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Items: 1 to 50 of 183

1.

Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors.

Kulén M, Núñez-Otero C, Cairns AG, Silver J, Lindgren AEG, Wede E, Singh P, Vielfort K, Bahnan W, Good JAD, Svensson R, Bergström S, Gylfe Å, Almqvist F.

Medchemcomm. 2019 Oct 17;10(11):1966-1987. doi: 10.1039/c9md00405j. eCollection 2019 Nov 1.

2.

Synthesis of Densely Functionalized N-Alkenyl 2-Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2-Pyridones.

Singh P, Cairns AG, Adolfsson DE, Ådén J, Sauer UH, Almqvist F.

Org Lett. 2019 Aug 16. doi: 10.1021/acs.orglett.9b02549. [Epub ahead of print]

PMID:
31419146
3.

Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis.

Flentie K, Harrison GA, Tükenmez H, Livny J, Good JAD, Sarkar S, Zhu DX, Kinsella RL, Weiss LA, Solomon SD, Schene ME, Hansen MR, Cairns AG, Kulén M, Wixe T, Lindgren AEG, Chorell E, Bengtsson C, Krishnan KS, Hultgren SJ, Larsson C, Almqvist F, Stallings CL.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10510-10517. doi: 10.1073/pnas.1818009116. Epub 2019 May 6.

4.

A role for the auxin precursor anthranilic acid in root gravitropism via regulation of PIN-FORMED protein polarity and relocalisation in Arabidopsis.

Doyle SM, Rigal A, Grones P, Karady M, Barange DK, Majda M, Pařízková B, Karampelias M, Zwiewka M, Pěnčík A, Almqvist F, Ljung K, Novák O, Robert S.

New Phytol. 2019 Aug;223(3):1420-1432. doi: 10.1111/nph.15877. Epub 2019 Jun 7.

PMID:
31038751
5.

Viral mimetic priming enhances α-synuclein-induced degeneration: Implications for Parkinson's disease.

Olsen LK, Cairns AG, Ådén J, Moriarty N, Cabre S, Alamilla VR, Almqvist F, Dowd E, McKernan DP.

Brain Behav Immun. 2019 Aug;80:525-535. doi: 10.1016/j.bbi.2019.04.036. Epub 2019 Apr 25.

PMID:
31029796
6.

Visible-Light-Mediated Synthesis of β-Chloro Ketones from Aryl Cyclopropanes.

Petzold D, Singh P, Almqvist F, König B.

Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8577-8580. doi: 10.1002/anie.201902473. Epub 2019 May 22.

PMID:
30901148
7.

Pyridine-Fused 2-Pyridones via Povarov and A3 Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding.

Singh P, Adolfsson DE, Ådén J, Cairns AG, Bartens C, Brännström K, Olofsson A, Almqvist F.

J Org Chem. 2019 Apr 5;84(7):3887-3903. doi: 10.1021/acs.joc.8b03015. Epub 2019 Mar 20.

PMID:
30862161
8.

Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development.

Vain T, Raggi S, Ferro N, Barange DK, Kieffer M, Ma Q, Doyle SM, Thelander M, Pařízková B, Novák O, Ismail A, Enquist PA, Rigal A, Łangowska M, Ramans Harborough S, Zhang Y, Ljung K, Callis J, Almqvist F, Kepinski S, Estelle M, Pauwels L, Robert S.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6463-6472. doi: 10.1073/pnas.1809037116. Epub 2019 Mar 8.

9.

Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli.

Omattage NS, Deng Z, Pinkner JS, Dodson KW, Almqvist F, Yuan P, Hultgren SJ.

Nat Microbiol. 2018 Dec;3(12):1362-1368. doi: 10.1038/s41564-018-0255-y. Epub 2018 Oct 1.

10.

Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug Strategy.

Cairns AG, Vazquez-Romero A, Mahdi Moein M, Ådén J, Elmore CS, Takano A, Arakawa R, Varrone A, Almqvist F, Schou M.

ACS Chem Neurosci. 2018 Nov 21;9(11):2542-2547. doi: 10.1021/acschemneuro.8b00236. Epub 2018 Jun 19.

