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Items: 1 to 50 of 55

1.

A requirement for Gch1 and tetrahydrobiopterin in embryonic development.

Douglas G, Hale AB, Crabtree MJ, Ryan BJ, Hansler A, Watschinger K, Gross SS, Lygate CA, Alp NJ, Channon KM.

Dev Biol. 2015 Mar 1;399(1):129-138. doi: 10.1016/j.ydbio.2014.12.025. Epub 2014 Dec 31.

2.

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

Chuaiphichai S, McNeill E, Douglas G, Crabtree MJ, Bendall JK, Hale AB, Alp NJ, Channon KM.

Hypertension. 2014 Sep;64(3):530-40. doi: 10.1161/HYPERTENSIONAHA.114.03089. Epub 2014 Apr 28.

3.

Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction.

Cuculi F, Dall'Armellina E, Manlhiot C, De Caterina AR, Colyer S, Ferreira V, Morovat A, Prendergast BD, Forfar JC, Alp NJ, Choudhury RP, Neubauer S, Channon KM, Banning AP, Kharbanda RK.

Eur Heart J. 2014 Aug 1;35(29):1971-80. doi: 10.1093/eurheartj/eht434. Epub 2013 Oct 17.

PMID:
24135835
4.

Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification.

Douglas G, Van Kampen E, Hale AB, McNeill E, Patel J, Crabtree MJ, Ali Z, Hoerr RA, Alp NJ, Channon KM.

Eur Heart J. 2013 Nov;34(43):3378-88. doi: 10.1093/eurheartj/ehs240. Epub 2012 Sep 24.

5.

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.

Carnicer R, Hale AB, Suffredini S, Liu X, Reilly S, Zhang MH, Surdo NC, Bendall JK, Crabtree MJ, Lim GB, Alp NJ, Channon KM, Casadei B.

Circ Res. 2012 Aug 31;111(6):718-27. doi: 10.1161/CIRCRESAHA.112.274464. Epub 2012 Jul 12.

PMID:
22798524
6.

Spontaneous aortic thrombosis causing left main coronary occlusion in a man with secondary polycythemia.

Shah NC, Munir SM, Alp NJ.

JACC Cardiovasc Interv. 2011 Aug;4(8):934-5. doi: 10.1016/j.jcin.2011.05.015. No abstract available.

7.

Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins.

Reilly SN, Jayaram R, Nahar K, Antoniades C, Verheule S, Channon KM, Alp NJ, Schotten U, Casadei B.

Circulation. 2011 Sep 6;124(10):1107-17. doi: 10.1161/CIRCULATIONAHA.111.029223. Epub 2011 Aug 15.

PMID:
21844076
8.

Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.

Moens AL, Ketner EA, Takimoto E, Schmidt TS, O'Neill CA, Wolin MS, Alp NJ, Channon KM, Kass DA.

J Mol Cell Cardiol. 2011 Oct;51(4):564-9. doi: 10.1016/j.yjmcc.2011.05.017. Epub 2011 May 30.

9.

Acute myocarditis mimicking reverse Takotsubo cardiomyopathy.

Karamitsos TD, Bull S, Ferreira V, Alp NJ, Neubauer S.

Circulation. 2011 Jan 18;123(2):226-7. doi: 10.1161/CIRCULATIONAHA.110.967794. No abstract available. Erratum in: Circulation. 2011 Sep 20;124(12):e335.

PMID:
21242509
10.

Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection.

Ionova IA, Vásquez-Vivar J, Cooley BC, Khanna AK, Whitsett J, Herrnreiter A, Migrino RQ, Ge ZD, Regner KR, Channon KM, Alp NJ, Pieper GM.

Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H88-96. doi: 10.1152/ajpheart.00203.2010. Epub 2010 Apr 23.

11.

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.

Schmidt TS, McNeill E, Douglas G, Crabtree MJ, Hale AB, Khoo J, O'Neill CA, Cheng A, Channon KM, Alp NJ.

Clin Sci (Lond). 2010 May 6;119(3):131-42. doi: 10.1042/CS20090559.

PMID:
20337596
12.
13.

Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding.

Chamberlain J, Francis S, Brookes Z, Shaw G, Graham D, Alp NJ, Dower S, Crossman DC.

PLoS One. 2009;4(4):e5073. doi: 10.1371/journal.pone.0005073. Epub 2009 Apr 6.

14.

GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.

Tatham AL, Crabtree MJ, Warrick N, Cai S, Alp NJ, Channon KM.

J Biol Chem. 2009 May 15;284(20):13660-8. doi: 10.1074/jbc.M807959200. Epub 2009 Mar 13.

15.

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.

