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Items: 1 to 50 of 391

1.

Increased Red Cell KCNN4 Activity in Sporadic Hereditary Xerocytosis Associated With Enhanced Single Channel Pressure Sensitivity of PIEZO1 Mutant V598M.

Gnanasambandam R, Rivera A, Vandorpe DH, Shmukler BE, Brugnara C, Snyder LM, Andolfo I, Iolascon A, Silveira PA, Hamerschlak N, Gottlieb P, Alper SL.

Hemasphere. 2018 Oct;2(5):e55. doi: 10.1097/HS9.0000000000000055. Epub 2018 Oct 2.

PMID:
30887001
2.

Cellular and Immunohistochemical Changes in Anaphylactic Shock Induced in the Ovalbumin-Sensitized Wistar Rat Model.

Al-Salam S, Aburawi EH, Al-Hammadi S, Dhanasekaran S, Shafiuallah M, Yasin J, Sudhadevi M, Awwad A, Alper SL, Kazzam EE, Bellou A.

Biomolecules. 2019 Mar 13;9(3). pii: E101. doi: 10.3390/biom9030101.

3.

Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling.

Pollyea DA, Harris C, Rabe JL, Hedin BR, De Arras L, Katz S, Wheeler E, Bejar R, Walter MJ, Jordan CT, Pietras EM, Alper S.

Haematologica. 2019 Mar 7. pii: haematol.2018.214155. doi: 10.3324/haematol.2018.214155. [Epub ahead of print]

4.

Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts.

Chen CH, Bhasin S, Khanna P, Joshi M, Joslin PM, Saxena R, Amin S, Liu S, Sindhu S, Walker SR, Catalano P, Frank DA, Alper SL, Bhasin M, Bhatt RS.

Oncogenesis. 2019 Feb 22;8(3):15. doi: 10.1038/s41389-019-0121-7.

5.

Easy Volumeter in Detection of Breast Cancer-Related Lymphedema: A Validity Study.

Engin O, Akalın E, Sarıbay E, Aslan C, Şahin E, Alper S.

Lymphat Res Biol. 2019 Feb 8. doi: 10.1089/lrb.2018.0040. [Epub ahead of print]

PMID:
30735097
6.

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity.

Chun J, Zhang JY, Wilkins MS, Subramanian B, Riella C, Magraner JM, Alper SL, Friedman DJ, Pollak MR.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3712-3721. doi: 10.1073/pnas.1820414116. Epub 2019 Feb 7.

PMID:
30733285
7.

Targeted Metabolomic Profiling of Peritoneal Dialysis Effluents Shows Anti-oxidative Capacity of Alanyl-Glutamine.

Wiesenhofer FM, Herzog R, Boehm M, Wagner A, Unterwurzacher M, Kasper DC, Alper SL, Vychytil A, Aufricht C, Kratochwill K.

Front Physiol. 2019 Jan 21;9:1961. doi: 10.3389/fphys.2018.01961. eCollection 2018.

8.

Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation.

Duran D, Zeng X, Jin SC, Choi J, Nelson-Williams C, Yatsula B, Gaillard J, Furey CG, Lu Q, Timberlake AT, Dong W, Sorscher MA, Loring E, Klein J, Allocco A, Hunt A, Conine S, Karimy JK, Youngblood MW, Zhang J, DiLuna ML, Matouk CC, Mane S, Tikhonova IR, Castaldi C, López-Giráldez F, Knight J, Haider S, Soban M, Alper SL, Komiyama M, Ducruet AF, Zabramski JM, Dardik A, Walcott BP, Stapleton CJ, Aagaard-Kienitz B, Rodesch G, Jackson E, Smith ER, Orbach DB, Berenstein A, Bilguvar K, Vikkula M, Gunel M, Lifton RP, Kahle KT.

Neuron. 2019 Feb 6;101(3):429-443.e4. doi: 10.1016/j.neuron.2018.11.041. Epub 2018 Dec 18.

PMID:
30578106
9.

The evil eye effect: vertical pupils are perceived as more threatening.

Alper S, Us EO, Tasman DR.

Cogn Emot. 2018 Nov 28:1-12. doi: 10.1080/02699931.2018.1550741. [Epub ahead of print]

PMID:
30486750
10.