PMID:
29901990
11.

Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.

Kulén M, Lindgren M, Hansen S, Cairns AG, Grundström C, Begum A, van der Lingen I, Brännström K, Hall M, Sauer UH, Johansson J, Sauer-Eriksson AE, Almqvist F.

J Med Chem. 2018 May 10;61(9):4165-4175. doi: 10.1021/acs.jmedchem.8b00289. Epub 2018 Apr 27.

PMID:
29667825
12.

Testing Syndromes of Psychopathology in Parent and Youth Ratings Across Societies.

Ivanova MY, Achenbach TM, Rescorla LA, Guo J, Althoff RR, Kan KJ, Almqvist F, Begovac I, Broberg AG, Chahed M, da Rocha MM, Dobrean A, Döepfner M, Erol N, Fombonne E, Fonseca AC, Forns M, Frigerio A, Grietens H, Hewitt-Ramirez N, Juarez F, Kajokienė I, Kanbayashi Y, Kim YA, Larsson B, Leung P, Liu X, Maggiolini A, Minaei A, Moreira PAS, Oh KJ, Petot D, Pisa C, Pomalima R, Roussos A, Rudan V, Sawyer M, Shahini M, Ferreira de Mattos Silvares E, Simsek Z, Steinhausen HC, Szirovicza L, Valverde J, Viola L, Weintraub S, Metzke CW, Wolanczyk T, Woo B, Zhang EY, Zilber N, Žukauskienė R, Verhulst FC.

J Clin Child Adolesc Psychol. 2019 Jul-Aug;48(4):596-609. doi: 10.1080/15374416.2017.1405352. Epub 2018 Jan 24.

PMID:
29364720
13.

Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin.

Jain N, Ådén J, Nagamatsu K, Evans ML, Li X, McMichael B, Ivanova MI, Almqvist F, Buxbaum JN, Chapman MR.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12184-12189. doi: 10.1073/pnas.1708805114. Epub 2017 Oct 30.

14.

Thiazolino 2-Pyridone Amide Isosteres As Inhibitors of Chlamydia trachomatis Infectivity.

Good JAD, Kulén M, Silver J, Krishnan KS, Bahnan W, Núñez-Otero C, Nilsson I, Wede E, de Groot E, Gylfe Å, Bergström S, Almqvist F.

J Med Chem. 2017 Nov 22;60(22):9393-9399. doi: 10.1021/acs.jmedchem.7b00716. Epub 2017 Nov 3.

PMID:
29053275
15.

Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease.

Pokrzywa M, Pawełek K, Kucia WE, Sarbak S, Chorell E, Almqvist F, Wittung-Stafshede P.

PLoS One. 2017 Sep 1;12(9):e0184117. doi: 10.1371/journal.pone.0184117. eCollection 2017.

16.

Regio- and Stereoselective Alkylation of Pyridine-N-oxides: Synthesis of Substituted Piperidines and Pyridines.

Barange DK, Johnson MT, Cairns AG, Olsson R, Almqvist F.

Org Lett. 2016 Dec 16;18(24):6228-6231. Epub 2016 Nov 28.

PMID:
27978656
17.

Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria.

Hall M, Grundström C, Begum A, Lindberg MJ, Sauer UH, Almqvist F, Johansson J, Sauer-Eriksson AE.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14733-14738. doi: 10.1073/pnas.1614028114. Epub 2016 Dec 5.

18.

Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system.

Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM.

Oncogene. 2016 Dec 1;35(48):6262-6269. doi: 10.1038/onc.2016.158. Epub 2016 May 9.

19.

Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens.

Shaffer CL, Good JA, Kumar S, Krishnan KS, Gaddy JA, Loh JT, Chappell J, Almqvist F, Cover TL, Hadjifrangiskou M.

mBio. 2016 Apr 26;7(2):e00221-16. doi: 10.1128/mBio.00221-16.

20.

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.

Good JA, Andersson C, Hansen S, Wall J, Krishnan KS, Begum A, Grundström C, Niemiec MS, Vaitkevicius K, Chorell E, Wittung-Stafshede P, Sauer UH, Sauer-Eriksson AE, Almqvist F, Johansson J.

