

Glover L, Hutchinson S, Alsford S, Horn D.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7225-30. doi: 10.1073/pnas.1600344113. Epub 2016 May 25.


Correction: Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes.

Zoltner M, Leung KF, Alsford S, Horn D, Field MC.

PLoS Pathog. 2015 Nov 23;11(11):e1005291. doi: 10.1371/journal.ppat.1005291. eCollection 2015 Nov. No abstract available.


Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes.

Zoltner M, Leung KF, Alsford S, Horn D, Field MC.

PLoS Pathog. 2015 Oct 22;11(10):e1005236. doi: 10.1371/journal.ppat.1005236. eCollection 2015 Oct. Erratum in: PLoS Pathog. 2015 Nov;11(11):e1005291. PLoS Pathog. 2016 Feb;12(2):e1005432.


Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes.

Glover L, Alsford S, Baker N, Turner DJ, Sanchez-Flores A, Hutchinson S, Hertz-Fowler C, Berriman M, Horn D.

Nat Protoc. 2015 Jan;10(1):106-33. doi: 10.1038/nprot.2015.005. Epub 2014 Dec 11.


Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei.

Alsford S, Currier RB, Guerra-Assunção JA, Clark TG, Horn D.

PLoS Pathog. 2014 May 15;10(5):e1004130. doi: 10.1371/journal.ppat.1004130. eCollection 2014 May.


Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control.

Glover L, Hutchinson S, Alsford S, McCulloch R, Field MC, Horn D.

Cell Microbiol. 2013 Dec;15(12):1984-93. doi: 10.1111/cmi.12215. Epub 2013 Oct 10. Review.


Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA.

Gould MK, Bachmaier S, Ali JA, Alsford S, Tagoe DN, Munday JC, Schnaufer AC, Horn D, Boshart M, de Koning HP.

Antimicrob Agents Chemother. 2013 Oct;57(10):4882-93. doi: 10.1128/AAC.00508-13. Epub 2013 Jul 22.


Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy.

Alsford S, Field MC, Horn D.

Trends Parasitol. 2013 May;29(5):207-12. doi: 10.1016/ Epub 2013 Apr 17.


DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes.

Glover L, Alsford S, Horn D.

PLoS Pathog. 2013 Mar;9(3):e1003260. doi: 10.1371/journal.ppat.1003260. Epub 2013 Mar 28.


Genetic dissection of drug resistance in trypanosomes.

Alsford S, Kelly JM, Baker N, Horn D.

Parasitology. 2013 Oct;140(12):1478-91. doi: 10.1017/S003118201300022X. Epub 2013 Apr 3. Review.


Telomeres, tethers and trypanosomes.

Field MC, Horn D, Alsford S, Koreny L, Rout MP.

Nucleus. 2012 Nov-Dec;3(6):478-86. doi: 10.4161/nucl.22167. Epub 2012 Sep 19.


Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei.

Alsford S, Horn D.

Nucleic Acids Res. 2012 Nov 1;40(20):10150-60. doi: 10.1093/nar/gks813. Epub 2012 Aug 31.


Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes.

Alsford S, duBois K, Horn D, Field MC.

Expert Rev Mol Med. 2012 May 29;14:e13. doi: 10.1017/erm.2012.7. Review.


NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions.

DuBois KN, Alsford S, Holden JM, Buisson J, Swiderski M, Bart JM, Ratushny AV, Wan Y, Bastin P, Barry JD, Navarro M, Horn D, Aitchison JD, Rout MP, Field MC.

PLoS Biol. 2012;10(3):e1001287. doi: 10.1371/journal.pbio.1001287. Epub 2012 Mar 27.


High-throughput decoding of antitrypanosomal drug efficacy and resistance.

Alsford S, Eckert S, Baker N, Glover L, Sanchez-Flores A, Leung KF, Turner DJ, Field MC, Berriman M, Horn D.

Nature. 2012 Jan 25;482(7384):232-6. doi: 10.1038/nature10771.


High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.

Alsford S, Turner DJ, Obado SO, Sanchez-Flores A, Glover L, Berriman M, Hertz-Fowler C, Horn D.

Genome Res. 2011 Jun;21(6):915-24. doi: 10.1101/gr.115089.110. Epub 2011 Mar 1.


Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes.

Alsford S, Horn D.

Mol Cell Biol. 2011 May;31(9):1822-32. doi: 10.1128/MCB.01026-10. Epub 2011 Feb 28.


Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.

Baker N, Alsford S, Horn D.

Mol Biochem Parasitol. 2011 Mar;176(1):55-7. doi: 10.1016/j.molbiopara.2010.11.010. Epub 2010 Nov 18.


RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease.

Alsford S, Kemp LE, Kawahara T, Horn D.

Mol Biochem Parasitol. 2010 Nov;174(1):70-3. doi: 10.1016/j.molbiopara.2010.06.006. Epub 2010 Jun 14.


DNA breaks as triggers for antigenic variation in African trypanosomes.

Alsford S, Horn D, Glover L.

Genome Biol. 2009;10(6):223. doi: 10.1186/gb-2009-10-6-223. Epub 2009 Jun 8. Review.


Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.

Kawahara T, Siegel TN, Ingram AK, Alsford S, Cross GA, Horn D.

Mol Microbiol. 2008 Aug;69(4):1054-68. doi: 10.1111/j.1365-2958.2008.06346.x. Epub 2008 Jul 9.


Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei.

Alsford S, Horn D.

Mol Biochem Parasitol. 2008 Sep;161(1):76-9. doi: 10.1016/j.molbiopara.2008.05.006. Epub 2008 Jun 7.


RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei.

Alsford S, Horn D.

Mol Biochem Parasitol. 2007 May;153(1):77-9. Epub 2007 Jan 21. No abstract available.


Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects.

Alsford S, Kawahara T, Glover L, Horn D.

Mol Biochem Parasitol. 2005 Dec;144(2):142-8. Epub 2005 Sep 6.


Multiplex analysis of RNA interference defects in Trypanosoma brucei.

Alsford S, Glover L, Horn D.

Mol Biochem Parasitol. 2005 Jan;139(1):129-32. No abstract available.


Trypanosomatid histones.

Alsford S, Horn D.

Mol Microbiol. 2004 Jul;53(2):365-72. Review.


Diversity and dynamics of the minichromosomal karyotype in Trypanosoma brucei.

Alsford S, Wickstead B, Ersfeld K, Gull K.

Mol Biochem Parasitol. 2001 Mar;113(1):79-88.


Segregation of minichromosomes in trypanosomes: implications for mitotic mechanisms.

Gull K, Alsford S, Ersfeld K.

Trends Microbiol. 1998 Aug;6(8):319-23. Review.


A fluorescence in situ hybridisation study of the regulation of histone mRNA levels during the cell cycle of Trypanosoma brucei.

Ersfeld K, Docherty R, Alsford S, Gull K.

Mol Biochem Parasitol. 1996 Oct 30;81(2):201-9.


Molecular forms of tegumental and muscle acetylcholinesterases of Schistosoma.

Camacho M, Alsford S, Agnew A.

Parasitology. 1996 Feb;112 ( Pt 2):199-204.


Nicotinic acetylcholine receptors on the surface of the blood fluke Schistosoma.

Camacho M, Alsford S, Jones A, Agnew A.

Mol Biochem Parasitol. 1995 Apr;71(1):127-34.


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