Editorial overview: Tuning the innate immune response to pathogens.

Alper S, Lenz LL.

Curr Opin Immunol. 2018 Oct;54:vi-ix. doi: 10.1016/j.coi.2018.10.001. No abstract available.

PMID:
30342707
11.

Cross-cultural consistency and relativity in the enjoyment of thinking versus doing.

Buttrick N, Choi H, Wilson TD, Oishi S, Boker SM, Gilbert DT, Alper S, Aveyard M, Cheong W, Čolić MV, Dalgar I, Doğulu C, Karabati S, Kim E, Knežević G, Komiya A, Laclé CO, Ambrosio Lage C, Lazarević LB, Lazarević D, Lins S, Blanco Molina M, Neto F, Orlić A, Petrović B, Arroyo Sibaja M, Torres Fernández D, Vanpaemel W, Voorspoels W, Wilks DC.

J Pers Soc Psychol. 2018 Jul 23. doi: 10.1037/pspp0000198. [Epub ahead of print]

PMID:
30035566
12.

Functional Genomics in Murine Macrophages.

Lee FF, Alper S.

Methods Mol Biol. 2018;1809:289-298. doi: 10.1007/978-1-4939-8570-8_18.

PMID:
29987795
13.

De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus.

Furey CG, Choi J, Jin SC, Zeng X, Timberlake AT, Nelson-Williams C, Mansuri MS, Lu Q, Duran D, Panchagnula S, Allocco A, Karimy JK, Khanna A, Gaillard JR, DeSpenza T, Antwi P, Loring E, Butler WE, Smith ER, Warf BC, Strahle JM, Limbrick DD, Storm PB, Heuer G, Jackson EM, Iskandar BJ, Johnston JM, Tikhonova I, Castaldi C, López-Giráldez F, Bjornson RD, Knight JR, Bilguvar K, Mane S, Alper SL, Haider S, Guclu B, Bayri Y, Sahin Y, Apuzzo MLJ, Duncan CC, DiLuna ML, Günel M, Lifton RP, Kahle KT.

Neuron. 2018 Jul 25;99(2):302-314.e4. doi: 10.1016/j.neuron.2018.06.019. Epub 2018 Jul 5.

PMID:
29983323
14.

Noninvasive Immunohistochemical Diagnosis and Novel MUC1 Mutations Causing Autosomal Dominant Tubulointerstitial Kidney Disease.

Živná M, Kidd K, Přistoupilová A, Barešová V, DeFelice M, Blumenstiel B, Harden M, Conlon P, Lavin P, Connaughton DM, Hartmannová H, Hodaňová K, Stránecký V, Vrbacká A, Vyleťal P, Živný J, Votruba M, Sovová J, Hůlková H, Robins V, Perry R, Wenzel A, Beck BB, Seeman T, Viklický O, Rajnochová-Bloudíčková S, Papagregoriou G, Deltas CC, Alper SL, Greka A, Bleyer AJ, Kmoch S.

J Am Soc Nephrol. 2018 Sep;29(9):2418-2431. doi: 10.1681/ASN.2018020180. Epub 2018 Jul 2.

PMID:
29967284
15.

Comparison of pro- and anti-inflammatory responses in paired human primary airway epithelial cells and alveolar macrophages.

Mubarak RA, Roberts N, Mason RJ, Alper S, Chu HW.

Respir Res. 2018 Jun 25;19(1):126. doi: 10.1186/s12931-018-0825-9.

16.

Acquired and genetic host susceptibility factors and microbial pathogenic factors that predispose to nontuberculous mycobacterial infections.

Honda JR, Alper S, Bai X, Chan ED.

Curr Opin Immunol. 2018 Oct;54:66-73. doi: 10.1016/j.coi.2018.06.001. Epub 2018 Jun 21. Review.

PMID:
29936307
17.

Monocyte function in patients with myelodysplastic syndrome.

Pollyea DA, Hedin BR, O'Connor BP, Alper S.

J Leukoc Biol. 2018 Sep;104(3):641-647. doi: 10.1002/JLB.5AB1017-419RR. Epub 2018 Apr 14.

PMID:
29656609
18.

UBD modifies APOL1-induced kidney disease risk.