Cell Chem Biol. 2016 Mar 17;23(3):404-14. doi: 10.1016/j.chembiol.2016.02.013.

21.

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity.

Good JA, Silver J, Núñez-Otero C, Bahnan W, Krishnan KS, Salin O, Engström P, Svensson R, Artursson P, Gylfe Å, Bergström S, Almqvist F.

J Med Chem. 2016 Mar 10;59(5):2094-108. doi: 10.1021/acs.jmedchem.5b01759. Epub 2016 Feb 22.

PMID:
26849778
22.

Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice.

Chermenina M, Chorell E, Pokrzywa M, Antti H, Almqvist F, Strömberg I, Wittung-Stafshede P.

NPJ Parkinsons Dis. 2015 Dec 17;1:15024. doi: 10.1038/npjparkd.2015.24. eCollection 2015.

23.

Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation.

Singh P, Chorell E, Krishnan KS, Kindahl T, Åden J, Wittung-Stafshede P, Almqvist F.

Org Lett. 2015 Dec 18;17(24):6194-7. doi: 10.1021/acs.orglett.5b03190. Epub 2015 Dec 9.

PMID:
26650849
24.

Corrigendum: Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.

Nors Pedersen M, Foderà V, Horvath I, van Maarschalkerweerd A, Nørgaard Toft K, Weise C, Almqvist F, Wolf-Watz M, Wittung-Stafshede P, Vestergaard B.

Sci Rep. 2015 Oct 28;5:15692. doi: 10.1038/srep15692. No abstract available.

25.

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts.

Chorell E, Andersson E, Evans ML, Jain N, Götheson A, Åden J, Chapman MR, Almqvist F, Wittung-Stafshede P.

PLoS One. 2015 Oct 14;10(10):e0140194. doi: 10.1371/journal.pone.0140194. eCollection 2015.

26.

Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.

Nors Perdersen M, Foderà V, Horvath I, van Maarschalkerweerd A, Nørgaard Toft K, Weise C, Almqvist F, Wolf-Watz M, Wittung-Stafshede P, Vestergaard B.

Sci Rep. 2015 May 28;5:10422. doi: 10.1038/srep10422. Erratum in: Sci Rep. 2015;5:15692.

27.

Expansion of the Chlamydia trachomatis inclusion does not require bacterial replication.

Engström P, Bergström M, Alfaro AC, Syam Krishnan K, Bahnan W, Almqvist F, Bergström S.

Int J Med Microbiol. 2015 May;305(3):378-82. doi: 10.1016/j.ijmm.2015.02.007. Epub 2015 Feb 27.

28.

Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili.

Floyd KA, Moore JL, Eberly AR, Good JA, Shaffer CL, Zaver H, Almqvist F, Skaar EP, Caprioli RM, Hadjifrangiskou M.

PLoS Pathog. 2015 Mar 4;11(3):e1004697. doi: 10.1371/journal.ppat.1004697. eCollection 2015 Mar.

29.

Biological methods to enhance bone healing and fracture repair.

Verdonk R, Goubau Y, Almqvist FK, Verdonk P.

Arthroscopy. 2015 Apr;31(4):715-8. doi: 10.1016/j.arthro.2014.11.045. Epub 2015 Feb 11.

PMID:
25682328
30.

The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.

Evans ML, Chorell E, Taylor JD, Åden J, Götheson A, Li F, Koch M, Sefer L, Matthews SJ, Wittung-Stafshede P, Almqvist F, Chapman MR.

Mol Cell. 2015 Feb 5;57(3):445-55. doi: 10.1016/j.molcel.2014.12.025. Epub 2015 Jan 22.

31.

A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis.

Engström P, Krishnan KS, Ngyuen BD, Chorell E, Normark J, Silver J, Bastidas RJ, Welch MD, Hultgren SJ, Wolf-Watz H, Valdivia RH, Almqvist F, Bergström S.

mBio. 2014 Dec 30;6(1):e02304-14. doi: 10.1128/mBio.02304-14.

