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Items: 45


Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.

Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Ocaña A, Tersey SA, Mirmira RG.

Sci Signal. 2019 Dec 3;12(610). pii: eaax0715. doi: 10.1126/scisignal.aax0715.


Atf6α impacts cell number by influencing survival, death and proliferation.

Sharma RB, Snyder JT, Alonso LC.

Mol Metab. 2019 Sep;27S:S69-S80. doi: 10.1016/j.molmet.2019.06.005. Review.


T2D Risk Genes: Exome Sequencing Goes Straight to the Source.

Alonso LC.

Cell Metab. 2019 Jul 2;30(1):10-11. doi: 10.1016/j.cmet.2019.06.010.


DNA Damage Does Not Cause BrdU Labeling of Mouse or Human β-Cells.

Sharma RB, Darko C, Zheng X, Gablaski B, Alonso LC.

Diabetes. 2019 May;68(5):975-987. doi: 10.2337/db18-0761. Epub 2019 Mar 4.


ANRIL: A lncRNA at the CDKN2A/B Locus With Roles in Cancer and Metabolic Disease.

Kong Y, Hsieh CH, Alonso LC.

Front Endocrinol (Lausanne). 2018 Jul 24;9:405. doi: 10.3389/fendo.2018.00405. eCollection 2018. Review.


Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply.

Harmon DB, Wu C, Dedousis N, Sipula IJ, Stefanovic-Racic M, Schoiswohl G, O'Donnell CP, Alonso LC, Kershaw EE, Kelley EE, O'Doherty RM.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E758-E770. doi: 10.1152/ajpendo.00172.2018. Epub 2018 Aug 7.


Pancreatic Islet Embedding for Paraffin Sections.

Kong Y, Ebrahimpour P, Liu Y, Yang C, Alonso LC.

J Vis Exp. 2018 Jun 29;(136). doi: 10.3791/57931.


Children with type 1 diabetes who experienced a honeymoon phase had significantly lower LDL cholesterol 5 years after diagnosis.

Nwosu BU, Zhang B, Ayyoub SS, Choi S, Villalobos-Ortiz TR, Alonso LC, Barton BA.

PLoS One. 2018 May 16;13(5):e0196912. doi: 10.1371/journal.pone.0196912. eCollection 2018.


CDKN2A/B T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets.

Kong Y, Sharma RB, Ly S, Stamateris RE, Jesdale WM, Alonso LC.

Diabetes. 2018 May;67(5):872-884. doi: 10.2337/db17-1055. Epub 2018 Feb 6.


Partial clinical remission in type 1 diabetes: a comparison of the accuracy of total daily dose of insulin of <0.3 units/kg/day to the gold standard insulin-dose adjusted hemoglobin A1c of ≤9 for the detection of partial clinical remission.

Lundberg RL, Marino KR, Jasrotia A, Maranda LS, Barton BA, Alonso LC, Nwosu BU.

J Pediatr Endocrinol Metab. 2017 Aug 28;30(8):823-830. doi: 10.1515/jpem-2017-0019.


A predictive model for lack of partial clinical remission in new-onset pediatric type 1 diabetes.

Marino KR, Lundberg RL, Jasrotia A, Maranda LS, Thompson MJ, Barton BA, Alonso LC, Nwosu BU.

PLoS One. 2017 May 1;12(5):e0176860. doi: 10.1371/journal.pone.0176860. eCollection 2017.


Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.

Roth Flach RJ, Danai LV, DiStefano MT, Kelly M, Menendez LG, Jurczyk A, Sharma RB, Jung DY, Kim JH, Kim JK, Bortell R, Alonso LC, Czech MP.

J Biol Chem. 2016 Jul 29;291(31):16221-30. doi: 10.1074/jbc.M116.718932. Epub 2016 May 20.


Islet biology, the CDKN2A/B locus and type 2 diabetes risk.

Kong Y, Sharma RB, Nwosu BU, Alonso LC.

Diabetologia. 2016 Aug;59(8):1579-93. doi: 10.1007/s00125-016-3967-7. Epub 2016 May 7. Review.


In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy.

Choudhury SR, Fitzpatrick Z, Harris AF, Maitland SA, Ferreira JS, Zhang Y, Ma S, Sharma RB, Gray-Edwards HL, Johnson JA, Johnson AK, Alonso LC, Punzo C, Wagner KR, Maguire CA, Kotin RM, Martin DR, Sena-Esteves M.

