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Items: 1 to 50 of 401

1.

Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.

Watanabe M, Zhang J, Mansuri MS, Duan J, Karimy JK, Delpire E, Alper SL, Lifton RP, Fukuda A, Kahle KT.

Sci Signal. 2019 Oct 15;12(603). pii: eaaw9315. doi: 10.1126/scisignal.aaw9315.

PMID:
31615901
2.

Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background.

Lannon H, Shah SS, Dias L, Blackler D, Alper SL, Pollak MR, Friedman DJ.

Kidney Int. 2019 Aug 1. pii: S0085-2538(19)30777-X. doi: 10.1016/j.kint.2019.07.010. [Epub ahead of print]

PMID:
31611067
3.

Inflammation via myeloid differentiation primary response gene 88 signaling mediates the fibrotic response to implantable synthetic poly(ethylene glycol) hydrogels.

Amer LD, Saleh LS, Walker C, Thomas S, Janssen WJ, Alper S, Bryant SJ.

Acta Biomater. 2019 Sep 27. pii: S1742-7061(19)30664-6. doi: 10.1016/j.actbio.2019.09.043. [Epub ahead of print]

PMID:
31568879
4.

APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore.

Shah SS, Lannon H, Dias L, Zhang JY, Alper SL, Pollak MR, Friedman DJ.

J Am Soc Nephrol. 2019 Sep 26. pii: ASN.2019020114. doi: 10.1681/ASN.2019020114. [Epub ahead of print]

PMID:
31558683
5.

Nontuberculous Mycobacteria Show Differential Infectivity and Use Phospholipids to Antagonize LL-37.

Honda JR, Hess T, Carlson R, Kandasamy P, Nieto Ramirez LM, Norton GJ, Virdi R, Islam MN, Mehaffy C, Hasan NA, Epperson LE, Hesser D, Alper S, Strong M, Flores SC, Voelker DR, Dobos KM, Chan ED.

Am J Respir Cell Mol Biol. 2019 Sep 23. doi: 10.1165/rcmb.2018-0278OC. [Epub ahead of print]

PMID:
31545652
6.

Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.

Shmukler BE, Rivera A, Bhargava P, Nishimura K, Hsu A, Kim EH, Trudel M, Rust MB, Hubner CA, Brugnara C, Alper SL.

Blood Cells Mol Dis. 2019 Nov;79:102346. doi: 10.1016/j.bcmd.2019.102346. Epub 2019 Jul 17.

PMID:
31352162
7.

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.

Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, Ronco L, Elonga E, Carter TA, Gnirke A, Melanson M, Hartland K, Wieder N, Hsu JC, Deltas C, Hughey R, Bleyer AJ, Kmoch S, Živná M, Barešova V, Kota S, Schlondorff J, Heiman M, Alper SL, Wagner F, Weins A, Golub TR, Lander ES, Greka A.

Cell. 2019 Jul 25;178(3):521-535.e23. doi: 10.1016/j.cell.2019.07.002.

PMID:
31348885
8.

Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6.

Talbot BE, Vandorpe DH, Stotter BR, Alper SL, Schlondorff JS.

J Biol Chem. 2019 Aug 23;294(34):12655-12669. doi: 10.1074/jbc.RA119.008299. Epub 2019 Jul 2.

PMID:
31266804
9.

The Peritoneal Surface Proteome in a Model of Chronic Peritoneal Dialysis Reveals Mechanisms of Membrane Damage and Preservation.

Boehm M, Herzog R, Klinglmüller F, Lichtenauer AM, Wagner A, Unterwurzacher M, Beelen RHJ, Alper SL, Aufricht C, Kratochwill K.

Front Physiol. 2019 May 14;10:472. doi: 10.3389/fphys.2019.00472. eCollection 2019.

10.

Erythrocyte ion content and dehydration modulate maximal Gardos channel activity in KCNN4 V282M/+ hereditary xerocytosis red cells.

Rivera A, Vandorpe DH, Shmukler BE, Andolfo I, Iolascon A, Archer NM, Shabani E, Auerbach M, Hamerschlak N, Morton J, Wohlgemuth JG, Brugnara C, Snyder LM, Alper SL.

Am J Physiol Cell Physiol. 2019 Aug 1;317(2):C287-C302. doi: 10.1152/ajpcell.00074.2019. Epub 2019 May 15.

