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Items: 1 to 50 of 113


Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair.

Herberg S, McDermott AM, Dang PN, Alt DS, Tang R, Dawahare JH, Varghai D, Shin JY, McMillan A, Dikina AD, He F, Lee YB, Cheng Y, Umemori K, Wong PC, Park H, Boerckel JD, Alsberg E.

Sci Adv. 2019 Aug 28;5(8):eaax2476. doi: 10.1126/sciadv.aax2476. eCollection 2019 Aug.


Covalently tethering siRNA to hydrogels for localized, controlled release and gene silencing.

Nguyen MK, Huynh CT, Gilewski A, Wilner SE, Maier KE, Kwon N, Levy M, Alsberg E.

Sci Adv. 2019 Aug 28;5(8):eaax0801. doi: 10.1126/sciadv.aax0801. eCollection 2019 Aug.


Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration.

McDermott AM, Herberg S, Mason DE, Collins JM, Pearson HB, Dawahare JH, Tang R, Patwa AN, Grinstaff MW, Kelly DJ, Alsberg E, Boerckel JD.

Sci Transl Med. 2019 Jun 5;11(495). pii: eaav7756. doi: 10.1126/scitranslmed.aav7756.


A microparticle approach for non-viral gene delivery within 3D human mesenchymal stromal cell aggregates.

Khalil AS, Yu X, Dang PN, Alsberg E, Murphy WL.

Acta Biomater. 2019 Sep 1;95:408-417. doi: 10.1016/j.actbio.2019.04.038. Epub 2019 Apr 18.


Gelatin microspheres releasing transforming growth factor drive in vitro chondrogenesis of human periosteum derived cells in micromass culture.

Kudva AK, Dikina AD, Luyten FP, Alsberg E, Patterson J.

Acta Biomater. 2019 May;90:287-299. doi: 10.1016/j.actbio.2019.03.039. Epub 2019 Mar 21.


Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells.

Sathy BN, Daly A, Gonzalez-Fernandez T, Olvera D, Cunniffe G, McCarthy HO, Dunne N, Jeon O, Alsberg E, Donahue TLH, Kelly DJ.

Acta Biomater. 2019 Apr 1;88:314-324. doi: 10.1016/j.actbio.2019.02.042. Epub 2019 Feb 27.


Cryopreserved cell-laden alginate microgel bioink for 3D bioprinting of living tissues.

Jeon O, Bin Lee Y, Hinton TJ, Feinberg AW, Alsberg E.

Mater Today Chem. 2019 Jun;12:61-70. doi: 10.1016/j.mtchem.2018.11.009. Epub 2019 Jan 14.


Nonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids.

Capeling MM, Czerwinski M, Huang S, Tsai YH, Wu A, Nagy MS, Juliar B, Sundaram N, Song Y, Han WM, Takayama S, Alsberg E, Garcia AJ, Helmrath M, Putnam AJ, Spence JR.

Stem Cell Reports. 2019 Feb 12;12(2):381-394. doi: 10.1016/j.stemcr.2018.12.001. Epub 2019 Jan 3.


Targeted Delivery of Bioactive Molecules for Vascular Intervention and Tissue Engineering.

Strobel HA, Qendro EI, Alsberg E, Rolle MW.

Front Pharmacol. 2018 Nov 21;9:1329. doi: 10.3389/fphar.2018.01329. eCollection 2018. Review.


Regeneration of Osteochondral Defects Using Developmentally Inspired Cartilaginous Templates.

Critchley S, Cunniffe G, O'Reilly A, Diaz-Payno P, Schipani R, McAlinden A, Withers D, Shin J, Alsberg E, Kelly DJ.

Tissue Eng Part A. 2019 Feb;25(3-4):159-171. doi: 10.1089/ten.TEA.2018.0046. Epub 2018 Dec 31.


Thiol-Epoxy "Click" Chemistry to Engineer Cytocompatible PEG-Based Hydrogel for siRNA-Mediated Osteogenesis of hMSCs.

Huynh CT, Liu F, Cheng Y, Coughlin KA, Alsberg E.

ACS Appl Mater Interfaces. 2018 Aug 8;10(31):25936-25942. doi: 10.1021/acsami.8b07167. Epub 2018 Jul 23.


RNA interfering molecule delivery from in situ forming biodegradable hydrogels for enhancement of bone formation in rat calvarial bone defects.

Nguyen MK, Jeon O, Dang PN, Huynh CT, Varghai D, Riazi H, McMillan A, Herberg S, Alsberg E.