Mol Ther. 2016 Aug;24(7):1247-57. doi: 10.1038/mt.2016.84. Epub 2016 Apr 27.


PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2.

Lakshmipathi J, Alvarez-Perez JC, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC, Garcia-Ocaña A.

Diabetes. 2016 May;65(5):1283-96. doi: 10.2337/db15-1398. Epub 2016 Feb 11.


Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor.

Stamateris RE, Sharma RB, Kong Y, Ebrahimpour P, Panday D, Ranganath P, Zou B, Levitt H, Parambil NA, O'Donnell CP, García-Ocaña A, Alonso LC.

Diabetes. 2016 Apr;65(4):981-95. doi: 10.2337/db15-0529. Epub 2016 Jan 6.


Early initiation of low-level parenteral dextrose induces an accelerated diabetic phenotype in septic C57BL/6J mice.

Singamsetty S, Shah FA, Guo L, Watanabe Y, McDonald S, Sharma R, Zhang Y, Alonso LC, O'Donnell CP, McVerry BJ.

Appl Physiol Nutr Metab. 2016 Jan;41(1):12-9. doi: 10.1139/apnm-2015-0213. Epub 2015 Sep 9.


Insulin demand regulates β cell number via the unfolded protein response.

Sharma RB, O'Donnell AC, Stamateris RE, Ha B, McCloskey KM, Reynolds PR, Arvan P, Alonso LC.

J Clin Invest. 2015 Oct 1;125(10):3831-46. doi: 10.1172/JCI79264. Epub 2015 Sep 21.


Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?

Sharma RB, Alonso LC.

Curr Diab Rep. 2014 Jun;14(6):492. doi: 10.1007/s11892-014-0492-2. Review.


Glucagon regulates hepatic kisspeptin to impair insulin secretion.

Song WJ, Mondal P, Wolfe A, Alonso LC, Stamateris R, Ong BW, Lim OC, Yang KS, Radovick S, Novaira HJ, Farber EA, Farber CR, Turner SD, Hussain MA.

Cell Metab. 2014 Apr 1;19(4):667-81. doi: 10.1016/j.cmet.2014.03.005.


Human β-cell regeneration: progress, hurdles, and controversy.

Jurczyk A, Bortell R, Alonso LC.

Curr Opin Endocrinol Diabetes Obes. 2014 Apr;21(2):102-8. doi: 10.1097/MED.0000000000000042. Review.


The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes.

Kilic G, Alvarez-Mercado AI, Zarrouki B, Opland D, Liew CW, Alonso LC, Myers MG Jr, Jonas JC, Poitout V, Kulkarni RN, Mauvais-Jarvis F.

PLoS One. 2014 Feb 3;9(2):e87941. doi: 10.1371/journal.pone.0087941. eCollection 2014.


Exogenous glucose administration impairs glucose tolerance and pancreatic insulin secretion during acute sepsis in non-diabetic mice.

Watanabe Y, Singamsetty S, Zou B, Guo L, Stefanovski D, Alonso LC, Garcia-Ocana A, O'Donnell CP, McVerry BJ.

PLoS One. 2013 Jun 24;8(6):e67716. doi: 10.1371/journal.pone.0067716. Print 2013.


Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.

Stamateris RE, Sharma RB, Hollern DA, Alonso LC.

Am J Physiol Endocrinol Metab. 2013 Jul 1;305(1):E149-59. doi: 10.1152/ajpendo.00040.2013. Epub 2013 May 14.


Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia.

Lee EJ, Alonso LC, Stefanovski D, Strollo HC, Romano LC, Zou B, Singamsetty S, Yester KA, McGaffin KR, Garcia-Ocana A, O'Donnell CP.

Eur J Appl Physiol. 2013 Feb;113(2):467-78. doi: 10.1007/s00421-012-2452-3. Epub 2012 Jul 17.


ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.

Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK.

Diabetes. 2012 Aug;61(8):2004-15. doi: 10.2337/db11-0802. Epub 2012 May 14.


Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus.

Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, Casinelli GP, Alonso LC, Vasavada RC, García-Ocana A.