32.

Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli.

Greene SE, Pinkner JS, Chorell E, Dodson KW, Shaffer CL, Conover MS, Livny J, Hadjifrangiskou M, Almqvist F, Hultgren SJ.

mBio. 2014 Oct 28;5(6):e02038. doi: 10.1128/mBio.02038-14.

33.

Design of a general-purpose European compound screening library for EU-OPENSCREEN.

Horvath D, Lisurek M, Rupp B, Kühne R, Specker E, von Kries J, Rognan D, Andersson CD, Almqvist F, Elofsson M, Enqvist PA, Gustavsson AL, Remez N, Mestres J, Marcou G, Varnek A, Hibert M, Quintana J, Frank R.

ChemMedChem. 2014 Oct;9(10):2309-26. doi: 10.1002/cmdc.201402126. Epub 2014 Jul 15.

PMID:
25044981
34.

Parent-teacher agreement on children's problems in 21 societies.

Rescorla LA, Bochicchio L, Achenbach TM, Ivanova MY, Almqvist F, Begovac I, Bilenberg N, Bird H, Dobrean A, Erol N, Fombonne E, Fonseca A, Frigerio A, Fung DS, Lambert MC, Leung PW, Liu X, Marković I, Markovic J, Minaei A, Ooi YP, Roussos A, Rudan V, Simsek Z, van der Ende J, Weintraub S, Wolanczyk T, Woo B, Weiss B, Weisz J, Zukauskiene R, Verhulst FC.

J Clin Child Adolesc Psychol. 2014;43(4):627-42. doi: 10.1080/15374416.2014.900719. Epub 2014 Apr 30.

PMID:
24787452
35.

Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity.

Dang HT, Chorell E, Uvell H, Pinkner JS, Hultgren SJ, Almqvist F.

Org Biomol Chem. 2014 Mar 28;12(12):1942-56. doi: 10.1039/c3ob42478b. Epub 2014 Feb 17.

36.

Isolation and characterization of anti-adenoviral secondary metabolites from marine actinobacteria.

Strand M, Carlsson M, Uvell H, Islam K, Edlund K, Cullman I, Altermark B, Mei YF, Elofsson M, Willassen NP, Wadell G, Almqvist F.

Mar Drugs. 2014 Jan 28;12(2):799-821. doi: 10.3390/md12020799.

37.

Synthesis of fluorescent ring-fused 2-pyridone peptidomimetics.

Krishnan KS, Bengtsson C, Good JA, Mirkhanov S, Chorell E, Johansson LB, Almqvist F.

J Org Chem. 2013 Dec 6;78(23):12207-13. doi: 10.1021/jo401844y. Epub 2013 Nov 14.

PMID:
24161000
38.

Modulation of curli assembly and pellicle biofilm formation by chemical and protein chaperones.

Andersson EK, Bengtsson C, Evans ML, Chorell E, Sellstedt M, Lindgren AE, Hufnagel DA, Bhattacharya M, Tessier PM, Wittung-Stafshede P, Almqvist F, Chapman MR.

Chem Biol. 2013 Oct 24;20(10):1245-54. doi: 10.1016/j.chembiol.2013.07.017. Epub 2013 Sep 12.

39.

Asymmetric synthesis of 2,4,5-trisubstituted Δ2-thiazolines.

Bengtsson C, Nelander H, Almqvist F.

Chemistry. 2013 Jul 22;19(30):9916-22. doi: 10.1002/chem.201301120. Epub 2013 Jun 17.

40.

Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: templation and inhibition involve oligomers with different structure.

Horvath I, Sellstedt M, Weise C, Nordvall LM, Krishna Prasad G, Olofsson A, Larsson G, Almqvist F, Wittung-Stafshede P.

Arch Biochem Biophys. 2013 Apr 15;532(2):84-90. doi: 10.1016/j.abb.2013.01.012. Epub 2013 Feb 9.

PMID:
23399432
41.

Age-specific prevalence of intellectual disability in Finland at the beginning of new millennium--multiple register method.

Westerinen H, Kaski M, Virta LJ, Almqvist F, Iivanainen M.