Zhang JY, Wang M, Tian L, Genovese G, Yan P, Wilson JG, Thadhani R, Mottl AK, Appel GB, Bick AG, Sampson MG, Alper SL, Friedman DJ, Pollak MR.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3446-3451. doi: 10.1073/pnas.1716113115. Epub 2018 Mar 12.

19.

Modulation of tubular solute reuptake in UMOD knockout mice.

Friedman DJ, Alper SL.

Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F238-F240. doi: 10.1152/ajprenal.00080.2018. Epub 2018 Mar 7. No abstract available.

PMID:
29513073
20.

What Can We Learn About Human Disease from the Nematode C. elegans?

Apfeld J, Alper S.

Methods Mol Biol. 2018;1706:53-75. doi: 10.1007/978-1-4939-7471-9_4. Review.

21.

Is Continuous Passive Motion Effective in Patients with Lymphedema? A Randomized Controlled Trial.

Kizil R, Dilek B, Şahin E, Engin O, Soylu AC, Akalin E, Alper S.

Lymphat Res Biol. 2018 Jun;16(3):263-269. doi: 10.1089/lrb.2017.0018. Epub 2018 Jan 17.

PMID:
29338639
22.

Effects of Alanyl-Glutamine Treatment on the Peritoneal Dialysis Effluent Proteome Reveal Pathomechanism-Associated Molecular Signatures.

Herzog R, Boehm M, Unterwurzacher M, Wagner A, Parapatics K, Májek P, Mueller AC, Lichtenauer A, Bennett KL, Alper SL, Vychytil A, Aufricht C, Kratochwill K.

Mol Cell Proteomics. 2018 Mar;17(3):516-532. doi: 10.1074/mcp.RA117.000186. Epub 2017 Dec 4.

23.

Revised prevalence estimate of possible Hereditary Xerocytosis as derived from a large U.S. Laboratory database.

Kaufman HW, Niles JK, Gallagher DR, Rivera A, Alper SL, Brugnara C, Snyder LM.

Am J Hematol. 2018 Jan;93(1):E9-E12. doi: 10.1002/ajh.24923. Epub 2017 Nov 23. No abstract available.

24.

Human SLC26A4/Pendrin STAS domain is a nucleotide-binding protein: Refolding and characterization for structural studies.

Sharma AK, Krieger T, Rigby AC, Zelikovic I, Alper SL.

Biochem Biophys Rep. 2016 Aug 26;8:184-191. doi: 10.1016/j.bbrep.2016.08.022. eCollection 2016 Dec.

25.

Alternative pre-mRNA splicing of Toll-like receptor signaling components in peripheral blood mononuclear cells from patients with ARDS.

Blumhagen RZ, Hedin BR, Malcolm KC, Burnham EL, Moss M, Abraham E, Huie TJ, Nick JA, Fingerlin TE, Alper S.

Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L930-L939. doi: 10.1152/ajplung.00247.2017. Epub 2017 Aug 3.

26.

Functional and Transcriptomic Characterization of Peritoneal Immune-Modulation by Addition of Alanyl-Glutamine to Dialysis Fluid.

Herzog R, Kuster L, Becker J, Gluexam T, Pils D, Spittler A, Bhasin MK, Alper SL, Vychytil A, Aufricht C, Kratochwill K.

Sci Rep. 2017 Jul 24;7(1):6229. doi: 10.1038/s41598-017-05872-2.

27.

Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction.

Alper SL.

Curr Top Membr. 2017;79:97-134. doi: 10.1016/bs.ctm.2017.01.001. Epub 2017 Feb 28. Review.

PMID:
28728825
28.

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.

Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT.

Nat Med. 2017 Aug;23(8):997-1003. doi: 10.1038/nm.4361. Epub 2017 Jul 10.

PMID:
28692063
29.

Loss of kAE1 expression in collecting ducts of end-stage kidneys from a family with SLC4A1 G609R-associated distal renal tubular acidosis.

Vichot AA, Zsengellér ZK, Shmukler BE, Adams ND, Dahl NK, Alper SL.

Clin Kidney J. 2017 Feb;10(1):135-140. doi: 10.1093/ckj/sfw074. Epub 2016 Aug 31.

30.