PMID:
31091145
11.

Increased Red Cell KCNN4 Activity in Sporadic Hereditary Xerocytosis Associated With Enhanced Single Channel Pressure Sensitivity of PIEZO1 Mutant V598M.

Gnanasambandam R, Rivera A, Vandorpe DH, Shmukler BE, Brugnara C, Snyder LM, Andolfo I, Iolascon A, Silveira PA, Hamerschlak N, Gottlieb P, Alper SL.

Hemasphere. 2018 Oct;2(5):e55. doi: 10.1097/HS9.0000000000000055. Epub 2018 Oct 2.

12.

Cellular and Immunohistochemical Changes in Anaphylactic Shock Induced in the Ovalbumin-Sensitized Wistar Rat Model.

Al-Salam S, Aburawi EH, Al-Hammadi S, Dhanasekaran S, Shafiuallah M, Yasin J, Sudhadevi M, Awwad A, Alper SL, Kazzam EE, Bellou A.

Biomolecules. 2019 Mar 13;9(3). pii: E101. doi: 10.3390/biom9030101.

13.

Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling.

Pollyea DA, Harris C, Rabe JL, Hedin BR, De Arras L, Katz S, Wheeler E, Bejar R, Walter MJ, Jordan CT, Pietras EM, Alper S.

Haematologica. 2019 Sep;104(9):e388-e392. doi: 10.3324/haematol.2018.214155. Epub 2019 Mar 7. No abstract available.

14.

Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts.

Chen CH, Bhasin S, Khanna P, Joshi M, Joslin PM, Saxena R, Amin S, Liu S, Sindhu S, Walker SR, Catalano P, Frank DA, Alper SL, Bhasin M, Bhatt RS.

Oncogenesis. 2019 Feb 22;8(3):15. doi: 10.1038/s41389-019-0121-7.

15.

Easy Volumeter in Detection of Breast Cancer-Related Lymphedema: A Validity Study.

Engin O, Akalın E, Sarıbay E, Aslan C, Şahin E, Alper S.

Lymphat Res Biol. 2019 Oct;17(5):543-549. doi: 10.1089/lrb.2018.0040. Epub 2019 Feb 14.

PMID:
30735097
16.

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity.

Chun J, Zhang JY, Wilkins MS, Subramanian B, Riella C, Magraner JM, Alper SL, Friedman DJ, Pollak MR.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3712-3721. doi: 10.1073/pnas.1820414116. Epub 2019 Feb 7.

17.

Targeted Metabolomic Profiling of Peritoneal Dialysis Effluents Shows Anti-oxidative Capacity of Alanyl-Glutamine.

Wiesenhofer FM, Herzog R, Boehm M, Wagner A, Unterwurzacher M, Kasper DC, Alper SL, Vychytil A, Aufricht C, Kratochwill K.

Front Physiol. 2019 Jan 21;9:1961. doi: 10.3389/fphys.2018.01961. eCollection 2018.

18.

Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation.

Duran D, Zeng X, Jin SC, Choi J, Nelson-Williams C, Yatsula B, Gaillard J, Furey CG, Lu Q, Timberlake AT, Dong W, Sorscher MA, Loring E, Klein J, Allocco A, Hunt A, Conine S, Karimy JK, Youngblood MW, Zhang J, DiLuna ML, Matouk CC, Mane S, Tikhonova IR, Castaldi C, López-Giráldez F, Knight J, Haider S, Soban M, Alper SL, Komiyama M, Ducruet AF, Zabramski JM, Dardik A, Walcott BP, Stapleton CJ, Aagaard-Kienitz B, Rodesch G, Jackson E, Smith ER, Orbach DB, Berenstein A, Bilguvar K, Vikkula M, Gunel M, Lifton RP, Kahle KT.

Neuron. 2019 Feb 6;101(3):429-443.e4. doi: 10.1016/j.neuron.2018.11.041. Epub 2018 Dec 18.

PMID:
30578106
19.

The evil eye effect: vertical pupils are perceived as more threatening.

Alper S, Us EO, Tasman DR.

Cogn Emot. 2019 Sep;33(6):1249-1260. doi: 10.1080/02699931.2018.1550741. Epub 2018 Nov 28.

PMID:
30486750
20.