J Intellect Disabil Res. 2014 Mar;58(3):285-95. doi: 10.1111/jir.12017. Epub 2013 Jan 21.

PMID:
23336674
42.

Enantioselective synthesis of substituted piperidines by addition of aryl Grignard reagents to pyridine N-oxides.

Hussain M, Banchelin TS, Andersson H, Olsson R, Almqvist F.

Org Lett. 2013 Jan 4;15(1):54-7. doi: 10.1021/ol303085q. Epub 2012 Dec 20.

PMID:
23256529
43.

Cross-informant agreement between parent-reported and adolescent self-reported problems in 25 societies.

Rescorla LA, Ginzburg S, Achenbach TM, Ivanova MY, Almqvist F, Begovac I, Bilenberg N, Bird H, Chahed M, Dobrean A, Döpfner M, Erol N, Hannesdottir H, Kanbayashi Y, Lambert MC, Leung PW, Minaei A, Novik TS, Oh KJ, Petot D, Petot JM, Pomalima R, Rudan V, Sawyer M, Simsek Z, Steinhausen HC, Valverde J, Ende Jv, Weintraub S, Metzke CW, Wolanczyk T, Zhang EY, Zukauskiene R, Verhulst FC.

J Clin Child Adolesc Psychol. 2013;42(2):262-73. doi: 10.1080/15374416.2012.717870. Epub 2012 Sep 25.

PMID:
23009025
44.

Childhood bullying and becoming a young father in a national cohort of Finnish boys.

Lehti V, Klomek AB, Tamminen T, Moilanen I, Kumpulainen K, Piha J, Almqvist F, Sourander A.

Scand J Psychol. 2012 Dec;53(6):461-6. doi: 10.1111/j.1467-9450.2012.00971.x. Epub 2012 Aug 24.

PMID:
22924804
45.

Promiscuous cross-seeding between bacterial amyloids promotes interspecies biofilms.

Zhou Y, Smith D, Leong BJ, Brännström K, Almqvist F, Chapman MR.

J Biol Chem. 2012 Oct 12;287(42):35092-103. doi: 10.1074/jbc.M112.383737. Epub 2012 Aug 13.

46.

Childhood predictors of becoming a teenage mother among Finnish girls.

Lehti V, Niemelä S, Heinze M, Sillanmäki L, Helenius H, Piha J, Kumpulainen K, Tamminen T, Almqvist F, Sourander A.

Acta Obstet Gynecol Scand. 2012 Nov;91(11):1319-25. doi: 10.1111/j.1600-0412.2012.01517.x. Epub 2012 Sep 18.

PMID:
22882123
47.

Psychosocial factors associated with becoming a young father in Finland: a nationwide longitudinal study.

Lehti V, Sourander A, Sillanmäki L, Helenius H, Tamminen T, Kumpulainen K, Almqvist F.

BMC Public Health. 2012 Jul 27;12:560. doi: 10.1186/1471-2458-12-560.

48.

Design, synthesis and evaluation of triazole functionalized ring-fused 2-pyridones as antibacterial agents.

Bengtsson C, Lindgren AE, Uvell H, Almqvist F.

Eur J Med Chem. 2012 Aug;54:637-46. doi: 10.1016/j.ejmech.2012.06.018. Epub 2012 Jun 18.

49.

The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation.

Hammer ND, McGuffie BA, Zhou Y, Badtke MP, Reinke AA, Brännström K, Gestwicki JE, Olofsson A, Almqvist F, Chapman MR.

J Mol Biol. 2012 Sep 21;422(3):376-89. doi: 10.1016/j.jmb.2012.05.043. Epub 2012 Jun 7.

50.

Childhood predictors of antipsychotic use among young people in Finland.

Gyllenberg D, Sourander A, Helenius H, Sillanmäki L, Huttunen J, Piha J, Kumpulainen K, Tamminen T, Moilanen I, Almqvist F.

Pharmacoepidemiol Drug Saf. 2012 Sep;21(9):964-71. doi: 10.1002/pds.3265. Epub 2012 Apr 4.

PMID:
22473622

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