Acta Biomater. 2018 Jul 15;75:105-114. doi: 10.1016/j.actbio.2018.06.007. Epub 2018 Jun 7.


A Modular Strategy to Engineer Complex Tissues and Organs.

Dikina AD, Alt DS, Herberg S, McMillan A, Strobel HA, Zheng Z, Cao M, Lai BP, Jeon O, Petsinger VI, Cotton CU, Rolle MW, Alsberg E.

Adv Sci (Weinh). 2018 Feb 14;5(5):1700402. doi: 10.1002/advs.201700402. eCollection 2018 May.


Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering.

Wong SA, Rivera KO, Miclau T 3rd, Alsberg E, Marcucio RS, Bahney CS.

Front Bioeng Biotechnol. 2018 May 15;6:58. doi: 10.3389/fbioe.2018.00058. eCollection 2018. Review.


Spatial Micropatterning of Growth Factors in 3D Hydrogels for Location-Specific Regulation of Cellular Behaviors.

Jeon O, Lee K, Alsberg E.

Small. 2018 Jun;14(25):e1800579. doi: 10.1002/smll.201800579. Epub 2018 May 21.


Assembly of Tissue-Engineered Blood Vessels with Spatially Controlled Heterogeneities.

Strobel HA, Hookway TA, Piola M, Fiore GB, Soncini M, Alsberg E, Rolle MW.

Tissue Eng Part A. 2018 Oct;24(19-20):1492-1503. doi: 10.1089/ten.TEA.2017.0492. Epub 2018 Aug 20.


High-density human mesenchymal stem cell rings with spatiotemporally-controlled morphogen presentation as building blocks for engineering bone diaphyseal tissue.

Herberg S, Varghai D, Cheng Y, Dikina AD, Dang PN, Rolle MW, Alsberg E.

Nanotheranostics. 2018 Feb 11;2(2):128-143. doi: 10.7150/ntno.23354. eCollection 2018.


Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three Dimensions.

Seo J, Shin JY, Leijten J, Jeon O, Bal Öztürk A, Rouwkema J, Li Y, Shin SR, Hajiali H, Alsberg E, Khademhosseini A.

ACS Appl Mater Interfaces. 2018 Apr 25;10(16):13293-13303. doi: 10.1021/acsami.7b17991. Epub 2018 Apr 13.


Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering.

McMillan A, Nguyen MK, Gonzalez-Fernandez T, Ge P, Yu X, Murphy WL, Kelly DJ, Alsberg E.

Biomaterials. 2018 Apr;161:240-255. doi: 10.1016/j.biomaterials.2018.01.006. Epub 2018 Jan 3.


An in-situ photocrosslinking microfluidic technique to generate non-spherical, cytocompatible, degradable, monodisperse alginate microgels for chondrocyte encapsulation.

Wang S, Bruning A, Jeon O, Long F, Alsberg E, Choi CK.

Biomicrofluidics. 2018 Jan 10;12(1):014106. doi: 10.1063/1.5017644. eCollection 2018 Jan.


High-throughput approaches for screening and analysis of cell behaviors.

Seo J, Shin JY, Leijten J, Jeon O, Camci-Unal G, Dikina AD, Brinegar K, Ghaemmaghami AM, Alsberg E, Khademhosseini A.

Biomaterials. 2018 Jan;153:85-101. doi: 10.1016/j.biomaterials.2017.06.022. Epub 2017 Jun 21. Review.


* Three-Dimensional Bioprinting of Polycaprolactone Reinforced Gene Activated Bioinks for Bone Tissue Engineering.

Cunniffe GM, Gonzalez-Fernandez T, Daly A, Sathy BN, Jeon O, Alsberg E, Kelly DJ.

Tissue Eng Part A. 2017 Sep;23(17-18):891-900. doi: 10.1089/ten.tea.2016.0498. Epub 2017 Aug 14.


Endochondral Ossification in Critical-Sized Bone Defects via Readily Implantable Scaffold-Free Stem Cell Constructs.

Dang PN, Herberg S, Varghai D, Riazi H, Varghai D, McMillan A, Awadallah A, Phillips LM, Jeon O, Nguyen MK, Dwivedi N, Yu X, Murphy WL, Alsberg E.

Stem Cells Transl Med. 2017 Jul;6(7):1644-1659. doi: 10.1002/sctm.16-0222. Epub 2017 Jun 8.


Reverse engineering development: Crosstalk opportunities between developmental biology and tissue engineering.