Editorial overview: Tuning the innate immune response to pathogens.

Alper S, Lenz LL.

Curr Opin Immunol. 2018 Oct;54:vi-ix. doi: 10.1016/j.coi.2018.10.001. No abstract available.

PMID:
30342707
21.

Cross-cultural consistency and relativity in the enjoyment of thinking versus doing.

Buttrick N, Choi H, Wilson TD, Oishi S, Boker SM, Gilbert DT, Alper S, Aveyard M, Cheong W, Čolić MV, Dalgar I, Doğulu C, Karabati S, Kim E, Knežević G, Komiya A, Laclé CO, Ambrosio Lage C, Lazarević LB, Lazarević D, Lins S, Blanco Molina M, Neto F, Orlić A, Petrović B, Arroyo Sibaja M, Torres Fernández D, Vanpaemel W, Voorspoels W, Wilks DC.

J Pers Soc Psychol. 2019 Nov;117(5):e71-e83. doi: 10.1037/pspp0000198. Epub 2018 Jul 23.

PMID:
30035566
22.

Functional Genomics in Murine Macrophages.

Lee FF, Alper S.

Methods Mol Biol. 2018;1809:289-298. doi: 10.1007/978-1-4939-8570-8_18.

23.

De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus.

Furey CG, Choi J, Jin SC, Zeng X, Timberlake AT, Nelson-Williams C, Mansuri MS, Lu Q, Duran D, Panchagnula S, Allocco A, Karimy JK, Khanna A, Gaillard JR, DeSpenza T, Antwi P, Loring E, Butler WE, Smith ER, Warf BC, Strahle JM, Limbrick DD, Storm PB, Heuer G, Jackson EM, Iskandar BJ, Johnston JM, Tikhonova I, Castaldi C, López-Giráldez F, Bjornson RD, Knight JR, Bilguvar K, Mane S, Alper SL, Haider S, Guclu B, Bayri Y, Sahin Y, Apuzzo MLJ, Duncan CC, DiLuna ML, Günel M, Lifton RP, Kahle KT.

Neuron. 2018 Jul 25;99(2):302-314.e4. doi: 10.1016/j.neuron.2018.06.019. Epub 2018 Jul 5.

24.

Noninvasive Immunohistochemical Diagnosis and Novel MUC1 Mutations Causing Autosomal Dominant Tubulointerstitial Kidney Disease.

Živná M, Kidd K, Přistoupilová A, Barešová V, DeFelice M, Blumenstiel B, Harden M, Conlon P, Lavin P, Connaughton DM, Hartmannová H, Hodaňová K, Stránecký V, Vrbacká A, Vyleťal P, Živný J, Votruba M, Sovová J, Hůlková H, Robins V, Perry R, Wenzel A, Beck BB, Seeman T, Viklický O, Rajnochová-Bloudíčková S, Papagregoriou G, Deltas CC, Alper SL, Greka A, Bleyer AJ, Kmoch S.

J Am Soc Nephrol. 2018 Sep;29(9):2418-2431. doi: 10.1681/ASN.2018020180. Epub 2018 Jul 2.

25.

Comparison of pro- and anti-inflammatory responses in paired human primary airway epithelial cells and alveolar macrophages.

Mubarak RA, Roberts N, Mason RJ, Alper S, Chu HW.

Respir Res. 2018 Jun 25;19(1):126. doi: 10.1186/s12931-018-0825-9.

26.

Acquired and genetic host susceptibility factors and microbial pathogenic factors that predispose to nontuberculous mycobacterial infections.

Honda JR, Alper S, Bai X, Chan ED.

Curr Opin Immunol. 2018 Oct;54:66-73. doi: 10.1016/j.coi.2018.06.001. Epub 2018 Jun 21. Review.

PMID:
29936307
27.

Monocyte function in patients with myelodysplastic syndrome.

Pollyea DA, Hedin BR, O'Connor BP, Alper S.

J Leukoc Biol. 2018 Sep;104(3):641-647. doi: 10.1002/JLB.5AB1017-419RR. Epub 2018 Apr 14.

28.

UBD modifies APOL1-induced kidney disease risk.

