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Items: 1 to 50 of 122

1.

Use of Renin Angiotensin System Blockers After Acute Kidney Injury: Balancing Tradeoffs.

Alpern RJ, Peixoto AJ.

JAMA Intern Med. 2018 Dec 1;178(12):1690-1692. doi: 10.1001/jamainternmed.2018.4757. No abstract available.

PMID:
30422208
2.

Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways.

Zacchia M, Tian X, Zona E, Alpern RJ, Preisig PA.

J Am Soc Nephrol. 2018 Jun;29(6):1720-1730. doi: 10.1681/ASN.2017121268. Epub 2018 Apr 20.

3.

Research in academic medical centers: two threats to sustainable support.

Levine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, Rothman PB, Schwinn DA, Shapiro LJ, Spiegel AM.

Sci Transl Med. 2015 May 27;7(289):289fs22. doi: 10.1126/scitranslmed.aac5200.

PMID:
26019216
4.

Treatment of severe metabolic alkalosis in a patient with congestive heart failure.

Peixoto AJ, Alpern RJ.

Am J Kidney Dis. 2013 May;61(5):822-7. doi: 10.1053/j.ajkd.2012.10.028. Epub 2013 Mar 5.

PMID:
23481366
5.

Defining hypercalciuria in nephrolithiasis.

Pak CY, Sakhaee K, Moe OW, Poindexter J, Adams-Huet B, Pearle MS, Zerwekh JE, Preminger GM, Wills MR, Breslau NA, Bartter FC, Brater DC, Heller HJ, Odvina CV, Wabner CL, Fordtran JS, Oh M, Garg A, Harvey JA, Alpern RJ, Snyder WH, Peters PC.

Kidney Int. 2011 Oct;80(7):777-82. doi: 10.1038/ki.2011.227. Epub 2011 Jul 20. Review.

6.

Competencies in premedical and medical education: the AAMC-HHMI report.

Alpern RJ, Belitsky R, Long S.

Perspect Biol Med. 2011 Winter;54(1):30-5. doi: 10.1353/pbm.2011.0001.

PMID:
21399381
7.

Acid regulation of NaDC-1 requires a functional endothelin B receptor.

Liu L, Zacchia M, Tian X, Wan L, Sakamoto A, Yanagisawa M, Alpern RJ, Preisig PA.

Kidney Int. 2010 Nov;78(9):895-904. doi: 10.1038/ki.2010.264. Epub 2010 Aug 11.

8.

RhoA required for acid-induced stress fiber formation and trafficking and activation of NHE3.

Yang X, Huang HC, Yin H, Alpern RJ, Preisig PA.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F1054-64. Epub 2007 Aug 8.

9.

Dietary acid, endothelins, and sleep.

Alpern RJ, Preisig PA.

Trans Am Clin Climatol Assoc. 2004;115:385-93; discussion 393-4.

10.

Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3.

Li S, Sato S, Yang X, Preisig PA, Alpern RJ.

J Clin Invest. 2004 Dec;114(12):1782-9.

11.

A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1.

Laghmani K, Sakamoto A, Yanagisawa M, Preisig PA, Alpern RJ.

Am J Physiol Renal Physiol. 2005 Apr;288(4):F732-9. Epub 2004 Dec 14.

12.

An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3.

Licht C, Laghmani K, Yanagisawa M, Preisig PA, Alpern RJ.

Kidney Int. 2004 Apr;65(4):1320-6.

13.

OKP cells express the Na-dicarboxylate cotransporter NaDC-1.

Aruga S, Pajor AM, Nakamura K, Liu L, Moe OW, Preisig PA, Alpern RJ.

Am J Physiol Cell Physiol. 2004 Jul;287(1):C64-72. Epub 2004 Feb 18.

14.

Treating dyslipidemia to slow the progression of chronic renal failure.

Palmer BF, Alpern RJ.

Am J Med. 2003 Apr 1;114(5):411-2. No abstract available.

PMID:
12714133
15.

Bicarbonate reabsorption and NHE-3 expression: abundance and activity are increased in Henle's loop of remnant rats.

Capasso G, Rizzo M, Pica A, Di Maio FS, Moe OW, Alpern RJ, De Santo NG.