Crabtree MJ, Tatham AL, Al-Wakeel Y, Warrick N, Hale AB, Cai S, Channon KM, Alp NJ.

J Biol Chem. 2009 Jan 9;284(2):1136-44. doi: 10.1074/jbc.M805403200. Epub 2008 Nov 14.

16.

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.

Ali ZA, Bursill CA, Douglas G, McNeill E, Papaspyridonos M, Tatham AL, Bendall JK, Akhtar AM, Alp NJ, Greaves DR, Channon KM.

Circulation. 2008 Sep 30;118(14 Suppl):S71-7. doi: 10.1161/CIRCULATIONAHA.107.753558.

PMID:
18824773
17.

Urban trench fever presenting as culture-negative endocarditis.

Jenkins NE, Ferguson DJ, Alp NJ, Harrison TG, Bowler IC.

QJM. 2009 Jan;102(1):63-5. doi: 10.1093/qjmed/hcn118. Epub 2008 Oct 3.

PMID:
18835881
18.

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.

Antoniades C, Shirodaria C, Van Assche T, Cunnington C, Tegeder I, Lötsch J, Guzik TJ, Leeson P, Diesch J, Tousoulis D, Stefanadis C, Costigan M, Woolf CJ, Alp NJ, Channon KM.

J Am Coll Cardiol. 2008 Jul 8;52(2):158-65. doi: 10.1016/j.jacc.2007.12.062.

19.

Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.

Moens AL, Takimoto E, Tocchetti CG, Chakir K, Bedja D, Cormaci G, Ketner EA, Majmudar M, Gabrielson K, Halushka MK, Mitchell JB, Biswal S, Channon KM, Wolin MS, Alp NJ, Paolocci N, Champion HC, Kass DA.

Circulation. 2008 May 20;117(20):2626-36. doi: 10.1161/CIRCULATIONAHA.107.737031. Epub 2008 May 12.

20.

Role of Chlamydia pneumoniae in atherosclerosis.

Watson C, Alp NJ.

Clin Sci (Lond). 2008 Apr;114(8):509-31. doi: 10.1042/CS20070298. Review.

PMID:
18336368
21.

Endothelial arginase II: a novel target for the treatment of atherosclerosis.

Ryoo S, Gupta G, Benjo A, Lim HK, Camara A, Sikka G, Lim HK, Sohi J, Santhanam L, Soucy K, Tuday E, Baraban E, Ilies M, Gerstenblith G, Nyhan D, Shoukas A, Christianson DW, Alp NJ, Champion HC, Huso D, Berkowitz DE.

Circ Res. 2008 Apr 25;102(8):923-32. doi: 10.1161/CIRCRESAHA.107.169573. Epub 2008 Feb 28.

PMID:
18309100
22.

Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.

Du YH, Guan YY, Alp NJ, Channon KM, Chen AF.

Circulation. 2008 Feb 26;117(8):1045-54. doi: 10.1161/CIRCULATIONAHA.107.748236. Epub 2008 Feb 11.

PMID:
18268143
23.

Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia.

Cosentino F, Hürlimann D, Delli Gatti C, Chenevard R, Blau N, Alp NJ, Channon KM, Eto M, Lerch P, Enseleit F, Ruschitzka F, Volpe M, Lüscher TF, Noll G.

Heart. 2008 Apr;94(4):487-92. Epub 2007 Oct 4.

PMID:
17916662
24.

Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease.

Schmidt TS, Alp NJ.

Clin Sci (Lond). 2007 Jul;113(2):47-63. Review.

PMID:
17555404
25.

Cardiac papillary fibroelastoma presenting with recurrent ventricular tachycardia.

Asrress KN, Mitchell AR, Evans B, Westaby S, Alp NJ.

Pacing Clin Electrophysiol. 2007 Jun;30(6):820-2.

PMID:
17547623
26.

Rescue angioplasty for failed thrombolysis in older patients: insights from the REACT trial.

Alp NJ, Gershlick AH, Carver A, Stevens SE, Wilcox R.

Int J Cardiol. 2008 Apr 10;125(2):254-7. Epub 2007 May 7.

PMID:
17482689
27.

A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression.

Takaya T, Hirata K, Yamashita T, Shinohara M, Sasaki N, Inoue N, Yada T, Goto M, Fukatsu A, Hayashi T, Alp NJ, Channon KM, Yokoyama M, Kawashima S.

Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1632-7. Epub 2007 Apr 26.

PMID:
17463333
28.

Increased in-stent stenosis in ApoE knockout mice: insights from a novel mouse model of balloon angioplasty and stenting.

