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Items: 37


Another hijack! Some enteroviruses co-opt the c10orf76/PI4KB complex for their own good.

Voilquin L, Di Mattia T, Alpy F.

EMBO Rep. 2020 Jan 9:e49876. doi: 10.15252/embr.201949876. [Epub ahead of print]


Faraway, so close! Functions of Endoplasmic reticulum-Endosome contacts.

Di Mattia T, Tomasetto C, Alpy F.

Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jan;1865(1):158490. doi: 10.1016/j.bbalip.2019.06.016. Epub 2019 Jun 26. Review.


A novel machine learning-derived decision tree including uPA/PAI-1 for breast cancer care.

Reix N, Lodi M, Jankowski S, Molière S, Luporsi E, Leblanc S, Scheer L, Ibnouhsein I, Benabu JC, Gabriele V, Guggiola A, Lessinger JM, Chenard MP, Alpy F, Bellocq JP, Neuberger K, Tomasetto C, Mathelin C.

Clin Chem Lab Med. 2019 May 27;57(6):901-910. doi: 10.1515/cclm-2018-1065.


Intracellular and Plasma Membrane Cholesterol Labeling and Quantification Using Filipin and GFP-D4.

Wilhelm LP, Voilquin L, Kobayashi T, Tomasetto C, Alpy F.

Methods Mol Biol. 2019;1949:137-152. doi: 10.1007/978-1-4939-9136-5_11.


[MOSPD2, an inter-organelle connector].

Di Mattia T, Tomasetto C, Alpy F.

Med Sci (Paris). 2019 Jan;35(1):23-25. doi: 10.1051/medsci/2018313. Epub 2019 Jan 23. French. No abstract available.


Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites.

Di Mattia T, Wilhelm LP, Ikhlef S, Wendling C, Spehner D, Nominé Y, Giordano F, Mathelin C, Drin G, Tomasetto C, Alpy F.

EMBO Rep. 2018 Jul;19(7). pii: e45453. doi: 10.15252/embr.201745453. Epub 2018 Jun 1.


STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites.

Wilhelm LP, Wendling C, Védie B, Kobayashi T, Chenard MP, Tomasetto C, Drin G, Alpy F.

EMBO J. 2017 May 15;36(10):1412-1433. doi: 10.15252/embj.201695917. Epub 2017 Apr 4.


Hemidesmosome integrity protects the colon against colitis and colorectal cancer.

De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, Méchine-Neuville A, Siebert S, Pfister V, Lepage P, Laquerriere P, Dembele D, Delanoye-Crespin A, Rodius S, Robine S, Kedinger M, Van Seuningen I, Simon-Assmann P, Chamaillard M, Labouesse M, Georges-Labouesse E.

Gut. 2017 Oct;66(10):1748-1760. doi: 10.1136/gutjnl-2015-310847. Epub 2016 Jul 1.


Touché! STARD3 and STARD3NL tether the ER to endosomes.

Wilhelm LP, Tomasetto C, Alpy F.

Biochem Soc Trans. 2016 Apr 15;44(2):493-8. doi: 10.1042/BST20150269. Review.


The phosphoinositide-binding protein TRAF4 modulates tight junction stability and migration of cancer cells.

Rousseau A, Wilhelm LP, Tomasetto C, Alpy F.

Tissue Barriers. 2014 Aug 8;2(4):e975597. doi: 10.4161/21688370.2014.975597. eCollection 2014.


Functional relationship between matrix metalloproteinase-11 and matrix metalloproteinase-14.

Buache E, Thai R, Wendling C, Alpy F, Page A, Chenard MP, Dive V, Ruff M, Dejaegere A, Tomasetto C, Rio MC.

Cancer Med. 2014 Oct;3(5):1197-210. doi: 10.1002/cam4.290. Epub 2014 Aug 1.


[TRAF4, a multifaceted protein involved in carcinoma progression].

Rousseau A, Tomasetto C, Alpy F.