Zhang JY, Wang M, Tian L, Genovese G, Yan P, Wilson JG, Thadhani R, Mottl AK, Appel GB, Bick AG, Sampson MG, Alper SL, Friedman DJ, Pollak MR.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3446-3451. doi: 10.1073/pnas.1716113115. Epub 2018 Mar 12.

29.

Modulation of tubular solute reuptake in UMOD knockout mice.

Friedman DJ, Alper SL.

Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F238-F240. doi: 10.1152/ajprenal.00080.2018. Epub 2018 Mar 7. No abstract available.

30.

What Can We Learn About Human Disease from the Nematode C. elegans?

Apfeld J, Alper S.

Methods Mol Biol. 2018;1706:53-75. doi: 10.1007/978-1-4939-7471-9_4. Review.

31.

Is Continuous Passive Motion Effective in Patients with Lymphedema? A Randomized Controlled Trial.

Kizil R, Dilek B, Şahin E, Engin O, Soylu AC, Akalin E, Alper S.

Lymphat Res Biol. 2018 Jun;16(3):263-269. doi: 10.1089/lrb.2017.0018. Epub 2018 Jan 17.

PMID:
29338639
32.

Effects of Alanyl-Glutamine Treatment on the Peritoneal Dialysis Effluent Proteome Reveal Pathomechanism-Associated Molecular Signatures.

Herzog R, Boehm M, Unterwurzacher M, Wagner A, Parapatics K, Májek P, Mueller AC, Lichtenauer A, Bennett KL, Alper SL, Vychytil A, Aufricht C, Kratochwill K.

Mol Cell Proteomics. 2018 Mar;17(3):516-532. doi: 10.1074/mcp.RA117.000186. Epub 2017 Dec 4.

33.

Revised prevalence estimate of possible Hereditary Xerocytosis as derived from a large U.S. Laboratory database.

Kaufman HW, Niles JK, Gallagher DR, Rivera A, Alper SL, Brugnara C, Snyder LM.

Am J Hematol. 2018 Jan;93(1):E9-E12. doi: 10.1002/ajh.24923. Epub 2017 Nov 23. No abstract available.

34.

Human SLC26A4/Pendrin STAS domain is a nucleotide-binding protein: Refolding and characterization for structural studies.

Sharma AK, Krieger T, Rigby AC, Zelikovic I, Alper SL.

Biochem Biophys Rep. 2016 Aug 26;8:184-191. doi: 10.1016/j.bbrep.2016.08.022. eCollection 2016 Dec.

35.

Alternative pre-mRNA splicing of Toll-like receptor signaling components in peripheral blood mononuclear cells from patients with ARDS.

Blumhagen RZ, Hedin BR, Malcolm KC, Burnham EL, Moss M, Abraham E, Huie TJ, Nick JA, Fingerlin TE, Alper S.

Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L930-L939. doi: 10.1152/ajplung.00247.2017. Epub 2017 Aug 3.

36.

Functional and Transcriptomic Characterization of Peritoneal Immune-Modulation by Addition of Alanyl-Glutamine to Dialysis Fluid.

Herzog R, Kuster L, Becker J, Gluexam T, Pils D, Spittler A, Bhasin MK, Alper SL, Vychytil A, Aufricht C, Kratochwill K.

Sci Rep. 2017 Jul 24;7(1):6229. doi: 10.1038/s41598-017-05872-2.

37.

Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction.

Alper SL.

Curr Top Membr. 2017;79:97-134. doi: 10.1016/bs.ctm.2017.01.001. Epub 2017 Feb 28. Review.

PMID:
28728825
38.

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.

Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT.

Nat Med. 2017 Aug;23(8):997-1003. doi: 10.1038/nm.4361. Epub 2017 Jul 10.

PMID:
28692063
39.

Loss of kAE1 expression in collecting ducts of end-stage kidneys from a family with SLC4A1 G609R-associated distal renal tubular acidosis.

Vichot AA, Zsengellér ZK, Shmukler BE, Adams ND, Dahl NK, Alper SL.

Clin Kidney J. 2017 Feb;10(1):135-140. doi: 10.1093/ckj/sfw074. Epub 2016 Aug 31.

40.

Genome-wide association study of erythrocyte density in sickle cell disease patients.

Ilboudo Y, Bartolucci P, Rivera A, Sedzro JC, Beaudoin M, Trudel M, Alper SL, Brugnara C, Galactéros F, Lettre G.