Marcucio RS, Qin L, Alsberg E, Boerckel JD.

J Orthop Res. 2017 Nov;35(11):2356-2368. doi: 10.1002/jor.23636. Epub 2017 Jul 31.


Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation.

Nguyen MK, McMillan A, Huynh CT, Schapira DS, Alsberg E.

J Mater Chem B. 2017 Jan 21;5(3):485-495. doi: 10.1039/C6TB01739H. Epub 2016 Dec 14.


Magnetic field application or mechanical stimulation via magnetic microparticles does not enhance chondrogenesis in mesenchymal stem cell sheets.

Dikina AD, Lai BP, Cao M, Zborowski M, Alsberg E.

Biomater Sci. 2017 Jun 27;5(7):1241-1245. doi: 10.1039/c7bm00061h.


Combined Administration of ASCs and BMP-12 Promotes an M2 Macrophage Phenotype and Enhances Tendon Healing.

Gelberman RH, Linderman SW, Jayaram R, Dikina AD, Sakiyama-Elbert S, Alsberg E, Thomopoulos S, Shen H.

Clin Orthop Relat Res. 2017 Sep;475(9):2318-2331. doi: 10.1007/s11999-017-5369-7. Epub 2017 May 1.


Corrigendum to "Sustained localized presentation of RNA interfering molecules from in situ forming hydrogels to guide stem cell osteogenic differentiation" [Biomaterials 35/24 (2014) 6278-6286].

Nguyen MK, Jeon O, Krebs MD, Schapira D, Alsberg E.

Biomaterials. 2017 May;125:12. doi: 10.1016/j.biomaterials.2017.02.008. Epub 2017 Feb 17. No abstract available.


Cellular Self-Assembly with Microsphere Incorporation for Growth Factor Delivery Within Engineered Vascular Tissue Rings.

Strobel HA, Dikina AD, Levi K, Solorio LD, Alsberg E, Rolle MW.

Tissue Eng Part A. 2017 Feb;23(3-4):143-155. doi: 10.1089/ten.TEA.2016.0260. Epub 2016 Dec 6.


Bone Morphogenetic Protein-2 Promotes Human Mesenchymal Stem Cell Survival and Resultant Bone Formation When Entrapped in Photocrosslinked Alginate Hydrogels.

Ho SS, Vollmer NL, Refaat MI, Jeon O, Alsberg E, Lee MA, Leach JK.

Adv Healthc Mater. 2016 Oct;5(19):2501-2509. doi: 10.1002/adhm.201600461. Epub 2016 Sep 1.


Tissue engineering and regenerative approaches to improving the healing of large bone defects.

Verrier S, Alini M, Alsberg E, Buchman SR, Kelly D, Laschke MW, Menger MD, Murphy WL, Stegemann JP, Schütz M, Miclau T, Stoddart MJ, Evans C.

Eur Cell Mater. 2016 Jul 19;32:87-110. Review.


Harnessing Topographical Cues for Tissue Engineering.

Carlier A, Alsberg E.

Tissue Eng Part A. 2016 Aug;22(15-16):995-6. doi: 10.1089/ten.TEA.2016.0188. Epub 2016 Aug 1. No abstract available.


3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering.

Daly AC, Cunniffe GM, Sathy BN, Jeon O, Alsberg E, Kelly DJ.

Adv Healthc Mater. 2016 Sep;5(18):2353-62. doi: 10.1002/adhm.201600182. Epub 2016 Jun 9.


Light-triggered RNA release and induction of hMSC osteogenesis via photodegradable, dual-crosslinked hydrogels.

Huynh CT, Nguyen MK, Naris M, Tonga GY, Rotello VM, Alsberg E.

Nanomedicine (Lond). 2016 Jun;11(12):1535-50. doi: 10.2217/nnm-2016-0088. Epub 2016 Jun 1.


In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel.

Wang S, Jeon O, Shankles PG, Liu Y, Alsberg E, Retterer ST, Lee BP, Choi CK.

Biomicrofluidics. 2016 Feb 3;10(1):011101. doi: 10.1063/1.4941339. eCollection 2016 Jan.


Sustained presentation of BMP-2 enhances osteogenic differentiation of human adipose-derived stem cells in gelatin hydrogels.

Samorezov JE, Headley EB, Everett CR, Alsberg E.

J Biomed Mater Res A. 2016 Jun;104(6):1387-97. doi: 10.1002/jbm.a.35668. Epub 2016 Feb 18.