Diabetes. 2012 May;61(5):1143-52. doi: 10.2337/db11-1154. Epub 2012 Mar 16.


Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18.

Pascoe J, Hollern D, Stamateris R, Abbasi M, Romano LC, Zou B, O'Donnell CP, Garcia-Ocana A, Alonso LC.

Diabetes. 2012 Mar;61(3):632-41. doi: 10.2337/db11-0991. Epub 2012 Feb 14.


Simultaneous measurement of insulin sensitivity, insulin secretion, and the disposition index in conscious unhandled mice.

Alonso LC, Watanabe Y, Stefanovski D, Lee EJ, Singamsetty S, Romano LC, Zou B, Garcia-Ocaña A, Bergman RN, O'Donnell CP.

Obesity (Silver Spring). 2012 Jul;20(7):1403-12. doi: 10.1038/oby.2012.36. Epub 2012 Feb 14.


Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation.

Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A.

Diabetes. 2011 Oct;60(10):2546-59. doi: 10.2337/db10-1783. Epub 2011 Sep 12.


Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes.

Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocaña A.

Diabetes. 2011 Feb;60(2):525-36. doi: 10.2337/db09-1305. Epub 2010 Oct 27.


Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice.

Levitt HE, Cyphert TJ, Pascoe JL, Hollern DA, Abraham N, Lundell RJ, Rosa T, Romano LC, Zou B, O'Donnell CP, Stewart AF, Garcia-Ocaña A, Alonso LC.

Diabetologia. 2011 Mar;54(3):572-82. doi: 10.1007/s00125-010-1919-1. Epub 2010 Oct 9.


Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness.

Woodske ME, Yokoe T, Zou B, Romano LC, Rosa TC, Garcia-Ocana A, Alonso LC, O'Donnell CP, McVerry BJ.

Crit Care Med. 2009 Sep;37(9):2596-603. doi: 10.1097/CCM.0b013e3181a9338a.


Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice.

Yokoe T, Alonso LC, Romano LC, Rosa TC, O'Doherty RM, Garcia-Ocana A, Minoguchi K, O'Donnell CP.

J Physiol. 2008 Feb 1;586(3):899-911. Epub 2007 Nov 22.


Glucose infusion in mice: a new model to induce beta-cell replication.

Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, Garcia-Ocaña A.

Diabetes. 2007 Jul;56(7):1792-801. Epub 2007 Mar 30.


Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity.

Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocana A, O'Doherty RM, Polotsky VY, O'Donnell CP.

Am J Respir Crit Care Med. 2007 Apr 15;175(8):851-7. Epub 2007 Feb 1.


Single molecule electron transfer dynamics in complex environments.

Leite VB, Alonso LC, Newton M, Wang J.

Phys Rev Lett. 2005 Sep 9;95(11):118301. Epub 2005 Sep 8.


Molecular genetic and endocrine mechanisms of hair growth.

Alonso LC, Rosenfield RL.

Horm Res. 2003;60(1):1-13. Review.


Oestrogens and puberty.

Alonso LC, Rosenfield RL.

Best Pract Res Clin Endocrinol Metab. 2002 Mar;16(1):13-30. Review.


Functional characterization of soluble and membrane-bound forms of vaccinia virus complement control protein (VCP).

Rosengard AM, Alonso LC, Korb LC, Baldwin WM 3rd, Sanfilippo F, Turka LA, Ahearn JM.

Mol Immunol. 1999 Jul;36(10):685-97.


Helium-ion-induced human cataractogenesis.

Blakely EA, Daftari IK, Meecham WJ, Alonso LC, Collier JM, Kroll SM, Gillette EL, Lee AC, Lett JT, Cox AB, Castro JR, Char DH.

Adv Space Res. 1994 Oct;14(10):501-5.


Genetic resistance to disease and abiotic factors of genetically modified crops.

Alonso LC.

Prog Lipid Res. 1994;33(1-2):175-83. No abstract available.


The theory of the pairing of telocentric chromosomes in triploids and trisomics.

Kimber G, Alonso LC.

Can J Genet Cytol. 1984 Jun;26(3):231-6.


[Spontaneous pneumothorax complicating asthma; presentation of two cases].


Rev Cubana Pediatr. 1956 Jan;28(1):33-44. Spanish. No abstract available.


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