Ali ZA, Alp NJ, Lupton H, Arnold N, Bannister T, Hu Y, Mussa S, Wheatcroft M, Greaves DR, Gunn J, Channon KM.

Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):833-40. Epub 2007 Jan 4.

PMID:
17204666
29.

Severe endothelial dysfunction in the aorta of a mouse model of Fabry disease; partial prevention by N-butyldeoxynojirimycin treatment.

Heare T, Alp NJ, Priestman DA, Kulkarni AB, Qasba P, Butters TD, Dwek RA, Clarke K, Channon KM, Platt FM.

J Inherit Metab Dis. 2007 Feb;30(1):79-87. Epub 2006 Dec 25.

PMID:
17189993
30.

'Full-house' rheumatic heart disease.

Mathew S, Channon KM, Alp NJ.

Int J Cardiol. 2007 Mar 20;116(2):e55-6. Epub 2006 Nov 7.

PMID:
17084919
31.

Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.

Adlam D, Bendall JK, De Bono JP, Alp NJ, Khoo J, Nicoli T, Yokoyama M, Kawashima S, Channon KM.

Exp Physiol. 2007 Jan;92(1):119-26. Epub 2006 Sep 28.

32.

Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissue.

de Bono JP, Warrick N, Bendall JK, Channon KM, Alp NJ.

Nitric Oxide. 2007 Feb;16(1):1-9. Epub 2006 May 2.

PMID:
16647284
33.
34.

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.

Cai S, Khoo J, Mussa S, Alp NJ, Channon KM.

Diabetologia. 2005 Sep;48(9):1933-40. Epub 2005 Jul 21.

PMID:
16034613
35.

Candida prosthetic valve endocarditis cured by caspofungin therapy without valve replacement.

Rajendram R, Alp NJ, Mitchell AR, Bowler IC, Forfar JC.

Clin Infect Dis. 2005 May 1;40(9):e72-4. Epub 2005 Mar 23.

PMID:
15825018
36.

Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.

Khoo JP, Zhao L, Alp NJ, Bendall JK, Nicoli T, Rockett K, Wilkins MR, Channon KM.

Circulation. 2005 Apr 26;111(16):2126-33. Epub 2005 Apr 11.

PMID:
15824200
37.
38.

Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo.

Schäfer A, Alp NJ, Cai S, Lygate CA, Neubauer S, Eigenthaler M, Bauersachs J, Channon KM.

Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1720-6. Epub 2004 Jul 8.

PMID:
15242858
39.

Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.

Khoo JP, Nicoli T, Alp NJ, Fullerton J, Flint J, Channon KM.

Mol Genet Metab. 2004 Jul;82(3):251-4.

PMID:
15234340
40.

EPR quantification of vascular nitric oxide production in genetically modified mouse models.

Khoo JP, Alp NJ, Bendall JK, Kawashima S, Yokoyama M, Zhang YH, Casadei B, Channon KM.

Nitric Oxide. 2004 May;10(3):156-61.

PMID:
15158695
41.

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.

Alp NJ, McAteer MA, Khoo J, Choudhury RP, Channon KM.

Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):445-50. Epub 2004 Jan 5.

PMID:
14707037
42.

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.

Alp NJ, Channon KM.

Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):413-20. Epub 2003 Dec 4. Review.

PMID:
14656731
43.

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

Alp NJ, Mussa S, Khoo J, Cai S, Guzik T, Jefferson A, Goh N, Rockett KA, Channon KM.

J Clin Invest. 2003 Sep;112(5):725-35.

44.

In-stent restenosis and atherosclerosis in a human saphenous vein graft.

Alp NJ, Gunn J, Channon KM.

Heart. 2003 Feb;89(2):132. No abstract available.

45.

Increased intimal hyperplasia in experimental vein graft stenting compared to arterial stenting: comparisons in a new rabbit model of stent injury.

Alp NJ, West NE, Arnold N, Gunn J, Banning AP, Channon KM.

Cardiovasc Res. 2002 Oct;56(1):164-72.

PMID:
12237177
46.
47.

Semi-permanent cardiac pacing in severe tetanus.

Millo JL, Culshaw MC, Alp NJ, Salmon JB.

Br J Anaesth. 2002 Jun;88(6):882. No abstract available.

PMID:
12173219
48.

Thrombolysis for acute massive pulmonary embolism during pregnancy.

Yap LB, Alp NJ, Forfar JC.

Int J Cardiol. 2002 Feb;82(2):193-4. No abstract available.

PMID:
11853911
49.

A rapid troponin-I-based protocol for assessing acute chest pain.

Alp NJ, Bell JA, Shahi M.

QJM. 2001 Dec;94(12):687-94.

PMID:
11744789
50.

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