Genome-wide association study of erythrocyte density in sickle cell disease patients.

Ilboudo Y, Bartolucci P, Rivera A, Sedzro JC, Beaudoin M, Trudel M, Alper SL, Brugnara C, Galactéros F, Lettre G.

Blood Cells Mol Dis. 2017 Jun;65:60-65. doi: 10.1016/j.bcmd.2017.05.005. Epub 2017 May 13.

PMID:
28552477
31.

A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy.

Skorecki KL, Lee JH, Langefeld CD, Rosset S, Tzur S, Wasser WG, Shemer R, Hawkins GA, Divers J, Parekh RS, Li M, Sampson MG, Kretzler M, Pollak MR, Shah S, Blackler D, Nichols B, Wilmot M, Alper SL, Freedman BI, Friedman DJ.

Nephrol Dial Transplant. 2018 Feb 1;33(2):323-330. doi: 10.1093/ndt/gfw451.

32.

Erythrocytes from hereditary xerocytosis patients heterozygous for KCNN4 V282M exhibit increased spontaneous Gardos channel-like activity inhibited by senicapoc.

Rivera A, Vandorpe DH, Shmukler BE, Gallagher DR, Fikry CC, Kuypers FA, Brugnara C, Snyder LM, Alper SL.

Am J Hematol. 2017 Jun;92(6):E108-E110. doi: 10.1002/ajh.24716. Epub 2017 Apr 29. No abstract available.

33.

NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Iα leucine zipper in vascular function.

Sharma AK, Birrane G, Anklin C, Rigby AC, Alper SL.

J Biol Chem. 2017 Apr 28;292(17):7052-7065. doi: 10.1074/jbc.M117.781260. Epub 2017 Mar 9.

34.

Intercalated Cell Depletion and Vacuolar H+-ATPase Mistargeting in an Ae1 R607H Knockin Model.

Mumtaz R, Trepiccione F, Hennings JC, Huebner AK, Serbin B, Picard N, Ullah AKMS, Păunescu TG, Capen DE, Lashhab RM, Mouro-Chanteloup I, Alper SL, Wagner CA, Cordat E, Brown D, Eladari D, Hübner CA.

J Am Soc Nephrol. 2017 May;28(5):1507-1520. doi: 10.1681/ASN.2016020169. Epub 2016 Dec 8.

35.

WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats.

Bhuiyan MIH, Song S, Yuan H, Begum G, Kofler J, Kahle KT, Yang SS, Lin SH, Alper SL, Subramanya AR, Sun D.

J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1.

36.

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.

Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT.

Sci Rep. 2016 Oct 26;6:35986. doi: 10.1038/srep35986.

37.

Addition of Alanyl-Glutamine to Dialysis Fluid Restores Peritoneal Cellular Stress Responses - A First-In-Man Trial.

Kratochwill K, Boehm M, Herzog R, Gruber K, Lichtenauer AM, Kuster L, Csaicsich D, Gleiss A, Alper SL, Aufricht C, Vychytil A.

PLoS One. 2016 Oct 21;11(10):e0165045. doi: 10.1371/journal.pone.0165045. eCollection 2016.

38.

A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.

Lupo F, Tibaldi E, Matte A, Sharma AK, Brunati AM, Alper SL, Zancanaro C, Benati D, Siciliano A, Bertoldi M, Zonta F, Storch A, Walker RH, Danek A, Bader B, Hermann A, De Franceschi L.

Blood. 2016 Dec 22;128(25):2976-2987. doi: 10.1182/blood-2016-07-727321. Epub 2016 Oct 14.

39.

4-Aminopyridine, A Blocker of Voltage-Dependent K+ Channels, Restores Blood Pressure and Improves Survival in the Wistar Rat Model of Anaphylactic Shock.

Bellou A, Al-Hammadi S, Aburawi EH, Dhanasekaran S, Nemmar A, Oulhaj A, Shafiuallah M, Zerrouki M, Yasin J, Bellou L, Alper SL, Bellou S, Kazzam E.

Crit Care Med. 2016 Nov;44(11):e1082-e1089.

PMID:
27270180
40.

Novel Innate Immune Genes Regulating the Macrophage Response to Gram Positive Bacteria.