Blood Cells Mol Dis. 2017 Jun;65:60-65. doi: 10.1016/j.bcmd.2017.05.005. Epub 2017 May 13.

PMID:
28552477
41.

A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy.

Skorecki KL, Lee JH, Langefeld CD, Rosset S, Tzur S, Wasser WG, Shemer R, Hawkins GA, Divers J, Parekh RS, Li M, Sampson MG, Kretzler M, Pollak MR, Shah S, Blackler D, Nichols B, Wilmot M, Alper SL, Freedman BI, Friedman DJ.

Nephrol Dial Transplant. 2018 Feb 1;33(2):323-330. doi: 10.1093/ndt/gfw451.

42.

Erythrocytes from hereditary xerocytosis patients heterozygous for KCNN4 V282M exhibit increased spontaneous Gardos channel-like activity inhibited by senicapoc.

Rivera A, Vandorpe DH, Shmukler BE, Gallagher DR, Fikry CC, Kuypers FA, Brugnara C, Snyder LM, Alper SL.

Am J Hematol. 2017 Jun;92(6):E108-E110. doi: 10.1002/ajh.24716. Epub 2017 Apr 29. No abstract available.

43.

NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Iα leucine zipper in vascular function.

Sharma AK, Birrane G, Anklin C, Rigby AC, Alper SL.

J Biol Chem. 2017 Apr 28;292(17):7052-7065. doi: 10.1074/jbc.M117.781260. Epub 2017 Mar 9.

44.

Intercalated Cell Depletion and Vacuolar H+-ATPase Mistargeting in an Ae1 R607H Knockin Model.

Mumtaz R, Trepiccione F, Hennings JC, Huebner AK, Serbin B, Picard N, Ullah AKMS, Păunescu TG, Capen DE, Lashhab RM, Mouro-Chanteloup I, Alper SL, Wagner CA, Cordat E, Brown D, Eladari D, Hübner CA.

J Am Soc Nephrol. 2017 May;28(5):1507-1520. doi: 10.1681/ASN.2016020169. Epub 2016 Dec 8.

45.

WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats.

Bhuiyan MIH, Song S, Yuan H, Begum G, Kofler J, Kahle KT, Yang SS, Lin SH, Alper SL, Subramanya AR, Sun D.

J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1.

46.

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.

Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT.

Sci Rep. 2016 Oct 26;6:35986. doi: 10.1038/srep35986.

47.

Addition of Alanyl-Glutamine to Dialysis Fluid Restores Peritoneal Cellular Stress Responses - A First-In-Man Trial.

Kratochwill K, Boehm M, Herzog R, Gruber K, Lichtenauer AM, Kuster L, Csaicsich D, Gleiss A, Alper SL, Aufricht C, Vychytil A.

PLoS One. 2016 Oct 21;11(10):e0165045. doi: 10.1371/journal.pone.0165045. eCollection 2016.

48.

A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.

Lupo F, Tibaldi E, Matte A, Sharma AK, Brunati AM, Alper SL, Zancanaro C, Benati D, Siciliano A, Bertoldi M, Zonta F, Storch A, Walker RH, Danek A, Bader B, Hermann A, De Franceschi L.

Blood. 2016 Dec 22;128(25):2976-2987. doi: 10.1182/blood-2016-07-727321. Epub 2016 Oct 14.

49.

4-Aminopyridine, A Blocker of Voltage-Dependent K+ Channels, Restores Blood Pressure and Improves Survival in the Wistar Rat Model of Anaphylactic Shock.

Bellou A, Al-Hammadi S, Aburawi EH, Dhanasekaran S, Nemmar A, Oulhaj A, Shafiuallah M, Zerrouki M, Yasin J, Bellou L, Alper SL, Bellou S, Kazzam E.

Crit Care Med. 2016 Nov;44(11):e1082-e1089.

PMID:
27270180
50.

Novel Innate Immune Genes Regulating the Macrophage Response to Gram Positive Bacteria.

Alper S, Warg LA, De Arras L, Flatley BR, Davidson EJ, Adams J, Smith K, Wohlford-Lenane CL, McCray PB Jr, Pedersen BS, Schwartz DA, Yang IV.

Genetics. 2016 Sep;204(1):327-36. doi: 10.1534/genetics.115.185314. Epub 2016 Jun 29.

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