Biol Aujourdhui. 2014;208(4):299-310. doi: 10.1051/jbio/2014026. Epub 2015 Apr 3. French.


TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration.

Rousseau A, McEwen AG, Poussin-Courmontagne P, Rognan D, Nominé Y, Rio MC, Tomasetto C, Alpy F.

PLoS Biol. 2013 Dec;11(12):e1001726. doi: 10.1371/journal.pbio.1001726. Epub 2013 Dec 3.


Stromal matrix metalloproteinase-11 is involved in the mammary gland postnatal development.

Tan J, Buache E, Alpy F, Daguenet E, Tomasetto CL, Ren GS, Rio MC.

Oncogene. 2014 Jul 31;33(31):4050-9. doi: 10.1038/onc.2013.434. Epub 2013 Oct 21.


STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER.

Alpy F, Rousseau A, Schwab Y, Legueux F, Stoll I, Wendling C, Spiegelhalter C, Kessler P, Mathelin C, Rio MC, Levine TP, Tomasetto C.

J Cell Sci. 2013 Dec 1;126(Pt 23):5500-12. doi: 10.1242/jcs.139295. Epub 2013 Oct 8.


START ships lipids across interorganelle space.

Alpy F, Tomasetto C.

Biochimie. 2014 Jan;96:85-95. doi: 10.1016/j.biochi.2013.09.015. Epub 2013 Sep 25. Review.


Perispeckles are major assembly sites for the exon junction core complex.

Daguenet E, Baguet A, Degot S, Schmidt U, Alpy F, Wendling C, Spiegelhalter C, Kessler P, Rio MC, Le Hir H, Bertrand E, Tomasetto C.

Mol Biol Cell. 2012 May;23(9):1765-82. doi: 10.1091/mbc.E12-01-0040. Epub 2012 Mar 14.


In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis.

Blaise S, Kneib M, Rousseau A, Gambino F, Chenard MP, Messadeq N, Muckenstrum M, Alpy F, Tomasetto C, Humeau Y, Rio MC.

PLoS One. 2012;7(2):e30917. doi: 10.1371/journal.pone.0030917. Epub 2012 Feb 17.


Deficiency in trefoil factor 1 (TFF1) increases tumorigenicity of human breast cancer cells and mammary tumor development in TFF1-knockout mice.

Buache E, Etique N, Alpy F, Stoll I, Muckensturm M, Reina-San-Martin B, Chenard MP, Tomasetto C, Rio MC.

Oncogene. 2011 Jul 21;30(29):3261-73. doi: 10.1038/onc.2011.41. Epub 2011 Feb 28.


TRAF4, at the Crossroad between Morphogenesis and Cancer.

Rousseau A, Rio MC, Alpy F.

Cancers (Basel). 2011 Jun 21;3(2):2734-49. doi: 10.3390/cancers3022734.


Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation.

Edwards MM, Mammadova-Bach E, Alpy F, Klein A, Hicks WL, Roux M, Simon-Assmann P, Smith RS, Orend G, Wu J, Peachey NS, Naggert JK, Lefebvre O, Nishina PM.

J Biol Chem. 2010 Mar 5;285(10):7697-711. doi: 10.1074/jbc.M109.069575. Epub 2010 Jan 4.


Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature.

Bonuccelli G, Casimiro MC, Sotgia F, Wang C, Liu M, Katiyar S, Zhou J, Dew E, Capozza F, Daumer KM, Minetti C, Milliman JN, Alpy F, Rio MC, Tomasetto C, Mercier I, Flomenberg N, Frank PG, Pestell RG, Lisanti MP.

Am J Pathol. 2009 May;174(5):1650-62. doi: 10.2353/ajpath.2009.080648.


[START domain-containing proteins: a review of their role in lipid transport and exchange].

Alpy F, Legueux F, Bianchetti L, Tomasetto C.

Med Sci (Paris). 2009 Feb;25(2):181-91. doi: 10.1051/medsci/2009252181. Review. French.


Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis.