Kidney Int. 2002 Dec;62(6):2126-35.

16.

Role of c-SRC and ERK in acid-induced activation of NHE3.

Tsuganezawa H, Sato S, Yamaji Y, Preisig PA, Moe OW, Alpern RJ.

Kidney Int. 2002 Jul;62(1):41-50.

17.

The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis.

Laghmani K, Preisig PA, Alpern RJ.

J Nephrol. 2002 Mar-Apr;15 Suppl 5:S75-87. Review.

PMID:
12027224
18.

2001 presidential address.

Alpern RJ.

J Am Soc Nephrol. 2002 Apr;13(4):1119-23. No abstract available.

19.

Glucagon acutely inhibits but chronically activates Na(+)/H(+) antiporter 3 activity in OKP cells.

Amemiya M, Kusano E, Muto S, Tabei K, Ando Y, Alpern RJ, Asano Y.

Exp Nephrol. 2002;10(1):26-33.

PMID:
11803202
20.

Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis.

Laghmani K, Preisig PA, Moe OW, Yanagisawa M, Alpern RJ.

J Clin Invest. 2001 Jun;107(12):1563-9.

21.

ET(B) receptor activation causes exocytic insertion of NHE3 in OKP cells.

Peng Y, Amemiya M, Yang X, Fan L, Moe OW, Yin H, Preisig PA, Yanagisawa M, Alpern RJ.

Am J Physiol Renal Physiol. 2001 Jan;280(1):F34-42.

22.

Acid incubation causes exocytic insertion of NHE3 in OKP cells.

Yang X, Amemiya M, Peng Y, Moe OW, Preisig PA, Alpern RJ.

Am J Physiol Cell Physiol. 2000 Aug;279(2):C410-9.

23.

Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney.

Aruga S, Wehrli S, Kaissling B, Moe OW, Preisig PA, Pajor AM, Alpern RJ.

Kidney Int. 2000 Jul;58(1):206-15.

24.

Renal citrate metabolism and urinary citrate excretion in the infant rat.

Melnick JZ, Preisig PA, Alpern RJ, Baum M.

Kidney Int. 2000 Mar;57(3):891-7.

25.

Role of glucocorticoids in acidosis.

Hamm LL, Ambühl PM, Alpern RJ.

Am J Kidney Dis. 1999 Nov;34(5):960-5. No abstract available.

PMID:
10561158
26.

ETB receptor activation leads to activation and phosphorylation of NHE3.

Peng Y, Moe OW, Chu T, Preisig PA, Yanagisawa M, Alpern RJ.

Am J Physiol. 1999 Apr;276(4):C938-45. doi: 10.1152/ajpcell.1999.276.4.C938.

PMID:
10199826
27.

Incubation of OKP cells in low-K+ media increases NHE3 activity after early decrease in intracellular pH.

Amemiya M, Tabei K, Kusano E, Asano Y, Alpern RJ.

Am J Physiol. 1999 Mar;276(3):C711-6. doi: 10.1152/ajpcell.1999.276.3.C711.

PMID:
10069999
28.

Glucocorticoids enhance acid activation of the Na+/H+ exchanger 3 (NHE3).

Ambühl PM, Yang X, Peng Y, Preisig PA, Moe OW, Alpern RJ.

J Clin Invest. 1999 Feb;103(3):429-35.

29.

Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia.

Melnick JZ, Preisig PA, Haynes S, Pak CY, Sakhaee K, Alpern RJ.

Kidney Int. 1998 Nov;54(5):1670-4.

30.

Renal Na/H exchanger NHE-3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states.

Loffing J, Lötscher M, Kaissling B, Biber J, Murer H, Seikaly M, Alpern RJ, Levi M, Baum M, Moe OW.

J Am Soc Nephrol. 1998 Sep;9(9):1560-7.

31.

Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cells.

Tsuganezawa H, Preisig PA, Alpern RJ.

Kidney Int. 1998 Aug;54(2):394-8.

32.

Renal cortical mitochondrial aconitase is regulated in hypo- and hypercitraturia.

Melnick JZ, Preisig PA, Moe OW, Srere P, Alpern RJ.