Alper S, Warg LA, De Arras L, Flatley BR, Davidson EJ, Adams J, Smith K, Wohlford-Lenane CL, McCray PB Jr, Pedersen BS, Schwartz DA, Yang IV.

Genetics. 2016 Sep;204(1):327-36. doi: 10.1534/genetics.115.185314. Epub 2016 Jun 29.

41.

Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion.

Knauf F, Thomson RB, Heneghan JF, Jiang Z, Adebamiro A, Thomson CL, Barone C, Asplin JR, Egan ME, Alper SL, Aronson PS.

J Am Soc Nephrol. 2017 Jan;28(1):242-249. doi: 10.1681/ASN.2016030279. Epub 2016 Jun 16.

42.

Functional characterization of novel ABCB6 mutations and their clinical implications in familial pseudohyperkalemia.

Andolfo I, Russo R, Manna F, De Rosa G, Gambale A, Zouwail S, Detta N, Pardo CL, Alper SL, Brugnara C, Sharma AK, De Franceschi L, Iolascon A.

Haematologica. 2016 Aug;101(8):909-17. doi: 10.3324/haematol.2016.142372. Epub 2016 May 5.

43.

Extracellular Cl(-) regulates human SO4 (2-)/anion exchanger SLC26A1 by altering pH sensitivity of anion transport.

Wu M, Heneghan JF, Vandorpe DH, Escobar LI, Wu BL, Alper SL.

Pflugers Arch. 2016 Aug;468(8):1311-32. doi: 10.1007/s00424-016-1823-8. Epub 2016 Apr 29.

44.

Structural characterization of the C-terminal coiled-coil domains of wild-type and kidney disease-associated mutants of apolipoprotein L1.

Sharma AK, Friedman DJ, Pollak MR, Alper SL.

FEBS J. 2016 May;283(10):1846-62. doi: 10.1111/febs.13706. Epub 2016 Apr 1.

45.

Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke.

Zhao H, Nepomuceno R, Gao X, Foley LM, Wang S, Begum G, Zhu W, Pigott VM, Falgoust LM, Kahle KT, Yang SS, Lin SH, Alper SL, Hitchens TK, Hu S, Zhang Z, Sun D.

J Cereb Blood Flow Metab. 2017 Feb;37(2):550-563. doi: 10.1177/0271678X16631561. Epub 2016 Jul 20.

46.

Authors' response to "Comment on: 'Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia'".

Shmukler BE, Lawson ND, Paw BH, Alper SL.

Haematologica. 2016 Jan;101(1):e39. doi: 10.3324/haematol.2015.137810. No abstract available.

47.

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.

Olabisi OA, Zhang JY, VerPlank L, Zahler N, DiBartolo S 3rd, Heneghan JF, Schlöndorff JS, Suh JH, Yan P, Alper SL, Friedman DJ, Pollak MR.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):830-7. doi: 10.1073/pnas.1522913113. Epub 2015 Dec 23.

48.

Atypical patterns of segregation of familial enlargement of the vestibular aqueduct.

Muskett JA, Chattaraj P, Heneghan JF, Reimold FR, Shmukler BE, Brewer CC, King KA, Zalewski CK, Shawker TH, Butman JA, Kenna MA, Chien WW, Alper SL, Griffith AJ.

Laryngoscope. 2016 Jul;126(7):E240-7. doi: 10.1002/lary.25737. Epub 2015 Oct 20.

49.

The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity.

Tubman VN, Mejia P, Shmukler BE, Bei AK, Alper SL, Mitchell JR, Brugnara C, Duraisingh MT.

Antimicrob Agents Chemother. 2015 Oct 12;60(1):613-6. doi: 10.1128/AAC.01668-15. Print 2016 Jan.

50.

TUR-PSO: A cross-sectional, study investigating quality of life and treatment status of psoriasis patients in Turkey.

Atakan N, Yazici AC, Özarmağan G, İnalÖz HS, Gürer MA, Sabuncu İ, Kİremİtçİ Ü, Alper S, Aytekİn S, Arican Ö, Polat M, Doğan S, Aldİnç E.

J Dermatol. 2016 Mar;43(3):298-304. doi: 10.1111/1346-8138.13081. Epub 2015 Sep 14.

PMID:
26365805

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