Kédinger V, Alpy F, Baguet A, Polette M, Stoll I, Chenard MP, Tomasetto C, Rio MC.

PLoS One. 2008;3(10):e3518. doi: 10.1371/journal.pone.0003518. Epub 2008 Oct 27. Erratum in: PLoS ONE. 2008;3(11). doi: 10.1371/annotation/2019a487-1af6-4f4e-882a-16398799e882.


MLN64 and MENTHO, two mediators of endosomal cholesterol transport.

Alpy F, Tomasetto C.

Biochem Soc Trans. 2006 Jun;34(Pt 3):343-5. Review.


Characterization of the putative cholesterol transport protein metastatic lymph node 64 in the brain.

King SR, Smith AG, Alpy F, Tomasetto C, Ginsberg SD, Lamb DJ.

Neuroscience. 2006;139(3):1031-8. Epub 2006 Mar 23.


The expression pattern of laminin isoforms in Hirschsprung disease reveals a distal peripheral nerve differentiation.

Alpy F, Ritié L, Jaubert F, Becmeur F, Méchine-Neuville A, Lefebvre O, Arnold C, Sorokin L, Kedinger M, Simon-Assmann P.

Hum Pathol. 2005 Oct;36(10):1055-65. Epub 2005 Sep 6.


Generation of a conditionally null allele of the laminin alpha1 gene.

Alpy F, Jivkov I, Sorokin L, Klein A, Arnold C, Huss Y, Kedinger M, Simon-Assmann P, Lefebvre O.

Genesis. 2005 Oct;43(2):59-70.


Give lipids a START: the StAR-related lipid transfer (START) domain in mammals.

Alpy F, Tomasetto C.

J Cell Sci. 2005 Jul 1;118(Pt 13):2791-801. Review.


MLN64 is involved in actin-mediated dynamics of late endocytic organelles.

Hölttä-Vuori M, Alpy F, Tanhuanpää K, Jokitalo E, Mutka AL, Ikonen E.

Mol Biol Cell. 2005 Aug;16(8):3873-86. Epub 2005 Jun 1.


Spatial and temporal distribution of the traf4 genes during zebrafish development.

Kedinger V, Alpy F, Tomasetto C, Thisse C, Thisse B, Rio MC.

Gene Expr Patterns. 2005 Apr;5(4):545-52. Epub 2004 Dec 15.


Functional characterization of the MENTAL domain.

Alpy F, Latchumanan VK, Kedinger V, Janoshazi A, Thiele C, Wendling C, Rio MC, Tomasetto C.

J Biol Chem. 2005 May 6;280(18):17945-52. Epub 2005 Feb 17.


[Membrane receptors borrow an indirect path against cancer].

Alpy F, Mathelin C.

Bull Cancer. 2004 Apr;91(4):300. French. No abstract available.


Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module.

Degot S, Le Hir H, Alpy F, Kedinger V, Stoll I, Wendling C, Seraphin B, Rio MC, Tomasetto C.

J Biol Chem. 2004 Aug 6;279(32):33702-15. Epub 2004 May 27.


Metastatic lymph node 64 (MLN64), a gene overexpressed in breast cancers, is regulated by Sp/KLF transcription factors.

Alpy F, Boulay A, Moog-Lutz C, Andarawewa KL, Degot S, Stoll I, Rio MC, Tomasetto C.

Oncogene. 2003 Jun 12;22(24):3770-80.


MENTHO, a MLN64 homologue devoid of the START domain.

Alpy F, Wendling C, Rio MC, Tomasetto C.

J Biol Chem. 2002 Dec 27;277(52):50780-7. Epub 2002 Oct 18.


The steroidogenic acute regulatory protein homolog MLN64, a late endosomal cholesterol-binding protein.

Alpy F, Stoeckel ME, Dierich A, Escola JM, Wendling C, Chenard MP, Vanier MT, Gruenberg J, Tomasetto C, Rio MC.

J Biol Chem. 2001 Feb 9;276(6):4261-9. Epub 2000 Oct 26.

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