Kidney Int. 1998 Jul;54(1):160-5.

33.

Effects of thyroid hormone on the neonatal renal cortical Na+/H+ antiporter.

Baum M, Dwarakanath V, Alpern RJ, Moe OW.

Kidney Int. 1998 May;53(5):1254-8.

34.

Liddle's syndrome.

Palmer BF, Alpern RJ.

Am J Med. 1998 Mar;104(3):301-9. Review. No abstract available.

PMID:
9552093
35.

Chronic hyperosmolality increases NHE3 activity in OKP cells.

Ambühl P, Amemiya M, Preisig PA, Moe OW, Alpern RJ.

J Clin Invest. 1998 Jan 1;101(1):170-7.

36.

Media acidification inhibits TGF beta-mediated growth suppression in cultured rabbit proximal tubule cells.

Tovbin D, Franch HA, Alpern RJ, Preisig PA.

Proc Assoc Am Physicians. 1997 Nov;109(6):572-9.

PMID:
9394419
37.

Metabolic alkalosis.

Palmer BF, Alpern RJ.

J Am Soc Nephrol. 1997 Sep;8(9):1462-9. Review.

38.

Adaptation to low-K+ media increases H(+)-K(+)-ATPase but not H(+)-ATPase-mediated pHi recovery in OMCD1 cells.

Guntupalli J, Onuigbo M, Wall S, Alpern RJ, DuBose TD Jr.

Am J Physiol. 1997 Aug;273(2 Pt 1):C558-71.

PMID:
9277353
39.

Pathogenesis of edema formation in the nephrotic syndrome.

Palmer BF, Alpern RJ.

Kidney Int Suppl. 1997 Jun;59:S21-7. Review.

PMID:
9185099
40.

Intracellular acidosis activates c-Src.

Yamaji Y, Tsuganezawa H, Moe OW, Alpern RJ.

Am J Physiol. 1997 Mar;272(3 Pt 1):C886-93.

PMID:
9124524
41.

Does hyperphosphaturia underlie hypercalciuria?

Alpern RJ, Sakhaee K.

Lancet. 1997 Feb 22;349(9051):518-9. No abstract available.

PMID:
9048785
42.
43.

Chronic metabolic acidosis enhances NHE-3 protein abundance and transport activity in the rat thick ascending limb by increasing NHE-3 mRNA.

Laghmani K, Borensztein P, Ambühl P, Froissart M, Bichara M, Moe OW, Alpern RJ, Paillard M.

J Clin Invest. 1997 Jan 1;99(1):24-30.

44.

Adenosine triphosphate citrate lyase mediates hypocitraturia in rats.

Melnick JZ, Srere PA, Elshourbagy NA, Moe OW, Preisig PA, Alpern RJ.

J Clin Invest. 1996 Nov 15;98(10):2381-7.

45.

Hensin: a matrix protein determinant of epithelial polarity.

Alpern RJ.

J Clin Invest. 1996 Nov 15;98(10):2189-90. No abstract available.

46.

Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney.

Ambühl PM, Amemiya M, Danczkay M, Lötscher M, Kaissling B, Moe OW, Preisig PA, Alpern RJ.

Am J Physiol. 1996 Oct;271(4 Pt 2):F917-25.

PMID:
8898023
47.

Role of tyrosine kinase pathways in ETB receptor activation of NHE3.

Chu TS, Tsuganezawa H, Peng Y, Cano A, Yanagisawa M, Alpern RJ.

Am J Physiol. 1996 Sep;271(3 Pt 1):C763-71.

PMID:
8843705
48.

Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells.

Chu TS, Peng Y, Cano A, Yanagisawa M, Alpern RJ.

J Clin Invest. 1996 Mar 15;97(6):1454-62.

49.

Glucocorticoids regulate NHE-3 transcription in OKP cells.

Baum M, Amemiya M, Dwarakanath V, Alpern RJ, Moe OW.

Am J Physiol. 1996 Jan;270(1 Pt 2):F164-9.

PMID:
8769835
50.

Presentation of the 1995 Jean Hamburger Award to Donald W. Seldin.

Alpern RJ.

Kidney Int. 1995 Dec;48(6):2036-9. No abstract available.

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