Controlled Dual Growth Factor Delivery From Microparticles Incorporated Within Human Bone Marrow-Derived Mesenchymal Stem Cell Aggregates for Enhanced Bone Tissue Engineering via Endochondral Ossification.

Dang PN, Dwivedi N, Phillips LM, Yu X, Herberg S, Bowerman C, Solorio LD, Murphy WL, Alsberg E.

Stem Cells Transl Med. 2016 Feb;5(2):206-17. doi: 10.5966/sctm.2015-0115. Epub 2015 Dec 23.


Photocleavable Hydrogels for Light-Triggered siRNA Release.

Huynh CT, Nguyen MK, Tonga GY, Longé L, Rotello VM, Alsberg E.

Adv Healthc Mater. 2016 Feb 4;5(3):305-310. doi: 10.1002/adhm.201500778. Epub 2015 Dec 7.


Spatially organized differentiation of mesenchymal stem cells within biphasic microparticle-incorporated high cell density osteochondral tissues.

Solorio LD, Phillips LM, McMillan A, Cheng CW, Dang PN, Samorezov JE, Yu X, Murphy WL, Alsberg E.

Adv Healthc Mater. 2015 Oct 28;4(15):2306-13. doi: 10.1002/adhm.201500598. Epub 2015 Sep 15.


Engineered cartilaginous tubes for tracheal tissue replacement via self-assembly and fusion of human mesenchymal stem cell constructs.

Dikina AD, Strobel HA, Lai BP, Rolle MW, Alsberg E.

Biomaterials. 2015 Jun;52:452-62. doi: 10.1016/j.biomaterials.2015.01.073. Epub 2015 Mar 18.


Dual Ionic and Photo-Crosslinked Alginate Hydrogels for Micropatterned Spatial Control of Material Properties and Cell Behavior.

Samorezov JE, Morlock CM, Alsberg E.

Bioconjug Chem. 2015 Jul 15;26(7):1339-47. doi: 10.1021/acs.bioconjchem.5b00117. Epub 2015 Apr 9.


In-situ formation of growth-factor-loaded coacervate microparticle-embedded hydrogels for directing encapsulated stem cell fate.

Jeon O, Wolfson DW, Alsberg E.

Adv Mater. 2015 Apr 1;27(13):2216-23. doi: 10.1002/adma.201405337. Epub 2015 Feb 23.


Microcomputed tomography: approaches and applications in bioengineering.

Boerckel JD, Mason DE, McDermott AM, Alsberg E.

Stem Cell Res Ther. 2014 Dec 29;5(6):144. doi: 10.1186/scrt534. Review.


Improved cell infiltration of highly porous nanofibrous scaffolds formed by combined fiber-fiber charge repulsions and ultra-sonication.

Jeong SI, Burns NA, Bonino CA, Kwon IK, Khan SA, Alsberg E.

J Mater Chem B. 2014 Dec 14;2(46):8116-8122.


Spatial control of cell gene expression by siRNA gradients in biodegradable hydrogels.

Hill MC, Nguyen MK, Jeon O, Alsberg E.

Adv Healthc Mater. 2015 Apr 2;4(5):714-22. doi: 10.1002/adhm.201400458. Epub 2014 Dec 22.


Spatial regulation of controlled bioactive factor delivery for bone tissue engineering.

Samorezov JE, Alsberg E.

Adv Drug Deliv Rev. 2015 Apr;84:45-67. doi: 10.1016/j.addr.2014.11.018. Epub 2014 Nov 29. Review.


Multilayered Inorganic Microparticles for Tunable Dual Growth Factor Delivery.

Yu X, Khalil A, Dang PN, Alsberg E, Murphy WL.

Adv Funct Mater. 2014 May 28;24(20):3082-3093.


Improved conduction and increased cell retention in healed MI using mesenchymal stem cells suspended in alginate hydrogel.

Panda NC, Zuckerman ST, Mesubi OO, Rosenbaum DS, Penn MS, Donahue JK, Alsberg E, Laurita KR.

J Interv Card Electrophysiol. 2014 Nov;41(2):117-27. doi: 10.1007/s10840-014-9940-9. Epub 2014 Sep 19.


Mathematical modelling of glycosaminoglycan production by stem cell aggregates incorporated with growth factor-releasing polymer microspheres.

Fu AS, Solorio LD, Alsberg E, Saidel GM.

J Tissue Eng Regen Med. 2017 Feb;11(2):481-488. doi: 10.1002/term.1940. Epub 2014 Jul 22.


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